Design, synthesis, and biological evaluation of alcyopterosin a and illudalane derivatives as anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 6, 2006, Pages 1863-1870

  Finkielsztein, Liliana M ^a   Bruno, Ana M ^a   Renou, Sergio G ^a   Moltrasio Iglesias, Graciela Y ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Alcyopterosin A; Anticancer; Illudalane derivatives; Synthesis

Indexed keywords

2 (7 BROMO 4,6 DIMETHYLINDAN 5 YL)ETHAN 1 OL; 2(7 BROMO 2,2,4,6 DIMETHYLINDAN 5 YL)ETHAN 1 OL; ALCYOPTEROSIN A; ANTINEOPLASTIC AGENT; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DNA BINDING; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; TUMOR CELL LINE; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELLS, CULTURED; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HUMANS; OXIDATION-REDUCTION; SESQUITERPENES;

EID: 32044455497     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.033     Document Type: Article

References (21)

1. A. Wolf-Rainer Curr. Med. Chem. 8 2001 583 and references therein
2. T. Murakami, and N. Tanaka Prog. Chem. Org. Nat. Prod. 54 1988 1 and references therein
3. A. Arnone, R. Cardillo, V. Di Modugno, and G. Nasini J. Chem. Soc., Perkin Trans. 1 1989 1995
4. P. Sengupta, M. Sen, S.K. Niyogi, S.C. Pakrashi, and E. Ali Phytochemistry 15 1976 995
5. U.F. Castillo, Y. Sakagama, M. Alonso-Amelot, and M. Ojiva Tetrahedron 55 1999 12295
6. K. Yoshihira, M. Fukuoka, M. Kuroyanagi, S. Natori, M. Umeda, T. Morohoshi, M. Enomoto, and M. Saito Chem. Pharm. Bull. 26 1978 2346
7. H. Sheridan, S. Lemon, N. Frankish, P. McArdle, T. Higgins, J. James, and P. Bhandari Eur. J. Med. Chem. 25 1990 603
8. J.A. Palermo, M.F. Rodríguez Brasco, C. Spagnuolo, and A.M. Seldes J. Org. Chem. 65 2000 4482
9. R. Tanaka, Y. Nakano, D. Suzuki, H. Urabe, and F. Sato J. Am. Chem. Soc. 124 2002 9682
10. E.N. Alesso, D.E. Bianchi, L.M. Finkielsztein, B. Lantaño, G.Y. Moltrasio, and J.M. Aguirre Tetrahedron Lett. 36 1995 3299
11. S.E. Asís, A.M. Bruno, A.R. Martínez, M.V. Sevilla, C.H. Gaozza, A.M. Romano, J.D. Coussio, and G. Ciccia Il Farmaco 54 1999 517
12. M.C. Alley, D.A. Scudiero, A. Monks, M.L. Hursey, M.J. Czerwinski, D.L. Fine, B.J. Abbot, J.G. Mayo, R.H. Shoemaker, and M.R. Boyd Cancer Res. 48 1988 589
13. M.R. Grever, S.A. Schepartz, and B.A. Chabner Semin. Oncol. 19 1992 622
14. M.R. Boyd, and K.D. Paull Drug Dev. Res. 34 1995 91
15. A. Monks, D. Scudiero, P. Skehan, R. Shoemaker, K. Paull, D. Vistica, C. Hose, J. Langley, P. Cronise, A. Vaigro-Wolff, M. Gray-Goodrich, H. Campbell, J. Mayo, and M. Boyd J. Natl. Cancer Inst. 83 1991 757
16. J.N. Weinstein, T.G. Myers, P.M. O'Connor, S.H. Friend, A.J. Fornace Jr., K.W. Kohn, T. Fojo, S.E. Bates, L.V. Rubinstein, N.L. Anderson, J.K. Buolamwini, W.W. van Osdol, A.P. Monks, D.A. Scudiero, E.A. Sausville, D.W. Zaharevitz, B. Bunow, V.N. Viswanadhan, G.S. Johnson, R.E. Wittes, and K.D. Paull Science 275 1997 343
17. Data concerning the NCI screening methods in detail are accessible from the NCI via the Internet from the following address: http://dtp.nci.nih.gov/ branches/btb/ivclsp.html..
18. P. Kovacic, J.R. Ames, P. Lumme, H. Elo, O. Cox, H. Jackson, L.A. Rivera, L. Ramírez, and M.D. Ryan Anti-Cancer Drug Des. 1 1986 197
19. G. Wulff, J. Gimpel, J. Feld, and I. Hufnagel Makromolekul. Chem. 183 1982 2459 2467
20. Serban, A.; Watson, K. G.; Bird, G. J.; Farquharson, G.; Cross, L. E. U.S. Patent 4,952,722, 1990.
21. Chem. Abstr. 114 1991 163696