Unrelated cord blood transplantation for newly diagnosed patients with severe acquired aplastic anemia using a reduced-intensity conditioning: High graft rejection, but good survival

Bone Marrow Transplantation

Volumn 47, Issue 9, 2012, Pages 1186-1190

  Liu, H L ^a   Sun, Z M ^a   Geng, L Q ^a   Wang, X B ^a   Ding, K Y ^a   Tang, B I ^a   Tong, J ^a   Wang, Z Y ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

cord blood transplantation; graft failure; severe aplastic anemia

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN A; FLUDARABINE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY;

ADOLESCENT; ADULT; ADVERSE OUTCOME; APLASTIC ANEMIA; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; DISEASE SEVERITY; DRUG USE; FEMALE; GRAFT FAILURE; GRAFT REJECTION; GRAFT VERSUS HOST REACTION; HUMAN; MALE; MORTALITY; OVERALL SURVIVAL; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SURVIVAL RATE; SURVIVAL TIME; TREATMENT RESPONSE; UNRELATED DONORS;

ADOLESCENT; ADULT; ANEMIA, APLASTIC; ANTILYMPHOCYTE SERUM; CHILD; CHILD, PRESCHOOL; CORD BLOOD STEM CELL TRANSPLANTATION; CYCLOPHOSPHAMIDE; CYCLOSPORINE; FEMALE; GRAFT REJECTION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MIDDLE AGED; MYCOPHENOLIC ACID; SURVIVAL ANALYSIS; TRANSPLANTATION CONDITIONING; VIDARABINE; YOUNG ADULT;

EID: 84865964354     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2011.251     Document Type: Article

References (28)

