Does an L-glutamine-containing, glucose-free, oral rehydration solution reduce stool output and time to rehydrate in children with acute diarrhoea? A double-blind randomized clinical trial

Journal of Health, Population and Nutrition

Volumn 25, Issue 3, 2007, Pages 278-284

  Gutiérrez, Claudia ^a   Villa, Sofía ^b   Mota, Felipe R ^a   Calva, Juan J ^c  

^a HOSPITAL INFANTIL DE MÉXICO FEDERICO GÓMEZ   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

Child; Clinical trials; Dehydration; Diarrhoea; Double blind method; Glucose; Glutamine; Mexico; Oral rehydration solutions; Oral rehydration therapy; Randomized controlled trials; Rehydration; Rotavirus

Indexed keywords

BICARBONATE; GLUCOSE; GLUTAMINE; ORAL REHYDRATION SOLUTION; POTASSIUM CHLORIDE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; WORLD HEALTH ORGANIZATION ORAL REHYDRATION SOLUTION;

ACUTE DISEASE; ARTICLE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; FEMALE; FLUID THERAPY; HUMAN; INFANT; INFANTILE DIARRHEA; MALE; METHODOLOGY; MEXICO; OSMOLARITY; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; TIME; TREATMENT OUTCOME;

ACUTE DISEASE; BICARBONATES; CHILD, PRESCHOOL; DIARRHEA; DIARRHEA, INFANTILE; DOUBLE-BLIND METHOD; FEMALE; FLUID THERAPY; GLUCOSE; GLUTAMINE; HUMANS; INFANT; MALE; MEXICO; OSMOLAR CONCENTRATION; POTASSIUM CHLORIDE; REHYDRATION SOLUTIONS; SODIUM CHLORIDE; TIME FACTORS; TREATMENT OUTCOME;

ROTAVIRUS;

EID: 36949004514     PISSN: 16060997     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Bhan MK, Mahalanabis D, Fontaine O, Pierce NF. Clinical trials of improved oral rehydration salt formulations: a review. Bull World Health Organ 1994; 72:945-55.
2. Levine SA, Nath SK, Tse CM, Yun C, Donowitz M. L-glutamine in intestinal sodium absorption: lessons for physiology, pathobiology, and therapy for diarrhea. Gastroenterology 1994;106:1698-702.
3. Said HM, Van Voorhis K, Ghishan FK, Abumurad N, Nylander W, Redha R. Transport characteristics of glutamine in human intestinal brush-border membrane vesicles. Am J Physiol 1989;256:G240-5.
4. Ribeiro Junior H, Ribeiro T, Mattos A, Palmeira. C, Fernandez D, Sant'Ana I et al. Treatment of acute diarrhea with oral rehydration solutions containing glutamine. J Am Coll Nutr 1994;13:25 1-5.
5. Gómez SF. Desnutrición. Bol Med Hosp Infant Mex 1946;3:543-51.
6. King CK, Glass R, Bresee JS, Duggan C, and Centers for Disease Control and Prevention. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recommendation Report 2003;52(RR16):1-16.
7. World Health Organization. A manual for the treatment of acute diarrhoea for use by physicians and other senior health workers. Bull World Health Organ 2000;78:1246-55.
8. Sandhu BK and European Society of Pediatric Gastroenterology, Hepatology and Nutrition Working Group on Acute Diarrhoea. Practical guidelines for the management of gastroenteritis in children. J Pediatr Gastroenterol Nutr 2001;33(Suppl 2):S36-9.
9. Brown GW. Sample size. Am J Dis Child 1988;142: 1213-5.
10. Silva AC, Santos-Neto MS, Soares AM, Fonteles MC, Guerrant RL, Lima AA. Efficacy of a glutamine-based oral rehydration solution on the electrolyte and water absorption in a rabbit model of secretory diarrhea induced by cholera toxin. J Pediatr Gastroenterol Nutr 1998;26:513-9.
11. Center for Disease Control and Prevention. Outbreak of severe rotavirus gastroenteritis among children. Jamaica, 2003. MMWR 2003; 52:1103-5.
12. Mota-Hernandez F, Gutierrez-Camacho C, Villa-Contreras S, Calva-Mercado J, Arias CF, Padilla-Noriega L et al. Prognosis of rotavirus diarrhea. Salud Publica Mex 2001;43:524-8.
13. Mota-Hernandez F, Gutierrez-Camacho C, Cabrales-Martinez RG, Villa-Contreras S. Continuous oral rehydration or with fractionated doses in acute diarrhea-induced dehydration in children. Salud Publica Mex 2002;44:21-5.
14. Reid S, McQuillan S, Losek J. Hypoglycemia complicating dehydration due to acute gastroenteritis. Clin Pediatr (Phila) 2003;42:641-6.
15. Ronan A, Azad AK, Rahman O, Phillips RE, Bennish ML. Hyperglycemia during childhood diarrhea. J Pediatr 1997;130:45-51.
16. Yurdakök K, Özmert E, Yalcin SS, Coskun T. Rehydration of moderately dehydrated children with transient glucose intolerance using rice oral rebydration solution. Acta Paediatr 1999;88:34-7.
17. Özmert E, Yurdakök K, Aslan D, Yalcin SS, Yardim M. Clinical characteristics of transient glucose intolerance during acute diarrhoea. Acta Paediatr 1999;88:1071-3.