Obesity: Changing asthma in the 21st century

American Journal of Respiratory and Critical Care Medicine

Volumn 186, Issue 5, 2012, Pages 395-396

  Dixon, Anne E ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; DEXAMETHASONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEPTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ASTHMA; CORTICOSTEROID THERAPY; EDITORIAL; EOSINOPHIL; FATTY LIVER; FORCED EXPIRATORY VOLUME; HUMAN; KUPFFER CELL; LUNG ALVEOLUS MACROPHAGE; LUNG FUNCTION; LUNG LAVAGE; MACROPHAGE; MACROPHAGE FUNCTION; METABOLISM; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHAGOCYTOSIS; PRIORITY JOURNAL;

ANIMALS; ASTHMA; HUMANS; MICE; OBESITY; RISK FACTORS;

EID: 84865828177     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201206-1092ED     Document Type: Editorial

References (19)

1. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, Singh GM, Gutierrez HR, Lu Y, Bahalim AN, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011;377:557-567.
2. Beuther DA, Sutherland ER. Overweight, obesity, and incident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007;175:661-666. (Pubitemid 46536480)
3. Vortmann M, Eisner MD. BMI and health status among adults with asthma. Obesity (Silver Spring) 2008;16:146-152. (Pubitemid 351271964)
4. Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. Influence of body mass index on the response to asthma controller agents. Eur Respir J 2006;27:495-503. (Pubitemid 43372522)
5. Salome CM, King GG, Berend N. Physiology of obesity and effects on lung function. J Appl Physiol 2010;108:206-211.
6. Lugogo NL, Hollingsworth JW, Howell DL, Que LG, Francisco D, Church TD, Potts-Kant EN, Ingram JL, Wang Y, Jung S-H, et al. Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. Am J Respir Crit Care Med 2012;186:404-411.
7. Shore SA. Obesity and asthma: lessons from animal models. J Appl Physiol 2007;102:516-528. (Pubitemid 46220879)
8. Shore SA. Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol 2010;108:735-743.
9. Mathis D, Shoelson SE. Immunometabolism: an emerging frontier. Nat Rev Immunol 2011;11:81.
10. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012;18:363-374.
11. Mancuso P, Gottschalk A, Phare SM, Peters-Golden M, Lukacs NW, Huffnagle GB. Leptin-deficient mice exhibit impaired host defense in gram-negative pneumonia. J Immunol 2002;168:4018-4024. (Pubitemid 34298407)
12. Mancuso P, Peters-Golden M, Goel D, Goldberg J, Brock TG, Greenwald-Yarnell M, Myers MG Jr. Disruption of leptin receptor- STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia. J Immunol 2011;186: 1081-1090.
13. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med 2008;178:682-687.
14. Sutherland ER, Goleva E, King TS, Lehman E, Stevens AD, Jackson LP, Stream AR, Fahy JV. Cluster analysis of obesity and asthma phenotypes. PLoS ONE 2012;7:e36631.
15. Williams AS, Chen L, Kasahara DI, Wurmbrand AP, Shore SA. Obesity and airway responsiveness: role of TNFR2. Pulm Pharmacol Ther 2012; Epub ahead of print.
16. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol 2005;115:103-109. (Pubitemid 40075428)
17. Huang K, Rabold R, Abston E, Schofield B, Misra V, Galdzicka E, Lee H, Biswal S, Mitzner W, Tankersley CG. Effects of leptin deficiency on postnatal lung development in mice. J Appl Physiol 2008;105:249-259.
18. Kirwin SM, Bhandari V, Dimatteo D, Barone C, Johnson L, Paul S, Spitzer AR, Chander A, Hassink SG, Funanage VL. Leptin enhances lung maturity in the fetal rat. Pediatr Res 2006;60:200-204. (Pubitemid 44297593)
19. Jain M, Budinger GR, Lo A, Urich D, Rivera SE, Ghosh AK, Gonzalez A, Chiarella SE, Marks K, Donnelly HK, et al. Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma. Am J Respir Crit Care Med 2011;183:1490-1498.