-
1
-
-
53149107465
-
Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer
-
Ali SM, Carney WP, Esteva FJ, Fornier M, Harris L, Kostler WJ, Lotz JP, Luftner D, Pichon MF, Lipton A (2008) Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer. Cancer 113: 1294-1301
-
(2008)
Cancer
, vol.113
, pp. 1294-1301
-
-
Ali, S.M.1
Carney, W.P.2
Esteva, F.J.3
Fornier, M.4
Harris, L.5
Kostler, W.J.6
Lotz, J.P.7
Luftner, D.8
Pichon, M.F.9
Lipton, A.10
-
2
-
-
0034808379
-
Is circulating HER-2 more than just a tumor marker?
-
Baselga J (2001) Is circulating HER-2 more than just a tumor marker? Clin Cancer Res 7: 2605-2607
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2605-2607
-
-
Baselga, J.1
-
3
-
-
84857236823
-
Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): A randomised, open-label, multicentre, phase 3 trial
-
Baselga J, Bradbury I, Eidtmann H, Di Cosimo S, de Azambuja E, Aura C, Gomez H, Dinh P, Fauria K, Van Dooren V, Aktan G, Goldhirsch A, Chang TW, Horvath Z, Coccia-Portugal M, Domont J, Tseng LM, Kunz G, Sohn JH, Semiglazov V, Lerzo G, Palacova M, Probachai V, Pusztai L, Untch M, Gelber RD, Piccart-Gebhart M (2012) Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial. Lancet 379: 596-598
-
(2012)
Lancet
, vol.379
, pp. 596-598
-
-
Baselga, J.1
Bradbury, I.2
Eidtmann, H.3
Di Cosimo, S.4
De Azambuja, E.5
Aura, C.6
Gomez, H.7
Dinh, P.8
Fauria, K.9
Van Dooren, V.10
Aktan, G.11
Goldhirsch, A.12
Chang, T.W.13
Horvath, Z.14
Coccia-Portugal, M.15
Domont, J.16
Tseng, L.M.17
Kunz, G.18
Sohn, J.H.19
Semiglazov, V.20
Lerzo, G.21
Palacova, M.22
Probachai, V.23
Pusztai, L.24
Untch, M.25
Gelber, R.D.26
Piccart-Gebhart, M.27
more..
-
4
-
-
20544460650
-
Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer
-
Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL, Hunt KK, Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN (2005) Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 23: 3676-3685
-
(2005)
J Clin Oncol
, vol.23
, pp. 3676-3685
-
-
Buzdar, A.U.1
Ibrahim, N.K.2
Francis, D.3
Booser, D.J.4
Thomas, E.S.5
Theriault, R.L.6
Pusztai, L.7
Green, M.C.8
Arun, B.K.9
Giordano, S.H.10
Cristofanilli, M.11
Frye, D.K.12
Smith, T.L.13
Hunt, K.K.14
Singletary, S.E.15
Sahin, A.A.16
Ewer, M.S.17
Buchholz, T.A.18
Berry, D.19
Hortobagyi, G.N.20
more..
