Tumor-stroma ratio is an independent predictor for survival in esophageal squamous cell carcinoma

Journal of Thoracic Oncology

Volumn 7, Issue 9, 2012, Pages 1457-1461

  Wang, Kai ^a   Ma, Wei ^a   Wang, Jianbo ^a   Yu, Liang ^b   Zhang, Xiaomei ^b   Wang, Zhenbo ^b   Tan, Bingxu ^a   Wang, Nana ^a   Bai, Bing ^a   Yang, Shengsi ^a   Liu, Houqiang ^c   Zhu, Shengjie ^c   Cheng, Yufeng ^a  

^a SHANDONG UNIVERSITY   (China)

^b BINZHOU MEDICAL UNIVERSITY   (China)

^c Wendeng Central Hospital of Weihai   (China)

Author keywords

Esophageal neoplasms; Squamous cell carcinoma; Survival; Tumor stroma ratio

Indexed keywords

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; DISEASE FREE SURVIVAL; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS RESECTION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PREDICTOR VARIABLE; PRIORITY JOURNAL; SURVIVAL RATE; TISSUE SECTION; TUMOR STROMA RATIO;

EID: 84865693829     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e318260dfe8     Document Type: Article

References (15)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
2. de Kruijf EM, van Nes JG, van de Velde CJ, et al. Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients. Breast Cancer Res Treat 2011;125:687-696.
3. Courrech Staal EF, Wouters MW, van Sandick JW, et al. The stromal part of adenocarcinomas of the oesophagus: does it conceal targets for therapy? Eur J Cancer 2010;46:720-728.
4. Mesker WE, Liefers GJ, Junggeburt JM, et al. Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients. Cell Oncol 2009;31:169-178.
5. de Kruijf EM, van Nes JG, van de Velde CJ, et al. Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients. Breast Cancer Res Treat 2011;125:687-696.
6. Liu YP, Ma L, Wang SJ, et al. Prognostic value of lymph node metastases and lymph node ratio in esophageal squamous cell carcinoma. Eur J Surg Oncol 2010;36:155-159.
7. Smit JK, Pultrum BB, van Dullemen HM, Van Dam GM, Groen H, Plukker JT. Prognostic factors and patterns of recurrence in esophageal cancer assert arguments for extended two-field transthoracic esophagectomy. Am J Surg 2010;200:446-453.
8. Bissell MJ Radisky D. Putting tumours in context. Nat Rev Cancer 2001;1:46-54. (Pubitemid 33741880)
9. Lorusso G Rüegg C. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem Cell Biol 2008;130:1091-1103.
10. Massagué J. TGFbeta in Cancer. Cell 2008;134:215-230.
11. Kojima Y, Acar A, Eaton EN, et al. Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci USA 2010;107:20009-20014.
12. Balsamo M, Scordamaglia F, Pietra G, et al. Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity. Proc Natl Acad Sci USA 2009;106:20847-20852.
13. Udagawa T Wood M. Tumor-stromal cell interactions and opportunities for therapeutic intervention. Curr Opin Pharmacol 2010;10:369-374.
14. Shimoda M, Mellody KT, Orimo A. Carcinoma-associated fibroblasts are a rate-limiting determinant for tumour progression. Semin Cell Dev Biol 2010;21:19-25.
15. Courrech Staal EF, Smit VT, van Velthuysen ML, et al. Reproducibility and validation of tumour stroma ratio scoring on oesophageal adenocarcinoma biopsies. Eur J Cancer 2011: 375-382.