Intestinal drug transport via the proton-coupled amino acid transporter PAT1 (SLC36A1) is inhibited by gly-Xaa dipeptides

Molecular Pharmaceutics

Volumn 9, Issue 9, 2012, Pages 2761-2769

  FrØlund, Sidsel ^a   Langthaler, Louise ^a,b   Kall, Morten A ^b   Holm, René ^a,b   Nielsen, Carsten Uhd ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

Caco 2 cells; food effects; gaboxadol; Gly containing dipeptides; intestinal absorption; oral absorption; PAT1; Pharmacokinetics; rat; SLC36A1

Indexed keywords

AMINO ACID TRANSPORTER; DIPEPTIDE DERIVATIVE; GABOXADOL; GLYCINE; GLYCINE XAA DIPEPTIDE; PHENYLALANINE; PROLINE; PROTON COUPLED AMINO ACID TRANSPORTER1; SARCOSINE; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ADMINISTRATION, ORAL; AMINO ACID TRANSPORT SYSTEMS; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DIPEPTIDES; GLYCINE; HUMANS; INTESTINAL ABSORPTION; INTESTINES; ISOXAZOLES; MALE; OOCYTES; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; SYMPORTERS; XENOPUS LAEVIS;

EID: 84865961065     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300345e     Document Type: Article

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