메뉴 건너뛰기




Volumn 83, Issue 6, 2012, Pages 305-320

A mechanistic study of the effect of doxorubicin/adriamycin on the estrogen response in a breast cancer model

Author keywords

Breast cancer; Doxorubicin; Epidermal growth factor receptor; Estrogen; Estrogen receptor

Indexed keywords

DOXORUBICIN; ESTRADIOL;

EID: 84865856891     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000341394     Document Type: Article
Times cited : (22)

References (87)
  • 1
    • 84873214937 scopus 로고    scopus 로고
    • NCI: SEER cancer statistics review 1975-2007. National Cancer Institute, 2011, tables 1.23-21.28
    • NCI: SEER cancer statistics review 1975-2007. National Cancer Institute, 2011, tables 1.23-21.28.
  • 6
    • 0029157380 scopus 로고
    • Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells
    • Teixeira C, Reed JC, Pratt MA: Estrogen promotes chemotherapeutic drug resistance by a mechanism involving Bcl-2 proto-oncogene expression in human breast cancer cells. Cancer Res 1995; 55: 3902-3907.
    • (1995) Cancer Res , vol.55 , pp. 3902-3907
    • Teixeira, C.1    Reed, J.C.2    Pratt, M.A.3
  • 7
    • 0032854766 scopus 로고    scopus 로고
    • Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7
    • Leung LK, Wang TT: Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7. Breast Cancer Res Treat 1999; 55: 73-83.
    • (1999) Breast Cancer Res Treat , vol.55 , pp. 73-83
    • Leung, L.K.1    Wang, T.T.2
  • 9
    • 0017640687 scopus 로고
    • Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function
    • Benjamin RS, Riggs CE Jr, Bachur NR: Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Cancer Res 1977; 37: 1416-1420.
    • (1977) Cancer Res , vol.37 , pp. 1416-1420
    • Benjamin, R.S.1    Riggs Jr., C.E.2    Bachur, N.R.3
  • 13
    • 34247208633 scopus 로고    scopus 로고
    • Plasma and tissue pharmacokinetics of epirubicin and paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer
    • Hunz M, Jetter A, Warm M, Pantke E, Tuscher M, Hempel G, Jaehde U, Untch M, Kurbacher C, Fuhr U: Plasma and tissue pharmacokinetics of epirubicin and paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer. Clin Pharmacol Ther 2007; 81: 659-668.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 659-668
    • Hunz, M.1    Jetter, A.2    Warm, M.3    Pantke, E.4    Tuscher, M.5    Hempel, G.6    Jaehde, U.7    Untch, M.8    Kurbacher, C.9    Fuhr, U.10
  • 15
    • 1842554875 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells
    • Sharma G, Tyagi AK, Singh RP, Chan DC, Agarwal R: Synergistic anti-cancer effects of grape seed extract and conventional cytotoxic agent doxorubicin against human breast carcinoma cells. Breast Cancer Res Treat 2004; 85: 1-12.
    • (2004) Breast Cancer Res Treat , vol.85 , pp. 1-12
    • Sharma, G.1    Tyagi, A.K.2    Singh, R.P.3    Chan, D.C.4    Agarwal, R.5
  • 16
    • 72449139148 scopus 로고    scopus 로고
    • Molecular profile and cell cycle in MCF-7 and MCF-7/DOX cells exposed to conventional and liposomal forms of doxorubicin
    • Rusetskaya NV, Lukyanova NY, Chekhun VF: Molecular profile and cell cycle in MCF-7 and MCF-7/DOX cells exposed to conventional and liposomal forms of doxorubicin. Exp Oncol 2009; 31: 140-143.
