Trefoil factors in saliva and gingival tissues of patients with chronic periodontitis

Journal of Periodontology

Volumn 83, Issue 9, 2012, Pages 1129-1138

  Chaiyarit, Ponlatham ^a   Chayasadom, Anek ^a   Wara Aswapati, Nawarat ^a   Hormdee, Doodsadee ^a   Sittisomwong, Sapatporn ^b   Nakaresisoon, Sirinun ^c   Samson, Mie Hessellund ^d   Pitiphat, Waranuch ^a   Giraud, Andrew S ^e  

^a KHON KAEN UNIVERSITY   (Thailand)

^b MINISTRY OF PUBLIC HEALTH   (Thailand)

^c Dental Division   (Thailand)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

^e ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

Enzyme linked immunosorbent assay; Immunohistochemistry; Periodontitis; Saliva; Trefoil factor

Indexed keywords

ESTROGEN; PEPTIDE; SIGNAL PEPTIDE; TFF1 PROTEIN, HUMAN; TFF3 PROTEIN, HUMAN; TREFOIL FACTOR; TUMOR SUPPRESSOR PROTEIN;

ADULT; AGED; AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ARTICLE; BACTERIAL LOAD; BACTEROIDES; CHEMISTRY; CHRONIC PERIODONTITIS; EPITHELIUM; EPITHELIUM CELL; FEMALE; GINGIVA; GINGIVA BLEEDING; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTAL POCKET; PORPHYROMONAS GINGIVALIS; SALIVA; TOOTH PLAQUE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ADULT; AGED; BACTERIAL LOAD; BACTEROIDES; CHRONIC PERIODONTITIS; DENTAL PLAQUE; EPITHELIAL CELLS; EPITHELIUM; ESTROGENS; FEMALE; GINGIVA; GINGIVAL HEMORRHAGE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; PEPTIDES; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PORPHYROMONAS GINGIVALIS; SALIVA; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 84865971375     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2011.110431     Document Type: Article

References (44)

