Prognostic significance of glutathione peroxidase 1 (GPX1) down-regulation and correlation with aberrant promoter methylation in human gastric cancer

Anticancer Research

Volumn 32, Issue 8, 2012, Pages 3169-3175

  Min, Sun Young ^a   Kim, Hee Sung ^b   Jung, Eun Jung ^a   Jung, Eun Ji ^a   Jee, Chang Do ^a   Kim, Woo Ho ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Gachon University   (South Korea)

Author keywords

Glutathione peroxidase 1; Glutathione peroxidase 3; Methylation; Stomach cancer

Indexed keywords

GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 3;

ADVANCED CANCER; ARTICLE; CANCER INVASION; CANCER SURVIVAL; CLINICAL FEATURE; CORRELATION ANALYSIS; DNA METHYLATION; DOWN REGULATION; GENE; GENE EXPRESSION; GENE SILENCING; GPX 1 GENE; GPX 3 GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; STOMACH CANCER;

BASE SEQUENCE; CELL LINE, TUMOR; DNA METHYLATION; DNA PRIMERS; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GLUTATHIONE PEROXIDASE; HUMANS; PROGNOSIS; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS;

EID: 84865680715     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, Kim HM, Kim WJ, Yamamoto H, Yamashita N, Yano T, Ikeda T, Itohara S, Inazawa J, Abe T, Hagiwara A, Yamagishi H, Ooe A, Kaneda A, Sugimura T, Ushijima T, Bae SC and Ito Y: Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 109: 113-124, 2002.
2. Ushijima T and Sasako M: Focus on gastric cancer. Cancer Cell 5: 121-125, 2004.
3. Sepulveda AR, Yao Y, Yan W, Park DI, Kim JJ, Gooding W, Abudayyeh S and Graham DY: CpG methylation and reduced expression of O 6-methylguanine DNA methyltransferase is associated with Helicobacter pylori infection. Gastroenterology 138: 1836-1844, 2010.
4. Kaneda A, Kaminishi M, Yanagihara K, Sugimura T and Ushijima T: Identification of silencing of nine genes in human gastric cancers. Cancer Res 62: 6645-6650, 2002.
5. Jee CD, Kim MA, Jung EJ, Kim J and Kim WH: Identification of genes epigenetically silenced by CpG methylation in human gastric carcinoma. Eur J Cancer 45: 1282-1293, 2009.
6. Miyamoto Y, Koh YH, Park YS, Fujiwara N, Sakiyama H, Misonou Y, Ookawara T, Suzuki K, Honke K and Taniguchi N: Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. Biol Chem 384: 567-574, 2003.
7. Crawford EL, Khuder SA, Durham SJ, Frampton M, Utell M, Thilly WG, Weaver DA, Ferencak WJ, Jennings CA, Hammersley JR, Olson DA and Willey JC: Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res 60: 1609-1618, 2000.
8. Arthur JR: The glutathione peroxidases. Cell Mol Life Sci 57: 1825-1835, 2000.
9. Wang JY, Yang IP, Wu DC, Huang SW, Wu JY and Juo SH: Functional glutathione peroxidase 3 polymorphisms associated with increased risk of Taiwanese patients with gastric cancer. Clin Chim Acta 411: 1432-1436, 2010.
10. Gologan A, Graham DY and Sepulveda AR: Molecular markers in Helicobacter pylori-associated gastric carcinogenesis. Clin Lab Med 25: 197-222, 2005.
11. Augusto AC, Miguel F, Mendonça S, Pedrazzoli J and Gurgueira SA: Oxidative stress expression status associated to Helicobacter pylori virulence in gastric diseases. Clinical Biochemistry 40: 615-622, 2007.
12. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R and Gladyshev VN: Characterization of mammalian selenoproteomes. Science 300: 1439-1443, 2003.
13. Wu M, Kang MM, Schoene NW and Cheng WH: Selenium compounds activate early barriers of tumorigenesis. J Biol Chem 285: 12055-12062, 2010.
14. Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, Parsons JK, Bearden JD, 3rd, Crawford ED, Goodman GE, Claudio J, Winquist E, Cook ED, Karp DD, Walther P, Lieber MM, Kristal AR, Darke AK, Arnold KB, Ganz PA, Santella RM, Albanes D, Taylor PR, Probstfield JL, Jagpal TJ, Crowley JJ, Meyskens FL Jr., Baker LH and Coltman CA Jr.: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 301: 39-51, 2009.
15. Yu YP, Yu G, Tseng G, Cieply K, Nelson J, Defrances M, Zarnegar R, Michalopoulos G and Luo JH: Glutathione peroxidase 3, deleted or methylated in prostate cancer, suppresses prostate cancer growth and metastasis. Cancer Res 67: 8043-8050, 2007.
16. Schmutzler C, Mentrup B, Schomburg L, Hoang-Vu C, Herzog V and Kohrle J: Selenoproteins of the thyroid gland: expression, localization and possible function of glutathione peroxidase 3. Biol Chem 388: 1053-1059, 2007.
17. Murawaki Y, Tsuchiya H, Kanbe T, Harada K, Yashima K, Nozaka K, Tanida O, Kohno M, Mukoyama T, Nishimuki E, Kojo H, Matsura T, Takahashi K, Osaki M, Ito H, Yodoi J and Shiota G: Aberrant expression of selenoproteins in the progression of colorectal cancer. Cancer Lett 259: 218-230, 2008.
18. Lodygin D, Epanchintsev A, Menssen A, Diebold J and Hermeking H: Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res 65: 4218-4227, 2005.
19. Lee OJ, Schneider-Stock R, McChesney PA, Kuester D, Roessner A, Vieth M, Moskaluk CA and El-Rifai W: Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis. Neoplasia 7: 854-861, 2005.
20. Peng DF, Razvi M, Chen H, Washington K, Roessner A, Schneider-Stock R and El-Rifai W: DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma. Gut 58: 5-15, 2009.
21. Brigelius-Flohe R and Kipp A: Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta 1790: 1555-1568, 2009.
22. Yoo EJ, Park SY, Cho NY, Kim N, Lee HS and Kang GH: Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks. Virchows Arch 452: 515-524, 2008.
23. Shin SH, Park SY, Ko JS, Kim N and Kang GH: Aberrant CpG island hypermethylation in pediatric gastric mucosa in association with Helicobacter pylori infection. Arch Pathol Lab Med 135:759-765, 2011.
24. Farinati F, Cardin R, Degan P, Rugge M, Mario FD, Bonvicini P and Naccarato R: Oxidative DNA damage accumulation in gastric carcinogenesis. Gut 42: 351-356, 1998.