Depression and sexual dysfunction in chronic kidney disease: A narrative review of the evidence in areas of significant unmet need

Nephrology Dialysis Transplantation

Volumn 27, Issue 9, 2012, Pages 3420-3428

  Vecchio, Mariacristina ^a   Palmer, Suetonia C ^b   Tonelli, Marcello ^c   Johnson, David W ^d   Strippoli, Giovanni F M ^a,e,f,g  

^a Consorzio Mario Negri Sud ^*  (Italy)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c UNIVERSITY OF ALBERTA   (Canada)

^d UNIVERSITY OF QUEENSLAND   (Australia)

^e Diaverum Medical Scientific Office   (Sweden)

^f UNIVERSITY OF SYDNEY   (Australia)

^g UNIVERSITY OF BARI   (Italy)

Author keywords

depressive disorder; kidney failure; quality of life; sexual dysfunction; treatment outcome

Indexed keywords

ANTIDEPRESSANT AGENT; FLUOXETINE; PAROXETINE; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; S ADENOSYLMETHIONINE; SERTRALINE; SILDENAFIL; TESTOSTERONE; VARDENAFIL;

ANDROGEN DEFICIENCY; CHRONIC KIDNEY DISEASE; COGNITIVE THERAPY; DEPRESSION; DIAGNOSTIC ACCURACY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE ASSOCIATION; ERECTILE DYSFUNCTION; EVIDENCE BASED MEDICINE; FEMALE SEXUAL DYSFUNCTION; FEMALE SEXUAL FUNCTION INDEX; HEALTH CARE NEED; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; INTERVENTION STUDY; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MALE SEXUAL DYSFUNCTION; NARRATIVE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PREVALENCE; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; PSYCHOLOGICAL RATING SCALE; PSYCHOTHERAPY; QUALITY OF LIFE; QUESTIONNAIRE; RENAL REPLACEMENT THERAPY; REVIEW; RISK BENEFIT ANALYSIS; SCREENING TEST; SEXUAL DYSFUNCTION; SYSTEMATIC REVIEW; THERAPY EFFECT; UNSPECIFIED SIDE EFFECT;

DEPRESSION; HEALTH SERVICES NEEDS AND DEMAND; HUMANS; RENAL INSUFFICIENCY, CHRONIC; SEXUAL DYSFUNCTIONS, PSYCHOLOGICAL;

EID: 84865791252     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfs135     Document Type: Review

References (77)

