Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Kang, Sungkwon ^a   Kim, Chae Un ^b   Gu, Xiaoling ^a   Owens, Roisin M ^a   van Rijn, Sarah J ^a   Boonyaleepun, Vanissra ^a   Mao, Yuxin ^b   Springer, Timothy A ^c   Jin, Moonsoo M ^a  

^a School of Operations Research and Industrial Engineering   (United States)

^b Harvard Medical School ^*  (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; HUMAN RHINOVIRUS; HYDROGEN BOND; NONHUMAN; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; HUMANS; HYDROGEN BONDING; INTERCELLULAR ADHESION MOLECULE-1; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; STRUCTURAL HOMOLOGY, PROTEIN;

HUMAN RHINOVIRUS SP.;

EID: 84865596223     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0044124     Document Type: Article

References (45)

1. Hynes RO, (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
2. Luo BH, Carman CV, Springer TA, (2007) Structural basis of integrin regulation and signaling. Annu Rev Immunol 25: 619-647.
3. Springer TA, Wang JH, (2004) The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion. Adv Protein Chem 68: 29-63.
4. Marlin SD, Springer TA, (1987) Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 51: 813-819.
5. Gahmberg CG, (1997) Leukocyte adhesion: CD11/CD18 integrins and intercellular adhesion molecules. Curr Opin Cell Biol 9: 643-650.
6. Ostermann G, Weber KS, Zernecke A, Schroder A, Weber C, (2002) JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes. Nat Immunol 3: 151-158.
7. Dustin ML, Rothlein R, Bhan AK, Dinarello CA, Springer TA, (1986) Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol 137: 245-254.
8. Tomita Y, Nishiyama T, Watanabe H, Fujiwara M, Sato S, (1990) Expression of intercellular adhesion molecule-1 (ICAM-1) on renal-cell cancer: possible significance in host immune responses. Int J Cancer 46: 1001-1006.
9. Roland CL, Dineen SP, Toombs JE, Carbon JG, Smith CW, et al. (2010) Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts. Exp Biol Med (Maywood) 235: 263-270.
10. Nelson H, Ramsey PS, Donohue JH, Wold LE, (1994) Cell adhesion molecule expression within the microvasculature of human colorectal malignancies. Clin Immunol Immunopathol 72: 129-136.
11. Maurer CA, Friess H, Kretschmann B, Wildi S, Muller C, et al. (1998) Over-expression of ICAM-1, VCAM-1 and ELAM-1 might influence tumor progression in colorectal cancer. Int J Cancer 79: 76-81.
12. Kelly CP, O'Keane JC, Orellana J, Schroy PC 3rd, Yang S, et al (1992) Human colon cancer cells express ICAM-1 in vivo and support LFA-1-dependent lymphocyte adhesion in vitro. Am J Physiol 263: G864-870.
13. Chen X, Wong R, Khalidov I, Wang AY, Leelawattanachai J, et al. (2011) Inflamed leukocyte-mimetic nanoparticles for molecular imaging of inflammation. Biomaterials 32: 7651-7661.
14. Buitrago D, Keutgen XM, Crowley M, Filicori F, Aldailami H, et al. (2011) Intercellular Adhesion Molecule-1 (ICAM-1) is Upregulated in Aggressive Papillary Thyroid Carcinoma. Ann Surg Oncol.
15. Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG, (1998) The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc Natl Acad Sci U S A 95: 4140-4145.
16. Xiao T, Takagi J, Coller BS, Wang JH, Springer TA, (2004) Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 432: 59-67.
17. Shimaoka M, Xiao T, Liu JH, Yang Y, Dong Y, et al. (2003) Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 112: 99-111.
18. Shimaoka M, Takagi J, Springer TA, (2002) Conformational regulation of integrin structure and function. Annu Rev Biophys Biomol Struct 31: 485-516.
19. Takagi J, Petre BM, Walz T, Springer TA, (2002) Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling. Cell 110: 599-511.
20. Song G, Yang Y, Liu JH, Casasnovas JM, Shimaoka M, et al. (2005) An atomic resolution view of ICAM recognition in a complex between the binding domains of ICAM-3 and integrin alphaLbeta2. Proc Natl Acad Sci U S A 102: 3366-3371.
