Arginase inhibition alleviates hypertension associated with diabetes: Effect on endothelial dependent relaxation and NO production

Vascular Pharmacology

Volumn 57, Issue 5-6, 2012, Pages 194-200

  El Bassossy, Hany M ^a,b   El Fawal, Rania ^a   Fahmy, Ahmed ^a  

^a Zagazig University   (Egypt)

^b KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Aorta; Arginase; Diabetes; Hypertension

Indexed keywords

ACETYLCHOLINE; ADVANCED GLYCATION END PRODUCT; ARGINASE; CITRULLINE; ENDOTHELIUM DERIVED RELAXING FACTOR; NITRIC OXIDE; NORVALINE; ORNITHINE; PHENYLEPHRINE; POTASSIUM CHLORIDE; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL REACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RAT; STREPTOZOCIN DIABETES; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; TREATMENT DURATION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA, THORACIC; ARGINASE; BLOOD PRESSURE; CITRULLINE; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYPERTENSION; MALE; NITRIC OXIDE; ORNITHINE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; VALINE; VASODILATION;

EID: 84865641748     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.01.001     Document Type: Article

References (45)

1. Akbari C.M., LoGerfo F.W. Diabetes and peripheral vascular disease. J. Vasc. Surg. 1999, 30:373-384.
2. Altan V.M. The pharmacology of diabetic complications. Curr. Med. Chem. 2003, 10:1317-1327.
3. Anderson M.M., Requena J.R., Crowley J.R., Thorpe S.R., Heinecke J.W. The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation. J. Clin. Invest. 1999, 104:103-113.
4. Baluchnejadmojarad T., Roghani M., Homayounfar H., Hosseini M. Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats. J. Ethnopharmacol. 2003, 85:139-144.
5. Barham D., Trinder P. An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst 1972, 97:142-145.
6. Beckman J.S. Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 1996, 9:836-844.
7. Berkowitz D.E., White R., Li D., Minhas K.M., Cernetich A., Kim S., Burke S., Shoukas A.A., Nyhan D., Champion H.C., Hare J.M. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation 2003, 108:2000-2006.
8. Bivalacqua T.J., Hellstrom W.J., Kadowitz P.J., Champion H.C. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. Biochem. Biophys. Res. Commun. 2001, 283:923-927.
9. Bivalacqua T.J., Usta M.F., Champion H.C., Kadowitz P.J., Hellstrom W.J.G. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. J. Androl. 2003, 24:S17-S37.
10. Caldwell R.B., Zhang W., Romero M.J., Caldwell R.W. Vascular dysfunction in retinopathy - an emerging role for arginase. Brain Res. Bull. 2010, 81:303-309.
11. Cederbaum S.D., Yu H., Grody W.W., Kern R.M., Yoo P., Iyer R.K. Arginases I and II: do their functions overlap?. Mol. Genet. Metab. 2004, 81(Suppl. 1):S38-S44.
12. Crabtree M.J., Channon K.M. Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide 2011, 25:81-88.
13. Demougeot C., Prigent-Tessier A., Marie C., Berthelot A. Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats. J. Hypertens. 2005, 23:971-978.
14. El-Bassossy H.M., El-Maraghy N.N., El-Fayoumi H.M., Watson M.L. Haem oxygenase-1 induction protects against tumour necrosis factor alpha impairment of endothelial-dependent relaxation in rat isolated pulmonary artery. Br. J. Pharmacol. 2009, 158:1527-1535.
15. El-Bassossy H.M., El-Moselhy M.A., Mahmoud M.F. Pentoxifylline alleviates vascular impairment in insulin resistance via TNF-α inhibition. Naunyn Schmiedebergs Arch. Pharmacol. 2011, 384:277-285.
16. El-Bassossy H.M., Fahmy A., Badawy D. Cinnamaldehyde protects from the hypertension associated with diabetes. Food Chem. Toxicol. 2011, 49:3007-3012.
17. Ensunsa J.L., Symons J.D., Lanoue L., Schrader H.R., Keen C.L. Reducing arginase activity via dietary manganese deficiency enhances endothelium-dependent vasorelaxation of rat aorta. Exp. Biol. Med. 2004, 229:1143-1153.
18. Fuentes J.M., Campo M.L., Soler G. Kinetics and inhibition by some amino acids of lactating rat mammary gland arginase. Arch. Int. Physiol. Biochim. Biophys. 1994, 102:255-258.
19. Holowatz L.A., Thompson C.S., Kenney W.L. Acute ascorbate supplementation alone or combined with arginase inhibition augments reflex cutaneous vasodilation in aged human skin. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H2965-H2970.
20. Hunter A., Downs C.E. The inhibition of arginase by amino acids. J. Biol. Chem. 1945, 157:427-446.
