Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children

Annals of Surgery

Volumn 250, Issue 4, 2009, Pages 514-522

  Branski, Ludwik K ^a   Herndon, David N ^a   Barrow, Robert E ^a   Kulp, Gabriela A ^a   Klein, Gordon L ^a   Suman, Oscar E ^a   Przkora, Rene ^a   Meyer, Walter ^a   Huang, Ted ^a   Lee, Jong O ^a   Chinkes, David L ^a   Mlcak, Ronald P ^a   Jeschke, Marc G ^a  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHOLESTEROL; GLUCOSE; GROWTH HORMONE; HUMAN GROWTH HORMONE; OSTEOCALCIN; PARATHYROID HORMONE; PLACEBO; PROTEIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; TRIACYLGLYCEROL;

ACROMEGALY; AEROBIC EXERCISE; ARTICLE; BICYCLE ERGOMETER; BICYCLE ERGOMETRY; BLOOD CHEMISTRY; BODY COMPOSITION; BODY FAT; BODY HEIGHT; BODY SURFACE; BODY WEIGHT; BONE METABOLISM; BONE MINERAL; BRAIN PSEUDOTUMOR; BURN; BURN PATIENT; CALCIUM BLOOD LEVEL; CALORIMETRY; CHILD; CHILD GROWTH; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG WITHDRAWAL; ENERGY EXPENDITURE; EPIPHYSIS CLOSURE; EPIPHYSIS DISEASE; EXERCISE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GROWTH HORMONE BLOOD LEVEL; GYNECOMASTIA; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HEART WORK; HIRSUTISM; HOSPITAL DISCHARGE; HUMAN; HYPERCALCEMIA; HYPERGLYCEMIA; HYPERMETABOLISM; ISOKINETIC EXERCISE; LEAN BODY WEIGHT; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REST; SCAR FORMATION; SCHOOL CHILD; SIDE EFFECT; SINGLE BLIND PROCEDURE; TREADMILL ERGOMETRY; TREADMILL EXERCISE; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; VIRILIZATION; WEIGHT CHANGE;

ANALYSIS OF VARIANCE; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; BURNS; CARDIAC OUTPUT; CHILD; ENERGY METABOLISM; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; OSTEOCALCIN; PARATHYROID HORMONE; PLACEBOS; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 70349659715     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3181b8f9ca     Document Type: Article

References (43)

