메뉴 건너뛰기




Volumn 12, Issue 5, 2012, Pages 555-563

Safety of engineered allergen-specific immunotherapy vaccines

Author keywords

allergen; allergy; engineered vaccines; immunotherapy; safety

Indexed keywords

ALLERGEN; BESTATIN; BUPIVACAINE; CALCITRIOL; DNA VACCINE; EPITOPE; FOOD ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 13; LIPOPLEX; LIPOSOME; PLASMID DNA; POLLEN EXTRACT; PROTEIN VP1; VACCINE;

EID: 84865976131     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e328357ca53     Document Type: Review
Times cited : (38)

References (66)
  • 2
    • 29544438445 scopus 로고    scopus 로고
    • Allergic disease and sensitization in Steiner school children
    • Floistrup H, Swartz J, Bergstrom A, et al. Allergic disease and sensitization in Steiner school children. J Allergy Clin Immunol 2006; 117:59-66.
    • (2006) J Allergy Clin Immunol , vol.117 , pp. 59-66
    • Floistrup, H.1    Swartz, J.2    Bergstrom, A.3
  • 3
    • 50249230114 scopus 로고
    • Prophylactic inoculation against hayfever
    • Noon L. Prophylactic inoculation against hayfever. Lancet 1911; 1:1572-1573.
    • (1911) Lancet , vol.1 , pp. 1572-2157
    • Noon, L.1
  • 5
    • 34247569209 scopus 로고
    • Serological evidence of immunity with coexisting sensitization in a type of human allergy
    • Cooke RA, Barnard JH, Hebald S, Stull A. Serological evidence of immunity with coexisting sensitization in a type of human allergy. J Exp Med 1935; 62:733-750.
    • (1935) J Exp Med , vol.62 , pp. 733-775
    • Cooke, R.A.1    Barnard, J.H.2    Hebald, S.3    Stull, A.4
  • 7
    • 0031736285 scopus 로고    scopus 로고
    • Allergen immunotherapy: Therapeutic vaccines for allergic diseases. A WHO position paper
    • Bousquet J, Lockey R, Malling HJ. Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper. J Allergy Clin Immunol 1998; 102:558-562.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 558-656
    • Bousquet, J.1    Lockey, R.2    Malling, H.J.3
  • 8
    • 0033549827 scopus 로고    scopus 로고
    • Long-term clinical efficacy of grasspollen immunotherapy
    • Durham SR, Walker SM, Varga EM, et al. Long-term clinical efficacy of grasspollen immunotherapy. N Engl J Med 1999; 341:468-475.
    • (1999) N Engl J Med , vol.341 , pp. 468-547
    • Durham, S.R.1    Walker, S.M.2    Varga, E.M.3
  • 9
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PATstudy)
    • Möller C, Dreborg S, Ferdousi HA, et al. Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PATstudy). J Allergy Clin Immunol 2002; 109:251-256.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 251-325
    • Möller, C.1    Dreborg, S.2    Ferdousi, H.A.3
  • 10
    • 3042758886 scopus 로고    scopus 로고
    • Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001
    • Bernstein DI, Wanner M, Borish L, et al. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001. J Allergy Clin Immunol 2004; 113:1129-1136.
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 1129-2113
    • Bernstein, D.I.1    Wanner, M.2    Borish, L.3
  • 11
    • 80053546277 scopus 로고    scopus 로고
    • T cell epitope-based allergy vaccines
    • Larché M. T cell epitope-based allergy vaccines. Curr Top Microbiol Immunol 2011; 352:107-119.
    • (2011) Curr Top Microbiol Immunol , vol.352 , pp. 107-111
    • Larché, M.1
  • 12
    • 84861963114 scopus 로고    scopus 로고
    • Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives
    • Linhart B, Valenta R. Mechanisms underlying allergy vaccination with recombinant hypoallergenic allergen derivatives. Vaccine 2012; 30:4328-4335.
    • (2012) Vaccine , vol.30 , pp. 4328-4433
    • Linhart, B.1    Valenta, R.2
  • 13
    • 0036598404 scopus 로고    scopus 로고
    • The future of antigen-specific immunotherapy of allergy
    • Valenta R. The future of antigen-specific immunotherapy of allergy. Nat Rev Immunol 2002; 2:446-453.
