CCL20 Is Associated with Neurodegeneration Following Experimental Traumatic Brain Injury and Promotes Cellular Toxicity In Vitro

Translational Stroke Research

Volumn 3, Issue 3, 2012, Pages 357-363

  Leonardo, Christopher C ^a   Musso, James ^a   Das, Mahasweta ^a   Rowe, Derrick D ^a   Collier, Lisa A ^a   Mohapatra, Shyam ^a   Pennypacker, Keith R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Chemokine; Hypoxia; Inflammation; Ischemia; MIP 3 ; Rodent

Indexed keywords

GLUCOSE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DISEASE ASSOCIATION; IN VITRO STUDY; MALE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRAUMATIC BRAIN INJURY; WHITE MATTER;

EID: 84865762742     PISSN: 18684483     EISSN: 1868601X     Source Type: Journal    
DOI: 10.1007/s12975-012-0203-8     Document Type: Article

References (19)

1. Rutland-Brown W, Langlois JA, Thomas KE, Xi YL. Incidence of traumatic brain injury in the United States, 2003. J Head Trauma Rehabil. 2006; 21(6): 544-8.
2. Ghajar J. Traumatic brain injury. Lancet. 2000; 356(9233): 923-9.
3. Raghupathi R. Cell death mechanisms following traumatic brain injury. Brain Pathol. 2004; 14(2): 215-22.
4. Das M, Leonardo CC, Rangooni S, Mohapatra SS, Mohapatra S, Pennypacker KR. Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats. J Neuroinflammation. 2011; 8: 148.
5. Freyaldenhoven T, Ali S, Schmued L. Systemic administration of MPTP induces thalamic neuronal degeneration in mice. Brain Res. 1997; 759: 9-17.
6. Duckworth EA, Butler TL, De Mesquita D, Collier SN, Collier L, Pennypacker KR. Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res. 2005; 1042(1): 29-36.
7. Hall AA, Guyer AG, Leonardo CC, Ajmo Jr CT, Collier LA, Willing AE, et al. Human umbilical cord blood cells directly suppress ischemic oligodendrocyte cell death. J Neurosci Res. 2009; 87(2): 333-41.
8. Rowe DD, Leonardo CC, Hall AA, Shahaduzzaman MD, Collier LA, Willing AE, et al. Cord blood administration induces oligodendrocyte survival through alterations in gene expression. Brain Res. 2010; 1366: 172-88.
9. Shimizu Y, Murata H, Kashii Y, Hirano K, Kunitani H, Higuchi K, et al. CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3alpha might be involved in the amplification of local necroinflammatory response in the liver. Hepatology. 2001; 34(2): 311-9.
10. Dalgard CL, Cole JT, Kean WS, Lucky JJ, Sukumar G, McMullen DC, et al. The cytokine temporal profile in rat cortex after controlled cortical impact. Front Mol Neurosci. 2012; 5: 6. Epub 2012/02/01.
11. Ajmo Jr CT, Vernon DO, Collier L, Hall AA, Garbuzova-Davis S, Willing A, et al. The spleen contributes to stroke-induced neurodegeneration. J Neurosci Res. 2008; 86: 2227-34.
12. Okuaki Y, Miyazaki H, Zeniya M, Ishikawa T, Ohkawa Y, Tsuno S, et al. Splenectomy-reduced hepatic injury induced by ischemia/reperfusion in the rat. Liver. 1996; 16(3): 188-94.
13. Jaeschke H. Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol. 2000; 15(7): 718-24.
14. Fan C, Zwacka RM, Engelhardt JF. Therapeutic approaches for ischemia/reperfusion injury in the liver. J Mol Med. 1999; 77(8): 577-92.
15. Jiang H, Meng F, Li W, Tong L, Qiao H, Sun X. Splenectomy ameliorates acute multiple organ damage induced by liver warm ischemia reperfusion in rats. Surgery. 2007; 141(1): 32-40.
16. Savas MC, Ozguner M, Ozguner IF, Delibas N. Splenectomy attenuates intestinal ischemia-reperfusion-induced acute lung injury. J Pediatr Surg. 2003; 38(10): 1465-70.
17. Walker PA, Shah SK, Jimenez F, Gerber MH, Xue H, Cutrone R, et al. Intravenous multipotent adult progenitor cell therapy for traumatic brain injury: preserving the blood brain barrier via an interaction with splenocytes. Exp Neurol. 2010; 225(2): 341-52.
18. Lee ST, Chu K, Jung KH, Kim SJ, Kim DH, Kang KM, et al. Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke. Brain. 2008; 131(Pt 3): 616-29.
19. Li M, Li F, Luo C, Shan Y, Zhang L, Qian Z, et al. Immediate splenectomy decreases mortality and improves cognitive function of rats after severe traumatic brain injury. J Trauma. 2011; 71(1): 141-7.