Cadmium uptake kinetics in rat hepatocytes: Correction for albumin binding

Toxicological Sciences

Volumn 72, Issue 1, 2003, Pages 19-30

  DelRaso, N J ^a   Foy, B D ^b   Gearhart, J M ^c   Frazier, J M ^a  

^a AIR FORCE RESEARCH LABORATORY   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

Author keywords

Albumin; Cadmium; Hepatocytes; In vitro; Kinetics

Indexed keywords

BOVINE SERUM ALBUMIN; BUFFER; CADMIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CELL TRANSPORT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DIFFUSION; LIVER CELL CULTURE; LIVER METABOLISM; MALE; MATHEMATICAL COMPUTING; NONHUMAN; PROTEIN BINDING; RAT; SCATCHARD PLOT; TOXICOKINETICS;

ANIMALS; BINDING, COMPETITIVE; CADMIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; EGTAZIC ACID; HEPATOCYTES; LIVER; MALE; MODELS, BIOLOGICAL; RATS; RATS, INBRED F344; SERUM ALBUMIN, BOVINE;

ANIMALIA; BOVINAE;

EID: 0037342462     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg009     Document Type: Article

References (43)

1. Aoki, Y., and Suzuki, K. T. (1987). Characterization of cadmium-binding proteins detected in rat liver by Western-blotting technique. J. Biochem. Toxicol. 2, 67-71.
2. Baker, K. J., and Bradley, S. E. (1966). Binding of sulfobromophthalein (BSP) sodium by plasma albumin. Its role in hepatic BSP extraction. J. Clin. Invest. 45, 281-287.
3. Barry, P. H., and Diamond, J. M. (1984). Effects of unstirred layers on membrane phenomena. Physiol. Rev. 64, 763-872.
4. Bass, L., and Pond, S. M. (1988). The puzzle of rates of cellular uptake of protein-bound ligands. In Pharmacodynamics: Mathematical and Statistical Approaches to Metabolism and Distribution of Chemicals and Drugs. (A. Pecile and A. Rescigno, Eds.), pp. 241-265. Plenum, London.
5. Blazka, M. E., and Shaikh, Z. A. (1992). Cadmium and mercury accumulation in rat hepatocytes: Interactions with other metal ions. Toxicol. Appl. Pharmacol. 113, 118-125.
6. Bobilya, D. J., Briske-Anderson, M., and Reeves, P. G. (1992). Zinc transport into endothelial cells is a facilitated process. J. Cell. Physiol. 151, 1-7.
7. DelRaso, N. J., and Frazier, J. M. (1999). Effect of culture conditions prior to exposure on cadmium cytotoxicity in primary rat hepatocytes. Toxicol. Methods 9, 97-114.
8. Din, W. S., and Frazier, J. M. (1985). Protective effect of metallothionein on cadmium toxicity in isolated rat hepatocytes. Biochem. J. 230, 395-402.
9. Dudley, R. E., Svoboda, D. J., and Klaassen, C. D. (1982). Acute exposure of cadmium causes severe liver injury in rats. Toxicol. Appl. Pharmacol. 65, 302-313.
10. Failla, M. L., and Cousins, R. J. (1978). Zinc accumulation and metabolism in primary cultures of adult rat liver cells: Regulation by glucocorticoids. Biochim. Biophys. Acta 543, 293-304.
11. Failla, M. L., Cousins, R. J., and Mascenik, M. J. (1979). Cadmium accumulation and metabolism by rat liver parenchymal cells in primary monolayer culture. Biochim. Biophys. Acta 583, 63-72.
12. Foulkes, E. C., and Blanck, S. (1990). Acute cadmium uptake by rabbit kidneys: Mechanism and effects. Toxicol. Appl. Pharmacol. 102, 464-473.
13. Frazier, J. M. (1981). Effect of excess zinc on cadmium disappearance from rat plasma following intravenous injection. Fundam. Appl. Pharmacol. 1, 452-456.
14. Frazier, J. M. (1995). Biokinetic modeling and in vitro assays: Application of in vitro systems to the prediction of in vitro biokinetics. Toxicol. in Vitro 9, 527-536.
15. Frazier, J. M., and Kingsley, B. S. (1976). Kinetics of cadmium transport in the isolated perfused liver. Toxicol. Appl. Pharmacol. 38, 583-593.
16. Frazier, J. M., and Kingsley, B. S. (1977). Cadmium kinetics in the isolated perfused rat liver: An example of a general method for investigating metal metabolism. In Clinical Chemistry and Chemical Toxicology of Metals (S. S. Brown, Ed.), pp. 33-36. Elsevier, Amsterdam.
17. Gautum, A., Ng, O.-C., and Boyer, J. L. (1987). Isolated rat hepatocyte couplets in short-term culture: Structural characteristics and plasma membrane reorganization. Hepatology 7, 216-223.
18. Giroux, E. L., and Henkin, R. I. (1972). Competition for zinc among serum albumin and amino acids. Biochim. Biophys. Acta 273, 64-72.
