Rabies: Still a uniformly fatal disease? historical occurrence, epidemiological trends, and paradigm shifts

Current Infectious Disease Reports

Volumn 14, Issue 4, 2012, Pages 408-422

  Feder, Henry M ^a   Petersen, Brett W ^b   Robertson, Kis L ^b   Rupprecht, Charles E ^b  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b NATIONAL CENTER FOR EMERGING AND ZOONOTIC INFECTIOUS DISEASES   (United States)

Author keywords

Biomedical paradigm shifts; Encephalitis; Experimental therapy; Infectious diseases; Lyssavirus; Public health; Rabies; Rabies prophylaxis; Rabies survivors; Virus

Indexed keywords

AMANTADINE; KETAMINE; MIDAZOLAM; RABIES IMMUNOGLOBULIN; RABIES VACCINE; RIBAVIRIN; VIRUS ANTIBODY; VIRUS ANTIGEN;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC PROPHYLAXIS; ANTIBODY DETECTION; ANTIBODY RESPONSE; ANTIGEN DETECTION; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CHILD; COMA THERAPY; DRUG TREATMENT FAILURE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOSTIMULATION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; OUTCOME ASSESSMENT; POST EXPOSURE PROPHYLAXIS; PRESCHOOL CHILD; RABIES; SCHOOL CHILD; THERAPY; TREND STUDY; VACCINATION; VIRUS NEUTRALIZATION; VIRUS TRANSMISSION;

EID: 84865616324     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-012-0268-2     Document Type: Article

References (100)

