The polarity protein partitioning-defective 1 (PAR-1) regulates dendritic spine morphogenesis through phosphorylating postsynaptic density protein 95 (PSD-95)

Journal of Biological Chemistry

Volumn 287, Issue 36, 2012, Pages 30781-30788

  Wu, Qian ^a   DiBona, Victoria L ^a   Bernard, Laura P ^a   Zhang, Huaye ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC-CELLS; CELLULAR CONTEXTS; CELLULAR PROCESS; DENDRITIC SPINE; DIRECTIONAL MIGRATION; EXCITATORY SYNAPTIC INPUTS; HIPPOCAMPAL NEURONS; POLARITY PROTEINS; POSTSYNAPTIC DENSITIES; SCAFFOLDING PROTEINS; SERINE RESIDUES;

AMINO ACIDS; CELL PROLIFERATION; NEURONS; PHOSPHORYLATION; PROTEINS;

MORPHOLOGY;

PARTITIONING DEFECTIVE 1 PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN SERINE THREONINE KINASE; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; EMBRYO; ENZYME ACTIVITY; HIPPOCAMPUS; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RAT; REGULATORY MECHANISM;

AMINO ACID MOTIFS; ANIMALS; CELLS, CULTURED; DENDRITIC SPINES; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RATS; SYNAPSES;

EID: 84865775312     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.351452     Document Type: Article

References (24)

1. Fiala, J. C., Spacek, J., and Harris, K. M. (2002) Dendritic spine pathology: cause or consequence of neurological disorders? Brain Res. Brain Res. Rev. 39, 29-54
2. Penzes, P., Cahill, M. E., Jones, K. A., VanLeeuwen, J. E., and Woolfrey, K. M. (2011) Dendritic spine pathology in neuropsychiatric disorders. Nat. Neurosci. 14, 285-293
3. Zhang, H., and Macara, I. G. (2006) The polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesis. Nat. Cell Biol. 8, 227-237
4. Zhang, H., and Macara, I. G. (2008) The PAR-6 polarity protein regulates dendritic spine morphogenesis through p190 RhoGAP and the Rho GTPase. Dev. Cell 14, 216-226
5. Kemphues, K. J., Priess, J. R., Morton, D. G., and Cheng, N. S. (1988) Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52, 311-320
6. Drewes, G., Ebneth, A., Preuss, U., Mandelkow, E. M., and Mandelkow, E. (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89, 297-308
7. Ebneth, A., Drewes, G., Mandelkow, E. M., and Mandelkow, E. (1999) Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells. Cell Motil. Cytoskeleton 44, 209-224
8. Goldstein, B., and Macara, I. G. (2007) The PAR proteins: fundamental players in animal cell polarization. Dev. Cell 13, 609-622
9. Matenia, D., and Mandelkow, E. M. (2009) The tau of MARK: a polarized view of the cytoskeleton. Trends Biochem. Sci. 34, 332-342
10. Segu, L., Pascaud, A., Costet, P., Darmon, M., and Buhot, M. C. (2008) Impairment of spatial learning and memory in ELKL motif kinase 1 (EMK1/MARK2) knock-out mice. Neurobiol. Aging 29, 231-240
11. Maussion, G., Carayol, J., Lepagnol-Bestel, A. M., Tores, F., Loe-Mie, Y., Milbreta, U., Rousseau, F., Fontaine, K., Renaud, J., Moalic, J. M., Philippi, A., Chedotal, A., Gorwood, P., Ramoz, N., Hager, J., and Simonneau, M. (2008) Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Hum. Mol. Genet. 17, 2541-2551
12. Wiznerowicz, M., and Trono, D. (2003) Conditional suppression of cellular genes: lentiviral vector-mediated drug-inducible RNA interference. J. Virol. 77, 8957-8961
13. Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., and Youle, R. J. (2004) Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J. Cell Biol. 164, 493-499
14. Hurov, J. B., Watkins, J. L., and Piwnica-Worms, H. (2004) Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr. Biol. 14, 736-741
15. Suzuki, A., Hirata, M., Kamimura, K., Maniwa, R., Yamanaka, T., Mizuno, K., Kishikawa, M., Hirose, H., Amano, Y., Izumi, N., Miwa, Y., and Ohno, S. (2004) aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr. Biol. 14, 1425-1435
16. Mandelkow, E. M., Thies, E., Trinczek, B., Biernat, J., and Mandelkow, E. (2004) MARK/PAR-1 kinase is a regulator of microtubule-dependent transport in axons. J. Cell Biol. 167, 99-110
17. Zhang, Y., Guo, H., Kwan, H., Wang, J. W., Kosek, J., and Lu, B. (2007) PAR-1 kinase phosphorylates Dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction. Neuron 53, 201-215
18. Hayashi, K., Suzuki, A., Hirai, S., Kurihara, Y., Hoogenraad, C. C., and Ohno, S. (2011) Maintenance of dendritic spine morphology by partitioning-defective 1b through regulation of microtubule growth. J. Neurosci. 31, 12094-12103
19. Bayraktar, J., Zygmunt, D., and Carthew, R. W. (2006) PAR-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryo. J. Cell Sci. 119, 711-721
20. Krahn, M. P., Egger-Adam, D., and Wodarz, A. (2009) PP2A antagonizes phosphorylation of Bazooka by PAR-1 to control apical-basal polarity in dividing embryonic neuroblasts. Dev. Cell 16, 901-908
21. Nam, S. C., Mukhopadhyay, B., and Choi, K. W. (2007) Antagonistic functions of PAR-1 kinase and protein phosphatase 2A are required for localization of Bazooka and photoreceptor morphogenesis in Drosophila. Dev. Biol. 306, 624-635
22. Jaworski, T., Lechat, B., Demedts, D., Gielis, L., Devijver, H., Borghgraef, P., Duimel, H., Verheyen, F., Kügler, S., and Van Leuven, F. (2011) Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration. Am. J. Pathol. 179, 2001-2015
23. Craven, S. E., El-Husseini, A. E., and Bredt, D. S. (1999) Synaptic targeting of the postsynaptic density protein PSD-95 mediated by lipid and protein motifs. Neuron 22, 497-509
24. Murakoshi, H., and Yasuda, R. (2012) Postsynaptic signaling during plasticity of dendritic spines. Trends Neurosci. 35, 135-143