Glutamine for chemotherapy induced diarrhea: A metaanalysis

Asia Pacific Journal of Clinical Nutrition

Volumn 21, Issue 3, 2012, Pages 380-385

  Sun, Juxian ^a   Wang, Hui ^a   Hu, Heping ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Chemotherapy; Diarrhea; Glutamine; Meta analysis; Prophylactic

Indexed keywords

ANTIDIARRHEAL AGENT; ANTINEOPLASTIC AGENT; GLUTAMINE;

ARTICLE; CHEMICALLY INDUCED DISORDER; DIARRHEA; ENTERIC FEEDING; HUMAN; META ANALYSIS; NEOPLASM; PARENTERAL NUTRITION; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ANTIDIARRHEALS; ANTINEOPLASTIC AGENTS; DIARRHEA; ENTERAL NUTRITION; GLUTAMINE; HUMANS; NEOPLASMS; PARENTERAL NUTRITION; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84865600976     PISSN: 09647058     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Li Y, Yu Z, Liu F, Tan L, Wu B, Li J. Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori. 2006;92:396-401.
2. Li Y, Ping X, Yu B, Liu F, Ni X, Li J. Clinical trial: prophylactic intravenous alanyl-glutamine reduces the severity of gastrointestinal toxicity induced by chemotherapy--a randomized crossover study. Aliment Pharmacol Ther. 2009; 30:452-8.
3. Levine SA, Nath SK, Tse CM, Yun C, Donowitz M. Lglutamine in intestinal sodium absorption: lessons for physiology, pathobiology, and therapy for diarrhea. Gastroenterology. 1994;106:1698-702.
4. O'Dwyer S, Smith R, Hwang T, Wilmore DW. Maintenance of small bowel mucosa with glutamine enriched parenteral nutrition. J Parenter Enteral Nutr. 1989;13:579-85.
5. Sornsuvit C, Komindr S, Chuncharunee S, Wanikiat P, Archararit N, Santanirand P. Pilot Study: effects of parenteral glutamine dipeptide supplementation on neutrophil functions and prevention of chemotherapy-induced side-effects in acute myeloid leukaemia patients. J Int Med Res. 2008; 36:1383-91.
6. Gutiérrez C, Villa S, Mota FR, Calva JJ. Does an Lglutamine-containing, glucose-free, oral rehydration solution reduce stool output and time to rehydrate in children with acute diarrhoea? A double-blind randomized clinical trial. J Health Popul Nutr. 2007;25:278-84.
7. Huffman FG, Walgren ME. L-glutamine supplementation improves nelfinavir-associated diarrhea in HIV-infected individuals. HIV Clin Trials. 2003;4:324-9.
8. Pytlík R, Benes P, Patorková M, Chocenská E, Gregora E, Procházka B, Kozák T. Standardized parenteral alanylglutamine dipeptide supplementation is not beneficial in autologous transplant patients: a randomized, double-blind, placebo controlled study. Bone Marrow Transplant. 2002; 30:953-61.
9. Coghlin Dickson TM, Wong RM, offrin RS, Shizuru JA, Johnston LJ, Hu WW, Blume KG, Stockerl-Goldstein KE. Effect of oral glutamine supplementation during bone marrow transplantation. J Parenter Enteral Nutr. 2000;24:61-6.
10. Van Zaanen HC, van der Lelie H, Timmer JG, Fürst P, Sauerwein HP. Parenteral glutamine dipeptide supplementation does not amelioratechemotherapy-induced toxicity. Cancer. 1994;74:2879-84.
11. Jebb SA, Marcus R, Elia M. A pilot study of oral glutamine supplementation in patients receiving bone marrow transplants. Clin Nutr. 1995;14:162-5.
12. Bozzetti F, Biganzoli L, Gavazzi C, Cappuzzo F, Carnaghi C, Buzzoni R, Dibartolomeo M, Baietta E. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition. 1997;13:748-51.
13. Daniele B, Perrone F, Gallo C, Pignata S, De Martino S, De Vivo R, Barletta E, Tambaro R, Abbiati R, D'Agostino L. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut. 2001;48:28-33.
14. Jadad AR, Moore A, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1-12.
15. Song D, Shi B, Xue H, Li Y, Yu B, Xu Z, Liu F, Li J. Green fluorescent protein labeling Escherichia coli TG1 confirms intestinal bacterial translocation in a rat model of chemotherapy. Curr Microbiol. 2006;52:69-73.
16. Li Y, Li J, Jiang J, Li N, Wang X, Wang Z, Wu B, Liu F. Glycyl-glutamine-supplemented long-term total parenteral nutrition selectively improves structure and function in heterotopic small-bowel autotransplantation in the pig. Transpl Int. 2003;16:866-71.
17. Furst P. Intracellular muscle free amino-acids; their measurement and function. Proc Nutr Soc. 1983;42:451-62.
18. Scheppach W, Dusel G, Kuhn T, Loges C, Karch H, Bartram HP, Richter F, Christl SU, Kasper H. Effect of Lglutamine and n-butyrate on the restitution of rat colonic mucosa after acid induced injury. Gut. 1996;38:878-85.
19. Leita{ogonek}o RF, Ribeiro RA, Lira AM, Silva LR, Bellaguarda EA, Macedo FD, Sousa RB, Brito GA. Glutamine and alanyl-glutamine accelerate the recovery from 5-fluorouracil-induced experimental oral mucositis in hamster. Cancer Chemother Pharmacol. 2008;61:215-22.
20. Kessel A, Toubi E, Pavlotzky E, Mogilner J, Coran AG, Lurie M, Karry R, Sukhotnik I. Treatment with glutamine is associated with down-regulation of Toll-like receptor- 4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipopolysaccharide endotoxaemia in a rat. Clin Exp Immunol. 2008;151:341-7.
21. MacFie J. Enteral versus parenteral nutrition: the significance of bacterial translocation and gut-barrier function. Nutrition. 2000;16:606-11.
22. Fox AD, Kripke SA, De Paula J, Berman JM, Settle RG, Rombeau JL. Effect of a glutamine-supplemented enteral diet on methotrexate-induced enterocolitis. JPEN J Parenter Enteral Nutr. 1988;12:325-31.
23. Grant JP, Snyder PJ. Use of L-glutamine in total parenteral nutrition. J Surg Res. 1988;44:506-13.
24. Kozelsky TF, Meyers GE, Sloan JA, Shanahan TG, Dick SJ, Moore RL, et al. Phase III double-blind study of glutamine versus placebo for the prevention of acute diarrhea in patients receiving pelvic radiation therapy. J Clin Oncol. 2003; 21:1669-74.
25. Bode BP. Kaminksi M, Souba WW, Li AP. Glutamine transport in isolated human hepatocytes and transformed liver cells. Hepatology. 1995;21:511-20.