A vaccine formulation consisting of nucleocapsid-like particles from Dengue-2 and the fusion protein P64k-domain III from Dengue-1 induces a protective immune response against the homologous serotypes in mice

Acta Tropica

Volumn 124, Issue 2, 2012, Pages 107-112

  Lazo, Laura ^a   Gil, Lázaro ^a   López, Carlos ^a   Valdés, Iris ^a   Blanco, Aracelys ^a   Pavón, Alequis ^b   Romero, Yaremis ^a   Guzmán, María G ^b   Guillén, Gerardo ^a   Hermida, Lisset ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b INSTITUTO DE MEDICINA TROPICAL PEDRO KOURÍ   (Cuba)

Author keywords

Adjuvant; Capsid; Dengue; Domain III; P64k; Vaccine

Indexed keywords

ALUMINUM POTASSIUM SULFATE; GAMMA INTERFERON; HYBRID PROTEIN; NUCLEOCAPSID PROTEIN; P64K DOMAIN III FUSION PROTEIN; PLACEBO; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS LIKE PARTICLE VACCINE;

DENGUE FEVER; IMMUNE RESPONSE; PROTEIN; RODENT; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE RELEASE; DENGUE; DENGUE VIRUS 1; DENGUE VIRUS 2; DRUG FORMULATION; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOPOTENTIATION; IN VITRO STUDY; INFECTION PREVENTION; MOUSE; NONHUMAN; PROTEIN ASSEMBLY; SEROTYPE; UPREGULATION; VIRUS NUCLEOCAPSID;

ADJUVANTS, IMMUNOLOGIC; ALUM COMPOUNDS; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CAPSID PROTEINS; DENGUE; DENGUE VACCINES; DENGUE VIRUS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MICE; MICE, INBRED BALB C; NEUTRALIZATION TESTS; SURVIVAL ANALYSIS; VACCINES, SYNTHETIC; VACCINES, VIRUS-LIKE PARTICLE; VIRAL FUSION PROTEINS;

ANIMALIA; DENGUE VIRUS TYPE 2; MIRIDAE; MUS; PRIMATES;

EID: 84865721180     PISSN: 0001706X     EISSN: 18736254     Source Type: Journal    
DOI: 10.1016/j.actatropica.2012.06.006     Document Type: Article

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