    • (2002) Nat Rev Immunol , vol.2 , pp. 446-545
    • Valenta, R.1
  • 14
    • 76349094087 scopus 로고    scopus 로고
    • Developments in allergen-specific immunotherapy: From allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin e and T cell reactivity
    • Focke M, Swoboda I, Marth K, et al. Developments in allergen-specific immunotherapy: from allergen extracts to allergy vaccines bypassing allergen-specific immunoglobulin E and T cell reactivity. Clin Exp Allergy 2010; 40:385-397.
    • (2010) Clin Exp Allergy , vol.40 , pp. 385-439
    • Focke, M.1    Swoboda, I.2    Marth, K.3
  • 15
    • 78650901420 scopus 로고    scopus 로고
    • Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy
    • Worm M, Lee HH, Kleine-Tebbe J, et al. Development and preliminary clinical evaluation of a peptide immunotherapy vaccine for cat allergy. J Allergy Clin Immunol 2011; 127:89-97.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 89-99
    • Worm, M.1    Lee, H.H.2    Kleine-Tebbe, J.3
  • 16
    • 0014786859 scopus 로고
    • Studies on 'allergoids' prepared from naturally occurring allergens. I. Assay of allergenicity and antigenicity of formalinized rye group i component
    • Marsh DG, Lichtenstein LM, Campbell DH. Studies on 'allergoids' prepared from naturally occurring allergens. I. Assay of allergenicity and antigenicity of formalinized rye group I component. Immunology 1970; 18:705-722.
    • (1970) Immunology , vol.18 , pp. 705-772
    • Marsh, D.G.1    Lichtenstein, L.M.2    Campbell, D.H.3
  • 17
    • 77957565546 scopus 로고    scopus 로고
    • Efficacy and safety of a glutaraldehyde-modified house dust mite extract in allergic rhinitis
    • Riechelmann H, Schmutzhard J, van der Werf JF, et al. Efficacy and safety of a glutaraldehyde-modified house dust mite extract in allergic rhinitis. Am J Rhinol Allergy 2010; 24:e104-e109.
    • (2010) Am J Rhinol Allergy , vol.24
    • Riechelmann, H.1    Schmutzhard, J.2    Van Der Werf, J.F.3
  • 18
    • 80053201701 scopus 로고    scopus 로고
    • Safety of specific immunotherapy using a depigmented and polymerised extract of dermatophagoides pteronyssinus in children under five years of age
    • Hernández N, Ibero M, Ridao M, et al. Safety of specific immunotherapy using a depigmented and polymerised extract of dermatophagoides pteronyssinus in children under five years of age. Allergol Immunopathol (Madr) 2011; 39: 267-270.
    • (2011) Allergol Immunopathol (Madr) , vol.39 , pp. 267-327
    • Hernández, N.1    Ibero, M.2    Ridao, M.3
  • 19
    • 77950045625 scopus 로고    scopus 로고
    • Depigmented and polymerised house dust mite allergoid: Allergen content, induction of IgG4 and clinical response
    • Gallego MT, Iraola V, Himly M, et al. Depigmented and polymerised house dust mite allergoid: allergen content, induction of IgG4 and clinical response. Int Arch Allergy Immunol 2010; 153:61-69.
    • (2010) Int Arch Allergy Immunol , vol.153 , pp. 61-66
    • Gallego, M.T.1    Iraola, V.2    Himly, M.3
  • 20
    • 77953644176 scopus 로고    scopus 로고
    • Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma
    • Pfaar O, Klimek L, Sager A, et al. Safety of a depigmented, polymerized vaccine for the treatment of allergic rhinoconjunctivitis and allergic asthma. Am J Rhinol Allergy 2010; 24:220-225.
    • (2010) Am J Rhinol Allergy , vol.24 , pp. 220-222
    • Pfaar, O.1    Klimek, L.2    Sager, A.3
  • 21
    • 78349299047 scopus 로고    scopus 로고
    • Immunotherapy with depigmentedpolymerized mixed tree pollen extract: A clinical trial and responder analysis
    • Pfaar O, Robinson DS, Sager A, et al. Immunotherapy with depigmentedpolymerized mixed tree pollen extract: a clinical trial and responder analysis. Allergy 2011; 65:1614-1621.
