Life-threatening complications following multidose methotrexate for medical management of ectopic pregnancy

BMJ Case Reports

Volumn , Issue , 2012, Pages

  Dasari, Papa ^a   Sagili, Haritha ^a  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMPICILLIN; ANTIPYRETIC AGENT; ASCORBIC ACID; CEFTRIAXONE; CHORIONIC GONADOTROPIN BETA SUBUNIT; FLUCONAZOLE; FOLINIC ACID; FRESH FROZEN PLASMA; GENTAMICIN; INOTROPIC AGENT; MEROPENEM; METHOTREXATE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; STEROID; VITAMIN B COMPLEX;

ABDOMINAL DISTENSION; ACINETOBACTER BAUMANNII; ADULT; ANEMIA; ANTIBIOTIC SENSITIVITY; AORTA VALVE REGURGITATION; ARTICLE; BACTERIAL ENDOCARDITIS; BLOOD CULTURE; BONE MARROW DEPRESSION; BONE MARROW SUPPRESSION; CANDIDIASIS; CASE REPORT; CONJUNCTIVAL HEMORRHAGE; CONSERVATIVE TREATMENT; DIARRHEA; DIFFERENTIAL DIAGNOSIS; DRUG FEVER; DRUG MEGADOSE; DRUG RESPONSE; DYSPNEA; ECHOCARDIOGRAPHY; ECTOPIC PREGNANCY; EXPECTANT THERAPY; FEMALE; FEVER; FLUID SHIFT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTENSIVE CARE UNIT; INTERMITTENT MANDATORY VENTILATION; KLEBSIELLA PNEUMONIAE; MEDICATION ERROR; MELENA; MITRAL VALVE STENOSIS; MOUTH ULCER; NEUTROPENIA; PLASMA TRANSFUSION; PNEUMONIA; PREGNANCY TEST; PRIMIGRAVIDA; PRIORITY JOURNAL; RHEUMATIC HEART DISEASE; SEPTICEMIA; SHOCK; SIDE EFFECT; SKIN PIGMENTATION; SUBCONJUNCTIVAL HEMORRHAGE; SYNCHRONIZE INTERMITTENT MANDATORY VENTILATION; THIRD SPACE FLUID COLLECTION; THORAX RADIOGRAPHY; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TRANSVAGINAL ECHOGRAPHY; URINE CULTURE; VOMITING;

EID: 84865661885     PISSN: None     EISSN: 1757790X     Source Type: Journal    
DOI: 10.1136/bcr-03-2012-6023     Document Type: Article

References (19)

1. Stovall TG, Ling FW, Buster JE. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril 1989;51:435.
2. Isaacs JD Jr, McGehee RP, Cowan BD. Life-threatening neutropenia following methotrexate treatment of ectopic pregnancy: a report of two cases. Obstet Gynecol 1996;88:694-6. (Pubitemid 26331181)
3. Kumtepe Y, Kadanali S. Medical treatment of ruptured with haemodynamically stable and unruptured ectopic pregnancy patients. Eur J Obstet Gynecol Reprod Biol 2004;116:221-25. (Pubitemid 39195139)
4. Rabischong B, Tran X, Sleiman AA, et al. Predictive factors of failure in management of ectopic pregnancy with single dose methotrexate: a general population based analysis from the Auvergne Register, France. Fertil Steril 2011;95:401-4.
5. Soliman KB, Saleh NM, Omran AA. Safety and efficacy of systemic methotrexate in the treatment of unruptured tubal pregnancy. Saudi Med J 2006;27:1005-10. (Pubitemid 44612773)
6. Guvendag Guven ES, Dilbaz S, Dilbaz B, et al. Comparison of single and multi dose methotrexate therapy for unrutured tubal ectopic pregnancy: a prospective randomised study. Acta Obstet Gynecol Scand 2010;89:889-95.
7. Bamhart KT, Gosman G, Ashby R, et al. The medical management of ectopic pregnancy: a meta analysis comparing 'single dose' and 'multidose' regimens. Obstet Gynecol 2003;101:778-84. (Pubitemid 36390071)
8. Dilbaz S, Caliskan E, Dilbaz B, et al. Predictors of methotrexate treatment failure in ectopic pregnancy. J Reprod Med 2006;51:87-93. (Pubitemid 43277276)
9. Sivalingam VN, Duncun WC, Kirk E, et al. Diagnosis and management of ectopic pregnancy. J Fam Plann Reprod Health Care 2011;37:231-40.
10. Methotrexate side-effects. http://www.drugs.com/sfx/methotrexate-side- effects.html
11. Methotrexate Official FDA information, side-effects and uses. http://www.drugs.com/pro/methotrexate.html
12. Methotrexate sensitivity (MTHFR) 2 mutations. National reference Laboratory. http://www.aruplab.com
13. Castaldo P, Magi S, Nasti AA, et al. Clinical pharmacogenetics of methotrexate. Curr Drug Metab 2011;12:278-86.
14. Santucci R, Levêque D, Herbrecht R. Cola beverages and delayed elimination of methotrexate. Br J Clin Pharmacol 2010;70:762-4.
15. Faganel Kotnik B, Grabnar I, Bohanec Grabar P, et al. Association of genetic polymorphism in the folate metabolic pathway with methotrexate pharmacokinetics and toxicity in childhood acute lymphoblastic leukaemia and malignant lymphoma. Eur J Clin Pharmacol 2011;67:993-1006.
16. D'Angelo V, Ramaglia M, Iannotta A, et al. Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants. Cancer Chemother Pharmacol 2011;68:1339-46.
17. Flombaum CD, Meyers PA. High dose leucovorin as sole therapy for methotrexate toxicity. J Clin Oncol 1999;17:1589-94. (Pubitemid 29220869)
18. Carole K, Marion W, Selina M, et al. Improving the safety of methotrexate therapy: assessing risks and toxicity (SMART). http://www.pharmacare.unibas.ch
19. Stoller RG, Hande KR, Jacobs SA, et al. Use of plasma kinetics to predict and prevent methotrexate toxicity. N Eng J Med 1977;297:630-4. (Pubitemid 8200049)