The medical management of ectopic pregnancy: A meta-analysis comparing "single dose" and "multidose" regimens

Obstetrics and Gynecology

Volumn 101, Issue 4, 2003, Pages 778-784

  Barnhart, Kurt T ^a   Gosman, Gabriella ^b   Ashby, Rachel ^b   Sammel, Mary ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; FOLINIC ACID; METHOTREXATE;

ABDOMINAL PAIN; ADULT; ALOPECIA; CALCULATION; CLINICAL PROTOCOL; CLINICAL TRIAL; ECTOPIC PREGNANCY; FEMALE; FETUS HEART RATE; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MEDICAL LITERATURE; MEDLINE; META ANALYSIS; MULTIPLE DRUG DOSE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NAUSEA; PRIORITY JOURNAL; REVIEW; SIDE EFFECT; SINGLE DRUG DOSE; TREATMENT FAILURE; TREATMENT OUTCOME; VOMITING;

EID: 0037381073     PISSN: 00297844     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0029-7844(02)03158-7     Document Type: Review

References (39)

1. Ectopic pregnancy - United States, 1990-1992. MMWR Morb Mortal Wkly Rep. 44:(3):1995;46-48.
2. Advanced report of final mortality statistics, 1992. 1994;US Department of Health and Human Services, Public Health Service, CDC, Hyattsville, Maryland.
3. Fylstra D. Tubal pregnancy A review of current diagnosis and treatment . Obstet Gynecol Surv. 53:1998;320-327.
4. Alexander J.M., Rouse D.J., Varner E., Austin J.M. Treatment of the small unruptured ectopic pregnancy A cost analysis of methotrexate versus laparoscopy . Obstet Gynecol. 88:1996;123-126.
5. Carson S.A., Buster J.E. Ectopic pregnancy. N Engl J Med. 329:1993;1174-1181.
6. Barnhart K.T., Esposito M., Coutifaris C. An update on the medical management of ectopic pregnancy. Obstet Gynecol Clin North Am. 27:2000;653-667.
7. Calabresi P., Chabner B.A. Antineoplastic agents. Gilman A., Goodman L.S., Goodman A. Goodman and Gilman's the pharmacological basis of therapeutics. 8th: 1990;1275-1276 Macmillan Publishing Co, New York.
8. Farber S., Diamond L.K., Mercer R.D., Sylvester R.F., Wolff V.A. Temporary remissions in acute leukemia in children produced by folic antagonist 4-amethopteroylglutamic acid (aminopterin). N Engl J Med. 238:1948;787-793.
9. Hertz R. Folic acid antagonists Effects on the cell and the patient. Clinical staff conference at NIH . Ann Intern Med. 59:1963;931-956.
10. Stovall T.G., Ling F.W., Gray L.A., Carson S.A., Buster J.E. Methotrexate treatment of unruptured ectopic pregnancy A report of 100 cases . Obstet Gynecol. 77:1991;749-753.
11. Stovall T.G., Ling F.W. Single-dose methotrexate An expanded clinical trial . Am J Obstet Gynecol. 168:1993;1759-1765.
12. Corsan G.H., Karacan M., Qasim S., Bohrer M.K., Ransom M.X., Kemmann K. Identification of hormonal parameters for successful systemic single-dose methotrexate therapy in ectopic pregnancy. Hum Reprod. 10:1995;2719-2722.
13. Glock J.J., Johnson J.V., Brumsted J.R. Efficacy and safety of single-dose systemic methotrexate in the treatment of ectopic pregnancy. Fertil Steril. 62:1994;716-721.
14. Gross Z., Rodriguez J.J., Stalnaker B.L. Ectopic pregnancy Non-surgical, outpatient evaluation and single-dose methotrexate treatment . J Reprod Med. 40:1995;371-374.
15. Hajenius P.J., Engelsbel S., Mol B.W., Van der Veen F., Ankum W.M., Bossuyt P.M., et al. Randomized trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy. Lancet. 350:1997;774-779.
16. Henry M.A., Gentry W.L. Single injection of methotrexate for treatment of ectopic pregnancies. Am J Obstet Gynecol. 171:1994;1584-1587.
17. Ransom M.X., Garcia A.J., Bohrer M., Corsan G.H., Kemmann K. Serum progesterone as a predictor of methotrexate success in the treatment of ectopic pregnancy. Obstet Gynecol. 83:1994;1033-1037.