    • (2011) Allergy , vol.65 , pp. 1614-2162
    • Pfaar, O.1    Robinson, D.S.2    Sager, A.3
  • 22
    • 77953525685 scopus 로고    scopus 로고
    • Efficacy, safety, and immunological effects of a 2-year immunotherapy with Depigoid birch pollen extract: A randomized, double-blind, placebo-controlled study
    • Höiby AS, Strand V, Robinson DS, et al. Efficacy, safety, and immunological effects of a 2-year immunotherapy with Depigoid birch pollen extract: a randomized, double-blind, placebo-controlled study. Clin Exp Allergy 2010; 40:1062-1070.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1062-1107
    • Höiby, A.S.1    Strand, V.2    Robinson, D.S.3
  • 23
    • 77953798672 scopus 로고    scopus 로고
    • Safety of a rush immunotherapy build-up schedule with depigmented polymerized allergen extracts
    • Brehler R, Klimek L, Pfaar O, et al. Safety of a rush immunotherapy build-up schedule with depigmented polymerized allergen extracts. Allergy Asthma Proc 2010; 31:e31-e38.
    • (2010) Allergy Asthma Proc , vol.31
    • Brehler, R.1    Klimek, L.2    Pfaar, O.3
  • 24
    • 84855791137 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy
    • Pfaar O, Urry Z, Robinson DS, et al. A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy. Allergy 2012; 67:272-279.
    • (2012) Allergy , vol.67 , pp. 272-327
    • Pfaar, O.1    Urry, Z.2    Robinson, D.S.3
  • 25
    • 39749123322 scopus 로고    scopus 로고
    • Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy
    • Kahlert H, Suck R, Weber B, et al. Characterization of a hypoallergenic recombinant Bet v 1 variant as a candidate for allergen-specific immunotherapy. Int Arch Allergy Immunol 2008; 145:193-206.
    • (2008) Int Arch Allergy Immunol , vol.145 , pp. 193-220
    • Kahlert, H.1    Suck, R.2    Weber, B.3
  • 26
    • 84865993265 scopus 로고    scopus 로고
    • Clinical results with a hypoallergenic recombinant birch pollen allergen derivative [abstract]
    • Presented at, 6-10 June, Warsaw, Poland
    • Rak S. Clinical results with a hypoallergenic recombinant birch pollen allergen derivative [abstract]. Presented at XXVIII EAACI congress; 6-10 June 2009; Warsaw, Poland.
    • (2009) XXVIII EAACI Congress
    • Rak, S.1
  • 27
    • 80052290262 scopus 로고    scopus 로고
    • Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen
    • Toda M, Reese G, Gadermaier G, et al. Protein unfolding strongly modulates the allergenicity and immunogenicity of Pru p 3, the major peach allergen. J Allergy Clin Immunol 2011; 128:1022-1030.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 1022-1103
    • Toda, M.1    Reese, G.2    Gadermaier, G.3
  • 28
    • 80054993020 scopus 로고    scopus 로고
    • In search of a vaccine for mouse allergy: Significant reduction of Mus m 1 allergenicity by structureguided single-point mutations
    • Ferrari E, Breda D, Longhi R, et al. In search of a vaccine for mouse allergy: significant reduction of Mus m 1 allergenicity by structureguided single-point mutations. Int Arch Allergy Immunol 2012; 157:226-237.
    • (2012) Int Arch Allergy Immunol , vol.157 , pp. 226-323
    • Ferrari, E.1    Breda, D.2    Longhi, R.3
  • 29
    • 76949100653 scopus 로고    scopus 로고
    • Targeting the cysteinestabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy
    • Gadermaier G, Jahn-Schmid B, Vogel L, et al. Targeting the cysteinestabilized fold of Art v 1 for immunotherapy of Artemisia pollen allergy. Mol Immunol 2010; 47:1292-1298.
    • (2010) Mol Immunol , vol.47 , pp. 1292-2129
    • Gadermaier, G.1    Jahn-Schmid, B.2    Vogel, L.3
  • 30
    • 79951809149 scopus 로고    scopus 로고
    • Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination
    • Vrtala S, Fohr M, Campana R, et al. Genetic engineering of trimers of hypoallergenic fragments of the major birch pollen allergen, Bet v 1, for allergy vaccination. Vaccine 2011; 29:2140-2148.
