Improved outcome of patients older than 30 years receiving HLA-identical sibling hematopoietic stem cell transplantation for severe acquired aplastic anemia using fludarabine-based conditioning: A comparison with conventional conditioning regimen

Haematologica

Volumn 94, Issue 9, 2009, Pages 1312-1315

  Maury, Sébastien ^a   Bacigalupo, Andrea ^b   Anderlini, Paolo ^c   Aljurf, Mahmoud ^d   Marsh, Judith ^e   Socié, Gérard ^f   Oneto, Rosi ^b   Passweg, Jakob R ^g  

^a HENRI MONDOR HOSPITAL   (France)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

^e KING S COLLEGE HOSPITAL   (United Kingdom)

^f SAINT LOUIS HOSPITAL   (France)

^g GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Aplastic anemia; Conditioning regimen; Fludarabine; Stem cell transplantation

Indexed keywords

CYCLOPHOSPHAMIDE; FLUDARABINE; THYMOCYTE ANTIBODY;

ADULT; APLASTIC ANEMIA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; GRAFT FAILURE; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA SYSTEM; HUMAN; LOW DRUG DOSE; RISK ASSESSMENT; SURVIVAL RATE; TREATMENT OUTCOME;

ADULT; AGED; ANEMIA, APLASTIC; ANTILYMPHOCYTE SERUM; CYCLOPHOSPHAMIDE; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA ANTIGENS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LIVING DONORS; MALE; MIDDLE AGED; MYELOABLATIVE AGONISTS; RETROSPECTIVE STUDIES; SIBLINGS; SURVIVAL RATE; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; VIDARABINE;

EID: 70349148649     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2009.006916     Document Type: Article

References (19)

1. Marsh JC, Ball SE, Darbyshire P, Gordon-Smith EC, Keidan AJ, Martin A, et al. Guidelines for the diagnosis and management of acquired aplastic anaemia. Br J Haematol 2003;123:782-801. (Pubitemid 37533290)
2. George ER, Storb R. Allogeneic Hematopoietic Cell Transplantation for Aplastic Anemia. In: Blume KG, Forman SJ, Thomas ED, editors. Thomas' Hematopoietic Cell Transplantation. Boston: Blackwell; 2004. p. 981-1001
3. Doney K, Leisenring W, Storb R, Appelbaum FR. Primary treatment of acquired aplastic anemia: outcomes with bone marrow transplantation and immunosuppressive therapy. Seattle Bone Marrow Transplant Team. Ann Intern Med 1997;126:107-115 (Pubitemid 27058584)
4. Bacigalupo A, Hows J, Gluckman E, Nissen C, Marsh J, Van Lint MT, et al. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br J Haematol 1988;70:177-182 (Pubitemid 18238126)
5. Passweg JR, Socie G, Hinterberger W, Bacigalupo A, Biggs JC, Camitta BM, et al. Bone marrow transplantation for severe aplastic anemia: has outcome improved? Blood 1997;90:858-864
6. Bacigalupo A, Brand R, Oneto R, Bruno B, Socie G, Passweg J, et al. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy - The European Group for Blood and Marrow Transplantation experience. Semin Hematol 2000;37:69-80. (Pubitemid 30080248)
7. Ades L, Mary JY, Robin M, Ferry C, Porcher R, Esperou H, Ribaud P, Devergie A, Traineau R, Gluckman E, Socie G. Long-term outcome after bone marrow transplantation for severe aplastic anemia. Blood 2004;103:2490-2497 (Pubitemid 38392998)
8. Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 2006;108:2509-2519 (Pubitemid 44776983)
9. Marsh JC. Treatment of acquired aplastic anemia. Haematologica 2007;92:2-5
10. Ringden O, Remberger M, Svenberg P, Svahn BM, Dahllof G, Gustafsson B, et al. Fludarabine-based disease-specific conditioning or conventional myeloablative conditioning in hematopoietic stem cell transplantation for treatment of non-malignant diseases. Bone Marrow Transplant 2007;39:383-388 (Pubitemid 46487302)
11. Kumar R, Prem S, Mahapatra M, Seth T, Chowdhary DR, Mishra P, et al. Fludarabine, cyclophosphamide and horse antithymocyte globulin conditioning regimen for allogeneic peripheral blood stem cell transplantation performed in non-HEPA filter rooms for multiply transfused patients with severe aplastic anemia. Bone Marrow Transplant 2006;37:745-749
12. Itala M, Aho H, Remes K. Reduced-intensity conditioning and blood stem cell transplantation from an HLA-identical sibling for severe aplastic anaemia: two patients with successful engraftment but a fatal post-transplant lymphoproliferative disorder in the other. Hematol J 2004;5:440-443 (Pubitemid 39359281)
13. Srinivasan R, Takahashi Y, McCoy JP, Espinoza-Delgado I, Dorrance C, Igarashi T, et al. Overcoming graft rejection in heavily transfused and allo-immunised patients with bone marrow failure syndromes using fludarabine- based haematopoietic cell transplantation. Br J Haematol 2006;133:305-314
14. Resnick IB, Aker M, Shapira MY, Tsirigotis PD, Bitan M, Abdul-Hai A, et al. Allogeneic stem cell transplantation for severe acquired aplastic anaemia using a fludarabine-based preparative regimen. Br J Haematol 2006;133:649-654 (Pubitemid 43742782)
15. Gomez-Almaguer D, Vela-Ojeda J, Jaime-Perez JC, Gutierrez-Aguirre CH, Cantu-Rodriguez OG, Sobrevilla-Calvo P, et al. Allografting in patients with severe, refractory aplastic anemia using peripheral blood stem cells and a fludarabine-based conditioning regimen: the Mexican experience. Am J Hematol 2006;81:157-161 (Pubitemid 43297254)
16. George B, Mathews V, Viswabandya A, Kavitha ML, Srivastava A, Chandy M. Fludarabine and cyclophosphamide based reduced intensity conditioning (RIC) regimens reduce rejection and improve outcome in Indian patients undergoing allogeneic stem cell transplantation for severe aplastic anemia. Bone Marrow Transplant 2007;40:13-18 (Pubitemid 47018409)
17. Bacigalupo A, Locatelli F, Lanino E, Marsh J, Socie G, Maury S, et al. Fludarabine, cyclophosphamide and anti-thymocyte globulin for alternative donor transplants in acquired severe aplastic anemia: a report from the EBMT-SAA Working Party. Bone Marrow Transplant 2005;36:947-950 (Pubitemid 41741556)
18. Champlin RE, Perez WS, Passweg JR, Klein JP, Camitta BM, Gluckman E, et al. Bone marrow transplantation for severe aplastic anemia: a randomized controlled study of conditioning regimens. Blood 2007;109:4582-4585 (Pubitemid 46743430)
19. Casado LF, Steegmann JL, Pico M, Requena MJ, Ramirez M, Madero L, et al. Study of chimerism in long-term survivors after bone marrow transplantation for severe acquired aplastic anemia. Bone Marrow Transplant 1996;18:405-9.s (Pubitemid 26283693)