No additional copies of HERV-Fc1 in the germ line of multiple sclerosis patients

Virology Journal

Volumn 9, Issue , 2012, Pages

  Nissen, Kari K ^a   Laska, Magdalena J ^a   Hansen, Bettina ^a   Pedersen, Finn S ^a   Nexø, Bjørn A ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

HERV Fc1; Multiple sclerosis; Provirus copy number

Indexed keywords

ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOGENOUS RETROVIRUS; FEMALE; GENE DOSAGE; GENE INSERTION; GENOME; GERM LINE; HUMAN; HUMAN ENDOGENOUS RETROVIRUS FC1; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; SEX RATIO; SOUTHERN BLOTTING; X CHROMOSOME;

BLOTTING, SOUTHERN; DNA COPY NUMBER VARIATIONS; ENDOGENOUS RETROVIRUSES; FEMALE; GERM CELLS; HUMANS; MALE; MULTIPLE SCLEROSIS;

ANIMALIA; HUMAN ENDOGENOUS RETROVIRUSES;

EID: 84865830371     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-9-188     Document Type: Article

References (18)

1. Initial sequencing and analysis of the human genome. Lander ES, Linton LM, Birren B, et al. Nature 2001 409 860 921 10.1038/35057062 11237011
2. Identification of endogenous retroviral reading frames in the human genome. Villesen P, Aagaard L, Wiuf C, Pedersen FS, Retrovirol 2004 1 32 10.1186/1742-4690-1-32
3. Molecular identification of a novel retrovirus repeatedly isolated from patients with multiple sclerosis. The Collaborative Research Group on Multiple Sclerosis. Perron H, Garson JA, Bedin F, Beseme F, Paranhos-Baccala G, Komurian-Pradel F, Mallet F, Tuke PW, Voisset C, Blond JL, Lalande B, Seigneurin JM, Mandrand B, Proc Natl Acad Sci U S A 1997 94 7583 7588 10.1073/pnas.94.14. 7583 9207135
4. B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity. Brudek T, Christensen T, Aagaard L, Petersen T, Hansen HJ, Møller-Larsen A, Retrovirol 2009 6 104 10.1186/1742-4690-6-104
5. Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease. Perron H, Germi R, Bernard C, Garcia-Montojo M, Deluen C, Farinelli L, Faucard R, Veas F, Stefas I, Fabriek BO, Van-Horssen J, Van-der-Valk P, Gerdil C, Mancuso R, Saresella M, Clerici M, Marcel S, Creange A, Cavaretta R, Caputo D, Arru G, Morand P, Lang AB, Sotgiu S, Ruprecht K, Rieckmann P, Villoslada P, Chofflon M, Boucraut J, Pelletier J, Hartung H-P, Mult Scler J 2012 March:doi: 10.1177/1352458512441381
6. Human endogenous retroviruses and multiple sclerosis: innocent bystanders or disease determinants? Antony JM, Deslauriers AM, Bhat RK, Ellestad KK, Power C, Biochimica et biophysica acta 2011 1812 162 76 10.1016/j.bbadis.2010.07.016 20696240
7. Melanoma, Darwinian medicine and the inner world. Krone B, Grange JM, J Cancer Res Clin Oncol 2010 136 1787 94 10.1007/s00432-010-0949-x 20852885
8. The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. Nexø BA, Christensen T, Frederiksen J, Møller-Larsen A, Oturai AB, Villesen P, Hansen B, Nissen KK, Laska MJ, Petersen TS, Bonnesen S, Hedemand A, Wu T, Wang X, Zhang X, Brudek T, Maric R, Søndergaard HB, Sellebjerg F, Brusgaard K, Kjeldbjerg AL, Rasmussen HB, Nielsen AL, Nyegaard M, Petersen T, Børglum AD, Pedersen FS, PloS ONE 2011 6 16652 10.1371/journal.pone.0016652 21311761
9. Expression of HERV-Fc1, a human endogenous retrovirus, is increased in patients with active Multiple Sclerosis. Laska MJ, Brudek T, Nissen KK, Christensen T, Møller-Larsen A, Petersen T, Nexø BA, J Virol 2012 86 3713 3722 10.1128/JVI.06723-11 22278236
10. Genetic Association of Multiple Sclerosis with the Marker rs391745 near the Endogenous Retroviral Locus HERV-Fc1: Analysis of Disease Subtypes. Hansen B, Oturai AB, Harbo HF, Celius EG, Nissen KK, Laska MJ, Søndergaard HB, Petersen T, Nexø BA, PLoS ONE 2011 6 26438 10.1371/journal.pone.0026438 22039488
11. AKR murine leukemia virus genome: frequency of sequences in DNA of high-, low-, and non-virus-yielding mouse strains. Lowy DR, Chattopadhyay SK, Teich NM, Rowe WP, Levine AS, Proc Natl Acad Sci U S A 1974 71 3555 3559 10.1073/pnas.71.9.3555 4372624
12. Human-specific integrations of the HERV-K endogenous retrovirus family. Medstrand P, Mager DL, J Virol 1998 72 9782 7 9811713
13. Insertional polymorphisms of full-length endogenous retroviruses in humans. Turner G, Barbulescu M, Su M, Jensen-Seaman MI, Kidd KK, Lenz J, Current Biol 2001 11 1531 5 10.1016/S0960-9822(01)00455-9
14. Insertional polymorphisms: a new lease of life for endogenous retroviruses in human disease. Moyes D, Griffiths DJ, Venables PJ, Trends in Genet 2007 23 326 33 10.1016/j.tig.2007.05.004
15. Characterization of the low-copy HERV-Fc family: evidence for recent integrations in primates of elements with coding envelope genes. Benit L, Virol 2003 312 159 168 10.1016/S0042-6822(03)00163-6
16. Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis. Mameli G, Poddighe L, Astone V, Delogu G, Arru G, Sotgiu S, Serra C, Dolei A, J Virol. Methods 2009 161 98 206 10.1016/j.jviromet.2009.05.024 19505508
17. Pig transgenesis by Sleeping Beauty DNA transposition. Jakobsen JE, Li J, Kragh PM, Moldt B, Lin L, Liu Y, Schmidt M, Winther KD, Schyth BD, Holm IE, Vajta G, Bolund L, Callesen H, Jørgensen AL, Nielsen AL, Mikkelsen JG, Transgenic Res 2011 20 533 45 10.1007/s11248-010-9438-x 20803249
18. The first sequenced carnivore genome shows complex host-endogenous retrovirus relationships. Barrio ÁM, Ekerljung M, Jern P, Benachenhou F, Sperber GO, Bongcam-Rudloff E, Blomberg J, Andersson G, PloS ONE 2011 6 19832 10.1371/journal.pone.0019832 21589882