    • (2011) Vaccine , vol.29 , pp. 2140-2214
    • Vrtala, S.1    Fohr, M.2    Campana, R.3
  • 31
    • 78651063436 scopus 로고    scopus 로고
    • Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy
    • Saarne T, Neimert-Andersson T, Grönlund H, et al. Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model for cat allergy. Allergy 2011; 66:255-263.
    • (2011) Allergy , vol.66 , pp. 255-326
    • Saarne, T.1    Neimert-Andersson, T.2    Grönlund, H.3
  • 32
    • 4043133762 scopus 로고    scopus 로고
    • Vaccine engineering improved by hybrid technology
    • Linhart B, Valenta R. Vaccine engineering improved by hybrid technology. Int Arch Allergy Immunol 2004; 134:324-331.
    • (2004) Int Arch Allergy Immunol , vol.134 , pp. 324-333
    • Linhart, B.1    Valenta, R.2
  • 33
    • 77950942365 scopus 로고    scopus 로고
    • Recombinant fusion proteins assembling der p 1 and der p 2 allergens from Dermatophagoides pteronyssinus
    • Bussières L, Bordas-Le Floch V, Bulder I, et al. Recombinant fusion proteins assembling Der p 1 and Der p 2 allergens from Dermatophagoides pteronyssinus. Int Arch Allergy Immunol 2010; 153:141-151.
    • (2010) Int Arch Allergy Immunol , vol.153 , pp. 141-215
    • Bussières, L.1    Bordas-Le Floch, V.2    Bulder, I.3
  • 34
    • 80052768250 scopus 로고    scopus 로고
    • In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity
    • Nilsson OB, Adedoyin J, Rhyner C, et al. In vitro evolution of allergy vaccine candidates, with maintained structure, but reduced B cell and T cell activation capacity. PLoS One 2011; 6:e24558.
    • (2011) PLoS One , vol.6
    • Nilsson, O.B.1    Adedoyin, J.2    Rhyner, C.3
  • 35
    • 0032826306 scopus 로고    scopus 로고
    • Genetically engineered and synthetic allergen derivatives: Candidates for vaccination against type i allergy
    • Valenta R, Vrtala S, Focke-Tejkl M, et al. Genetically engineered and synthetic allergen derivatives: candidates for vaccination against type I allergy. Biol Chem 1999; 380:815-824.
    • (1999) Biol Chem , vol.380 , pp. 815-882
    • Valenta, R.1    Vrtala, S.2    Focke-Tejkl, M.3
  • 36
    • 0035464780 scopus 로고    scopus 로고
    • Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination
    • Focke M, Mahler V, Ball T, et al. Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination. FASEB J 2001; 15:2042-2044.
    • (2001) FASEB J , vol.15 , pp. 2042-2204
    • Focke, M.1    Mahler, V.2    Ball, T.3
  • 37
    • 0014829537 scopus 로고
    • Carrier function in antihapten immune responses. II. Specific properties of carrier cells capable of enhancing antihapten antibody responses
    • Paul WE, Katz DH, Goidl EA, et al. Carrier function in antihapten immune responses. II. Specific properties of carrier cells capable of enhancing antihapten antibody responses. J Exp Med 1970; 132:283-299.
    • (1970) J Exp Med , vol.132 , pp. 283-329
    • Paul, W.E.1    Katz, D.H.2    Goidl, E.A.3
  • 38
    • 6344278432 scopus 로고    scopus 로고
    • Nonanaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination
    • Focke M, Linhart B, Hartl A, et al. Nonanaphylactic surface-exposed peptides of the major birch pollen allergen, Bet v 1, for preventive vaccination. Clin Exp Allergy 2004; 34:1525-1533.
    • (2004) Clin Exp Allergy , vol.34 , pp. 1525-2153
    • Focke, M.1    Linhart, B.2    Hartl, A.3
  • 39
    • 79953657092 scopus 로고    scopus 로고
    • Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy
    • Twaroch TE, Focke M, Civaj V, et al. Carrier-bound, nonallergenic Ole e 1 peptides for vaccination against olive pollen allergy. J Allergy Clin Immunol 2011; 128:178-184.
