A new strategy of using o18-labeled iodoacetic acid for mass spectrometry-based protein quantitation

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 7, 2012, Pages 1293-1297

  Wang, Shunhai ^a   Kaltashov, Igor A ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Pharmacokinetics; Protein quantitation; Stable isotope labeling

Indexed keywords

BIOPHARMACEUTICAL SECTORS; CARBOXYLIC OXYGEN; DYNAMIC RANGE; HUMAN SERUM TRANSFERRIN (HTF); INTACT PROTEINS; IODOACETIC ACID; ISOTOPE LABELING; LABELING STRATEGY; PH CONDITION; PHARMACOKINETIC STUDIES; PROTEIN THERAPEUTICS; QUANTITATIVE PROTEOMICS; SAMPLE PROCESSING; SIDE-CHAINS; STABLE-ISOTOPE LABELING;

AMINO ACIDS; ISOTOPES; MASS SPECTROMETRY; MOLECULAR BIOLOGY; PHARMACOKINETICS;

PEPTIDES;

CYSTEINE; IODOACETIC ACID; OXYGEN 18; REAGENT; TRANSFERRIN; WATER; OXYGEN; PEPTIDE FRAGMENT; PROTEIN;

ALKYLATION; ARTICLE; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PH; PROTEIN ANALYSIS; PROTEIN STABILITY; PROTEOMICS; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; AMINO ACID SEQUENCE; CHEMISTRY; ELECTROSPRAY MASS SPECTROMETRY; FEASIBILITY STUDY; HUMAN; METHODOLOGY; MOLECULAR GENETICS;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, LIQUID; CYSTEINE; FEASIBILITY STUDIES; HUMANS; HYDROGEN-ION CONCENTRATION; IODOACETIC ACID; ISOTOPE LABELING; MOLECULAR SEQUENCE DATA; OXYGEN ISOTOPES; PEPTIDE FRAGMENTS; PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRANSFERRIN;

EID: 84865840287     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0396-9     Document Type: Article

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