1. Evans RW, Manninen DL, Garrison LP, Jr et al. The quality of life of patients with end-stage renal disease. N Engl J Med 1985; 312: 553-559.
2. Murtagh FE, Addington-Hall J, Higginson IJ. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis 2007; 14: 82-99.
3. Tong A, Sainsbury P, Chadban S et al. Patients' experiences and perspectives of living with CKD. Am J Kidney Dis 2009; 53: 689-700.
4. Tong A, Sainsbury P, Carter SM et al. Patients' priorities for health research: focus group study of patients with chronic kidney disease. Nephrol Dial Transplant 2008; 23: 3206-3214.
5. Weisbord SD, Fried LF, Mor MK et al. Renal provider recognition of symptoms in patients on maintenance hemodialysis. Clin J Am Soc Nephrol 2007; 2: 960-967.
6. Fukunishi I, Kitaoka T, Shirai T et al. Psychiatric disorders among patients undergoing hemodialysis therapy. Nephron 2002; 91: 344-347.
7. Hedayati SS, Bosworth HB, Kuchibhatla M et al. The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients. Kidney Int 2006; 69: 1662-1668.
8. Hedayati SS, Minhajuddin AT, Toto RD et al. Validation of depression screening scales in patients with CKD. Am J Kidney Dis 2009; 54: 433-439.
9. Navaneethan SD, Vecchio M, Johnson DW et al. Prevalence and correlates of self-reported sexual dysfunction in CKD: a meta-analysis of observational studies. Am J Kidney Dis 2010; 56: 670-685.
10. Snow V, Lascher S, Mottur-Pilson C. Pharmacologic treatment of acute major depression and dysthymia. American College of Physicians-American Society of Internal Medicine. Ann Intern Med 2000; 132: 738-742.
11. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: prevalence and predictors. JAMA 1999; 281: 537-544.
12. Vecchio M, Navaneethan SD, Johnson DW et al. Treatment options for sexual dysfunction in patients with chronic kidney disease: a systematic review of randomized controlled trials. Clin J Am Soc Nephrol 2010; 5: 985-995.
13. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders 4th edn Revised. Washington, DC: Psychiatric Press Inc., 2000.
14. Cruz LN, Fleck MP, Polanczyk CA. Depression as a determinant of quality of life in patients with chronic disease: data from Brazil. Soc Psychiatry Psychiatr Epidemiol 2010; 45: 953-961.
15. Hedayati SS, Minhajuddin AT, Afshar M et al. Association between major depressive episodes in patients with chronic kidney disease and initiation of dialysis, hospitalization, or death. JAMA 2010; 303: 1946-1953.
16. National Collaborating Center for Mental Health. The NICE Guideline on the Management and Treatment of Depression in Adults (Updated Edition) 2010; London, UKNational Institute for Health and Clinical Excellence.
17. Craven JL, Rodin GM, Littlefield C. The Beck Depression Inventory as a screening device for major depression in renal dialysis patients. Int J Psychiatry Med 1988; 18: 365-374.
18. Watnick S, Wang P-L, Demadura T et al. Validation of 2 depression screening tools in dialysis patients. Am J Kidney Dis 2005; 46: 919-924.
19. Craven JL, Rodin GM, Johnson L et al. The diagnosis of major depression in renal dialysis patients. Psychosom Med 1987; 49: 482-492.
20. Thombs BD, Arthurs E, El-Baalbaki G et al. Risk of bias from inclusion of patients who already have diagnosis of or are undergoing treatment for depression in diagnostic accuracy studies of screening tools for depression: systematic review. BMJ 2011; 343: d4825.
21. Martin J, Blum T, Beach S et al. Subclinical depression and performance at work. Soc Psychiatry Psychiatr Epidemiol 2007; 31: 3-9.
22. Chachamovich E, Fleck M, Laidlaw K et al. Impact of major depression and subsyndromal symptoms on quality of life and attitudes toward aging in an international sample of older adults. Gerontologist 2008; 48: 593-602.
23. Haq I, Zainulabdin F, Naqvi A et al. Psychosocial aspects of dialysis and renal transplant. J Pak Med Assoc 1991; 41: 99-100.
24. Penley JA, Wiebe JS, Nwosu A. Psychometric properties of the Spanish Beck Depression Inventory-II in a medical sample. Psychol Assess 2003; 15: 569-577.
25. Raimundo P, Ravasco P, Proenca V et al. Does nutrition play a role in the quality of life of patients under chronic haemodialySisa . Nutr Hosp 2006; 21: 139-144.