    • (2011) J Allergy Clin Immunol , vol.128 , pp. 178-218
    • Twaroch, T.E.1    Focke, M.2    Civaj, V.3
  • 40
    • 84862776765 scopus 로고    scopus 로고
    • Carrier-bound nonallergenic der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients: Experimental Allergy and Immunology
    • Chen KW, Focke-Tejkl M, Blatt K, et al. Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients: Experimental Allergy and Immunology. Allergy 2012; 67:609-621.
    • (2012) Allergy , vol.67 , pp. 609-662
    • Chen, K.W.1    Focke-Tejkl, M.2    Blatt, K.3
  • 41
    • 84872672837 scopus 로고    scopus 로고
    • Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy
    • (in press
    • Twaroch TE, Focke M, Fleischmann K, et al. Carrier-bound Alt a 1 peptides without allergenic activity for vaccination against Alternaria alternata allergy. Clin Exp Allergy (in press).
    • Clin Exp Allergy
    • Twaroch, T.E.1    Focke, M.2    Fleischmann, K.3
  • 42
    • 80053485690 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy: Towards combination vaccines for allergic and infectious diseases
    • Edlmayr J, Niespodziana K, Focke-Tejkl M, et al. Allergen-specific immunotherapy: towards combination vaccines for allergic and infectious diseases. Curr Top Microbiol Immunol 2011; 352:121-140.
    • (2011) Curr Top Microbiol Immunol , vol.352 , pp. 121-214
    • Edlmayr, J.1    Niespodziana, K.2    Focke-Tejkl, M.3
  • 43
    • 76349083910 scopus 로고    scopus 로고
    • A combination vaccine for allergy and rhinovirus infections based on rhinovirus-derived surface protein VP1 and a nonallergenic peptide of the major timothy grass pollen allergen Phl p 1
    • Edlmayr J, Niespodziana K, Linhart B, et al. A combination vaccine for allergy and rhinovirus infections based on rhinovirus-derived surface protein VP1 and a nonallergenic peptide of the major timothy grass pollen allergen Phl p 1. J Immunol 2009; 182:6298-6306.
    • (2009) J Immunol , vol.182 , pp. 6298-6630
    • Edlmayr, J.1    Niespodziana, K.2    Linhart, B.3
  • 44
    • 79953657255 scopus 로고    scopus 로고
    • A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS
    • Niespodziana K, Focke-Tejkl M, Linhart B, et al. A hypoallergenic cat vaccine based on Fel d 1-derived peptides fused to hepatitis B PreS. J Allergy Clin Immunol 2011; 127:1562-1570.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 1562-2157
    • Niespodziana, K.1    Focke-Tejkl, M.2    Linhart, B.3
  • 45
    • 33644892768 scopus 로고    scopus 로고
    • Comparative immunogenicity of a PreS/S hepatitis B vaccine in non and low responders to conventional vaccine
    • Rendi-Wagner P, Shouval D, Genton B, et al. Comparative immunogenicity of a PreS/S hepatitis B vaccine in non and low responders to conventional vaccine. Vaccine 2006; 24:2781-2789.
    • (2006) Vaccine , vol.24 , pp. 2781-3278
    • Rendi-Wagner, P.1    Shouval, D.2    Genton, B.3
  • 46
    • 79251554655 scopus 로고    scopus 로고
    • Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation
    • Edlmayr J, Niespodziana K, Popow-Kraupp T, et al. Antibodies induced with recombinant VP1 from human rhinovirus exhibit cross-neutralisation. Eur Respir J 2011; 37:44-52.
    • (2011) Eur Respir J , vol.37 , pp. 44-45
    • Edlmayr, J.1    Niespodziana, K.2    Popow-Kraupp, T.3
  • 47
    • 78650834553 scopus 로고    scopus 로고
    • Derp2-mutant gene vaccine inhibits airway inflammation and up-regulates Toll-like receptor 9 in an allergic asthmatic mouse model
    • Wang X, Yang Q, Wang P, et al. Derp2-mutant gene vaccine inhibits airway inflammation and up-regulates Toll-like receptor 9 in an allergic asthmatic mouse model. Asian Pac J Allergy Immunol 2010; 28:287-293.
