Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment-analysis of the age-cardiomyocytes electric capacitance dependence

Journal of Cardiovascular Translational Research

Volumn 5, Issue 3, 2012, Pages 321-332

  Polak, Sebastian ^a   Fijorek, Kamil ^b  

^a JAGIELLONIAN UNIVERSITY   (Poland)

^b CRACOW UNIVERSITY OF ECONOMICS   (Poland)

Author keywords

Cardiomyocyte electric capacitance; Human cardiomyocyte; Inter individual variability; Virtual population

Indexed keywords

MOXIFLOXACIN; POTASSIUM CHANNEL HERG;

AGE; ARTICLE; CARDIOTOXICITY; CELL VOLUME; DRUG SAFETY; ELECTRIC CAPACITANCE; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART VENTRICLE; HODGKIN HUXLEY EQUATION; ION CURRENT; PRIORITY JOURNAL; QT INTERVAL; RISK ASSESSMENT; SIMULATION; ACTION POTENTIAL; ADOLESCENT; ADULT; AGED; AGING; BIOLOGICAL MODEL; CELL MEMBRANE; CHEMICALLY INDUCED DISORDER; CHILD; COMPUTER SIMULATION; DRUG EFFECT; DRUG SCREENING; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; REPRODUCIBILITY; STATISTICAL MODEL; TIME; TOXICITY TESTING; VALIDATION STUDY;

MAMMALIA;

ACTION POTENTIALS; ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CELL MEMBRANE; CHILD; CHILD, PRESCHOOL; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; ELECTRIC CAPACITANCE; FEMALE; HEART DISEASES; HUMANS; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; MODELS, STATISTICAL; MYOCYTES, CARDIAC; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TIME FACTORS; TOXICITY TESTS; YOUNG ADULT;

EID: 84865842390     PISSN: 19375387     EISSN: 19375395     Source Type: Journal    
DOI: 10.1007/s12265-012-9357-8     Document Type: Article

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