Intrathecal PLCβ3 oligodeoxynucleotides antisense potentiates acute morphine efficacy and attenuates chronic morphine tolerance

Brain Research

Volumn 1472, Issue , 2012, Pages 38-44

  Zhou, Quanhong ^a   Xue, Ying ^a   Chen, Moxi ^a   Xu, Tao ^a   Wang, Jing ^a   Zhang, Xin ^a   Wang, Li ^a   Cui, Derong ^a   Zhang, Xiaoli ^a   Jiang, Wei ^a  

^a Shanghai Sixth People's Hospital   (China)

Author keywords

Intrathecal administration; Morphine; Oligodeoxynucleotide antisense; Oligodeoxynucleotide mismatch; PLC 3; Tolerance

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MORPHINE; PHOSPHOLIPASE C BETA3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG TOLERANCE; ENZYME ACTIVITY; GENE SILENCING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SINGLE DRUG DOSE; SPINAL CORD; TAIL FLICK TEST;

ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; INJECTIONS, SPINAL; MALE; MORPHINE; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PHOSPHOLIPASE C BETA; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

RATTUS;

EID: 84865677950     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2012.06.030     Document Type: Article

References (18)

1. V. Allen, P. Swigart, R. Cheung, S. Cockcroft, and M. Katan Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2 ion concentrations Biochem. J. 327 1997 545 552
2. E. Bianchi, D. Lehmann, E. Vivoli, M. Norcini, and C. Ghelardini Involvement of PLC-beta3 in the effect of morphine on memory retrieval in passive avoidance task J. Psychopharmacol. 24 2010 891 896
3. E. Bianchi, M. Norcini, A. Smrcka, and C. Ghelardini Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia J. Neurochem. 111 2009 171 180
4. G.G. Chen, A. Chalazonitis, K.F. Shen, and S.M. Crain Inhibitor of cyclic AMP-dependent protein kinase blocks opioid-induced prolongation of the action potential of mouse sensory ganglion neurons in dissociated cell cultures Brain Res. 462 1988 372 377
5. N. Galeotti, G.B. Stefano, M. Guarna, E. Bianchi, and C. Ghelardini Signaling pathway of morphine induced acute thermal hyperalgesia in mice Pain 123 2006 294 305
6. M. Javan, A. Ahmadiani, F. Motamadi, and B. Kazemi Changes in G proteins genes expression in rat lumbar spinal cord support the inhibitory effect of chronic pain on the development of tolerance to morphine analgesia Neurosci. Res. 53 2005 250 256
7. E.K. Joseph, O. Bogen, N. Alessandri-Haber, and J.D. Levine PLC-beta 3 signals upstream of PKC epsilon in acute and chronic inflammatory hyperalgesia Pain 132 2007 67 73
8. L. Langerman, M.I. Zakowski, B. Piskoun, and G.J. Grant Hot plate versus tail flick: evaluation of acute tolerance to continuous morphine infusion in the rat model J. Pharmacol. Toxicol. Methods 34 1 1995 23 27
9. N.J. Liu, S. Chakrabarti, and A.R. Gintzler Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas Brain Res. 1010 2004 1 9
10. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1 1951 265 275
11. J.L. Mathews, A.V. Smrcka, and J.M. Bidlack A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence J. Neurosci. 28 2008 12183 12189
12. T. Ono, M. Inoue, M.H. Rashid, K. Sumikawa, and H. Ueda Stimulation of peripheral nociceptor endings by low dose morphine and its signaling mechanism Neurochem. Int. 41 2002 399 407
13. M.H. Ossipov, J. Lai, T. King, T.W. Vanderah, and F. Porreca Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure Biopolymers 80 2005 319 324
14. J.C. Probst, and T. Skutella Elevated messenger RNA levels after antisense oligodeoxynucleotide treatment in vitro and in vivo Biochem. Biophys. Res. Commun. 225 1996 861 868
15. K.F. Shen, and S.M. Crain Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture Brain Res. 491 1989 227 242
16. R.V. Storkson, A. Kjorsvik, A. Tjolsen, and K. Hole Lumbar catheterization of the spinal subarachnoid space in the rat J. Neurosci. Methods 65 1996 167 172
17. T.W. Vanderah, L.R. Gardell, S.E. Burgess, M. Ibrahim, A. Dogrul, C.M. Zhong, E.T. Zhang, T.P. Malan Jr., M.H. Ossipov, J. Lai, and F. Porreca Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance J. Neurosci. 20 2000 7074 7079
18. W. Xie, G.M. Samoriski, J.P. McLaughlin, V.A. Romoser, A. Smrcka, P.M. Hinkle, J.M. Bidlack, R.A. Gross, H. Jiang, and D. Wu Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids Proc. Natl. Acad. Sci. U. S. A. 96 1999 10385 10390