Efficacy of domperidone gel in an induced model of fescue toxicosis in periparturient mares

Theriogenology

Volumn 78, Issue 6, 2012, Pages 1361-1370

  Cross, D L ^a   Reinemeyer, C R ^b   Prado, J C ^b   Donnell, R L ^c   Bond, K G ^d   Farr, H ^d   Longhofer, S L ^d  

^a Equi Tox Inc   (United States)

^b East Tennessee Clinical Research Inc   (United States)

^c UNIVERSITY OF TENNESSEE   (United States)

^d Dechra Ltd   (United States)

Author keywords

Domperidone; Endophyte; Fescue; Horse; Neonate; Pregnancy

Indexed keywords

DOMPERIDONE; ERGOTAMINE DERIVATIVE; ERGOVALINE; PLACEBO;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIRTH; CHEMICALLY INDUCED DISORDER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; ERGOTISM; FEMALE; FESCUE; GEL; GESTATIONAL AGE; HORSE; HORSE DISEASE; LACTATION; LOLIUM; METABOLISM; MICROBIOLOGY; NEOTYPHODIUM; PILOT STUDY; POACEAE; PREGNANCY; PREGNANCY COMPLICATION; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ANIMALS; DOMPERIDONE; ERGOTAMINES; ERGOTISM; FEMALE; FESTUCA; GELS; GESTATIONAL AGE; HORSE DISEASES; HORSES; LACTATION; LOLIUM; NEOTYPHODIUM; PARTURITION; PILOT PROJECTS; PLACEBOS; POACEAE; PREGNANCY; PREGNANCY COMPLICATIONS; TREATMENT OUTCOME;

EQUIDAE;

EID: 84865749099     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2012.06.002     Document Type: Article

References (44)