    • (2010) Asian Pac J Allergy Immunol , vol.28 , pp. 287-329
    • Wang, X.1    Yang, Q.2    Wang, P.3
  • 48
    • 79251480431 scopus 로고    scopus 로고
    • Production and immunogenicity of hypoallergenic codon-optimized DNA vaccine encoding mature der p 1 allergen
    • Pulsawat P, Piboonpocanun S, Sirivichayakul S, et al. Production and immunogenicity of hypoallergenic codon-optimized DNA vaccine encoding mature Der p 1 allergen. J Investig Allergol Clin Immunol 2010; 20:582-590.
    • (2010) J Investig Allergol Clin Immunol , vol.20 , pp. 582-659
    • Pulsawat, P.1    Piboonpocanun, S.2    Sirivichayakul, S.3
  • 49
    • 84862785396 scopus 로고    scopus 로고
    • Induction of specific Th1responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1
    • Huang CF, Chu CH, Wu CC, et al. Induction of specific Th1responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1. Int Arch Allergy Immunol 2012; 158:142-150.
    • (2012) Int Arch Allergy Immunol , vol.158 , pp. 142-215
    • Huang, C.F.1    Chu, C.H.2    Wu, C.C.3
  • 52
    • 79952302102 scopus 로고    scopus 로고
    • A randomized controlled study of peanut oral immunotherapy: Clinical desensitization and modulation of the allergic response
    • Varshney P, Jones SM, Scurlock AM, et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011; 127:654-660.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 654-666
    • Varshney, P.1    Jones, S.M.2    Scurlock, A.M.3
  • 53
    • 79953698171 scopus 로고    scopus 로고
    • Seed-based oral vaccines as allergen-specific immunotherapies
    • Takaiwa F. Seed-based oral vaccines as allergen-specific immunotherapies. Hum Vaccin 2011; 7:357-366.
    • (2011) Hum Vaccin , vol.7 , pp. 357-436
    • Takaiwa, F.1
  • 54
    • 84856797778 scopus 로고    scopus 로고
    • Transgenic rice accumulating modified cedar pollen allergen Cry j 2 derivatives
    • Suzuki K, Yang L, Takaiwa F. Transgenic rice accumulating modified cedar pollen allergen Cry j 2 derivatives. J Biosci Bioeng 2012; 113:249-251.
    • (2012) J Biosci Bioeng , vol.113 , pp. 249-325
    • Suzuki, K.1    Yang, L.2    Takaiwa, F.3
  • 55
    • 79953730113 scopus 로고    scopus 로고
    • Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: Induction of allergen-specific oral tolerance without bystander suppression
    • Suzuki K, Kaminuma O, Yang L, et al. Prevention of allergic asthma by vaccination with transgenic rice seed expressing mite allergen: induction of allergen-specific oral tolerance without bystander suppression. Plant Biotechnol J 2011; 9:982-990.
    • (2011) Plant Biotechnol J , vol.9 , pp. 982-999
    • Suzuki, K.1    Kaminuma, O.2    Yang, L.3
  • 56
    • 80052989441 scopus 로고    scopus 로고
    • Vaccination with transgenic rice seed expressing mite allergen: A new option for asthma sufferers?
    • Hiroi T, Kaminuma O, Takaiwa F. Vaccination with transgenic rice seed expressing mite allergen: a new option for asthma sufferers? Expert Rev Vaccines 2011; 10:1249-1251.
    • (2011) Expert Rev Vaccines , vol.10 , pp. 1249-2125
    • Hiroi, T.1    Kaminuma, O.2    Takaiwa, F.3
  • 57
    • 84861382637 scopus 로고    scopus 로고
    • Expression of hypoallergenic der f 2 derivatives with altered intramolecular disulphide bonds induces the formation of novel ER-derived protein bodies in transgenic rice seeds
    • Yang L, Hirose S, Suzuki K, et al. Expression of hypoallergenic Der f 2 derivatives with altered intramolecular disulphide bonds induces the formation of novel ER-derived protein bodies in transgenic rice seeds. J Exp Bot 2012; 63:2947-2959.
