Inflammation, organomegaly, and muscle wasting despite hyperphagia in a mouse model of burn cachexia

Journal of Cachexia, Sarcopenia and Muscle

Volumn 3, Issue 3, 2012, Pages 199-211

  Pedroso, Felipe E ^a   Spalding, Paul B ^b   Cheung, Michael C ^b   Yang, Relin ^b   Gutierrez, Juan C ^b   Bonetto, Andrea ^a   Zhan, Rui ^c   Chan, Ho Lam ^b   Namias, Nicholas ^b   Koniaris, Leonidas G ^a   Zimmers, Teresa A ^a,b,c  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

Animal model; Metabolism; Muscle atrophy; Muscle wasting; Thermal injury

Indexed keywords

AMYLOID P COMPONENT; C REACTIVE PROTEIN; CD40 LIGAND; CXCL3 CHEMOKINE; FIBRINOGEN; HAPTOGLOBIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 3; MONOCYTE CHEMOTACTIC PROTEIN 5; MUSCLE RING FINGER 1 PROTEIN; ONCOSTATIN M; RANTES;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY COMPOSITION; BODY FAT; BODY MASS; BODY WEIGHT; BONE DENSITY; BURN; BURN CACHEXIA; CACHEXIA; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; HEART MASSAGE; HEART WEIGHT; HYPERPHAGIA; LEAN BODY WEIGHT; LIVER WEIGHT; MALE; MOUSE; MUSCLE ATROPHY; MUSCLE CELL; MUSCLE MASS; NONHUMAN; ORGAN WEIGHT; PLASMA; POLYDIPSIA; PRIORITY JOURNAL; SPLEEN WEIGHT; SURVIVAL; WEIGHT REDUCTION;

EID: 84865736276     PISSN: 21905991     EISSN: 21906009     Source Type: Journal    
DOI: 10.1007/s13539-012-0062-x     Document Type: Article

References (42)