1. Darbyshire S.J. Realignment of Festuca subgenus Schedonorus with the genus Lolium (Poaceae). Novon 1993, 3:239-243.
2. Shelby R.A., Dalrymple L.W. Incidence and distribution of the tall fescue endophyte in the United States. Plant Dis 1987, 71:783-786.
3. th Annual Convention of the American Association of Equine Practitioners 1999, 213-216.
4. Morgan-Jones G., Gams W. Notes on hyphomycetes, XLI. An endophyte of Festuca arundinacea an anamorph of Epichole typhina, new taxa in one or two sections of Acremonium. Mycotaxon 1982, 15:311-318.
5. Garrett L.W., Heimann E.D., Wilson L.L., Pfander W.H. Reproductive problems of pregnant mares grazing fescue pastures. J Anim Sci 1980, 51:237.
6. Boosinger T.R., Brendemuehl J.P., Bransby D.I., Wright J.C., Kemppainen R.J., Kee D.D. Prolonged gestation, decreased triiodothyronine concentration, and thyroid gland histomorphologic features in newborn foals of mares grazing Acremonion coenophialum-infected fescue. Am J Vet Res 1995, 56:66-69.
7. Monroe J.L., Cross D.L., Hudson L.W., Hendricks D.M., Kennedy S.W., Bridges W.C. Effect of selenium and endophyte-contaminated fescue on performance and reproduction in mares. J Equine Vet Sci 1988, 8:148-153.
8. Redmond L.M., Cross D.L., Strickland J.R., Kennedy S.W. Efficacy of domperidone and sulpiride as treatments for fescue toxicosis in horses. Am J Vet Res 1994, 55:722-729.
9. Putnam M.R., Bransby D.I., Schumacher J., Boosinger T.R., Bush L., Shelby R.A., et al. Effects of the fungal endophyte Acremonium coenophialum in fescue on pregnant mares and foal viability. Am J Vet Res 1991, 52:2071-2074.
10. Taylor M.C., Loch W.E., Ellersieck M. Toxicity in pregnant pony mares grazing Kentucky-31 fescue pastures. Nutr Rep Int 1985, 31:757-764.
11. Brendemuehl J.P., Williams M.A., Boosinger T.R., Ruffin D.C. Plasma progestagen, triiodothyronine, and cortisol concentrations in postdate gestation foals exposed in utero to the tall fescue endophyte Acremonium coenophialum. Proceedings of the 6th International Symposium on Equine Reproduction 1995, 53-59.
12. Loch W.E., Swantner L.D., Anderson R.R. The effects of four levels of endophyte-infected fescue seed in the diet of pregnant pony mares. J Reprod Fertil Suppl 1987, 35:535-538.
13. Rude B.J., Warren B.J., Lang D.J., Ryan P.L. Determination of pregnancy outcome of mares grazed on a non-toxic endophyte-infected tall fescue. J Anim Sci 2001, 79(Suppl 1):209-210.
14. Yates S.G., Plattner R.D., Garner G.B. Detection of ergopeptine alkaloids in endophyte-infected, toxic Ky-31 tall fescue by mass spectrometry/mass spectrometry. J Agric Food Chem 1985, 33:719-722.
15. Lehner A.F., Fitzgerald B.P., Hughes C.G., Tobin T., Camargo F.C., May J., et al. Serum concentrations of ergovaline/ergot alkaloids in late-term pregnant mares grazing endophyte-infected tall fescue pastures: A preliminary report. Adams AJ. Theriogenology 2008, 70:583.
16. De Lorme M.J.M., Lodge-Ivey S.L., Craig A.M. Physiological and digestive effects of Neotyphodium coenophialum-infected tall fescue fed to lambs. J Anim Sci 2007, 85:1199-1206.
17. Schultz C.L., Lodge-Ivey S.L., Bush L.P., Craig A.M., Strickland J.R. Effects of initial and extended exposure to an endophyte-infected tall fescue seed diet on faecal and urinary excretion of ergovaline and lysergic acid in mature geldings. N Z Vet J 2006, 54:178-184.
18. Belesky D.P., Stuedemann J.A., Plattner R.D., Wilkinson S.R. Ergopeptine alkaloids in grazed tall fescue. Agron J 1988, 80:209-212.
19. Lyons P.C., Plattner R.D., Bacon C.W. Occurrence of peptide and clavine ergot alkaloids in tall fescue grass. Science 1986, 232:487-489.
20. Strickland J.R., Cross D.L., Birrenkott G.P., Grimes L.W. Effect of ergovaline, loline, and dopamine antagonists on rat pituitary cell prolactin release in vitro. Am J Vet Res 1994, 55:716-721.
21. Roser J.F., Dudan F., Little T.V., Livesay-Wilkins P., Hillman R.B. Plasma prolactin concentrations in mares and their neonates after oxytocin induction of parturition. Domest Anim Endocrinol 1989, 6:101-110.
22. Arns M.J., Pruitt J.A., Sharp C. Influence of endophyte-infected tall fescue seed consumption on the establishment and maintenance of pregnancy in mares. Prof Anim Sci 1997, 13:118-123.
23. Youngblood R.C., Filipov N.M., Rude B.J., Christiansen D.L., Hopper R.M., Gerard P.D., Hill N.S. Effects of short-term early gestational exposure to endophyte-infected tall fescue diets on plasma 3,4-dihydroxyphenyl acetic acid and fetal development in mares. J Anim Sci 2004, 82:2919-2929.
24. Ben-Jonathan N., Hnasko R. Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 2001, 22:724-763.
25. Schinkel A.H., Wagenaar E., Mol C.A., van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 1996, 97:2517-2524.
26. Ireland F.A., Loch W.E., Worthy K., Anthony R.V. Effects of bromocriptine and perphenazine on prolactin and progesterone concentrations in pregnant pony mares during late gestation. J Reprod Fertil 1991, 92:179-186.
27. Earle W.E., Cross D.L., Hudson L.W., Redmond L.M., Kennedy S.W. Effect of energy supplementation on gravid mares grazing endophyte-infected fescue. J Equine Vet Sci 1990, 10:126. ,127,129-30.
28. Redmond L.M., Cross D.L., Gimenez T., Hudson L.W., Earle W.E., Kennedy S.W. The effect of phenothiazine and withdrawal time on gravid mares grazing endophyte-infected tall fescue. J Equine Vet Sci 1991, 11:17-22.
29. Rottinghaus G.E., Schultz C.L., Ross P.F., Hill N.S. An HPLC method for the detection of ergot in ground and pelleted feeds. J Vet Diagn Invest 1993, 5:242-247.
30. Giger R., Meier H.P., Küpfer U. [Length of gestation of Freiberger mares with mule and horse foals] Tragzeiten bei Freibergerstuten mit Maultier-bzw. Pferdefohlen. Schweiz Arch Tierheilkd 1997, 139:303-307.
31. Manual of histological staining methods of the Armed Forces Institute of Pathology 1968, 34. Routine staining procedures, Blakiston Division, McGraw-Hill. 3rd edition. L.G. Luna (Ed.).
32. Rottinghaus G.E., Garner G.B., Cornell C.N., Ellis J.L. HPLC method for quantitating ergovaline in endophyte-infested tall fescue: seasonal variation of ergovaline levels in stems with leaf sheaths, leaf blades, and seed heads. J Agric Food Chem 1991, 39:112-115.
33. Bush L., Schmidt D. Alkaloid content of meadow fescue and tall fescue with their natural endophytes. Proceedings of the International Conference on Harmful and Beneficial Microorganisms in Grassland, Pastures and Turf 1994, 259-266.
34. Tor-Agbidye J., Blythe L.L., Craig A.M. Correlation of endophyte toxins (ergovaline and lolitrem B) with clinical disease: fescue foot and perennial ryegrass staggers. Vet Hum Toxicol 2001, 43:140-146.
35. Breuhaus B.A. Thyroid function in mature horses ingesting endophyte-infected fescue seed. J Am Vet Med Assoc 2003, 223:340-345.
36. rd Annual Convention of the American Association of Equine Practitioners 1997, 407-408.
37. Brendemuehl J.P., Carson R.L., Wenzel J.G.W., Boosinger T.R., Shelby R.A. Effects of grazing endophyte-infected tall fescue on eCG and progestogen concentrations from gestation days 21 to 300 in the mare. Theriogenology 1996, 46:85-95.
38. th Equine Nutrition and physiology symposium 1987, 663-668.
39. th Annual Meeting of the American Association of Veterinary Laboratory Diagnosticians 1984, 325-336.
40. Cottrill C.M., Jeffers-Lo J., Ousey J.C., McGladdery A.J., Ricketts S.W., Silver M., et al. The placenta as a determinant of fetal well-being in normal and abnormal equine pregnancies. J Reprod Fertil Suppl 1991, 44:591-601.
41. Abney L.K., Oliver J.W., Reinemeyer C.R. Vasoconstrictive effects of tall fescue alkaloids on equine vasculature. J Equine Vet Sci 1993, 13:334-340.
42. McDowell K.J., Moore E.S., Parks A.G., Lawrence L.M. Use of Doppler ultrasonography on horses to detect vasoconstriction caused by endophyte infected tall fescue. J Equine Vet Sci 2009, 29:338-339.
43. Dyer D.C. Evidence that ergovaline acts on serotonin receptors. Life Sci 1993, 53:L223-L228.
44. Moris D.D., Meirs D.A., Merryman G.S. Passive transfer failure in horses: incidence and causative factors on a breeding farm. Am J Vet Res 1985, 46:2294-2299.