18. Saraj A.J., Wilcox J.G., Najmabadi S., Stein S.M., Johnson M.B., Paulson R.J. Resolution of hormonal markers of ectopic gestation A randomized trial comparing single-dose intra-muscular methotrexate with salpingostomy . Obstet Gynecol. 92:1998;989-994.
19. Stika C.S., Anderson L., Frederiksen M.C. Single-dose methotrexate for the treatment of ectopic pregnancy Northwestern Memorial Hospital three-year experience . Am J Obstet Gynecol. 174:1996;1840-1846.
20. Thoen L.D., Creinin M.D. Medical treatment of ectopic pregnancy with methotrexate. Fertil Steril. 68:1997;727-730.
21. Hidlebaugh D., O'Mara P. Clinical and financial analyses of ectopic pregnancy management at a large health plan. J Am Assoc Gynecol Laparosc. 4:1997;207-213.
22. Jimenez-Caraballo A., Rodriguez-Donoso G. A 6-year clinical trial of methotrexate therapy in the treatment of ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 79:1998;167-171.
23. Lecuru F., Robin F., Bernard J.P., Maizan de Malartic C., Mac-Cordick C., Boucaya V., et al. Single-dose methotrexate for unruptured ectopic pregnancy. Int J Gynaecol Obstet. 61:1998;253-259.
24. Lipscomb G.H., Bran D., McCord M.L., Portera J.C., Ling F.W. Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate. Am J Obstet Gynecol. 178:1998;1354-1358.
25. Sauer M.V., Gorrill M.J., Rodi I.A., Yeko T.R. Nonsurgical management of unruptured tubal pregnancy An extended clinical trial . Fertil Steril. 48:1987;752-755.
26. Yao M., Tulandi T., Falcone T. Treatment of ectopic pregnancy by systemic methotrexate transvaginal methotrexate, and operative laparoscopy. Int J Fertil. 41:1996;470-475.
27. Fernandez H., Bourget P., Ville Y., Lelaidier C., Frydman R. Treatment of unruptured tubal pregnancy with methotrexate Pharmacokinetic analysis of local versus intra-muscular administration . Fertil Steril. 62:1994;943-947.
28. McCord M.L., Muram D., Lipscomb G.H., Powell M.P., Arheart K.L. Methotrexate therapy for ectopic pregnancy in adolescents. J Pediatr Adolesc Gynecol. 9:1996;71-73.
29. Prapas J., Prapas N., Prapa S., Papanikolaou A., Papanikolaou N. Conservative treatment of ectopic pregnancy with intra-muscular administration of methotrexate (MTX/CV). Acta Eur Fertil. 23:1992;25-28.
30. Wolf G.C., Nickisch S.A., George K.E., Teicher J.R., Simms T.D. Completely nonsurgical management of ectopic pregnancies. Gynecol Obstet Invest. 37:1994;232-235.
31. Stovall T.G., Ling F.W., Buster J.E. Outpatient chemotherapy of unruptured ectopic pregnancy. Fertil Steril. 51:1989;435-438.
32. Stovall T.G., Ling F.W., Carson S.A., Buster J.E. Nonsurgical diagnosis and treatment of tubal pregnancy. Fertil Steril. 54:1990;537-538.
33. Stoval T.G., Ling F.W., Gray L.A. Single-dose methotrexate for treatment of ectopic pregnancy. Obstet Gynecol. 77:1991;754-757.
34. Lipscomb G.H., McCord M.L., Stovall T.G., Huff G., Portera S.G., Ling F.W. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med. 341:1999;1974-1978.
35. Mickey R.M., Greenland S. The impact of confounder selection criteria on effect estimation. Am J Epidemiol. 129:1989;125-137.
36. Medical management of tubal pregnancy. 1998;American College of Obstetricians and Gynecologists, Washington. ACOG practice bulletin no. 3.
37. Schoenfeld A., Mashiach R., Vardy M., Ovadia J. Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy. Obstet Gynecol. 80:1992;520-521.
38. Isaacs J.D., Mcgehee R.P., Cowan B.D. Life threatening neutropenia following methotrexate treatment of ectopic pregnancy A report of two cases . Obstet Gynecol. 88:1996;694-696.
39. Stroup D.F., Berlin J.A., Morton S.C., Olkin I., Williamson G.D., Rennie D., et al. Meta-analysis of observational studies in epidemiology A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) Group . JAMA. 283:2000;2008-2012.