    • (2009) Exp Oncol , vol.31 , pp. 140-143
    • Rusetskaya, N.V.1    Lukyanova, N.Y.2    Chekhun, V.F.3
  • 19
    • 50249163362 scopus 로고    scopus 로고
    • Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer
    • Yamashita H, Nishio M, Toyama T, Sugiura H, Kondo N, Kobayashi S, Fujii Y, Iwase H: Low phosphorylation of estrogen receptor alpha (ERalpha) serine 118 and high phosphorylation of ERalpha serine 167 improve survival in ER-positive breast cancer. Endocr Relat Cancer 2008; 15: 755-763.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 755-763
    • Yamashita, H.1    Nishio, M.2    Toyama, T.3    Sugiura, H.4    Kondo, N.5    Kobayashi, S.6    Fujii, Y.7    Iwase, H.8
  • 20
    • 59849087158 scopus 로고    scopus 로고
    • Hormone receptor dynamics in a receptive human endometrium
    • Critchley HO, Saunders PT: Hormone receptor dynamics in a receptive human endometrium. Reprod Sci 2009; 16: 191-199.
    • (2009) Reprod Sci , vol.16 , pp. 191-199
    • Critchley, H.O.1    Saunders, P.T.2
  • 21
    • 44549083871 scopus 로고    scopus 로고
    • The role of estrogen receptors in the control of energy and glucose homeostasis
    • Ropero AB, Alonso-Magdalena P, Quesada I, Nadal A: The role of estrogen receptors in the control of energy and glucose homeostasis. Steroids 2008; 73: 874-879.
    • (2008) Steroids , vol.73 , pp. 874-879
    • Ropero, A.B.1    Alonso-Magdalena, P.2    Quesada, I.3    Nadal, A.4
  • 22
    • 40749127983 scopus 로고    scopus 로고
    • Rapid signaling mechanisms of estrogens in the developing cerebellum
    • Belcher SM: Rapid signaling mechanisms of estrogens in the developing cerebellum. Brain Res Rev 2008; 57: 481-492.
    • (2008) Brain Res Rev , vol.57 , pp. 481-492
    • Belcher, S.M.1
  • 24
    • 77955374098 scopus 로고    scopus 로고
    • Update on estrogens and the skeleton
    • Khosla S: Update on estrogens and the skeleton. J Clin Endocrinol Metab 2010; 95: 3569-3577.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3569-3577
    • Khosla, S.1
  • 25
    • 72549085551 scopus 로고    scopus 로고
    • Genomic actions of estrogen receptor alpha: What are the targets and how are they regulated?
    • Welboren WJ, Sweep FC, Span PN, Stunnenberg HG: Genomic actions of estrogen receptor alpha: what are the targets and how are they regulated? Endocr Relat Cancer 2009; 16: 1073-1089.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 1073-1089
    • Welboren, W.J.1    Sweep, F.C.2    Span, P.N.3    Stunnenberg, H.G.4
  • 27
    • 63649099281 scopus 로고    scopus 로고
    • Novel actions of estrogen to promote proliferation: Integration of cytoplasmic and nuclear pathways
    • Fox EM, Andrade J, Shupnik MA: Novel actions of estrogen to promote proliferation: integration of cytoplasmic and nuclear pathways. Steroids 2009; 74: 622-627.
    • (2009) Steroids , vol.74 , pp. 622-627
    • Fox, E.M.1    Andrade, J.2    Shupnik, M.A.3
  • 28
    • 0037211754 scopus 로고    scopus 로고
    • Estrogen receptor phosphorylation
    • Lannigan DA: Estrogen receptor phosphorylation. Steroids 2003; 68: 1-9.
    • (2003) Steroids , vol.68 , pp. 1-9
    • Lannigan, D.A.1
  • 29
    • 0037069418 scopus 로고    scopus 로고
    • Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade
    • Wong CW, McNally C, Nickbarg E, Komm BS, Cheskis BJ: Estrogen receptor-interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci USA 2002; 99: 14783-14788.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14783-14788
    • Wong, C.W.1    McNally, C.2    Nickbarg, E.3    Komm, B.S.4    Cheskis, B.J.5
  • 31
    • 3042681854 scopus 로고    scopus 로고
    • 17beta-estradiolinduced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells
    • Chieffi P, Kisslinger A, Sinisi AA, Abbondanza C, Tramontano D: 17beta-estradiolinduced activation of ERK1/2 through endogenous androgen receptor-estradiol receptor alpha-Src complex in human prostate cells. Int J Oncol 2003; 23: 797-801.
