PKCα activation of p120-catenin serine 879 phospho-switch disassembles VE-cadherin junctions and disrupts vascular integrity

Circulation Research

Volumn 111, Issue 6, 2012, Pages 739-749

  Vandenbroucke St Amant, Emily ^a   Tauseef, Mohammad ^a   Vogel, Stephen M ^a   Gao, Xiao Pei ^a   Mehta, Dolly ^a   Komarova, Yulia A ^a   Malik, Asrar B ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

endothelium; inflammation; intercellular junctions; signal transduction; vascular permeability

Indexed keywords

CATENIN; LIPOPOLYSACCHARIDE; PROTEIN KINASE C ALPHA; PROTEIN P120; PROTEINASE ACTIVATED RECEPTOR 1; SERINE; THROMBIN; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD VESSEL PERMEABILITY; CELL JUNCTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTERNALIZATION; LUNG BLOOD VESSEL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADHERENS JUNCTIONS; ANIMALS; ANTIGENS, CD; CADHERINS; CAPILLARY PERMEABILITY; CATENINS; CELLS, CULTURED; ENDOTHELIAL CELLS; HUMANS; IMMUNOBLOTTING; LIPOPOLYSACCHARIDES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROVESSELS; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASE C-ALPHA; RECEPTOR, PAR-1; RNA INTERFERENCE; SERINE; THROMBIN;

EID: 84865866099     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.112.269654     Document Type: Article

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