Total cardiovascular risk, blood pressure variability and adrenergic overdrive in hypertension: Evidence, mechanisms and clinical implications

Current Hypertension Reports

Volumn 14, Issue 4, 2012, Pages 333-338

  Grassi, Guido ^a,b   Bombelli, Michele ^a   Brambilla, Gianmaria ^a   Trevano, Fosca Quarti ^a   Dell'Oro, Raffaella ^a   Mancia, Giuseppe ^a  

^a SAN GERARDO HOSPITAL   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

Ambulatory blood pressure monitoring; Blood pressure variability; Cardiovascular risk; Cardiovascular risk factors; Hypertension; Sympathetic nervous system

Indexed keywords

ALBUMIN; CREATININE;

ADRENERGIC ACTIVITY; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE VARIABILITY; CARDIOVASCULAR RISK; CAUSE OF DEATH; DISEASE ASSOCIATION; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HUMAN; HYPERTENSION; MICROALBUMINURIA; MORTALITY; OUTCOME ASSESSMENT; PRACTICE GUIDELINE; PREDICTION; PROGNOSIS; RISK ASSESSMENT; RISK FACTOR;

BLOOD PRESSURE; BLOOD PRESSURE MONITORING, AMBULATORY; CARDIOVASCULAR SYSTEM; HUMANS; HYPERTENSION; RECEPTORS, ADRENERGIC, BETA; RISK; SYMPATHETIC NERVOUS SYSTEM;

EID: 84865649173     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-012-0273-8     Document Type: Article

References (51)