1. CDC. Human rabies. MMWR. 1960;9:2.
2. CDC. Human rabies-Kentucky. MMWR. 1961;10:2.
3. CDC. Rabies-California. MMWR. 1961;10:2.
4. CDC. Rabies death-Kentucky. MMWR. 1961;10:8.
5. CDC. Rabies-Texas. MMWR. 1962;11:58.
6. CDC. Human rabies-Idaho. MMWR. 1962;11:395.
7. CDC. Human rabies death-Alabama. MMWR. 1963;12:300.
8. Gomez MR, Siekert RG, Hermann EC. A human case of skunk rabies. JAMA. 1965;194:101-335.
9. CDC. Human rabies death-West Virginia. MMWR. 1966;15:195.
10. Bell RG. Death from rabies in a 10 year old boy. South Dakota J Med. 1967;20:28-30.
11. Rubin RH, Sullivan L, Summers R, Gregg MB, Sikes RK. A case of human rabies in Kansas. J Infect Dis. 1970;122:318-22.
12. Emmons RW, Leonard LL, DeGenaro F, et al. A case of human rabies with prolonged survival. Intervirology. 1973;1:60-72.
13. Hattwick MAW, Hochberg FW, Landrigan PJ, Gregg MB. Skunk-Associated human rabies. JAMA. 1972;222:44-7.
14. Hattwick MAW, Weis TT, Stechschute CJ, Baer GM, Gregg MB. Recovery from rabies. Ann Intern Med. 1972;76:931-42.
15. CDC. Human rabies-New Jersey. MMWR. 1971;20:459-60.
16. Winkler WB, Fashinell TR, Leffingwell L, Howard P, Conomy JP. Airborne rabies transmission in a laboratory worker. JAMA. 1973;226:1219-21.
17. CDC. Human rabies-Kentucky. MMWR. 1973;22:325-6.
18. Sung JH, Hayano M, Mastri AG, Okagaki T. A case of human rabies and ultrastructure of the negri bodies. J Neuropathol Exp Neurol. 1976;35:541-59.
19. CDC. Human rabies-Maryland. MMWR. 1976;25:235-6.
20. CDC. Rabies in a laboratory worker-New York. 1977;26:183-184.
21. CDC. Human-To-human transmission of rabies by a corneal transplant-Idaho. 1979;28:109-11
22. CDC. Human rabies-Pennsylvania. MMWR. 1979;28:75-7.
23. CDC. Two suspected cases of human rabies-TX, WA. MMWR. 1979;28:292:297-8.
24. CDC. Human rabies-Oklahoma. MMWR. 1979;28:476-81.
25. CDC. Human rabies-Kentucky. MMWR. 1979;28:590-1.
26. CDC. Two suspected cases of human rabies-Texas, Washington. MMWR. 1979;28:292-8.
27. CDC. Human rabies-Oklahoma. MMWR. 1981;30:343-9.
28. CDC. Human rabies-Michigan. MMWR. 1983;32:159-60.
29. CDC. Human rabies-Pennsylvania. MMWR. 1984;33:633-5.
30. CDC. Human rabies-Texas. MMWR. 1991;40:132-3.
31. CDC. Human rabies-Texas, Arkansas, Georgia. MMWR. 1991;40:765-9.
32. CDC. Human rabies-Texas and California.MMWR. 1994;43:93-6.
33. CDC. Human rabies-New York. MMWR. 1993;42:799-806.
34. CDC. Human rabies-Alabama, Tennessee, and Texas. MMWR. 1995;44:269-72.
35. CDC. Human rabies-California. MMWR. 1994;43:455-7.
36. CDC. Human rabies-West Virginia. MMWR. 1995;44:86-7.
37. CDC. Human rabies-Washington. MMWR. 1995;44:625-7.
38. CDC. Human rabies-Connecticut. MMWR. 1996;45:207-9.
39. CDC. Human rabies-California. MMWR. 1996;45:353-6.
40. CDC. Human rabies-Kentucky and Montana. MMWR. 1997;46:397-400.
41. CDC. Human rabies-Montana and Washington. MMWR. 1997;46:770-4.
42. CDC. Human rabies-Texas and New Jersey.MMWR. 1998;47:1-4.
43. CDC. Human rabies-Virginia. MMWR. 1999;48:95-7.
44. CDC. Human rabies-California, Georgia, Minnesota, Ney York, and Wisconsin. MMWR. 2000;49:111-6.
45. CDC. Human rabies-Tennessee. MMWR. 2002;51:828-9.
46. CDC. Human rabies-California. MMWR. 2002;51:686-8.
47. CDC. Human rabies-Iowa. MMWR. 2003;52:47-8.
48. CDC. First human death associated with raccoon rabies-Virginia. MMWR. 2003;52:1102-3.
49. CDC. Human death associated with bat rabies-California, 2003. MMWR. 2004;53:33-5.
50. CDC. Investigation of rabies Infections in organ donor and transplant recipients-Alabama, Arkansas, Oklahoma, and Texas. MMWR. 2004;53:586-9.
51. CDC. Recovery of a patient from clinical rabies-Wisconsin. MMWR. 2004;53:1171-3.
52. CDC. Human rabies-Mississippi. MMWR. 2006;55:207-8.
53. CDC. http://www.cdc.gov/rabies/resources/news/2006-05-10.html
54. CDC. Human rabies-Indiana and California. MMWR. 2007;56:361-5.
55. CDC. Human rabies-Minnesota. MMWR. 2008;57:460-2.
56. CDC. Human rabies -Missouri. MMWR. 2008;58:1207-9.
57. CDC. Human rabies-Kentucky/Indiana. MMWR. 2008;59:393-6.
58. CDC. Presumptive abortive human rabies-Texas. MMWR. 2010;59:185-190. Report of a teenager exposed to bats in a Texas cave. First suggestion of abortive rabies and recovery without intensive care, possibly related to a low viral dose and non-bite exposure route of infection.
59. CDC. Human rabies-Michigan. MMWR. 2011;60:437-40.
