A whole-cell biosensor as in vitro alternative to skin irritation tests

Biosensors and Bioelectronics

Volumn 39, Issue 1, 2013, Pages 156-162

  Hofmann, Ute ^a   Michaelis, Stefanie ^b   Winckler, Thomas ^c   Wegener, Joachim ^b   Feller, Karl Heinz ^a  

^a UNIVERSITY OF APPLIED SCIENCES JENA   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Cell based assay; Electric cell substrate impedance sensing; Heat shock protein; Lab on a Chip; Reporter gene; Time lapse microscopy; Whole cell biosensor

Indexed keywords

CELL-BASED ASSAYS; HEAT SHOCK PROTEIN; IMPEDANCE SENSING; LAB ON A CHIP; REPORTER GENE; TIME-LAPSE MICROSCOPY; WHOLE-CELL BIOSENSORS;

BIOASSAY; BIOSENSORS; CELL CULTURE; GENES; SENSORS;

CELLS;

CADMIUM CHLORIDE; GREEN FLUORESCENT PROTEIN; HEAT SHOCK PROTEIN 72;

ANALYTIC METHOD; ARTICLE; CELL GROWTH; CELL STRUCTURE; CHEMICAL STRESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY TEST; DNA MODIFICATION; ELECTRIC CELL SUBSTRATE IMPEDANCE SENSING; FLUORESCENCE MICROSCOPY; GENE CONSTRUCT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; INTRACELLULAR SIGNALING; KERATINOCYTE; MICROFLUIDIC ANALYSIS; NON INVASIVE MEASUREMENT; OPTICAL BIOSENSOR; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; SENSITIVITY ANALYSIS; SKIN IRRITATION; SKIN TEST; STABLE TRANSFECTION; TIME; TIME LAPSE IMAGING; WHOLE CELL;

BIOSENSING TECHNIQUES; CADMIUM CHLORIDE; CELL LINE; CELL SURVIVAL; ELECTRIC IMPEDANCE; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; KERATINOCYTES; LAB-ON-A-CHIP DEVICES; SKIN IRRITANCY TESTS; TRANSFECTION;

EID: 84865790770     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2012.07.075     Document Type: Article

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