1. Madsen J, Nielsen O, Tornøe I, Thim L, Holmskov U. Tissue localization of human trefoil factors 1, 2, and 3. J Histochem Cytochem 2007;55:505-513.
2. Jagla W, Wiede A, Hinz M, et al. Secretion of TFF-peptides by human salivary glands. Cell Tissue Res 1999;298:161-166.
3. Devine DA, High AS, Owen PJ, Poulsom R, Bonass WA. Trefoil factor expression in normal and diseased human salivary glands. Hum Pathol 2000;31:509-515.
4. Kouznetsova I, Gerlach KL, Zahl C, Hoffmann W. Expression analysis of human salivary glands by laser microdissection: Differences between submandibular and labial glands. Cell Physiol Biochem 2010;26:375-382.
5. Kutta H, May J, Jaehne M, Münscher A, Paulsen FP. Antimicrobial defence mechanisms of the human parotid duct. J Anat 2006;208:609-619.
6. Storesund T, Schreurs O, Messelt EB, Kolltveit KM, Schenck K. Trefoil factor family 3 expression in the oral cavity. Eur J Oral Sci 2009;117:636-643.
7. Mori K, Fujii R, Kida N, et al. Complete primary structure of the human estrogen-responsive gene (pS2) product. J Biochem 1990;107:73-76.
8. Tomasetto C, Rio MC, Gautier C, et al. hSP, the domain-duplicated homolog of pS2 protein, is coexpressed with pS2 in stomach but not in breast carcinoma. EMBO J 1990;9:407-414.
9. Hauser F, Poulsom R, Chinery R, et al. hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 1993;90:6961-6965.
10. Vestergaard EM, Brynskov J, Ejskjaer K, et al. Immunoassays of human trefoil factors 1 and 2: Measured on serum from patients with inflammatory bowel disease. Scand J Clin Lab Invest 2004;64:146-156.
11. Samson MH, Chaiyarit P, Nortvig H, Vestergaard EM, Ernst E, Nexø E. Trefoil factor family peptides in human saliva and cyclical cervical mucus. Method evaluation and results on healthy individuals. Clin Chem Lab Med 2011;49:861-868.
12. Vestergaard EM, Nexø E, Wendt A, Guthmann F. Trefoil factors in human milk. Early Hum Dev 2008; 84:631-635.
13. Playford RJ, Marchbank T, Chinery R, et al. Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. Gastroenterology 1995;108: 108-116.
14. Tran CP, Cook GA, Yeomans ND, Thim L, Giraud AS. Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis. Gut 1999;44:636-642.
15. Cook GA, Familari M, Thim L, Giraud AS. The trefoil peptides TFF2 and TFF3 are expressed in rat lymphoid tissues and participate in the immune response. FEBS Lett 1999;456:155-159.
16. Dubeykovskaya Z, Dubeykovskiy A, Solal-Cohen J, Wang TC. Secreted trefoil factor 2 activates the CXCR4 receptor in epithelial and lymphocytic cancer cell lines. J Biol Chem 2009;284:3650-3662.
17. Tebbutt NC, Giraud AS, Inglese M, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med 2002;8:1089-1097.
18. Dossinger V, Kayademir T, Blin N, Gött P. Down-regulation of TFF expression in gastrointestinal cell lines by cytokines and nuclear factors. Cell Physiol Biochem 2002;12:197-206.
19. Baus-Loncar M, Giraud AS. Multiple regulatory pathways for trefoil factor (TFF) genes. Cell Mol Life Sci 2005;62:2921-2931.
20. Storesund T, Hayashi K, Kolltveit KM, Bryne M, Schenck K. Salivary trefoil factor 3 enhances migration of oral keratinocytes. Eur J Oral Sci 2008;116: 135-140.
21. Storesund T, Schenck K, Osmundsen H, Røed A, Helgeland K, Kolltveit KM. Signal transduction and gene transcription induced by TFF3 in oral keratin-ocytes. Eur J Oral Sci 2009;117:511-517.
22. Van De Bovenkamp JH, Korteland-Van Male AM, Büller HA, Einerhand AW, Dekker J. Infection with Helicobacter pylori affects all major secretory cell populations in the human antrum. Dig Dis Sci 2005; 50:1078-1086.
23. Rylev M, Kilian M. Prevalence and distribution of principal periodontal pathogens worldwide. J Clin Periodontol 2008;35(Suppl. 8):346-361.
24. Wara-aswapati N, Pitiphat W, Chanchaimongkon L, Taweechaisupapong S, Boch JA, Ishikawa I. Red bacterial complex is associated with the severity of chronic periodontitis in a Thai population. Oral Dis 2009;15:354-359.
25. Tatakis DN, Kumar PS. Etiology and pathogenesis of periodontal diseases. Dent Clin North Am 2005;49: 491-516, v.
26. Sanz M, Lang NP, Kinane DF, Berglundh T, Chapple I, Tonetti MS. Seventh European Workshop on Periodontology of the European Academy of Periodontology at the Parador at la Granja, Segovia, Spain. J Clin Periodontol 2011;38(Suppl. 11):1-2.
27. Kaufman E, Lamster IB. Analysis of saliva for periodontal diagnosis - A review. J Clin Periodontol 2000;27:453-465.
28. Zhang L, Henson BS, Camargo PM, Wong DT. The clinical value of salivary biomarkers for periodontal disease. Periodontol 2000 2009;51:25-37.
29. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
30. Wara-aswapati N, Surarit R, Chayasadom A, Boch JA, Pitiphat W. RANKL upregulation associated with periodontitis and Porphyromonas gingivalis. J Periodontol 2007;78:1062-1069.
31. Taupin D, Pedersen J, Familari M, Cook G, Yeomans N, Giraud AS. Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. Lab Invest 2001;81:397-408.
32. Srivatsa G, Giraud AS, Ulaganathan M, Yeomans ND, Dow C, Nicoll AJ. Biliary epithelial trefoil peptide expression is increased in biliary diseases. Histopa-thology 2002;40:261-268.
33. Chaiyarit P, Jintakanon D, Klanrit P, Siritapetawee M, Thongprasom K. Immunohistochemical analyses of survivin and heat shock protein 90 expression in patients with oral lichen planus. J Oral Pathol Med 2009;38:55-62.
34. Maeda H, Fujimoto C, Haruki Y, et al. Quantitative real-time PCR using TaqMan and SYBR Green for Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, tetQ gene and total bacteria. FEMS Immunol Med Microbiol 2003;39:81-86.
35. Jiang Y, Mishima H, Sakai S, Liu YK, Ohyabu Y, Uemura T. Gene expression analysis of major lineagedefining factors in human bone marrow cells: Effect of aging, gender, and age-related disorders. J Orthop Res 2008;26:910-917.
36. Panda A, Qian F, Mohanty S, et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol 2010;184:2518-2527.
37. Pathirana RD, O'Brien-Simpson NM, Reynolds EC. Host immune responses to Porphyromonas gingivalis antigens. Periodontol 2000 2010;52:218-237.
38. Karim AY, Kulczycka M, Kantyka T, et al. A novel matrix metalloprotease-like enzyme (karilysin) of the periodontal pathogen Tannerella forsythia ATCC 43037. Biol Chem 2010;391:105-117.
39. Gutner M, Chaushu S, Balter D, Bachrach G. Saliva enables the antimicrobial activity of LL-37 in the presence of proteases of Porphyromonas gingivalis. Infect Immun 2009;77:5558-5563.
40. Koziel J, Karim AY, Przybyszewska K, et al. Proteolytic inactivation of LL-37 by karilysin, a novel virulence mechanism of Tannerella forsythia. J Innate Immun 2010;2:288-293.
41. Peterson A, Menheniott TR, O'Connor LO, et al. Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans. Gastroenterology 2010;139:2005-2017.
42. Walker RA. Quantification of immunohistochemistry - Issues concerning methods, utility and semiquantitative assessment I. Histopathology 2006;49: 406-410.
43. Thim L, Madsen F, Poulsen SS. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 2002;32:519-527.
44. Poulsen SS, Kissow H, Hare K, Hartmann B, Thim L. Luminal and parenteral TFF2 and TFF3 dimer and monomer in two models of experimental colitis in the rat. Regul Pept 2005;126:163-171.