Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 905, Issue , 2012, Pages 54-60

  Wu, Shanshan ^a   Gao, Wenyuan ^a   Qiu, Feng ^b   Man, Shuli ^a   Fu, Shujun ^c   Liu, Changxiao ^d  

^a TIANJIN UNIVERSITY   (China)

^b INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^c International Joint Academy of Biotechnology and Medicine   (China)

^d TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

LC ESI MS MS; Paris H; Paris polyphylla; Pharmacokinetics; Polyphyllin D

Indexed keywords

ACTIVE COMPONENTS; AGILENT; ANALYTES; ANTI-TUMORS; AQUEOUS AMMONIUM; AVERAGE RECOVERY; CHROMATOGRAPHIC SEPARATIONS; ELECTROSPRAY IONIZATION MASS SPECTROMETRY; GINSENOSIDES; INTERNAL STANDARDS; LC-ESI-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMITS; MOBILE PHASE; PARIS H; PARIS POLYPHYLLA; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; PROTEIN PRECIPITATION; RAT PLASMA; SELECTED REACTION MONITORING; SIMULTANEOUS DETERMINATIONS; TRADITIONAL CHINESE MEDICINE; VALIDATED METHODS;

ACETONITRILE; AMMONIUM COMPOUNDS; BODY FLUIDS; C (PROGRAMMING LANGUAGE); LIQUID CHROMATOGRAPHY; PHARMACOKINETICS; PRECIPITATION (CHEMICAL); RATS; RHODIUM;

MASS SPECTROMETRY;

ACETONITRILE; AMMONIUM ACETATE; ANTINEOPLASTIC AGENT; GINSENOSIDE RH 2; PARIS H; PLANT MEDICINAL PRODUCT; POLYPHYLLIN D; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CHINESE MEDICINE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG STABILITY; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; PARIS POLYPHYLLA; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; SELECTED REACTION MONITORING; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANGIOSPERMS; ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIOSGENIN; DRUG STABILITY; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAPONINS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

PARIS POLYPHYLLA; RATTUS;

EID: 84865801309     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.08.002     Document Type: Article

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