    • (2003) Int J Oncol , vol.23 , pp. 797-801
    • Chieffi, P.1    Kisslinger, A.2    Sinisi, A.A.3    Abbondanza, C.4    Tramontano, D.5
  • 32
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS: Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 1997; 13: 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 34
    • 0021173495 scopus 로고
    • Cellular and molecular effects of adriamycin on dividing and nondividing cells
    • Barranco SC: Cellular and molecular effects of adriamycin on dividing and nondividing cells. Pharmacol Ther 1984; 24: 303-319.
    • (1984) Pharmacol Ther , vol.24 , pp. 303-319
    • Barranco, S.C.1
  • 36
    • 0034718770 scopus 로고    scopus 로고
    • Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells
    • Yun C, Lee JH, Park H, Jin YM, Park S, Park K, Cho H: Chemotherapeutic drug, adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells. Oncogene 2000; 19: 5163-5172.
    • (2000) Oncogene , vol.19 , pp. 5163-5172
    • Yun, C.1    Lee, J.H.2    Park, H.3    Jin, Y.M.4    Park, S.5    Park, K.6    Cho, H.7
  • 38
    • 0034014355 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis
    • Lobenhofer EK, Huper G, Iglehart JD, Marks JR: Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis. Cell Growth Differ 2000; 11: 99-110.
    • (2000) Cell Growth Differ , vol.11 , pp. 99-110
    • Lobenhofer, E.K.1    Huper, G.2    Iglehart, J.D.3    Marks, J.R.4
  • 39
    • 0025374582 scopus 로고
    • Hormonal modulation of HER-2/Neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines
    • Read LD, Keith D Jr, Slamon DJ, Katzenellenbogen BS: Hormonal modulation of HER-2/Neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines. Cancer Res 1990; 50: 3947-3951.
    • (1990) Cancer Res , vol.50 , pp. 3947-3951
    • Read, L.D.1    Keith Jr., D.2    Slamon, D.J.3    Katzenellenbogen, B.S.4
  • 41
    • 0029563173 scopus 로고
    • Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element
    • Arnold SF, Vorojeikina DP, Notides AC: Phosphorylation of tyrosine 537 on the human estrogen receptor is required for binding to an estrogen response element. J Biol Chem 1995; 270: 30205-30212.
    • (1995) J Biol Chem , vol.270 , pp. 30205-30212
    • Arnold, S.F.1    Vorojeikina, D.P.2    Notides, A.C.3
  • 42
    • 0027978187 scopus 로고
    • Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor
    • Arnold SF, Obourn JD, Jaffe H, Notides AC: Serine 167 is the major estradiol-induced phosphorylation site on the human estrogen receptor. Mol Endocrinol 1994; 8: 1208-1214.
    • (1994) Mol Endocrinol , vol.8 , pp. 1208-1214
    • Arnold, S.F.1    Obourn, J.D.2    Jaffe, H.3    Notides, A.C.4
  • 44
    • 0028046570 scopus 로고
    • Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms
    • Antoniotti S, Taverna D, Maggiora P, Sapei ML, Hynes NE, De Bortoli M: Oestrogen and epidermal growth factor down-regulate erbB-2 oncogene protein expression in breast cancer cells by different mechanisms. Br J Cancer 1994; 70: 1095-1101.
    • (1994) Br J Cancer , vol.70 , pp. 1095-1101
    • Antoniotti, S.1    Taverna, D.2    Maggiora, P.3    Sapei, M.L.4    Hynes, N.E.5    De Bortoli, M.6
  • 48
    • 0022348002 scopus 로고
    • Tamoxifen-citrate counteracts the antitumor effects of cytotoxic drugs in vitro
    • Hug V, Hortobagyi GN, Drewinko B, Finders M: Tamoxifen-citrate counteracts the antitumor effects of cytotoxic drugs in vitro. J Clin Oncol 1985; 3: 1672-1677.
