Synthesis and biological evaluation of novel 2,4-disubstituted-1,3- thiazoles as anti-Candida spp. agents

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 378-382

  Chimenti, Franco ^a   Bizzarri, Bruna ^a   Bolasco, Adriana ^a   Secci, Daniela ^a   Chimenti, Paola ^a   Granese, Arianna ^a   Carradori, Simone ^a   D'Ascenzio, Melissa ^a   Lilli, Daniela ^a   Rivanera, Daniela ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Candida spp.; Hantzsch reaction; Hydrazone; Thiazole

Indexed keywords

1 (FURAN 2 YLMETHYLENE) 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 (FURAN 2 YLMETHYLENE) 2 [4 (4 METHOXYPHENYL)THIAZOL 2 YL]HYDRAZINE; 1 (NAPHTHALEN 1 YLMETHYLENE) 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 (PYRIDIN 3 YLMETHYLENE) 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 (PYRIDIN 4 YLMETHYLENE) 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [(1H INDOL 3 YL)METHYLENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [1 (2 OXO 2H CHROMEN 3 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [1 (2 OXO 2H CHROMEN 3 YL)ETHYLIDENE] 2 [4 (4 METHOXYPHENYL)THIAZOL 2 Y]HYDRAZINE; 1 [1 (FURAN 2 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL) HYDRAZINE; 1 [1 (FURAN 2 YL)ETHYLIDENE] 2 [4 (4 METHOXYPHENYL) THIAZOL 2 YL]HYDRAZINE; 1 [1 (NAPHTHALEN 2 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [1 (PYRIDIN 2 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [1 (PYRIDIN 3 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [1 (PYRIDIN 4 YL)ETHYLIDENE] 2 (4 4 TOLYLTHIAZOL 2 YL)HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL) 2 [1 (NAPHTHALEN 2 YL)ETHYLIDENE]HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 (NAPHTHALEN 1 YLMETHYLENE)HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 (PYRIDIN 3 YLMETHYLENE)HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 (PYRIDIN 4 YLMETHYLENE)HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 [1 (PYRIDIN 2 YL)ETHYLIDENE]HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 [1 (PYRIDIN 3 YL)ETHYLIDENE]HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 [1 (PYRIDIN 4 YL) ETHYLIDENE]HYDRAZINE; 1 [4 (4 METHOXYPHENYL)THIAZOL 2 YL] 2 [1 (THIOPHEN 2 YL) ETHYLIDENE)HYDRAZINE; ANTIFUNGAL AGENT; CLOTRIMAZOLE; FLUCONAZOLE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANDIDA; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTIFUNGAL AGENTS; CANDIDA; DRUG EVALUATION, PRECLINICAL; MICROBIAL SENSITIVITY TESTS; THIAZOLES;

EID: 78650509856     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.10.027     Document Type: Article

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