-
5
-
-
0033559210
-
Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells
-
Codony-Servat J, Albanell J, Lopez-Talavera JC, Arribas J, Baselga J (1999) Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells. Cancer Res 59: 1196-1201
-
(1999)
Cancer Res
, vol.59
, pp. 1196-1201
-
-
Codony-Servat, J.1
Albanell, J.2
Lopez-Talavera, J.C.3
Arribas, J.4
Baselga, J.5
-
6
-
-
0036534121
-
Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer
-
Esteva FJ, Valero V, Booser D, Guerra LT,Murray JL, Pusztai L, CristofanilliM, Arun B, Esmaeli B, Fritsche HA, Sneige N, Smith TL, Hortobagyi GN (2002) Phase II study of weekly docetaxel and trastuzumab for patients with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 20: 1800-1808
-
(2002)
J Clin Oncol
, vol.20
, pp. 1800-1808
-
-
Esteva, F.J.1
Valero, V.2
Booser, D.3
Guerra Ltmurray, J.L.4
Pusztai, L.5
Cristofanilli, M.6
Arun, B.7
Esmaeli, B.8
Fritsche, H.A.9
Sneige, N.10
Smith, T.L.11
Hortobagyi, G.N.12
-
7
-
-
73949125361
-
Prognostic and predictive value of HER2 extracellular domain in metastatic breast cancer treated with lapatinib and paclitaxel in a randomized phase III study
-
Finn RS, Gagnon R, Di Leo A, Press MF, Arbushites M, Koehler M (2009) Prognostic and predictive value of HER2 extracellular domain in metastatic breast cancer treated with lapatinib and paclitaxel in a randomized phase III study. J Clin Oncol 27: 5552-5558
-
(2009)
J Clin Oncol
, vol.27
, pp. 5552-5558
-
-
Finn, R.S.1
Gagnon, R.2
Di Leo, A.3
Press, M.F.4
Arbushites, M.5
Koehler, M.6
-
8
-
-
84855297353
-
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
-
Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P (2012) Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 13: 25-32
-
(2012)
Lancet Oncol
, vol.13
, pp. 25-32
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
Roman, L.4
Tseng, L.M.5
Liu, M.C.6
Lluch, A.7
Staroslawska, E.8
De La Haba-Rodriguez, J.9
Im, S.A.10
Pedrini, J.L.11
Poirier, B.12
Morandi, P.13
Semiglazov, V.14
Srimuninnimit, V.15
Bianchi, G.16
Szado, T.17
Ratnayake, J.18
Ross, G.19
Valagussa, P.20
more..
-
9
-
-
33750313576
-
New guidelines for reporting of tumor marker studies in breast cancer research and treatment: REMARK
-
Hayes DF, Ethier S, Lippman ME (2006) New guidelines for reporting of tumor marker studies in breast cancer research and treatment: REMARK. Breast Cancer Res Treat 100: 237-238
-
(2006)
Breast Cancer Res Treat
, vol.100
, pp. 237-238
-
-
Hayes, D.F.1
Ethier, S.2
Lippman, M.E.3
-
10
-
-
0141956319
-
Her-2/neu-triggered intracellular tyrosine kinase activation: In vivo relevance of ligandindependent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment
-
Hudelist G, Kostler WJ, Attems J, Czerwenka K, Muller R, Manavi M, Steger GG, Kubista E, Zielinski CC, Singer CF (2003) Her-2/neu-triggered intracellular tyrosine kinase activation: in vivo relevance of ligandindependent activation mechanisms and impact upon the efficacy of trastuzumab-based treatment. Br J Cancer 89: 983-991
-
(2003)
Br J Cancer
, vol.89
, pp. 983-991
-
-
Hudelist, G.1
Kostler, W.J.2
Attems, J.3
Czerwenka, K.4
Muller, R.5
Manavi, M.6
Steger, G.G.7
Kubista, E.8
Zielinski, C.C.9
Singer, C.F.10
-
11
-
-
2442613063
-
Monitoring of serum Her-2/neu predicts histopathological response to neoadjuvant trastuzumab-based therapy for breast cancer