    • (1985) J Clin Oncol , vol.3 , pp. 1672-1677
    • Hug, V.1    Hortobagyi, G.N.2    Drewinko, B.3    Finders, M.4
  • 49
    • 0028090408 scopus 로고
    • Adjuvant CMFVP versus tamoxifen versus concurrent CMFVP and tamoxifen for postmenopausal, nodepositive, and estrogen receptor-positive breast cancer patients: A Southwest Oncology Group study
    • Rivkin SE, Green S, Metch B, Cruz AB, Abeloff MD, Jewell WR, Costanzi JJ, Farrar WB, Minton JP, Osborne CK: Adjuvant CMFVP versus tamoxifen versus concurrent CMFVP and tamoxifen for postmenopausal, nodepositive, and estrogen receptor-positive breast cancer patients: a Southwest Oncology Group study. J Clin Oncol 1994; 12: 2078-2085.
    • (1994) J Clin Oncol , vol.12 , pp. 2078-2085
    • Rivkin, S.E.1    Green, S.2    Metch, B.3    Cruz, A.B.4    Abeloff, M.D.5    Jewell, W.R.6    Costanzi, J.J.7    Farrar, W.B.8    Minton, J.P.9    Osborne, C.K.10
  • 51
    • 19344364880 scopus 로고    scopus 로고
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • Early Breast Cancer Trialists' Collaborative Group (EBCTCG): Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005; 365: 1687-1717.
    • (2005) Lancet , vol.365 , pp. 1687-1717
  • 56
    • 34249306702 scopus 로고    scopus 로고
    • Epidermal growth factor directs sex-specific steroid signaling through Src activation
    • Hitosugi T, Sasaki K, Sato M, Suzuki Y, Umezawa Y: Epidermal growth factor directs sex-specific steroid signaling through Src activation. J Biol Chem 2007; 282: 10697-10706.
    • (2007) J Biol Chem , vol.282 , pp. 10697-10706
    • Hitosugi, T.1    Sasaki, K.2    Sato, M.3    Suzuki, Y.4    Umezawa, Y.5
  • 57
    • 77449090238 scopus 로고    scopus 로고
    • Estrogenmediated regulation of IGF1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements
    • Hewitt SC, Li Y, Li L, Korach KS: Estrogenmediated regulation of IGF1 transcription and uterine growth involves direct binding of estrogen receptor alpha to estrogen-responsive elements. J Biol Chem 2010; 285: 2676-2685.
    • (2010) J Biol Chem , vol.285 , pp. 2676-2685
    • Hewitt, S.C.1    Li, Y.2    Li, L.3    Korach, K.S.4
  • 58
    • 25644447454 scopus 로고    scopus 로고
    • Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells
    • Lee YR, Park J, Yu HN, Kim JS, Youn HJ, Jung SH: Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells. Biochem Biophys Res Commun 2005; 336: 1221-1226.
    • (2005) Biochem Biophys Res Commun , vol.336 , pp. 1221-1226
    • Lee, Y.R.1    Park, J.2    Yu, H.N.3    Kim, J.S.4    Youn, H.J.5    Jung, S.H.6
  • 59
    • 0036152007 scopus 로고    scopus 로고
    • Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome
    • Apparao KB, Lovely LP, Gui Y, Lininger RA, Lessey BA: Elevated endometrial androgen receptor expression in women with polycystic ovarian syndrome. Biol Reprod 2002; 66: 297-304.
    • (2002) Biol Reprod , vol.66 , pp. 297-304
    • Apparao, K.B.1    Lovely, L.P.2    Gui, Y.3    Lininger, R.A.4    Lessey, B.A.5
  • 60
    • 0035036735 scopus 로고    scopus 로고
    • Estrogen suppression of EGFR expression in breast cancer cells: A possible mechanism to modulate growth
    • Yarden RI, Wilson MA, Chrysogelos SA: Estrogen suppression of EGFR expression in breast cancer cells: a possible mechanism to modulate growth. J Cell Biochem Suppl 2001;(suppl 36):232-246.