21. Jin M, Andricioaei I, Springer TA, (2004) Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics. Structure 12: 2137-2147.
22. Jin M, Song G, Carman CV, Kim YS, Astrof NS, et al. (2006) Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity. Proc Natl Acad Sci U S A 103: 5758-5763.
23. Oliveira MA, Zhao R, Lee WM, Kremer MJ, Minor I, et al. (1993) The structure of human rhinovirus 16. Structure 1: 51-68.
24. Casasnovas JM, Stehle T, Liu JH, Wang JH, Springer TA, (1998) A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc Natl Acad Sci U S A 95: 4134-4139.
25. Owens RM, Gu X, Shin M, Springer TA, Jin MM, (2010) Engineering of single Ig superfamily domain of intercellular adhesion molecule 1 (ICAM-1) for native fold and function. J Biol Chem 285: 15906-15915.
26. Zhang H, Casasnovas JM, Jin M, Liu JH, Gahmberg CG, et al. (2008) An unusual allosteric mobility of the C-terminal helix of a high-affinity alphaL integrin I domain variant bound to ICAM-5. Mol Cell 31: 432-437.
27. Lee JO, Rieu P, Arnaout MA, Liddington R, (1995) Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18). Cell 80: 631-638.
28. Emsley J, Knight CG, Farndale RW, Barnes MJ, Liddington RC, (2000) Structural basis of collagen recognition by integrin alpha2beta1. Cell 101: 47-56.
29. Sherman F, Stewart JW, Tsunasawa S, (1985) Methionine or not methionine at the beginning of a protein. Bioessays 3: 27-31.
30. Staunton DE, Merluzzi VJ, Rothlein R, Barton R, Marlin SD, et al. (1989) A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell 56: 849-853.
31. Kolatkar PR, Bella J, Olson NH, Bator CM, Baker TS, et al. (1999) Structural studies of two rhinovirus serotypes complexed with fragments of their cellular receptor. EMBO J 18: 6249-6259.
32. Olson NH, Kolatkar PR, Oliveira MA, Cheng RH, Greve JM, et al. (1993) Structure of a human rhinovirus complexed with its receptor molecule. Proc Natl Acad Sci U S A 90: 507-511.
33. Xiao C, Tuthill TJ, Bator Kelly CM, Challinor LJ, Chipman PR, et al. (2004) Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule. J Virol 78: 10034-10044.
34. Lee JO, Bankston LA, Arnaout MA, Liddington RC, (1995) Two conformations of the integrin A-domain (I-domain): a pathway for activation? Structure 3: 1333-1340.
35. Yin J, Beuscher AEt, Andryski SE, Stevens RC, Schultz PG, (2003) Structural plasticity and the evolution of antibody affinity and specificity. J Mol Biol 330: 651-656.
36. Bella J, Rossmann MG, (2000) ICAM-1 receptors and cold viruses. Pharm Acta Helv 74: 291-297.
37. Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, et al. (1989) The major human rhinovirus receptor is ICAM-1. Cell 56: 839-847.
38. Otwinowski Z, Minor W, (1997) Processing of X-ray diffraction data collected in oscillation mode. Macromolecular Crystallography, Pt A 276: 307-326.
39. McCoy AJ, (2007) Solving structures of protein complexes by molecular replacement with Phaser. Acta Crystallogr D Biol Crystallogr 63: 32-41.
40. Bailey S, (1994) The Ccp4 Suite- Programs for Protein Crystallography. Acta Crystallographica Section D-Biological Crystallography 50: 760-763.
41. Murshudov GN, Vagin AA, Dodson EJ, (1997) Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr 53: 240-255.
42. Emsley P, Cowtan K, (2004) Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60: 2126-2132.
43. Adams PD, Afonine PV, Bunkoczi G, Chen VB, Davis IW, et al. (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr 66: 213-221.
44. Zhang H, Astrof NS, Liu JH, Wang JH, Shimaoka M, (2009) Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems. FASEB J 23: 2735-2740.
45. Hadfield AT, Lee W, Zhao R, Oliveira MA, Minor I, et al. (1997) The refined structure of human rhinovirus 16 at 2.15 A resolution: implications for the viral life cycle. Structure 5: 427-441.