-
Köstler WJ, Steger GG, Soleiman A, Schwab B, Singer CF, Tomek S, Brodowicz T, Krainer M, Wiltschke C, Horvat R, Jakesz R, Zielinski CC (2004) Monitoring of serum Her-2/neu predicts histopathological response to neoadjuvant trastuzumab-based therapy for breast cancer. Anticancer Res 24: 1127-1130
-
(2004)
Anticancer Res
, vol.24
, pp. 1127-1130
-
-
Köstler, W.J.1
Steger, G.G.2
Soleiman, A.3
Schwab, B.4
Singer, C.F.5
Tomek, S.6
Brodowicz, T.7
Krainer, M.8
Wiltschke, C.9
Horvat, R.10
Jakesz, R.11
Zielinski, C.C.12
-
12
-
-
0037087535
-
Elevated serum her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer
-
Lipton A, Ali SM, Leitzel K, Demers L, Chinchilli V, Engle L, Harvey HA, Brady C, Nalin CM, Dugan M, Carney W, Allard J (2002) Elevated serum her-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J Clin Oncol 20: 1467-1472
-
(2002)
J Clin Oncol
, vol.20
, pp. 1467-1472
-
-
Lipton, A.1
Ali, S.M.2
Leitzel, K.3
Demers, L.4
Chinchilli, V.5
Engle, L.6
Harvey, H.A.7
Brady, C.8
Nalin, C.M.9
Dugan, M.10
Carney, W.11
Allard, J.12
-
13
-
-
80054817785
-
Human epidermal growth factor receptor 2 (HER2) extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic breast cancer receiving lapatinib monotherapy
-
Lipton A, Leitzel K, Ali SM, Carney W, Platek G, Steplewski K, Westlund R, Gagnon R, Martin AM, Maltzman J (2011) Human epidermal growth factor receptor 2 (HER2) extracellular domain levels are associated with progression-free survival in patients with HER2-positive metastatic breast cancer receiving lapatinib monotherapy. Cancer 117: 5013-5020
-
(2011)
Cancer
, vol.117
, pp. 5013-5020
-
-
Lipton, A.1
Leitzel, K.2
Ali, S.M.3
Carney, W.4
Platek, G.5
Steplewski, K.6
Westlund, R.7
Gagnon, R.8
Martin, A.M.9
Maltzman, J.10
-
14
-
-
78650492709
-
Lapatinib for breast cancer: A review of the current literature
-
MacFarlane RJ, Gelmon KA (2011) Lapatinib for breast cancer: a review of the current literature. Expert Opin Drug Saf 10: 109-121
-
(2011)
Expert Opin Drug Saf
, vol.10
, pp. 109-121
-
-
MacFarlane, R.J.1
Gelmon, K.A.2
-
15
-
-
33846677976
-
Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy
-
Mazouni C, Hall A, Broglio K, Fritsche H, Andre F, Esteva FJ, Hortobagyi GN, Buzdar AU, Pusztai L, Cristofanilli M (2007) Kinetics of serum HER-2/neu changes in patients with HER-2-positive primary breast cancer after initiation of primary chemotherapy. Cancer 109: 496-501
-
(2007)
Cancer
, vol.109
, pp. 496-501
-
-
Mazouni, C.1
Hall, A.2
Broglio, K.3
Fritsche, H.4
Andre, F.5
Esteva, F.J.6
Hortobagyi, G.N.7
Buzdar, A.U.8
Pusztai, L.9
Cristofanilli, M.10
-
16
-
-
23844534811
-
Reporting recommendations for tumor marker prognostic studies (REMARK)
-
McShane LM, Altman DG, Sauerbrei W, Taube SE, Gion M, Clark GM (2005) Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 97: 1180-1184
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1180-1184
-
-
McShane, L.M.1
Altman, D.G.2
Sauerbrei, W.3
Taube, S.E.4
Gion, M.5
Clark, G.M.6
-
17
-
-
0035874981
-
Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells
-
Molina MA, Codony-Servat J, Albanell J, Rojo F, Arribas J, Baselga J (2001) Trastuzumab (herceptin), a humanized anti-Her2 receptor monoclonal antibody, inhibits basal and activated Her2 ectodomain cleavage in breast cancer cells. Cancer Res 61: 4744-4749
-
(2001)
Cancer Res
, vol.61