    • (2012) J Exp Bot , vol.63 , pp. 2947-3295
    • Yang, L.1    Hirose, S.2    Suzuki, K.3
  • 58
    • 84856185013 scopus 로고    scopus 로고
    • Expression and characterization of natural-like recombinant der p 2 for sublingual immunotherapy
    • Bordas-Le Floch V, Bussières L, et al. Expression and characterization of natural-like recombinant Der p 2 for sublingual immunotherapy. Int Arch Allergy Immunol 2012; 158:157-167.
    • (2012) Int Arch Allergy Immunol , vol.158 , pp. 157-216
    • Bordas-Le Floch, V.1    Bussières, L.2
  • 59
    • 79956201500 scopus 로고    scopus 로고
    • Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice
    • Dioszeghy V, Mondoulet L, Dhelft V, et al. Epicutaneous immunotherapy results in rapid allergen uptake by dendritic cells through intact skin and downregulates the allergen-specific response in sensitized mice. J Immunol 2011; 186:5629-5637.
    • (2011) J Immunol , vol.186 , pp. 5629-6563
    • Dioszeghy, V.1    Mondoulet, L.2    Dhelft, V.3
  • 60
    • 84455202524 scopus 로고    scopus 로고
    • Epicutaneous allergen-specific immunotherapy ameliorates grass pollen-induced rhinoconjunctivitis: A double-blind, placebo-controlled dose escalation study
    • Senti G, von Moos S, Tay F, et al. Epicutaneous allergen-specific immunotherapy ameliorates grass pollen-induced rhinoconjunctivitis: a double-blind, placebo-controlled dose escalation study. J Allergy Clin Immunol 2012; 129:128-135.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 128-213
    • Senti, G.1    Von Moos, S.2    Tay, F.3
  • 61
    • 77958013242 scopus 로고    scopus 로고
    • Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts
    • Mondoulet L, Dioszeghy V, Vanoirbeek JA, et al. Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2011; 154:299-309.
    • (2011) Int Arch Allergy Immunol , vol.154 , pp. 299-330
    • Mondoulet, L.1    Dioszeghy, V.2    Vanoirbeek, J.A.3
  • 62
    • 84860486360 scopus 로고    scopus 로고
    • Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections
    • Senti G, Crameri R, Kuster D, et al. Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol 2012; 129:1290-1296.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1290-2129
    • Senti, G.1    Crameri, R.2    Kuster, D.3
  • 63
    • 33749436870 scopus 로고    scopus 로고
    • Immune Tolerance Network Group. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis
    • Creticos PS, Schroeder JT, Hamilton RG, et al. Immune Tolerance Network Group. Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 2006; 355:1445-1455.
    • (2006) N Engl J Med , vol.355 , pp. 1445-2145
    • Creticos, P.S.1    Schroeder, J.T.2    Hamilton, R.G.3
  • 64
    • 79951771386 scopus 로고    scopus 로고
    • Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide
    • Kaburaki Y, Fujimura T, Kurata K, et al. Induction of Th1 immune responses to Japanese cedar pollen allergen (Cry j 1) in mice immunized with Cry j 1 conjugated with CpG oligodeoxynucleotide. Comp Immunol Microbiol Infect Dis 2011; 34:157-161.
    • (2011) Comp Immunol Microbiol Infect Dis , vol.34 , pp. 157-216
    • Kaburaki, Y.1    Fujimura, T.2    Kurata, K.3
  • 65
    • 77951253745 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    • Jeffery LE, Burke F, Mura M, et al. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 2009; 183:5458-5467.
    • (2009) J Immunol , vol.183 , pp. 5458-5546
    • Jeffery, L.E.1    Burke, F.2    Mura, M.3
  • 66
    • 80053486806 scopus 로고    scopus 로고
    • Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergenspecific immunotherapy in a mouse model for cat allergy
    • Grundström J, Neimert-Andersson T, Kemi C, et al. Covalent coupling of vitamin D3 to the major cat allergen Fel d 1 improves the effects of allergenspecific immunotherapy in a mouse model for cat allergy. Int Arch Allergy Immunol 2012; 157:136-146.
    • (2012) Int Arch Allergy Immunol , vol.157 , pp. 136-214
    • Grundström, J.1    Neimert-Andersson, T.2    Kemi, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.