Is autophagy an avenue to modulate coxsackievirus replication and pathogenesis?

Future Microbiology

Volumn 7, Issue 8, 2012, Pages 921-924

  Luo, Honglin ^a   McManus, Bruce M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

ATG5; autophagic flux; autophagy; coxsackievirus; p62; viral replication site

Indexed keywords

CYTOPLASM PROTEIN; VIRUS PROTEIN;

ACINAR CELL; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL MATURATION; COXSACKIE VIRUS B3; COXSACKIE VIRUS INFECTION; GENE DELETION; HUMAN; IMMUNITY; IN VITRO STUDY; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; UNFOLDED PROTEIN RESPONSE; VIRUS LOAD; VIRUS PATHOGENESIS; VIRUS REPLICATION;

ANIMALS; AUTOPHAGY; COXSACKIEVIRUS INFECTIONS; ENTEROVIRUS B, HUMAN; HUMANS; VIRUS REPLICATION;

COXSACKIEVIRUS;

EID: 84865600889     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.12.67     Document Type: Review

References (23)

1. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell. Biol. 8(11), 931-937 (2007
2. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 132(1), 27-42 (2008
3. Shi J, Luo H. Interplay between the cellular autophagy machinery and positive-stranded RNA viruses. Acta Biochim. Biophys. Sin. (Shanghai) 44(5), 375-384 (2012
4. Luo H, Wong J, Wong B. Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc. Res. 85(2), 347-356 (2010
5. Kemball CC, Alirezaei M, Flynn CT et al. Coxsackievirus infection induces autophagy-like vesicles and megaphagosomes in pancreatic acinar cells in vivo. J. Virol. 84(23), 12110-12124 (2010
6. Wong J, Zhang J, Si X et al. Autophagosome supports coxsackievirus B3 replication in host cells. J. Virol. 82(18), 9143-9153 (2008
7. Yoon SY, Ha YE, Choi JE et al. Coxsackievirus B4 uses autophagy for replication after calpain activation in rat primary neurons. J. Virol. 82(23), 11976-11978 (2008
8. Alirezaei M, Flynn CT, Wood MR, Whitton JL. Pancreatic acinar cell-specific autophagy disruption reduces coxsackievirus replication and pathogenesis in vivo. Cell Host Microbe 11(3), 298-305 (2012
9. Kuma A, Hatano M, Matsui M et al. The role of autophagy during the early neonatal starvation period. Nature 432(7020), 1032-1036 (2004
10. Hashimoto D, Ohmuraya M, Hirota M et al. Involvement of autophagy in trypsinogen activation within the pancreatic acinar cells. J. Cell. Biol. 181(7), 1065-1072 (2008
11. Ait-Goughoulte M, Kanda T, Meyer K, Ryerse JS, Ray RB, Ray R. Hepatitis C virus genotype 1a growth and induction of autophagy. J. Virol. 82(5), 2241-2249 (2008
12. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 140(3), 313-326 (2010
13. Bjorkoy G, Lamark T, Pankiv S, Overvatn A, Brech A, Johansen T. Monitoring autophagic degradation of p62/SQSTM1. Methods Enzymol. 452, 181-197 (2009
14. Norman JM, Cohen GM, Bampton ET. The in vitro cleavage of the hAtg proteins by cell death proteases. Autophagy 6(8), 1042-1056 (2010
15. Talloczy Z, Jiang W, Virgin HWT et al. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc. Natl Acad. Sci. USA 99(1), 190-195 (2002
16. Ke PY, Chen SS. Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J. Clin. Invest. 121(1), 37-56 (2011
17. Zhang HM, Ye X, Su Y et al. Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J. Virol. 84(17), 8446-8459 (2010
18. Jackson WT, Giddings TH Jr, Taylor MP et al. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol. 3(5), e156 (2005
19. Yoon SY, Ha YE, Choi JE, Ahn J, Lee H, Kim DH. Autophagy in coxsackievirusinfected neurons. Autophagy 5(3), 388-389 (2009
20. Ebato C, Uchida T, Arakawa M et al. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 8(4), 325-332 (2008
21. Levine B, Yuan J. Autophagy in cell death: An innocent convict? J. Clin. Invest. 115(10), 2679-2688 (2005
22. Yousefi S, Perozzo R, Schmid I et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat. Cell. Biol. 8(10), 1124-1132 (2006
23. Zhao Z, Fux B, Goodwin M et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 4(5), 458-469 (2008