Effects of calmodulin-dependent protein kinase II inhibitor, KN-93, on electrophysiological features of rabbit hypertrophic cardiac myocytes

Journal of Huazhong University of Science and Technology - Medical Science

Volumn 32, Issue 4, 2012, Pages 485-489

  Ke, Jun ^a   Chen, Feng ^a   Zhang, Cuntai ^b   Xiao, Xing ^b   Tu, Jing ^a   Dai, Musen ^a   Wang, Xiaoping ^a   Chen, Bing ^a   Chen, Min ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Calmodulin dependent protein kinase II; Electrophysiology; KN 93; Myocardial hypertrophy; Perforated patch recording techniques

Indexed keywords

BENZYLAMINE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; SULFONAMIDE;

ANIMAL; ARTICLE; CARDIOMEGALY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; HEART MUSCLE CELL; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RABBIT;

ANIMALS; BENZYLAMINES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CARDIOMEGALY; FEMALE; MYOCYTES, CARDIAC; RABBITS; SULFONAMIDES;

EID: 84865662708     PISSN: 16720733     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11596-012-0084-9     Document Type: Article

References (15)

1. 2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure. Cardiovasc Res, 2004,63(3):476-486
2. Anderson ME. Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias. Pharmacol Ther, 2005,106 (1):39-55
3. Li Y, Ma J, Xiao JM, et al. Heterogeneity of action potential and ion currents in the left ventricular myocytes of the rabbit. Acta Physiologica Sinica, 2002,54(5):369-374
4. Gillis AM, Geonzon RA, Mathison HJ, et al. The effects of barium, dofetilide and 4-aminopyndine (4-AP) on ventricular repolarization in normal and hypertrophied rabbit heart. J Pharmacol Exp Ther,1998,285(1):262-270
5. Jafary FH. Devereux formula for left ventricular mass-be careful to use the right units of measurement. J Am Soc Echocardiogr, 2007,20(6):783-791
6. Fu LY, Wang F, Chen XS, et al. Perforated patch recording of L-type calcium current with β-escin in guinea pig ventricular myocytes. Acta Pharmacol Sin, 2003,24(11):1094-1098
7. Fan JS, Palade P. Perforated patch recording with beta-escin. Pflügers Arch, 1998,436(6):1021-1023
8. Sala M, Coppa F, Cappucciati C, et al. Antidepressants: their effects on cardiac channels, QT prolongation and Torsade de Pointes. Curr Opin Investig Drugs, 2006,7(3): 256-263
9. 2+ channels on early after-depolarizations. Biophys J, 2005,88(1):85-95
10. 2+ channel antagonism on ventricular arrhythmogenesis in murine hearts containing a modification in the Scn5a gene modelling human long QT syndrome. J Physiol, 2007,578(Pt 1):85-97
11. Qi X, Yeh YH, Chartier D, et al. The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome. Circ Arrhythm Electrophysiol, 2009,2(3): 295-304
12. Anderson ME. QT interval prolongation and arrhythmia: an unbreakable connection? J Intern Med, 2006,259(1): 81-90
13. Wu Y, Temple J, Zhang R, et al. Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation, 2002,106(10):1288-1293
14. Anderson ME. Calmodulin kinase and L-type calcium channels: A recipe for arrhythmias? Trends Cardiovasc Med, 2004,14(4):152-161
15. 2+ leak in heart failure. Circ Res, 2005,97(12): 1314-1322