    • (2001) J Cell Biochem Suppl , Issue.SUPPL. 36 , pp. 232-246
    • Yarden, R.I.1    Wilson, M.A.2    Chrysogelos, S.A.3
  • 61
    • 20844453021 scopus 로고    scopus 로고
    • Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus
    • Valley CC, Metivier R, Solodin NM, Fowler AM, Mashek MT, Hill L, Alarid ET: Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus. Mol Cell Biol 2005; 25: 5417-5428.
    • (2005) Mol Cell Biol , vol.25 , pp. 5417-5428
    • Valley, C.C.1    Metivier, R.2    Solodin, N.M.3    Fowler, A.M.4    Mashek, M.T.5    Hill, L.6    Alarid, E.T.7
  • 63
    • 0842286818 scopus 로고    scopus 로고
    • Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells
    • Okubo S, Kurebayashi J, Otsuki T, Yamamoto Y, Tanaka K, Sonoo H: Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells. Br J Cancer 2004; 90: 236-244.
    • (2004) Br J Cancer , vol.90 , pp. 236-244
    • Okubo, S.1    Kurebayashi, J.2    Otsuki, T.3    Yamamoto, Y.4    Tanaka, K.5    Sonoo, H.6
  • 65
    • 34247890106 scopus 로고    scopus 로고
    • Inhibition of the MAP kinase activity suppresses estrogen-induced breast tumor growth both in vitro and in vivo
    • Reddy KB, Glaros S: Inhibition of the MAP kinase activity suppresses estrogen-induced breast tumor growth both in vitro and in vivo. Int J Oncol 2007; 30: 971-975.
    • (2007) Int J Oncol , vol.30 , pp. 971-975
    • Reddy, K.B.1    Glaros, S.2
  • 66
  • 68
    • 35648964110 scopus 로고    scopus 로고
    • Using clinical trial data to tailor adjuvant treatments for individual patients
    • Regan MM, Gelber RD: Using clinical trial data to tailor adjuvant treatments for individual patients. Breast 2007; 16(suppl 2):S98-S104.
    • (2007) Breast , vol.16 , Issue.SUPPL. 2
    • Regan, M.M.1    Gelber, R.D.2
  • 71
    • 52049118324 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade in combination with conventional chemotherapy inhibits soft tissue sarcoma cell growth in vitro and in vivo
    • Ren W, Korchin B, Zhu QS, Wei C, Dicker A, Heymach J, Lazar A, Pollock RE, Lev D: Epidermal growth factor receptor blockade in combination with conventional chemotherapy inhibits soft tissue sarcoma cell growth in vitro and in vivo. Clin Cancer Res 2008; 14: 2785-2795.
    • (2008) Clin Cancer Res , vol.14 , pp. 2785-2795
    • Ren, W.1    Korchin, B.2    Zhu, Q.S.3    Wei, C.4    Dicker, A.5    Heymach, J.6    Lazar, A.7    Pollock, R.E.8    Lev, D.9
  • 73
    • 50549090299 scopus 로고    scopus 로고
    • Kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status
    • kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status. Int J Cancer 2008; 123: 1536-1544.
    • (2008) Int J Cancer , vol.123 , pp. 1536-1544
  • 76
    • 0035863471 scopus 로고    scopus 로고
    • Matrix metalloproteinase-7-mediated cleavage of FAS ligand protects tumor cells from chemotherapeutic drug cytotoxicity
    • Mitsiades N, Yu WH, Poulaki V, Tsokos M, Stamenkovic I: Matrix metalloproteinase-7-mediated cleavage of FAS ligand protects tumor cells from chemotherapeutic drug cytotoxicity. Cancer Res 2001; 61: 577-581.
    • (2001) Cancer Res , vol.61 , pp. 577-581
    • Mitsiades, N.1    Yu, W.H.2    Poulaki, V.3    Tsokos, M.4    Stamenkovic, I.5
  • 77
    • 0141502228 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis
    • Wetzel M, Rosenberg GA, Cunningham LA: Tissue inhibitor of metalloproteinases-3 and matrix metalloproteinase-3 regulate neuronal sensitivity to doxorubicin-induced apoptosis. Eur J Neurosci 2003; 18: 1050-1060.