60. Hemachudha T, Laothamatas J, Rupprecht CE. Human rabies: A disease of complex neuropathogenetic mechanisms and diagnostic challenges. Lancet Neurol. 2002;1:101-9. (Pubitemid 37163495)
61. CDC. Human rabies prevention-United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR. 2008;57(No. RR-03):1-26,28.
62. American Academy of Pediatrics. Rabies. In: Pickering LK, Baker CJ, Long SS, McMillan, editors. Red book report of the committee on infectious diseases, 28th ed. Elk Grove Village, IL: 2009. pages 552-559.
63. Fishbein DB, Robinson LE. Current Concepts: Rabies. N Engl J Med. 1993;329:1632-8.
64. Warrell MJ, Warrell DA. Rabies and other lyssavirus diseases. Lancet. 2004;363:959-69. (Pubitemid 38388332)
65. Plotkin SA. Rabies. Clin Infect Dis. 2000;30:4-12. (Pubitemid 30067053)
66. Wilde H. Failures of post-exposure rabies prophylaxis. Vaccine. 2007;25:7605-9. (Pubitemid 47554470)
67. Sudarshan MK, Madhusudana SN, Mahendra BJ, et al. Assessing the burden of human rabies in India: results of a national multicenter epidemiological survey. Int J Infect Dis. 2007;11:29-35. (Pubitemid 44937648)
68. Soun VV, Eidson M, Trimarchi CV, et al. Antemortem diagnosis of New York human rabies case and review of US cases. Int J Biomed Sci. 2006;2:433-44.
69. Hemachudha T, Wacharapluesadee S, Mitrabhakdi E, Wilde H, Morimoto K, Lewis RA. Pathophysiology of human paralytic rabies. J Neurovirol. 2005;11:93-100. (Pubitemid 40458379)
70. World Health Organization. WHO Expert Consultation on Rabies. WHO Tech Rep Ser. 2005;931.
71. Blanton JD, Robertson K, Palmer D, Rupprecht CE. Rabies surveillance in the United States during 2008. JAVMA. 2009;235:676-89.
72. Velasco-Villa A, Reeder SA, et al. Enzootic rabies elimination from dogs and reemergence in wild terrestrial carnivores, United States. Emerg Infect Dis. 2008;14:1849-54.
73. DeSerres G, Dallaire F, Cote M, Skowronski DM. Bat rabies in the United States and Canada from 1950 to 2007: Human cases with and without bat contact. Clin Infect Dis. 2008;46:1329-37. (Pubitemid 351589929)
74. Dacheau L, Reynes J-M, Buchy P, et al. A reliable diagnosis of rabies based on analysis of skin biopsy specimens. Clin Infect Dis. 2008;47:1410-7.
75. Blanton JD, Bowden NY, Eidson M, Wyatt JD, Hanlon CA. Rabies postexposure prophylaxis, New York, 1995-2000. EID. 2005;11:1921-7. (Pubitemid 43356090)
76. CDC. Use of a reduced (4-dose) vaccine schedule for postexposure prophylaxis to prevent human rabies: recommendations of the advisory committee on immunization practices. MMWR. 2010;59(RR-2):1-9. Current guide for human rabies postexposure prophylaxis in the United States. Essential recommendations in managing the exposed patient for use by clinicians.
77. Rupprecht CE, Gibbons RV. Prophylaxis against rabies. N Engl J Med. 2004;351:2626-35. (Pubitemid 39628584)
78. Feder Jr. HM, Nelson RS, Reiher HW. Bat bite? Lancet. 1997;350:1300. (Pubitemid 28037703)
79. Jackson AC. Recovery from rabies. N Engl J Med. 2005;352:2549-50. (Pubitemid 41007874)
80. Willoughby RE, Tieves KS, Hoffman GM, et al. Survival after treatment of rabies with induction of coma. N Engl J Med. 2005;352:2508-14. (Pubitemid 41007866)
81. Hu WT, Willoughby Jr. RE, Dhonau H, Mack KJ. Long-Term follow-up after treatment of rabies by induction of coma. N Engl J Med. 2007;357:945-6. (Pubitemid 47347348)
82. Blanton JD, Palmer D, Dyer J, Rupprecht CE. Rabies surveillance in the United States during 2010. J Am Vet Med Assoc. 2011;239:773-83. Summarizes the current laboratory-based surveillance of rabies in The United States. Lists the spatial occurrence of animal cases and provides an update of human rabies cases for 2010-11.
83. Dacheux L, Delmas O, Bourhy H. Human rabies encephalitis prevention and treatment: Progress since Pasteur's discovery. Infect Disord Drug Targets. 2011;11:251-99. Presents a historical and global overview of the progress in human rabies prophylaxis over the past century. Discusses some of the available options to human rabies diagnosis and management.
84. Malerczyk C, Detora L, Gniel D. Imported human rabies cases in Europe, the United States, and Japan, 1990 to 2010. J Trav Med. 2011;18:402-7. Details several cases of imported human rabies in both the New and Old World. Suggests that globalization and translocation of cases will continue to create clinical challenges for medical personnel in developed countries unfamiliar with rabies.