1. Mancia G, De Backer G, Dominiczak A, Management of Arterial Hypertension of the European Society of Hypertension, European Society of Cardiology, et al. Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2007;25:1105-87. The document includes the most recent recommendations on diagnosis and treatment of hypertension made by european experts. (Pubitemid 46924065)
2. Mancia G, Laurent S, Agabiti-Rosei E, et al. European Society of Hypertension. Reappraisal of European guidelines on hypertension management: A European Society of Hypertension Task Force document. J Hypertens. 2009;27:2121-58. The paper provides a critical upadte of the 2007 guidelines by discussing the evidence collected in importnat clinical trials published between 2007 and 2009.
3. Mancia G, Grassi G. Mechanisms and clinical implications of blood pressure variability. J Cardiovasc Pharmacol. 2000;35:S15-9.
4. Grassi G. Assessment of sympathetic cardiovascular drive in human hypertension: Achievements and perspectives. Hypertension. 2009;54:690-7. The review provides a comprehensive update of the most recent data collected on the role of the sympathetic nervous sytem in hypertension.
5. Thomas F, Rudnichi A, Bacri AM, et al. Cardiovascular mortality in hypertensive men according to presence of associated risk factors. Hypertension. 2001;37:1256-61. (Pubitemid 34163578)
6. Bombelli M, Facchetti R, Carugo S, et al. Left ventricular hypertrophy increases cardiovascular risk independently of in-office and outof-office blood pressure values. J Hypertens. 2009;27:2458-64.
7. Ruilope LM, Schmieder RE. Left ventricular hypertrophy and clinical outcomes in hypertensive patients. Am J Hypertens. 2008;21:500-8. (Pubitemid 351589672)
8. Zanchetti A, Hennig M, Hollweck R, et al. Baseline values but not treatment-induced changes in carotid intima-media thickness predict incident cardiovascular events in treated hypertensive patients: Findings in the European Lacidipine Study on Atherosclerosis (ELSA). Circulation. 2009;120:1084-90.
9. Simon A, Megnien JL, Chironi G. The value of carotid intimamedia thickness for predicting cardiovascular risk. Arterioscler Thromb Vasc Biol. 2010;30:182-5.
10. Cuspidi C, Ambrosioni E, Mancia G, APROS Investigators, et al. Role of echocardiography and carotid ultrasonography in stratifying risk in patients with essential hypertension: The Assessment of Prognostic Risk Observational Survey. J Hypertens. 2002;20:1307-14. (Pubitemid 34925675)
11. Viazzi F, Parodi D, Leoncini G, et al. Optimizing global risk evaluation in primary hypertension: The role of microalbuminuria and cardiovascular ultrasonography. J Hypertens. 2004;22:907-13. (Pubitemid 38680464)
12. Pontremoli R, Ravera M, Bezante GP, et al. Left ventricular geometry and function in patients with essential hypertension and microalbuminuria. J Hypertens. 1999;17:993-1000. (Pubitemid 29322188)
13. Mancia G, Zanchetti A. Blood pressure variability. In: Zanchetti A, Tarazi R, editors. Handbook of Hypertension. Pathophysiology of hypertension. 7th ed. Amsterdam: Elsevier; 1986. p. 125-52.
14. Sega R, Cesana G, Bombelli M, et al. Seasonal variations in home and ambulatory blood pressure in the PAMELA population. Pressione Arteriose Monitorate E Loro Associazioni. J Hypertens. 1998;16:1585-92. (Pubitemid 28515484)
15. Mancia G, Ferrari A, Gregorini L, et al. Blood pressure and heart rate variabilities in normotensive and hypertensive human beings. Circ Res. 1983;53:96-104. (Pubitemid 13031772)
16. Watson RD, Stallard TJ, Flinn RM, Littler WA. Factors determining direct arterial pressure and its variability in hypertensive man. Hypertension. 1980;2:333-41. (Pubitemid 10061138)
17. Pickering TG, Hall JE, Appel LJ, et al. Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: Alood pressure measurement in humans: A statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension. 2005;45:142-61.
18. Frattola A, Parati G, Cuspidi C, Albini F,Mancia G. Prognostic value of 24-hour blood pressure variability. J Hypertens. 1993;11:1133-7. (Pubitemid 23307888)
19. Sander D, Kukla C, Klingelhöfer J, Winbeck K, Conrad B. Relationship between circadian blood pressure patterns and progression of early carotid atherosclerosis: A 3-year follow-up study. Circulation. 2000;102:1536-41.
20. Bird AS, Blizard RA, Mann AH. Treating hypertension in the older person: An evaluation of the association of blood pressure level and its reduction with cognitive performance. J Hypertens. 1990;8:147-52. (Pubitemid 20167767)
21. Mancia G, Parati G, Hennig M, et al. ELSA Investigators. Relation between blood pressure variability and carotid artery damage in hypertension: Aaseline data from the European Lacidipine Study on Atherosclerosis (ELSA). J Hypertens. 2001;19:1981-9. (Pubitemid 33035803)
22. Sega R, Corrao G, Bombelli M, et al. Blood pressure variability and organ damage in a general population: results from the PAMELA study (Pressioni Arteriose Monitorate E Loro Associazioni). Hypertension. 2002;39:710-4. (Pubitemid 34165211)
23. Kikuya M, Hozawa A, Ohokubo T, et al. Prognostic significance of blood pressure and heart rate variabilities: The Ohasama study. Hypertension. 2000;36:901-6.
24. Mancia G, Bombelli M, Facchetti R, et al. Long-Term prognostic value of blood pressure variability in the general population: results of the Pressioni Arteriose Monitorate e Loro Associazioni Study. Hypertension. 2007;49:1265-70. The study findings provide evidence on the prognostic role exerted by blood pressure variability on fatal and non fatal cardiovascular events. (Pubitemid 46809367)