, pp. 4744-4749
-
-
Molina, M.A.1
Codony-Servat, J.2
Albanell, J.3
Rojo, F.4
Arribas, J.5
Baselga, J.6
-
18
-
-
0036187710
-
NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer
-
Molina MA, Saez R, Ramsey EE, Garcia-Barchino MJ, Rojo F, Evans AJ, Albanell J, Keenan EJ, Lluch A, Garcia-Conde J, Baselga J, Clinton GM (2002) NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer. Clin Cancer Res 8: 347-353
-
(2002)
Clin Cancer Res
, vol.8
, pp. 347-353
-
-
Molina, M.A.1
Saez, R.2
Ramsey, E.E.3
Garcia-Barchino, M.J.4
Rojo, F.5
Evans, A.J.6
Albanell, J.7
Keenan, E.J.8
Lluch, A.9
Garcia-Conde, J.10
Baselga, J.11
Clinton, G.M.12
-
19
-
-
3142769775
-
Prognostic and predictive impact of the HER-2/neu extracellular domain (ECD) in the serum of patients treated with chemotherapy for metastatic breast cancer
-
Mueller V, Witzel I, Luck HJ, Kohler G, von Minckwitz G, Mobus V, Sattler D, Wilczak W, Loning T, Jaenicke F, Pantel K, Thomssen C (2004) Prognostic and predictive impact of the HER-2/neu extracellular domain (ECD) in the serum of patients treated with chemotherapy for metastatic breast cancer. Breast Cancer Res Treat 86: 9-18
-
(2004)
Breast Cancer Res Treat
, vol.86
, pp. 9-18
-
-
Mueller, V.1
Witzel, I.2
Luck, H.J.3
Kohler, G.4
Von Minckwitz, G.5
Mobus, V.6
Sattler, D.7
Wilczak, W.8
Loning, T.9
Jaenicke, F.10
Pantel, K.11
Thomssen, C.12
-
20
-
-
34247588567
-
Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer
-
Scaltriti M, Rojo F, Ocana A, Anido J, Guzman M, Cortes J, Di Cosimo S, Matias-Guiu X, Ramon Y, Cajal S, Arribas J, Baselga J (2007) Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer. J Natl Cancer Inst 99: 628-638
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 628-638
-
-
Scaltriti, M.1
Rojo, F.2
Ocana, A.3
Anido, J.4
Guzman, M.5
Cortes, J.6
Di Cosimo, S.7
Matias-Guiu, X.8
Ramon, Y.9
Cajal, S.10
Arribas, J.11
Baselga, J.12
-
21
-
-
84856340091
-
HER2 shedding and serum HER2 extracellular domain: Biology and clinical utility in breast cancer
-
Tse C, Gauchez AS, Jacot W, Lamy PJ (2011) HER2 shedding and serum HER2 extracellular domain: biology and clinical utility in breast cancer. Cancer Treat Rev 38: 133-142
-
(2011)
Cancer Treat Rev
, vol.38
, pp. 133-142
-
-
Tse, C.1
Gauchez, A.S.2
Jacot, W.3
Lamy, P.J.4
-
22
-
-
79957601951
-
Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: Results from the TECHNO trial of the AGO and GBG study groups
-
Untch M, Fasching PA, Konecny GE, Hasmuller S, Lebeau A, Kreienberg R, Camara O, Muller V, du Bois A, Kuhn T, Stickeler E, Harbeck N, Hoss C, Kahlert S, Beck T, Fett W, Mehta KM, von Minckwitz G, Loibl S (2011) Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: results from the TECHNO trial of the AGO and GBG study groups. J Clin Oncol 29: 3351-3357
-
(2011)
J Clin Oncol
, vol.29
, pp. 3351-3357
-
-
Untch, M.1
Fasching, P.A.2
Konecny, G.E.3
Hasmuller, S.4
Lebeau, A.5
Kreienberg, R.6
Camara, O.7
Muller, V.8
Du Bois, A.9
Kuhn, T.10
Stickeler, E.11
Harbeck, N.12
Hoss, C.13
Kahlert, S.14
Beck, T.15
Fett, W.16
Mehta, K.M.17
Von Minckwitz, G.18
Loibl, S.19
-
23
-
-
84856444501
-
Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial
-