1. ABA. Burn incidence and treatment in the US: 2011 fact sheet. Chicago: American Burn Association; 2011. Accessed 23 Aug 2011.
2. ABA. American Burn Association, National Burn Repository. Chicago: American Burn Association; 2009.
3. Pereira C, Murphy K, Jeschke M, Herndon DN. Post burn muscle wasting and the effects of treatments. Int J Biochem Cell Biol. 2005; 37: 1948-61.
4. Jeschke MG, Gauglitz GG, Kulp GA, Finnerty CC, Williams FN, Kraft R, et al. Long-term persistence of the pathophysiologic response to severe burn injury. PLoS One. 2011; 6: e21245.
5. Hart DW, Wolf SE, Mlcak R, Chinkes DL, Ramzy PI, Obeng MK, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000; 128: 312-9.
6. Pearson E, Soroff HS, Reiss E. Metabolic derangements in burns. J Am Diet Assoc. 1956; 32: 223-8.
7. Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007; 11: R90.
8. Tan BH, Fearon KC. Cachexia: prevalence and impact in medicine. Curr Opin Clin Nutr Metab Care. 2008; 11: 400-7.
9. Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. Am J Clin Nutr. 2006; 83: 735-43.
10. Borsheim E, Chinkes DL, McEntire SJ, Rodriguez NR, Herndon DN, Suman OE. Whole body protein kinetics measured with a non-invasive method in severely burned children. Burns. 2010; 36: 1006-12.
11. Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, et al. Pathophysiologic response to severe burn injury. Ann Surg. 2008; 248: 387-401.
12. Strock LL, Singh H, Abdullah A, Miller JA, Herndon DN. The effect of insulin-like growth factor I on postburn hypermetabolism. Surgery. 1990; 108: 161-4.
13. Barrow RE, Hawkins HK, Aarsland A, Cox R, Rosenblatt J, Barrow LN, et al. Identification of factors contributing to hepatomegaly in severely burned children. Shock. 2005; 24: 523-8.
14. Jeschke MG, Micak RP, Finnerty CC, Herndon DN. Changes in liver function and size after a severe thermal injury. Shock. 2007; 28: 172-7.
15. Tomera JF, Lilford K. Co-modulation between acetylcholinesterase and cyclic nucleotide signal transduction systems in burn trauma. Methods Find Exp Clin Pharmacol. 1995; 17: 89-105.
16. Madihally SV, Toner M, Yarmush ML, Mitchell RN. Interferon gamma modulates trauma-induced muscle wasting and immune dysfunction. Ann Surg. 2002; 236: 649-57.
17. Tan Y, Peng X, Wang F, You Z, Dong Y, Wang S. Effects of tumor necrosis factor-alpha on the 26S proteasome and 19S regulator in skeletal muscle of severely scalded mice. J Burn Care Res. 2006; 27: 226-33.
18. Tzika AA, Astrakas LG, Cao H, Mintzopoulos D, Zhang Q, Padfield K, et al. Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma. Int J Mol Med. 2008; 21: 825-32.
19. Cheung MC, Spalding PB, Gutierrez JC, Balkan W, Namias N, Koniaris LG, et al. Body surface area prediction in normal, hypermuscular, and obese mice. J Surg Res. 2009; 153: 326-31.
20. Zimmers TA, Davies MV, Koniaris LG, Haynes P, Esquela AF, Tomkinson KN, et al. Induction of cachexia in mice by systemically administered myostatin. Science. 2002; 296: 1486-8.
21. Bonetto A, Aydogdu T, Kunzevitzky N, Guttridge DC, Khuri S, Koniaris LG, et al. STAT3 activation in skeletal muscle links muscle wasting and the acute phase response in cancer cachexia. PLoS One. 2011; 6: e22538.
22. Lang CH, Huber D, Frost RA. Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I. Am J Physiol Regul Integr Comp Physiol. 2007; 292: R328-36.
23. Fattori E, Cappelletti M, Costa P, Sellitto C, Cantoni L, Carelli M, et al. Defective inflammatory response in interleukin 6-deficient mice. J Exp Med. 1994; 180: 1243-50.
24. Strassmann G, Fong M, Windsor S, Neta R. The role of interleukin-6 in lipopolysaccharide-induced weight loss, hypoglycemia and fibrinogen production, in vivo. Cytokine. 1993; 5: 285-90.
25. Cuthbertson DP, Angeles Valero Zanuy MA, Leon Sanz ML. Post-shock metabolic response. 1942. Nutr Hosp. 2001; 16: 176-82. discussion 5-6.
26. Williams FN, Jeschke MG, Chinkes DL, Suman OE, Branski LK, Herndon DN. Modulation of the hypermetabolic response to trauma: temperature, nutrition, and drugs. J Am Coll Surg. 2009; 208: 489-502.
27. Mosier MJ, Pham TN, Klein MB, Gibran NS, Arnoldo BD, Gamelli RL, et al. Early enteral nutrition in burns: compliance with guidelines and associated outcomes in a multicenter study. J Burn Care Res. 2011; 32: 104-9.
28. Padfield KE, Zhang Q, Gopalan S, Tzika AA, Mindrinos MN, Tompkins RG, et al. Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle. J Trauma. 2006; 61: 280-92.
29. Black K, Garrett IR, Mundy GR. Chinese hamster ovarian cells transfected with the murine interleukin-6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology. 1991; 128: 2657-9.
30. Jin X, Zhang Z, Beer-Stolz D, Zimmers TA, Koniaris LG. Interleukin-6 inhibits oxidative injury and necrosis after extreme liver resection. Hepatology. 2007; 46: 802-12.
31. Zimmers TA, McKillop IH, Pierce RH, Yoo JY, Koniaris LG. Massive liver growth in mice induced by systemic interleukin 6 administration. Hepatology. 2003; 38: 326-34.
32. Jin X, Zimmers TA, Perez EA, Pierce RH, Zhang Z, Koniaris LG. Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair. Hepatology. 2006; 43: 474-84.
33. Zimmers TA, Pierce RH, McKillop IH, Koniaris LG. Resolving the role of IL-6 in liver regeneration. Hepatology. 2003; 38: 1590-1. author reply 1.
34. Jin X, Zimmers TA, Zhang Z, Peirce RH, Koniaris LG. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut. 2009.
35. Quinn R. Comparing rat's to human's age: how old is my rat in people years? Nutrition. 2005; 21: 775-7.
36. Gelfand JA, Donelan M, Hawiger A, Burke JF. Alternative complement pathway activation increases mortality in a model of burn injury in mice. J Clin Invest. 1982; 70: 1170-6.
37. Gauglitz GG, Williams FN, Herndon DN, Jeschke MG. Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs? Curr Opin Clin Nutr Metab Care. 2011; 14: 176-81.
38. Miller JT, Btaiche IF. Oxandrolone treatment in adults with severe thermal injury. Pharmacotherapy. 2009; 29: 213-26.
39. Jeschke MG, Herndon DN, Barrow RE. Insulin-like growth factor I in combination with insulin-like growth factor binding protein 3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats. Ann Surg. 2000; 231: 408-16.
40. Heszele MF, Price SR. Insulin-like growth factor I: the yin and yang of muscle atrophy. Endocrinology. 2004; 145: 4803-5.
41. Branski LK, Herndon DN, Barrow RE, Kulp GA, Klein GL, Suman OE, et al. Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children. Ann Surg. 2009; 250: 514-23.
42. von Haehling S, Morley JE, Coats AJ, Anker SD. Ethical guidelines for authorship and publishing in the Journal of Cachexia, Sarcopenia and Muscle. J Cachex Sarcopenia Muscle. 2010; 1: 7-8.