25. Pringle E, Phillips C, Thijs L, Syst-Eur investigators, et al. Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population. J Hypertens. 2003;21:2251-7. (Pubitemid 38293563)
26. Dawson SL, Manktelow BN, Robinson TG, Panerai RB, Potter JF. Which parameters of beat-To-beat blood pressure and variability best predict early outcome after acute ischemic stroke? Stroke. 2000;31:463-8. (Pubitemid 30078183)
27. Kikuya M, Ohkubo T, Metoki H, et al. Day-by-day variability of blood pressure and heart rate at home as a novel predictor of prognosis: The Ohasama study. Hypertension. 2008;52:1045-50. First demonstration of the potential importance of long-Term blood pressure varaibility on cardiovascular events.
28. Muntner P, Shimbo D, Tonelli M, et al. The relationship between visit-To-visit variability in systolic blood pressure and all-cause mortality in the general population: Findings from NHANES III, 1988 to 1994. Hypertension. 2011;57:160-6. The paper povides bew data on the prognostic importnance of blood pressure variability based on a large data base.
29. Rothwell PM, Howard SC, Dolan E, et al. Prognostic significance of visit-To-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375:895-905. The study, based on the analysis of the data collected in the Anglo-Scandinavian Cardiac Outcomes Trial Blood Pressure Lowering Arm [ASCOT-BPLA], provides evidence that visit-To-visit blood pressure variability may be a strong predictor of stroke.
30. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375:938-48.
31. Mancia G. Prognostic value of long-Term blood pressure variability: The evidence is growing. Hypertension. 2011;57:141-3.
32. Grassi G, Cattaneo BM, Seravalle G, Lanfranchi A, Mancia G. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension. 1998;31:68-72. (Pubitemid 28124694)
33. Seravalle G, Quarti-Trevano F. Dell'Oro R, et al. Sympathetic, baroreflex and metabolic abnormalities in the optimal, normal and high-normal blood pressure state. J Hypertens. 2010;28: E437.
34. Greenwood JP, Scott EM, Stoker JB, Mary DA. Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive. J Am Coll Cardiol. 2001;38:1711-7. (Pubitemid 33065459)
35. Schlaich MP, Kaye DM, Lambert E, et al. Relation between cardiac sympathetic activity and hypertensive left ventricular hypertrophy. Circulation. 2003;108:560-5. (Pubitemid 36961170)
36. Grassi G, Seravalle G, Quarti-Trevano F, et al. Sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction. Hypertension. 2009;53:205-9.
37. Grassi G, Seravalle G, Quarti-Trevano F, et al. Effects of hypertension and obesity on the sympathetic activation of heart failure patients. Hypertension. 2003;42:873-7. (Pubitemid 37413723)
38. Grassi G, Quarti-Trevano F, Seravalle G, et al. Early sympathetic activation in the initial clinical stages of chronic renal failure. Hypertension. 2011;57:846-51.
39. Grassi G, Dell'Oro R, Quarti-Trevano F, et al. Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia. 2005;48:1359-65. (Pubitemid 41186102)
40. Huggett RJ, Scott EM, Gilbey SG, et al. Impact of type 2 diabetes mellitus on sympathetic neural mechanisms in hypertension. Circulation. 2003;108:3097-101. (Pubitemid 38031798)
41. Cohn JN, Levine TB, Olivari MT, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311:819-23. (Pubitemid 14035089)
42. Zoccali C, Mallamaci F, Parlongo S, et al. Plasma norepinephrine predicts survival and incident cardiovascular events in patients with end-stage renal disease. Circulation. 2002;105:1354-9. (Pubitemid 34260428)
43. Rouleau JL, Packer M, Moyé L, et al. Prognostic value of neurohumoral activation in patients with an acute myocardial infarction: Effect of captopril. J Am Coll Cardiol. 1994;24:583-91. (Pubitemid 24295729)
44. Sander D, Winbeck K, Klingelhöfer J, Etgen T, Conrad B. Prognostic relevance of pathological sympathetic activation after acute thromboembolic stroke. Neurology. 2001;57:833-8. (Pubitemid 32845504)
45. Somers VK, Dyken ME, Mark AL, Abboud FM. Sympatheticnerve activity during sleep in normal subjects. N Engl J Med. 1993;328:303-7. (Pubitemid 23035328)
46. Kario K, Pickering TG, Hoshide S, et al. Morning blood pressure surge and hypertensive cerebrovascular disease: role of the α adrenergic sympathetic nervous system. Am J Hypertens. 2004;17:668-75. (Pubitemid 39091547)
47. Narkiewicz K, Winnicki M, Schroeder K, et al. Relationship between muscle sympathetic nerve activity and diurnal blood pressure profile. Hypertension. 2002;39:168-72. (Pubitemid 34098106)
48. Grassi G, Seravalle G, Quarti-Trevano F, et al. Adrenergic, metabolic, and reflex abnormalities in reverse and extreme dipper hypertensives. Hypertension. 2008;52:925-31.
49. Grassi G, Cattaneo B, Seravalle G, et al. Baroreflex modulation of minute-To-minute sympathetic nerve traffic variability in normotensive and hypertensive subjects. J Hypertens. 1998;16:S33.
50. Seravalle G, Dell'Oro R, Vailati S, et al. Baroreflex control of minute-To-minute sympathetic nerve traffic variability in heart failure and in hypertension. Eur Heart K. 1998;19:S144.
51. Dell'Oro R, Quarti-Trevano F, Facchetti R, et al. Overall, cyclic and non-cyclic 24-hour blood pressure variability and sympathetic nerve traffic in the elderly. J Hypertens. 2003;21:S213.