21. Huynh N.N., Harris E.E., Chin-Dusting J.F., Andrews K.L. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br. J. Pharmacol. 2009, 156:84-93.
22. Kang E.S., Ford K., Grokulsky G., Wang Y.B., Chiang T.M., Acchiardo S.R. Normal circulating adult human red blood cells contain inactive NOS proteins. J. Lab. Clin. Med. 2000, 135:444-451.
23. Kinoshita Y., Saito M., Satoh I., Shomori K., Suzuki H., Yamada M., Kono T., Satoh K. General administration of cyclohexenonic long-chain fatty alcohol ameliorates hyperreactivity of STZ-induced diabetic rat aorta. Life Sci. 2006, 78:1508-1514.
24. 2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase. J. Biol. Chem. 1992, 267:11374-11378.
25. Kuzkaya N., Weissmann N., Harrison D.G., Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J. Biol. Chem. 2003, 278:22546-22554.
26. Landmesser U., Dikalov S., Price S.R., McCann L., Fukai T., Holland S.M., Mitch W.E., Harrison D.G. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J. Clin. Invest. 2003, 111:1201-1209.
27. Maarsingh H., Volders H.H., Zaagsma J., Meurs H. l-ornithine causes deficiency and airway hyperresponsiveness in perfused guinea pig tracheal preparations in vitro. Naunyn Schmiedebergs Arch. Pharmacol. 2007, 375:151.
28. Maarsingh H., Zaagsma J., Meurs H. Arginine homeostasis in allergic asthma. Eur. J. Pharmacol. 2008, 585:375-384.
29. Morgan J.P., Morgan K.G. Calcium and cardiovascular function. Intracellular calcium levels during contraction and relaxation of mammalian cardiac and vascular smooth muscle as detected with aequorin. Am. J. Med. 1984, 77:33-46.
30. Morris C.R., Morris S.M., Hagar W., van Warmerdam J., Claster S., Kepka-Lenhart D., Machado L., Kuypers F.A., Vichinsky E.P. Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?. Am. J. Respir. Crit. Care Med. 2003, 168:63-69.
31. O'Rourke M.F., Nichols W.W. Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension. Hypertension 2005, 45:652-658.
32. Pacher P., Szabó C. Role of peroxynitrite in the pathogenesis of cardiovascular complications of diabetes. Curr. Opin. Pharmacol. 2006, 6:136-141.
33. Romero M.J., Platt D.H., Tawfik H.E., Labazi M., El-Remessy A.B., Bartoli M., Caldwell R.B., Caldwell R.W. Diabetes-induced coronary vascular dysfunction involves increased arginase activity. Circ. Res. 2008, 102:95-102.
34. Sampathkumar R., Balasubramanyam M., Rema M., Premanand C., Mohan V. A novel advanced glycation index and its association with diabetes and microangiopathy. Metabolism 2005, 54:1002-1007.
35. Santhanam L., Christianson D.W., Nyhan D., Berkowitz D.E. Arginase and vascular aging. J. Appl. Physiol. 2008, 105:1632-1642.
36. Shearer J.D., Richards J.R., Mills C.D., Caldwell M.D. Differential regulation of macrophage arginine metabolism: a proposed role in wound healing. Am. J. Physiol. Endocrinol. Metab. 1997, 272:E181-E190.
37. Somlyo A.P., Somlyo A.V. Signal transduction by G-proteins, Rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J. Physiol. 2000, 522:177-185.
38. Toth M., Kukor Z., Valent S. Chemical stabilization of tetrahydrobiopterin by l-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity. Mol. Hum. Reprod. 2002, 8:271-280.
39. Ugochukwu N.H., Cobourne M.K. Modification of renal oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with extracts from Gongronema latifolium leaves. Clin. Chim. Acta 2003, 336:73-81.
40. Vlassara H. The AGE-receptor in the pathogenesis of diabetic complications. Diabetes Metab. Res. Rev. 2001, 17:436-443.
41. Wautier M.P., Chappey O., Corda S., Stern D.M., Schmidt A.M., Wautier J.L. Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE. Am. J. Physiol. Endocrinol. Metab. 2001, 280:E685-E694.
42. Xavier F.E., Davel A.P., Rossoni L.V., Vassallo D.V. Time-dependent hyperreactivity to phenylephrine in aorta from untreated diabetic rats: role of prostanoids and calcium mobilization. Vascul. Pharmacol. 2003, 40:67-76.
43. Yang Z., Ming X.F. Recent advances in understanding endothelial dysfunction in atherosclerosis. Clin. Med. Res. 2006, 4:53-65.
44. Zhang C., Hein T.W., Wang W., Miller M.W., Fossum T.W., McDonald M.M., Humphrey J.D., Kuo L. Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles. Hypertension 2004, 44:935-943.
45. Zieman S.J., Melenovsky V., Clattenburg L., Corretti M.C., Capriotti A., Gerstenblith G., Kass D.A. Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J. Hypertens. 2007, 25:577-583.