26. Chin HJ, Song YR, Lee JJ et al. Moderately decreased renal function negatively affects the health-related quality of life among the elderly Korean population: a population-based study. Nephrol Dial Transplant 2008; 23: 2810-2817.
27. Bakr A, Amr M, Sarhan A et al. Psychiatric disorders in children with chronic renal failure. Pediatr Nephrol 2007; 22: 128-131.
28. Lowry MR, Atcherson E. A short-term follow-up of patients with depressive disorder on entry into home dialysis training. J Affect Disord 1980; 2: 219-227.
29. Abbey SE, Toner BB, Garfinkel PE et al. Self-report symptoms that predict major depression in patients with prominent physical symptoms. Int J Psychiatry Med 1990; 20: 247-258.
30. Arapaslan B, Soykan A, Soykan C et al. Cross-sectional assessment of psychiatric disorders in renal transplantation patients in Turkey: a preliminary study. Transplant Proc 2004; 36: 1419-1421.
31. Berney-Martinet S, Key F, Bell L et al. Psychological profile of adolescents with a kidney transplant. Pediatr Transplant 2009; 13: 701-710.
32. Soucie JM, McClellan WM. Early death in dialysis patients: risk factors and impact on incidence and mortality rates. J Am Soc Nephrol 1996; 7: 2169-2175.
33. Lopes AA, Bragg J, Young E et al. Depression as a predictor of mortality and hospitalization among hemodialysis patients in the United States and Europe. Kidney Int 2002; 62: 199-207.
34. Lopes AA, Albert JM, Young EWet al. Screening for depression in hemodialysis patients: associations with diagnosis, treatment, and outcomes in the DOPPS. Kidney Int 2004; 66: 2047-2053.
35. Dobbels F, Skeans MA, Snyder JJ et al. Depressive disorder in renal transplantation: an analysis of Medicare claims. Am J Kidney Dis 2008; 51: 819-828.
36. Cohen SD, Norris L, Acquaviva K et al. Screening, diagnosis, and treatment of depression in patients with end-stage renal disease. Clin J Am Soc Nephrol 2007; 2: 1332-1342.
37. Finkelstein FO, Wuerth D, Finkelstein SH. An approach to addressing depression in patients with chronic kidney disease. Blood Purif 2010; 29: 121-124.
38. Hedayati SS, Yalamanchili V, Finkelstein FO. A practical approach to the treatment of depression in patients with chronic kidney disease and end-stage renal disease. Kidney Int 2012; 81: 247-255.
39. Meijer A, Roseman M, Milette K et al. Depression screening and patient outcomes in cancer: a systematic review. PLoS One 2011; 6: e27181.
40. Thombs BD, Coyne JC, Cuijpers P et al. Rethinking recommendations for screening for depression in primary care. CMAJ 2012; ; 184: : 413-418.
41. National Institute for Health and Clinical Excellence. Depression in Adults with a Chronic Physical Health Problem. Treatment and Management. NICE Clinical Guideline 91 http://www.nice.org.uk (14 March 2012 date last accessed).
42. Strippoli GF, Craig JC, Schena FP. The number, quality, and coverage of randomized controlled trials in nephrology. J Am Soc Nephrol 2004; 15: 411-419.
43. Ancarani E, Biondi B, Bolletta A et al. Major depression complicating hemodialysis in patients with chronic renal failure: a multicenter, double-blind, controlled clinical trial of S-adenosyl-L-methionine versus placebo. Curr Ther Res Clin Exp 1993; 54: 680-686.
44. Blumenfield M, Levy NB, Spinowitz B et al. Fluoxetine in depressed patients on dialysis. Int J Psychiatry Med 1997; 27: 71-80.
45. Baines LS, Joseph JT, Jindal RM. Prospective randomized study of individual and group psychotherapy versus controls in recipients of renal transplants. Kidney Int 2004; 65: 1937-1942.
46. Koo JR, Yoon JY, Joo MH et al. Treatment of depression and effect of antidepression treatment on nutritional status in chronic hemodialysis patients. Am J Med Sci 2005; 329: 1-5.
47. Lii YC, Tsay SL, Wang TJ. Group intervention to improve quality of life in haemodialysis patients. J Clin Nurs 2007; 16: 268-275.
48. Duarte PS, Miyazaki MC, Blay SL et al. Cognitive-behavioral group therapy is an effective treatment for major depression in hemodialysis patients. Kidney Int 2009; 76: 414-421.
49. Chronic Kidney Disease Antidepressant Sertraline Trial (CAST). ClinicalTrials.gov identifier: NCT00946998. Available from: http:// clinicaltrials.gov/ct2/show/NCT00946998?term=depression+and+kidney&rank=1 (14 March 2012, date last accessed).