85. Johnson N, Brookes SM, Healy DM, Spencer Y, Hicks D, Nunez A, Wells G, Fooks AR. Pathology associated with a human case of rabies in the United Kingdom caused by European Bat Lyssavirus Type-2. Intervirology. 2011 Dec 6. [Epub ahead of publication]. Presents a case of human rabies due to a rabiesrelated lyssavirus. Demonstrates the limitations of the concept of a 'rabies-free' country, given the ubiquity of lyssaviruses in bats.
86. CDC. Human rabies from exposure to a vampire bat in Mexico-Louisiana, 2010. MMWR. 2011;60:1050-2.
87. Aramburo A, Willoughby RE, Bollen AW, Glaser CA, Hsieh CJ, Davis SL, Martin KW, Roy-Burman A. Failure of the Milwaukee protocol in a child with rabies. Clin Infect Dis. 2011;53:572-4. Describes treatment of a case of rabies in California. Despite application of an experimental protocol, the child succumbed after 30 days of hospitalization and intensive care.
88. Jackson AC. Rabies in the critical care unit: Diagnostic and therapeutic approaches. Can J Neurol Sci. 2011;38:689-95. Discusses some of the current controversies in rabies clinical therapy. Reviews potential options for future intervention.
89. Rawat AK, Rao SK. Survival of a rabies patient. Indian Pediatr. 2011;48:574.
90. Hooper DC, Roy A, Kean RB, Phares TW, Barkhouse DA. Therapeutic immune clearance of rabies virus from the CNS. Future Virol. 2011;6:387-97.
91. Smith TG, Wu X, Franka R, Rupprecht CE. Design of future rabies biologics and antiviral drugs. Adv Virus Res. 2011;79:345-63.
92. Franka R, Rupprecht CE. Treatment of rabies in the 21st century: Curing the incurable? Future Microbiol. 2011;6:1135-40. Lists some of the approaches used to treat human rabies cases. Presents a comparison of variables related to virus, dose, route, and host characteristics, in support of the thesis that rabies is a continuum of outcomes related to the complex temporal and biomedical dynamics of each case.
93. Willoughby RE, Roy-Burman A, Martin KW, Christensen JC, Westenkirschner DF, Fleck JD, Glaser C, Hyland K, Rupprecht CE. Generalised cranial artery spasm in human rabies. Dev Biol (Basel). 2008;131:367-75.
94. Willoughby RE, Opladen T, Maier T, Rhead W, Schmiedel S, Hoyer J, Drosten C, Rupprecht CE, Hyland K, Hoffmann GF. Tetrahydrobiopterin deficiency in human rabies. J Inherit Metab Dis. 2009;32:65-72.
95. Rubin J, David D, Willoughby Jr. RE, Rupprecht CE, Garcia C, Guarda DC, Zohar Z, Stamler A. Applying the Milwaukee protocol to treat canine rabies in Equatorial Guinea. Scand J Infect Dis. 2009;41:372-5.
96. Hunter M, Johnson N, Hedderwick S, McCaughey C, Lowry K, McConville J, Herron B, McQuaid S, Marston D, Goddard T, Harkess G, Goharriz H, Voller K, Solomon T, Willoughby RE, Fooks AR. Immunovirological correlates in human rabies treated with therapeutic coma. J Med Virol. 2010;82:1255-65. A case is described of a 37-year-old woman exposed to rabies virus in South Africa. The patient was treated with a therapeutic coma according to the "Milwaukee protocol," which failed to prevent her death. Rabies virus was isolated from CSF and saliva, antibody was demonstrated in serum and csf, and postmortem specimens demonstrated the presence of antigens, viral RNA, and rabies virus isolates in the CNS.
97. Hamir AN, Niezgoda M, Rupprecht CE. Recovery from and clearance of rabies virus in a domestic ferret. J Am Assoc Lab Anim Sci. 2011;50:248-51. Describes a case of spontaneous recovery after experimental rabies virus infection. Provides evidence of viral clearance from the CNS.
98. Jackson AC, Warrell MJ, Rupprecht CE, Ertl HC, Dietzschold B, O'Reilly M, Leach RP, Fu ZF, Wunner WH, Bleck TP, Wilde H. Management of rabies in humans. Clin Infect Dis. 2003;36:60-3. (Pubitemid 36099098)
99. Willoughby Jr. RE. A cure for a rabies? Sci Am. 2007;296:88-95.
100. CDC. Recovery of a patient from clinical rabies -California, 2011. MMWR 2012;61:61-5. This report details the latest survivor from rabies in the United States, after application of experimental treatment. The child was exposed to a suspect cat that was lost to follow-up. Treatment included extreme intensive care, coma induction, and anti-viral drugs.