1. Herndon DN, Tompkins RG. Support of the metabolic response to burn injury. Lancet. 2004;363:1895-1902.
2. Rutan RL, Herndon DN. Growth delay in postburn pediatric patients. Arch Surg. 1990;125:392-395.
3. Jeschke MG, Mlcak RP, Finnerty CC, et al. Burn size determines the inflammatory and hypermetabolic response. Crit Care. 2007;11:R90.
4. Gore DC, Honeycutt D, Jahoor F, et al. Effect of exogenous growth hormone on glucose utilization in burn patients. J Surg Res. 1991;51:518-523.
5. Gore DC, Honeycutt D, Jahoor F, et al. Effect of exogenous growth hormone on whole-body and isolated-limb protein kinetics in burned patients. Arch Surg. 1991;126:38-43.
6. Herndon DN, Barrow RE, Kunkel KR, et al. Effects of recombinant human growth hormone on donor-site healing in severely burned children. Ann Surg. 1990;212:424-429; discussion 430-431.
7. Jeschke MG, Barrow RE, Herndon DN. Recombinant human growth hormone treatment in pediatric burn patients and its role during the hepatic acute phase response. Crit Care Med. 2000;28:1578-1584.
8. Low JF, Herndon DN, Barrow RE. Effect of growth hormone on growth delay in burned children: a 3-year follow-up study. Lancet. 1999;354:1789.
9. Przkora R, Herndon DN, Suman OE, et al. Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients. Ann Surg. 2006;243:796-801; discussion 801-803.
10. Wilkins JP, Suman OE, Benjamin DA, et al. Comparison of self-reported and monitored compliance of daily injection of human growth hormone in burned children. Burns. 2003;29:697-701.
11. Hart DW, Wolf SE, Herndon DN, et al. Energy expenditure and caloric balance after burn: increased feeding leads to fat rather than lean mass accretion. Ann Surg. 2002;235:152-161.
12. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, et al. CDC Growth Charts: United States. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics. Advance Data. 2000;314:1-28.
13. Sahn DJ, DeMaria A, Kisslo J, et al. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58:1072-1083.
14. Mlcak RP, Jeschke MG, Barrow RE, et al. The influence of age and gender on resting energy expenditure in severely burned children. Ann Surg. 2006; 244:121-130.
15. Hart DW, Wolf SE, Chinkes DL, et al. Effects of early excision and aggressive enteral feeding on hypermetabolism, catabolism, and sepsis after severe burn. J Trauma. 2003;54:755-764.
16. Hart DW, Wolf SE, Mlcak R, et al. Persistence of muscle catabolism after severe burn. Surgery. 2000;128:312-319. (Pubitemid 30622500)
17. Yeong EK, Mann R, Engrav LH, et al. Improved burn scar assessment with use of a new scar-rating scale. J Burn Care Rehabil. 1997;18:353-355; discussion 352.
18. Jeschke MG, Przkora R, Suman OE, et al. Sex differences in the long-term outcome after a severe thermal injury. Shock. 2007;27:461-465.
19. Przkora R, Barrow RE, Jeschke MG, et al. Body composition changes with time in pediatric burn patients. J Trauma. 2006;60:968-971; discussion 971.
20. Rongen-Westerlaken C, Wit JM, De Muinck Keizer-Schrama SM, et al; Dutch Growth Hormone Working Group. Growth hormone treatment in Turner syndrome accelerates growth and skeletal maturation. Eur J Pediatr. 1992;151:477-481.
21. Kanaka-Gantenbein C. Hormone replacement treatment in Turner syndrome. Pediatr Endocrinol Rev. 2006;3(suppl 1):214-218.
22. de Zegher F, Ong KK, Ibanez L, et al. Growth hormone therapy in short children born small for gestational age. Horm Res. 2006;65(suppl 3):145-152.
23. Ramirez RJ, Wolf SE, Barrow RE, et al. Growth hormone treatment in pediatric burns: a safe therapeutic approach. Ann Surg. 1998;228:439-448.
24. Rodriguez-Arnao J, Jabbar A, Fulcher K, et al. Effects of growth hormone replacement on physical performance and body composition in GH deficient adults. Clin Endocrinol (Oxf). 1999;51:53-60.
25. Christiansen JS, Jorgensen JO. Beneficial effects of GH replacement therapy in adults. Acta Endocrinol (Copenh). 1991;125:7-13.
26. Hansen TB, Vahl N, Jorgensen JO, et al. Whole body and regional soft tissue changes in growth hormone deficient adults after one year of growth hormone treatment: a double-blind, randomized, placebo-controlled study. Clin Endo-crinol (Oxf). 1995;43:689-696.
27. Hart DW, Herndon DN, Klein G, et al. Attenuation of posttraumatic muscle catabolism and osteopenia by long-term growth hormone therapy. Ann Surg. 2001;233:827-834.
28. Klein GL, Wolf SE, Langman CB, et al. Effects of therapy with recombinant human growth hormone on insulin-like growth factor system components and serum levels of biochemical markers of bone formation in children after severe burn injury. J Clin Endocrinol Metab. 1998;83:21-24.
29. Cioffi WG, Gore DC, Rue LW III, et al. Insulin-like growth factor-1 lowers protein oxidation in patients with thermal injury. Ann Surg. 1994;220:310- 316; discussion 316-319.
30. Muller EE, Rigamonti AE, Cella SG. Mechanisms of action of GH. J Endocrinol Invest. 2003;26(suppl 10):2-15.
31. Jeschke MG, Klein D, Herndon DN. Insulin treatment improves the systemic inflammatory reaction to severe trauma. Ann Surg. 2004;239:553-560.
32. Thomas SJ, Morimoto K, Herndon DN, et al. The effect of prolonged euglycemic hyperinsulinemia on lean body mass after severe burn. Surgery. 2002;132:341-347.
33. Le Corvoisier P, Hittinger L, Chanson P, et al. Cardiac effects of growth hormone treatment in chronic heart failure: a meta-analysis. J Clin Endocri-nol Metab. 2007;92:180-185.
34. Cho GY, Jeong IK, Kim SH, et al. Effect of growth hormone on cardiac contractility in patients with adult onset growth hormone deficiency. Am J Cardiol. 2007;100:1035-1039.
35. Garrel DR, Gaudreau P, Zhang LM, et al. Chronic administration of growth hormone-releasing factor increases wound strength and collagen maturation in granulation tissue. J Surg Res. 1991;51:297-302.
36. Jorgensen PH, Oxlund H. Growth hormone increases the biomechanical strength and collagen deposition rate during the early phase of skin wound healing. Wound Repair Regen. 1996;4:40-47.
37. Herndon DN, Hawkins HK, Nguyen TT, et al. Characterization of growth hormone enhanced donor site healing in patients with large cutaneous burns. Ann Surg. 1995;221:649-656; discussion 656-659.
38. Barret JP, Dziewulski P, Jeschke MG, et al. Effects of recombinant human growth hormone on the development of burn scarring. Plast Reconstr Surg. 1999;104:726-729.
39. Oliveira GV, Chinkes D, Mitchell C, et al. Objective assessment of burn scar vascularity, erythema, pliability, thickness, and planimetry. Dermatol Surg. 2005;31:48-58.
40. Suman OE, Herndon DN. Effects of cessation of a structured and supervised exercise conditioning program on lean mass and muscle strength in severely burned children. Arch Phys Med Rehabil. 2007;88(12 Suppl 2):S24-S29.
41. Suman OE, Spies RJ, Celis MM, et al. Effects of a 12-wk resistance exercise program on skeletal muscle strength in children with burn injuries. J Appl Physiol. 2001;91:1168-1175.
42. Neugebauer CT, Serghiou MA, Marvin J. A comprehensive 8-12 week group music and movement program for severely burned children. Proceedings of the ABA. J Burn Care Rehabil. 2005;26:S85.
43. Celis MM, Suman OE, Huang TT, et al. Effect of a supervised exercise and physiotherapy program on surgical interventions in children with thermal injury. J Burn Care Rehabil. 2003;24:57-61; discussion 56.