Liquid chromatography-tandem mass spectrometric assay for the mutated BRAF inhibitor vemurafenib in human and mouse plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 889-890, Issue , 2012, Pages 144-147

  Sparidans, Rolf W ^a   Durmus, Selvi ^b   Schinkel, Alfred H ^b   Schellens, Jan H M ^b   Beijnen, Jos H ^a,b,c  

^a UTRECHT UNIVERSITY   (Netherlands)

^b NETHERLANDS CANCER INSTITUTE   (Netherlands)

^c SLOTERVAART HOSPITAL   (Netherlands)

Author keywords

LC MS MS; Mutated BRAF inhibitor; Plasma; Vemurafenib

Indexed keywords

ANALYTES; BIOANALYTICAL ASSAYS; CHROMATOGRAPHIC SYSTEMS; ELECTROSPRAY INTERFACES; HUMAN PLASMA SAMPLES; INTERNAL STANDARDS; ISOCRATIC ELUTION; LC-MS/MS; MOUSE PLASMA; MUTATED BRAF INHIBITOR; OCTADECYL SILICA; PROTEIN PRECIPITATION; QUANTITATIVE ASSAY; SELECTED REACTION MONITORING; SORAFENIB; TRIPLE-QUADRUPOLE MASS SPECTROMETER; VEMURAFENIB; WHOLE CALIBRATION;

ACETONITRILE; CALIBRATION; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL; PLASMAS; SILICA;

MAMMALS;

ACETONITRILE; FORMIC ACID; SORAFENIB; VEMURAFENIB;

ANALYTICAL EQUIPMENT; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HUMAN; ION MONITORING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MOUSE; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; INDOLES; MICE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS B-RAF; REGRESSION ANALYSIS; REPRODUCIBILITY OF RESULTS; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 84858294238     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.02.010     Document Type: Article

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