Hypoglycemic effects of brassinosteroid in diet-induced obese mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 303, Issue 5, 2012, Pages

  Esposito, Debora ^a   Kizelsztein, Pablo ^a   Komarnytsky, Slavko ^a,b   Raskin, Ilya ^a  

^a RUTGERS UNIVERSITY   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Diabetes; Glucose; Homobrassinolide; Insulin resistance; Phosphoenolpyruvate carboxykinase

Indexed keywords

28 HOMOBRASSINOLIDE; BRASSINOSTEROID; DEXAMETHASONE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (PYROPHOSPHATE); UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; BODY COMPOSITION; BODY WEIGHT; C57BL 6 MOUSE; CELL CULTURE; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; GENE EXPRESSION PROFILING; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEPATOMA CELL; HYPERGLYCEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; MOUSE; MUSCLE TISSUE; NONHUMAN; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BRASSINOSTEROIDS; CELL LINE; CYCLIC AMP; DIET, HIGH-FAT; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION; GLUCOSE-6-PHOSPHATASE; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; OBESITY; PHOSPHOENOLPYRUVATE CARBOXYKINASE (ATP); PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANDOM ALLOCATION; RNA, MESSENGER;

EID: 84865726866     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00024.2012     Document Type: Article

References (36)

1. Argaud D, Zhang Q, Pan W, Maitra S, Pilkis SJ, Lange AJ. Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5′-flanking sequence. Diabetes 45: 1563-1571, 1996.
2. Bajguz A, Tretyn A. The chemical characteristic and distribution of brassinosteroids in plants. Phytochemistry 62: 1027-1046, 2003.
3. Baron DL, Luo W, Janzen L, Pharis RP, Back TG. Structure-activity studies of brassinolide b-ring analogues. Phytochemistry 49: 1849-1858, 1998.
4. Bathori M, Toth N, Hunyadi A, Marki A, Zador E. Phytoecdysteroids and anabolic-androgenic steroids-structure and effects on humans. Curr Med Chem 15: 75-91, 2008.
5. Berasi SP, Huard C, Li D, Shih HH, Sun Y, Zhong W, Paulsen JE, Brown EL, Gimeno RE, Martinez RV. Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. J Biol Chem 281: 27167-27177, 2006.
6. Berggreen C, Gormand A, Omar B, Degerman E, Goransson O. Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes. Am J Physiol Endocrinol Metab 296: E635-E646, 2009.
7. Bunger L, Hill WG. Inbred lines of mice derived from long-term divergent selection on fat content and body weight. Mamm Genome 10: 645-648, 1999.
8. Chatelain F, Pegorier JP, Minassian C, Bruni N, Tarpin S, Girard J, Mithieux G. Development and regulation of glucose-6-phosphatase gene expression in rat liver, intestine, and kidney: in vivo and in vitro studies in cultured fetal hepatocytes. Diabetes 47: 882-889, 1998.
9. Clouse SD. Brassinosteroids. Plant counterparts to animal steroid hormones? Vitam Horm 65: 195-223, 2002.
10. Cope MB, Nagy TR, Fernandez JR, Geary N, Casey DE, Allison DB. Antipsychotic drug-induced weight gain: development of an animal model. Int J Obes 29: 607-614, 2005.
11. Esposito D, Komarnytsky S, Shapses S, Raskin I. Anabolic effect of plant brassinosteroid. FASEB J 25: 3708-3719, 2011.
12. Esposito D, Rathinasabapathy T, Poulev A, Komarnytsky S, Raskin I. Akt-dependent anabolic activity of natural and synthetic brassinosteroids in rat skeletal muscle cells. J Med Chem 54: 4057-4066, 2011.
13. Fujioka S, Yokota T. Biosynthesis and metabolism of brassinosteroids. Annu Rev Plant Biol 54: 137-164, 2003.
14. Gorelick-Feldman J, Maclean D, Ilic N, Poulev A, Lila MA, Cheng D, Raskin I. Phytoecdysteroids increase protein synthesis in skeletal muscle cells. J Agric Food Chem 56: 3532-3537, 2008.