50. Weisbord SD, Shields AM, Mor MK et al. Methodology of a randomized clinical trial of symptom management strategies in patients receiving chronic hemodialysis: the SMILE study. Contemp Clin Trials 2010; 31: 491-497.
51. Palmer BF. Sexual dysfunction in uremia. J Am Soc Nephrol 1999; 10: 1381-1388.
52. Finkelstein FO, Shirani S, Wuerth D et al. Therapy insight: sexual dysfunction in patients with chronic kidney disease. Nat Clin Pract Nephrol 2007; 3: 200-207.
53. Rosen R, Brown C, Heiman J et al. The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26: 191-208.
54. Palmer SC, Strippoli GFM. Sexual dysfunction in women requiring hemodialysis: a multinational cross-sectional study [abstract]. J Am Soc Nephrol 2011; 22: 504A.
55. Tiefer L. Female sexual dysfunction: a case study of disease mongering and activist resistance. PLoS Med 2006; 3: e178.
56. Moynihan R. The marketing of a disease: female sexual dysfunction. BMJ 2005; 330: 192-194.
57. Conrad P, Mackie T, Mehrotra A. Estimating the costs of medicalization. Soc Sci Med 2010; 70: 1943-1947.
58. Moynihan R. Major changes are proposed for definitions of female sexual dysfunction. BMJ 2010; 340: c830.
59. Rosen RC, Riley A, Wagner G et al. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology 1997; 49: 822-830.
60. Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther 2005; 31: 1-20.
61. Filocamo MT, Zanazzi M, Li Marzi V et al. Sexual dysfunction in women during dialysis and after renal transplantation. J Sex Med 2009; 6: 3125-3131.
62. Al Khallaf HH. Analysis of sexual functions in male nondiabetic hemodialysis patients and renal transplant recipients. Transpl Int 2010; 23: 176-181.
63. Tavallaii SA, Mirzamani M, Heshmatzade Behzadi A et al. Sexual function: a comparison between male renal transplant recipients and hemodialysis patients. J Sex Med 2009; 6: 142-148.
64. Barroso LV, Miranda EP, Cruz NI et al. Analysis of sexual function in kidney transplanted men. Transplant Proc 2008; 40: 3489-3491.
65. Goldstein I. The mutually reinforcing triad of depressive symptoms, cardiovascular disease, and erectile dysfunction. Am J Cardiol 2000; 86: 41F-45F.
66. Moynihan R. Drug for low sexual desire carries significant harms, FDA advisers find. BMJ 2010; 341: c3339.
67. Gungor O, Kircelli F, Carrero JJ et al. Endogenous testosterone and mortality in male hemodialysis patients: is it the result of aging?. Clin J Am Soc Nephrol 2010; 5: 2018-2023.
68. Carrero JJ, Qureshi AR, Nakashima A et al. Prevalence and clinical implications of testosterone deficiency in men with end-stage renal disease. Nephrol Dial Transplant 2011; 26: 184-190.
69. Bao J, Yu Q, Yu H et al. Erectile dysfunction in male hemodialysis patients in China-one center experience. Clin Nephrol 2011; 75: 135-140.
70. Albaaj F, Sivalingham M, Haynes P et al. Prevalence of hypogonadism in male patients with renal failure. Postgrad Med J 2006; 82: 693-696.
71. Carrero JJ, Barany P, Yilmaz MI et al. Testosterone deficiency is a cause of anaemia and reduced responsiveness to erythropoiesis-stimulating agents in men with chronic kidney disease. Nephrol Dial Transplant 2012; 27: 709-715.
72. Brockenbrough AT, Dittrich MO, Page ST et al. Transdermal androgen therapy to augment EPO in the treatment of anemia of chronic renal disease. Am J Kidney Dis 2006; 47: 251-262.
73. van Coevorden A, Stolear JC, Dhaene M et al. Effect of chronic oral testosterone undecanoate administration on the pituitary-testicular axes of hemodialyzed male patients. Clin Nephrol 1986; 26: 48-54.
74. Lawrence IG, Price DE, Howlett TA et al. Correcting impotence in the male dialysis patient: experience with testosterone replacement and vacuum tumescence therapy. Am J Kidney Dis 1998; 31: 313-319.
75. Canguven O, Aykose G, Albayrak S et al. Efficacy of testosterone gel in the treatment of erectile dysfunction in hypogonadal hemodialysis patients: a pilot study. Int J Impot Res 2010; 22: 140-145.
76. Johansen KL. Testosterone metabolism and replacement therapy in patients with end-stage renal disease. Semin Dial 2004; 17: 202-208.
77. Carrero JJ, Qureshi AR, Parini P et al. Low serum testosterone increases mortality risk among male dialysis patients. J Am Soc Nephrol 2009; 20: 613-620.