Gaboxadol has affinity for the proton-coupled amino acid transporter 1, SLC36A1 (hPAT1) - A modelling approach to determine IC50 values of the three ionic species of gaboxadol

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 3, 2011, Pages 192-198

  Frølund, Sidsel ^a   Rapin, Nicolas ^a   Nielsen, Carsten Uhd ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Affinity; Gaboxadol; Genetic algorithm; pKa value; SLC36A1 (hPAT1)

Indexed keywords

AMPHOLYTE; CARRIER PROTEIN; GABOXADOL; PROLINE; PROTEIN SLC36A1; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CELL STRAIN CACO 2; COMPUTER MODEL; DRUG PROTEIN BINDING; IC 50; PH; PKA; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID TRANSPORT SYSTEMS; CACO-2 CELLS; GABA AGONISTS; HUMANS; HYDROGEN-ION CONCENTRATION; INHIBITORY CONCENTRATION 50; ISOXAZOLES; MODELS, MOLECULAR; SYMPORTERS;

EID: 79251599996     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.11.009     Document Type: Article

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