19. Goresky, C. A., Bach, G. C., and Nadeau, B. E. (1973). On the uptake of materials by the intact liver. The transport and net removal of galactose. J. Clin. Invest. 52, 991-1009.
20. Goumakos, W., Laussac, J. P., and Sarkar, B. (1991). Binding of cadmium (II) and zinc (II) to human and dog serum albumin: An equilibrium dialysis and 113Cd-NMR study. Biochem. Cell Biol. 69, 809-820.
21. Gulden, M., Morchel, S., Tahan, S., and Seibert, H. (2002). Impact of protein binding on the availability and cytotoxic potency of organochlorine pesticides and chlorophenols in vitro. Toxicology 175, 201-213.
22. Kingsley, B. S., and Frazier, J. M. (1979). Cadmium transport in isolated perfused rat liver: Zinc-cadmium competition. Amer. J. Physiol. 236, C139-143.
23. Klug, S., Planas-Bohne, F., and Taylor, D. M. (1988). Factors influencing the uptake of cadmium into cells in vitro. Hum. Toxicol. 7, 545-549.
24. Kukongviriyapan, V., and Stacey, N. H. (1989). Comparison of uptake kinetics in freshly isolated suspensions and short-term primary cultures of rat hepatocytes. J. Cell. Physiol. 140, 491-497.
25. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
26. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxic assays. J. Immunol. Methods 65, 55-63.
27. Nordberg, G. F., Kjellstrom, T., and Nordberg, M. (1985). Kinetics and metabolism. In Cadmium and Health: A Toxicological and Epidemiological Appraisal: Exposure, Dose, and Metabolism (L. Friberg, C. G. Elinder, T. Kjellstrom, and G. F. Nordberg, Eds.), pp. 103-178, Vol. 1. CRC Press, Boca Raton, FL
28. Nordberg, G. F., and Nordberg, M. (1987). Different binding forms of cadmium: Implications for distribution and toxicity. Sangyo Ika Daigaku Zasshi 9, 153-164.
29. Perry, H. M., Jr., Erlanger, M., Yunice, A., Schoepfle, E., and Perry, E. F. (1970). Hypertension and tissue metal levels following intravenous cadmium, mercury, and zinc. Amer. J. Physiol. 219, 755-761.
30. Roberts, C. A., and Clark, J. M. (1988). In vivo depression of reserve albumin binding capacity by cadmium: A preliminary evaluation. Life Sci. 42, 1369-1374.
31. Sasser, L. B., and Jarboe, G. E. (1977). Intestinal absorption and retention of cadmium in neonatal rat. Toxicol. Appl. Pharmacol. 41, 423-431.
32. Scatchard, G. (1949). The attraction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51, 660-672.
33. Seglen, P. O. (1976). Preparation of isolated rat liver cells. Methods Cell Biol. 13, 29-83.
34. Seibert, H., Morchel, S., and Gulden, M. (2002). Factors influencing nominal effective concentrations of chemical compounds in vitro: Medium protein concentration. Toxicol. in Vitro 16, 289-297.
35. Shaikh, Z. A., Blazka, M. E., and Endo, T. (1995). Metal transport in cells: Cadmium uptake by rat hepatocytes and renal cortical epithelial cells. Environ. Health Perspect. 103, 73-75.
36. Stacey, N. H., Cantilena, L. R., and Klaassen, C. D. (1980). Cadmium toxicity and lipid peroxidation in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 53, 470-480.
37. Stacey, N. H., and Klaassen, C. D. (1980). Cadmium uptake by isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 55, 448-455.
38. Stacey, N. H., and Klaassen, C. D. (1981). Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes. J. Toxicol. Environ. Health 7, 139-147.
39. Story, D. L., Gee, S. J., Tyson, C. A., and Gould, D. H. (1983). Response of isolated hepatocytes to organic and inorganic cytotoxins. J. Toxicol. Environ. Health 11, 483-501.
40. Suzuki, K. T., Sunaga, H., Kobayashi, E., and Shimojo, N. (1986). Mercapt-albumin as a selective cadmium-binding protein in rat serum. Toxicol. Appl. Pharmacol. 86, 466-473.
41. Wanson, J.-C., Drochmans, P., Mosselmans, R., and Ronveaux, M.-F. (1977). Adult rat hepatocytes in primary monolayer culture: Ultrastructural characteristics of intercellular contacts and cell membrane differentiations. J. Cell Biol. 74, 858-877.
42. Weisiger, R. A., Pond, S. M., and Bass, L. (1989). Albumin enhances unidirectional fluxes of fatty acids across a lipid-water interface: Theory and experiments. Am. J. Physiol. 257, G904-916.
43. Weisiger, R. A., Pond, S., and Bass, L. (1991). Hepatic uptake of protein-bound ligands: Extended sinusoidal perfusion model. Am. J. Physiol. 261, G872-884.