1. Montané E, Ibán ez L, Vidal X, Ballarin E, Puig R, Garc?́a N et al. Epidemiology of aplastic anemia: a prospective multicenter study. Haematologica 2008; 93: 518-523. (Pubitemid 351536379)
2. Locasciulli A, Oneto R, Bacigalupo A, Socié G, Korthof E, Bekassy A et al. Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2007; 92: 11-18. (Pubitemid 46232653)
3. Gluckman E, Broxmeyer HA, Auerbach AD, Friedman HS, Douglas GW, Devergie A et al. Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical cord blood from an HLA-identical sibling. New Engl J Med 1989; 321: 1174-1178. (Pubitemid 19255814)
4. Prasad VK, Kurtzberg J. Umbilical cord blood transplantation for non-malignant diseases. Bone Marrow Transplant 2009; 44: 643-651.
5. Lau FY, Wong R, Chui CH, Cheng G. Successful engraftment in two adult patients with severe aplastic anemia using nonmyeloablative conditioning followed by unrelated HLA mismatched cord blood transplantation. J Hematother Stem Cell Res 2001; 10: 309-311. (Pubitemid 32423555)
6. Kusumi E, Miyakoshi S, Murashige N, Katayama Y, Kim SW, Yuji K et al. Successful reduced-intensity stem cell transplantation (RIST) with mismatched cord blood in a 70-yr-old patient with severe aplastic anemia (SAA). Bone Marrow Transplant 2003; 32: 1111-1112. (Pubitemid 37540746)
7. Mao P, Wang S, Wang S, Zhu Z, Liv Q, Xuv Y et al. Umbilical cord blood transplant for adult patients with severe aplastic anemia using antilymphocyte globulin and cyclophosphamide as conditioning therapy. Bone Marrow Transplant 2004; 33: 33-38. (Pubitemid 38159701)
8. Ohga S, Ichino K, Goto K, Hattori S, Nomura A, Takada H et al. Unrelated donor cord blood transplantation for childhood severe aplastic anemia after a modified conditioning. Pediatr Transplant 2006; 10: 497-500. (Pubitemid 43780685)
9. Bacigalupo A, Passweg J. Diagnosis and treatment of acquired aplastic anemia. Hematol Oncol Clin North Am 2009; 23: 159-170.
10. Srinivasan R, Takahashi Y, McCoy JP, Espinoza-Delgado I, Dorrance C, Igarashi T et al. Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine-based haematopoietic cell transplantation. Br J Haematol 2006; 133: 305-314.
11. Resnick IB, Aker M, Shapira MY, Tsirigotis PD, Bitan M, Abdul-Hai A et al. Allogeneic stem cell transplantation for severe acquired aplastic anaemia using a fludarabine-based preparative regimen. Br J Haematol 2006; 133: 649-654. (Pubitemid 43742782)
12. George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M. Fludarabine and cyclophosphamide based reduced intensity conditioning (RIC) regimens reduce rejection and improve outcome in Indian patients undergoing allogeneic stem cell transplantation for severe aplastic anemia. Bone Marrow Transplant 2007; 40: 13-18. (Pubitemid 47018409)
13. Maury S, Bacigalupo A, Anderlini P, Aljurf M, Marsh J, Socié G et al. Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: a comparison with conventional conditioning regimen. Haematologica 2009; 94: 1312-1315.
14. Marsh JC, Ball SE, Darbyshire P, Gordon-Smith EC, Keidan AJ, Martin A et al. Guidelines for the diagnosis and management of acquired aplastic anaemia. Br J Haematol 2003; 123: 782-801. (Pubitemid 37533290)
15. Yoshimi A, Kojima S, Taniguchi S, Hara J, Matsui T, Takahashi Y et al. Unrelated cord blood transplantation for severe aplastic anemia. Biol Blood Marrow Transplant 2008; 14: 1057-1063.
16. Chan KW, McDonald L, Lim D, Grimley MS, Grayson G, Wall DA. Unrelated cord blood transplantation in children with idiopathic severe aplastic anemia. Bone Marrow Transplant 2008; 42: 589-595.
17. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 2006; 108: 2509-2519.
18. Rocha V, Gluckman E, Eurocord-Netcord registry and European Blood and Marrow Transplant group. Improving outcomes of cord blood transplantation: HLA matching, cell dose and other graft-and transplantation-related factors. Br J Haematol 2009; 147: 262-274.
19. Ruggeri A, de Latour RP, Rocha V, Larghero J, Robin M, Rodrigues CA et al. Double cord blood transplantation in patients with high risk bone marrow failure syndromes. Br J Haematol 2008; 143: 404-408.
20. Lee JW, Kang HJ, Kim EK, Shin HY, Ahn HS. Successful salvage unrelated umbilical cord blood transplantation with two units after engraftment failure with single unit in severe aplastic anemia. J Korean Med Sci 2009; 24: 744-746.
21. Kang HJ, Lee JW, Kim H, Shin HY, Ahn HS. Successful first-line treatment with double umbilical cord blood transplantation in severe aplastic anemia. Bone Marrow Transplant 2010; 45: 955-956.
22. Yamamoto H, Kato D, Uchida N, Ishiwata K, Araoka H, Takagi S et al. Successful sustained engraftment after reduced-intensity umbilical cord blood transplantation for adult patients with severe aplastic anemia. Blood 2011; 117: 3240-3242.
23. Kojima S, Matsuyama T, Kato S, Kigasawa H, Kobayashi R, Kikuta A et al. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Blood 2002; 100: 799-803. (Pubitemid 34832604)
24. Deeg HJ, Amylon ID, Harris RE, Collins R, Beatty PG, Feig S et al. Marrow transplants from unrelated donors for patients with aplastic anemia: minimum effective dose of total body irradiation. Biol Blood Marrow Transplant 2001; 7: 208-215. (Pubitemid 32433247)
25. Takanashi M, Atsuta Y, Fujiwara K, Kodo H, Kai S, Sato H et al. The impact of anti-HLA antibodies on unrelated cord blood transplantations. Blood 2010; 116: 2839-2846.
26. Bacigalupo A, Bruno B, Saracco P, Di Bona E, Locasciulli A, Locatelli F, European Group for Blood and Marrow Transplantation (EBMT) Working Party on Severe Aplastic Anemia and the Gruppo Italino Trapianti di Midolio Osseo et al. Antilymphocyte globulin, cyclosporine, prednisolone, and granulocyte colonystimulating factor for severe aplastic anemia: an update of the GITMO/EBMT study on 100 patients. Blood 2000; 95: 1931-1934. (Pubitemid 30151628)
27. Gutman JA, Turtle CJ, Manley TJ, Heimfeld S, Bernstein ID, Riddell SR et al. Singleunit dominance after double-unit umbilical cord blood transplantation coincides with a specific CD8+ T-cell response against the nonengrafted unit. Blood 2010; 115: 757-765.
28. Rosenfeld S, Follmann D, Nunez O, Young NS. Antithymocyte globulin and cyclosporine for severe aplastic anemia: association between hematologic response and long-term outcome. J Am Med Assoc 2003; 289: 1130-1135. (Pubitemid 37430327)