Untch M, Loibl S, Bischoff J, Eidtmann H, Kaufmann M, Blohmer JU, Hilfrich J, Strumberg D, Fasching PA, Kreienberg R, Tesch H, Hanusch C, Gerber B, Rezai M, Jackisch C, Huober J, Kuhn T, Nekljudova V, von Minckwitz G (2012) Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-taxane-based chemotherapy (GeparQuinto, GBG 44): a randomised phase 3 trial. Lancet Oncol 13: 135-144
-
(2012)
Lancet Oncol
, vol.13
, pp. 135-144
-
-
Untch, M.1
Loibl, S.2
Bischoff, J.3
Eidtmann, H.4
Kaufmann, M.5
Blohmer, J.U.6
Hilfrich, J.7
Strumberg, D.8
Fasching, P.A.9
Kreienberg, R.10
Tesch, H.11
Hanusch, C.12
Gerber, B.13
Rezai, M.14
Jackisch, C.15
Huober, J.16
Kuhn, T.17
Nekljudova, V.18
Von Minckwitz, G.19
-
24
-
-
77951624086
-
Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: Results from the GeparQuattro Study
-
Untch M, Rezai M, Loibl S, Fasching PA, Huober J, Tesch H, Bauerfeind I, Hilfrich J, EidtmannH,Gerber B,Hanusch C, Kuhn T, du BoisA, Blohmer JU, Thomssen C, Dan Costa S, Jackisch C, Kaufmann M, Mehta K, von Minckwitz G (2010) Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro Study. J Clin Oncol 28: 2024-2031
-
(2010)
J Clin Oncol
, vol.28
, pp. 2024-2031
-
-
Untch, M.1
Rezai, M.2
Loibl, S.3
Fasching, P.A.4
Huober, J.5
Tesch, H.6
Bauerfeind, I.7
Hilfrich, J.8
Eidtmannhgerber Bhanusch, C.9
Kuhn, T.10
Boisa, D.11
Blohmer, J.U.12
Thomssen, C.13
Dan Costa, S.14
Jackisch, C.15
Kaufmann, M.16
Mehta, K.17
Von Minckwitz, G.18
-
25
-
-
78049309932
-
Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth
-
Vazquez-Martin A, Oliveras-Ferraros C, Cufi S, Del Barco S, Martin-Castillo B, Menendez JA (2011) Lapatinib, a dual HER1/HER2 tyrosine kinase inhibitor, augments basal cleavage of HER2 extracellular domain (ECD) to inhibit HER2-driven cancer cell growth. J Cell Physiol 226: 52-57
-
(2011)
J Cell Physiol
, vol.226
, pp. 52-57
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Cufi, S.3
Del Barco, S.4
Martin-Castillo, B.5
Menendez, J.A.6
-
26
-
-
79251587195
-
Integrating bevacizumab, everolimus, and lapatinib into current neoadjuvant chemotherapy regimen for primary breast cancer. Safety results of the GeparQuinto trial
-
von Minckwitz G, Eidtmann H, Loibl S, Blohmer JU, Costa SD, Fasching PA, Kreienberg R, Hilfrich J, Gerber B, Hanusch C, Fehm T, Strumberg D, Solbach C, Nekljudova V, Untch M (2011) Integrating bevacizumab, everolimus, and lapatinib into current neoadjuvant chemotherapy regimen for primary breast cancer. Safety results of the GeparQuinto trial. Ann Oncol 22: 301-306
-
(2011)
Ann Oncol
, vol.22
, pp. 301-306
-
-
Von Minckwitz, G.1
Eidtmann, H.2
Loibl, S.3
Blohmer, J.U.4
Costa, S.D.5
Fasching, P.A.6
Kreienberg, R.7
Hilfrich, J.8
Gerber, B.9
Hanusch, C.10
Fehm, T.11
Strumberg, D.12
Solbach, C.13
Nekljudova, V.14
Untch, M.15
-
27
-
-
77956182121
-
Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial
-
Witzel I, Loibl S, von Minckwitz G, Mundhenke C, Huober J, Hanusch C, Henschen S, Hauschild M, Lantzsch T, Tesch H, Latos K, Just M, Hilfrich J, Barinoff J, Eulenburg CZ, Roller M, Untch M, Muller V (2010) Monitoring serum HER2 levels during neoadjuvant trastuzumab treatment within the GeparQuattro trial. Breast Cancer Res Treat 123: 437-445
-
(2010)
Breast Cancer Res Treat
, vol.123
, pp. 437-445
-
-
Witzel, I.1
Loibl, S.2
Von Minckwitz, G.3
Mundhenke, C.4
Huober, J.5
Hanusch, C.6
Henschen, S.7
Hauschild, M.8
Lantzsch, T.9
Tesch, H.10
Latos, K.11
Just, M.12
Hilfrich, J.13
Barinoff, J.14
Eulenburg, C.Z.15
Roller, M.16
Untch, M.17
Muller, V.18
|