    • (2003) Eur J Neurosci , vol.18 , pp. 1050-1060
    • Wetzel, M.1    Rosenberg, G.A.2    Cunningham, L.A.3
  • 78
    • 33947536035 scopus 로고    scopus 로고
    • MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells
    • Nilsson UW, Garvin S, Dabrosin C: MMP-2 and MMP-9 activity is regulated by estradiol and tamoxifen in cultured human breast cancer cells. Breast Cancer Res Treat 2007; 102: 253-261.
    • (2007) Breast Cancer Res Treat , vol.102 , pp. 253-261
    • Nilsson, U.W.1    Garvin, S.2    Dabrosin, C.3
  • 79
    • 1442286386 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta and matrix metalloproteinases by estrogen and prolactin in breast cancer cells
    • Philips N, McFadden K: Inhibition of transforming growth factor-beta and matrix metalloproteinases by estrogen and prolactin in breast cancer cells. Cancer Lett 2004; 206: 63-68.
    • (2004) Cancer Lett , vol.206 , pp. 63-68
    • Philips, N.1    McFadden, K.2
  • 82
    • 0042697468 scopus 로고    scopus 로고
    • The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide
    • Brantley-Finley C, Lyle CS, Du L, Goodwin ME, Hall T, Szwedo D, Kaushal GP, Chambers TC: The JNK, ERK and p53 pathways play distinct roles in apoptosis mediated by the antitumor agents vinblastine, doxorubicin, and etoposide. Biochem Pharmacol 2003; 66: 459-469.
    • (2003) Biochem Pharmacol , vol.66 , pp. 459-469
    • Brantley-Finley, C.1    Lyle, C.S.2    Du, L.3    Goodwin, M.E.4    Hall, T.5    Szwedo, D.6    Kaushal, G.P.7    Chambers, T.C.8
  • 83
    • 0033625257 scopus 로고    scopus 로고
    • Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex
    • Waller AS, Sharrard RM, Berthon P, Maitland NJ: Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex. J Mol Endocrinol 2000; 24: 339-351.
    • (2000) J Mol Endocrinol , vol.24 , pp. 339-351
    • Waller, A.S.1    Sharrard, R.M.2    Berthon, P.3    Maitland, N.J.4
  • 84
    • 0037135630 scopus 로고    scopus 로고
    • Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
    • Masiello D, Cheng S, Bubley GJ, Lu ML, Balk SP: Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J Biol Chem 2002; 277: 26321-26326.
    • (2002) J Biol Chem , vol.277 , pp. 26321-26326
    • Masiello, D.1    Cheng, S.2    Bubley, G.J.3    Lu, M.L.4    Balk, S.P.5
  • 85
    • 84873219689 scopus 로고    scopus 로고
    • NCI: Clinical trials database. National Cancer Institute, 2011
    • NCI: Clinical trials database. National Cancer Institute, 2011.
  • 86
    • 66149155038 scopus 로고    scopus 로고
    • Role of biologic therapy and chemotherapy in hormone receptor-and HER2-positive breast cancer
    • Buzdar AU: Role of biologic therapy and chemotherapy in hormone receptor-and HER2-positive breast cancer. Ann Oncol 2009; 20: 993-999.
    • (2009) Ann Oncol , vol.20 , pp. 993-999
    • Buzdar, A.U.1
  • 87
    • 0029147851 scopus 로고
    • Immune complex kinase assays for mitogen-activated protein kinase and MEK
    • Reuter CW, Catling AD, Weber MJ: Immune complex kinase assays for mitogen-activated protein kinase and MEK. Methods Enzymol 1995; 255: 245-256.
    • (1995) Methods Enzymol , vol.255 , pp. 245-256
    • Reuter, C.W.1    Catling, A.D.2    Weber, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.