15. Govorko D, Logendra S, Wang Y, Esposito D, Komarnytsky S, Ribnicky D, Poulev A, Wang Z, Cefalu WT, Raskin I. Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line. Am J Physiol Endocrinol Metab 293: E1503-E1510, 2007.
16. Grove MD, Spencer GF, Rohwedder WK, Mandava N, Worley JF, Warthen JD, Steffens GL, Flippenanderson JL, Cook JC. Brassinolide, a plant growth-promoting steroid isolated from Brassica-napus pollen. Nature 281: 216-217, 1979.
17. Hanson RW, Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Annu Rev Biochem 66: 581-611, 1997.
18. Kim TW, Guan S, Sun Y, Deng Z, Tang W, Shang JX, Burlingame AL, Wang ZY. Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nat Cell Biol 11: 1254-1260, 2009.
19. Kim YD, Park KG, Lee YS, Park YY, Kim DK, Nedumaran B, Jang WG, Cho WJ, Ha J, Lee IK, Lee CH, Choi HS. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 57: 306-314, 2008.
20. Kirpichnikov D, McFarlane SI, Sowers JR. Metformin: an update. Ann Intern Med 137: 25-33, 2002.
21. Kizelsztein P, Govorko D, Komarnytsky S, Evans A, Wang Z, Cefalu WT, Raskin I. 20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model. Am J Physiol Endocrinol Metab 296: E433-E439, 2009.
22. Kuzmitsky BB, Mizulo NA. Study of Acute Toxicity of Epibrassinolide and its Preparative Forms: Technical Report. Minsk, Belarus: Academy of Sciences of Belarus, 1991 (1-44).
23. Longnus SL, Segalen C, Giudicelli J, Sajan MP, Farese RV, Van Obberghen E. Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo. Diabetologia 48: 2591-2601, 2005.
24. Losel R, Wehling M. Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol 4: 46-56, 2003.
25. Malikova J, Swaczynova J, Kolar Z, Strnad M. Anticancer and antiproliferative activity of natural brassinosteroids. Phytochemistry 69: 418-426, 2008.
26. Michelini FM, Berra A, Alche LE. The in vitro immunomodulatory activity of a synthetic brassinosteroid analogue would account for the improvement of herpetic stromal keratitis in mice. J Steroid Biochem Mol Biol 108: 164-170, 2008.
27. Michelini FM, Ramirez JA, Berra A, Galagovsky LR, Alche LE. In vitro and in vivo antiherpetic activity of three new synthetic brassinosteroid analogues. Steroids 69: 713-720, 2004.
28. Müssig C. Brassinosteroid-promoted growth. Plant Biol (Stuttg) 7: 110-117, 2005.
29. Nam KH, Li J. BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell 110: 203-212, 2002.
30. Rajas F, Bruni N, Montano S, Zitoun C, Mithieux G. The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology 117: 132-139, 1999.
31. Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate- activated protein kinase and malonyl coenzyme A. Obesity 14, Suppl 1: 25S-33S, 2006.
32. Schluter U, Kopke D, Altmann T, Mussig C. Analysis of carbohydrate metabolism of CPD antisense plants and the brassinosteroids deficient cbb1 mutant. Plant Cell Environ 25: 783-791, 2002.
33. Schmoll D, Allan BB, Burchell A. Cloning and sequencing of the 5′ region of the human glucose-6-phosphatase gene: transcriptional regulation by cAMP, insulin and glucocorticoids in H4IIE hepatoma cells. FEBS Lett 383: 63-66, 1996.
34. Wang ZY, Seto H, Fujioka S, Yoshida S, Chory J. BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature 410: 380-383, 2001.
35. Yu JQ, Huang LF, Hu WH, Zhou YH, Mao WH, Ye SF, Nogués S. A role for brassinosteroids in the regulation of photosynthesis in Cucumis sativus. J Exp Bot 55: 1135-1143, 2004.
36. Yuan L, Ziegler R, Hamann A. Inhibition of phosphoenolpyruvate carboxykinase gene expression by metformin in cultured hepatocytes. Chin Med J (Engl) 115: 1843-1848, 2002.