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Volumn 6, Issue 2, 2011, Pages 134-146

Current strategies to achieve further cardiac and renal protection through enhanced renin-angiotensin-aldosterone system inhibition

Author keywords

Aldosterone antagonists; Angiotensin converting enzyme inhibitor; Angiotensin receptor blocker; Combination therapy; Direct renin inhibitor; RAS blockade

Indexed keywords

ALBUMIN; ALDOSTERONE; ALISKIREN; AMLODIPINE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; BENAZEPRIL; CANDESARTAN; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; EPLERENONE; FUROSEMIDE; IRBESARTAN; LISINOPRIL; LOSARTAN; OLMESARTAN; PLACEBO; PRORENIN; RAMIPRIL; RENIN; SPIRONOLACTONE; TELMISARTAN; TRANDOLAPRIL; VALSARTAN;

EID: 79953836889     PISSN: 15748871     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488711795177912     Document Type: Review
Times cited : (32)

References (126)
  • 1
    • 0033945756 scopus 로고    scopus 로고
    • Oxidative stress may explain how hypertension is maintained by normal levels of angiotensin II
    • Romero JC, Reckelhoff JF. Oxidative stress may explain how hypertension is maintained by normal levels of angiotensin II. Braz J Med Biol Res 2000; 33: 653-60.
    • (2000) Braz J Med Biol Res , vol.33 , pp. 653-660
    • Romero, J.C.1    Reckelhoff, J.F.2
  • 2
    • 38049158437 scopus 로고    scopus 로고
    • Systematic review: Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension
    • Matchar DB, McCrory DC, Orlando LA, et al. Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Ann Intern Med 2008; 148: 16-29.
    • (2008) Ann Intern Med , vol.148 , pp. 16-29
    • Matchar, D.B.1    McCrory, D.C.2    Orlando, L.A.3
  • 3
    • 38049139424 scopus 로고    scopus 로고
    • Meta-analysis: Effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease
    • Kunz R, Friedrich C, Wolbers M, Mann JF. Meta-analysis: effect of monotherapy and combination therapy with inhibitors of the renin angiotensin system on proteinuria in renal disease. Ann Intern Med 2008; 148: 30-48.
    • (2008) Ann Intern Med , vol.148 , pp. 30-48
    • Kunz, R.1    Friedrich, C.2    Wolbers, M.3    Mann, J.F.4
  • 4
    • 7444237666 scopus 로고    scopus 로고
    • Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy
    • Barnett AH, Bain SC, Bouter P, et al. Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med 2004; 351: 1952-61.
    • (2004) N Engl J Med , vol.351 , pp. 1952-1961
    • Barnett, A.H.1    Bain, S.C.2    Bouter, P.3
  • 5
    • 42049107348 scopus 로고    scopus 로고
    • Telmisartan, ramipril, or both in patients at high risk for vascular events
    • Yusuf S, Teo KK, Pogue J, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008; 358: 1547-59.
    • (2008) N Engl J Med , vol.358 , pp. 1547-1559
    • Yusuf, S.1    Teo, K.K.2    Pogue, J.3
  • 6
    • 22144477948 scopus 로고    scopus 로고
    • Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: Results of prospectively designed overviews of randomized trials
    • Turnbull F, Neal B, Algert C, et al. Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials. Arch Intern Med 2005; 165: 1410-9.
    • (2005) Arch Intern Med , vol.165 , pp. 1410-1419
    • Turnbull, F.1    Neal, B.2    Algert, C.3
  • 7
    • 0028955321 scopus 로고
    • Overview of randomized trials of angiotensinconverting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials
    • Garg R, Yusuf S. Overview of randomized trials of angiotensinconverting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials. JAMA 1995; 273: 1450-6.
    • (1995) JAMA , vol.273 , pp. 1450-1456
    • Garg, R.1    Yusuf, S.2
  • 8
    • 0010838455 scopus 로고    scopus 로고
    • Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: A systematic overview of data from individual patients. ACEInhibitor Myocardial Infarction Collaborative Group
    • Flather MD, Yusuf S, Kober L, et al. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. ACEInhibitor Myocardial Infarction Collaborative Group. Lancet 2000; 355: 1575-81.
    • (2000) Lancet , vol.355 , pp. 1575-1581
    • Flather, M.D.1    Yusuf, S.2    Kober, L.3
  • 9
    • 0034688194 scopus 로고    scopus 로고
    • Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Sleight P, Pogue J, Bosch J, Davies R, Dagenais G. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med 2000; 342: 145-53.
    • (2000) N Engl J Med , vol.342 , pp. 145-153
    • Yusuf, S.1    Sleight, P.2    Pogue, J.3    Bosch, J.4    Davies, R.5    Dagenais, G.6
  • 10
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 1993; 329: 1456-62.
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 11
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001; 345: 851-60.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 12
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • Brenner BM, Cooper ME, de Zeeuw D, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345: 861-9.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3
  • 13
    • 0030604561 scopus 로고    scopus 로고
    • Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy
    • The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia)
    • The GISEN Group (Gruppo Italiano di Studi Epidemiologici in Nefrologia). Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy. Lancet 1997; 349: 1857-63.
    • (1997) Lancet , vol.349 , pp. 1857-1863
  • 14
    • 0033028679 scopus 로고    scopus 로고
    • How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure
    • MacFadyen RJ, Lee AF, Morton JJ, Pringle SD, Struthers AD. How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure? Heart 1999; 82: 57-61.
    • (1999) Heart , vol.82 , pp. 57-61
    • McFadyen, R.J.1    Lee, A.F.2    Morton, J.J.3    Pringle, S.D.4    Struthers, A.D.5
  • 15
    • 70349338941 scopus 로고    scopus 로고
    • Pharmacology: Defining the optimal dose of a new drug: A crucial decision
    • Heerspink HL, de Zeeuw D. Pharmacology: defining the optimal dose of a new drug: a crucial decision. Nat Rev Nephrol 2009; 5: 498-500.
    • (2009) Nat Rev Nephrol , vol.5 , pp. 498-500
    • Heerspink, H.L.1    de Zeeuw, D.2
  • 16
    • 0034762611 scopus 로고    scopus 로고
    • Intermittent nonadherence with ACE inhibitor treatment and its implications for clinical trials results
    • MacFadyen RJ, Fraser CG, Struthers AD. Intermittent nonadherence with ACE inhibitor treatment and its implications for clinical trials results. Heart 2001; 85: 213-4.
    • (2001) Heart , vol.85 , pp. 213-214
    • McFadyen, R.J.1    Fraser, C.G.2    Struthers, A.D.3
  • 17
    • 0029065095 scopus 로고
    • A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension
    • Gradman AH, Arcuri KE, Goldberg AI, et al. A randomized, placebo-controlled, double-blind, parallel study of various doses of losartan potassium compared with enalapril maleate in patients with essential hypertension. Hypertension 1995; 25: 1345-50.
    • (1995) Hypertension , vol.25 , pp. 1345-1350
    • Gradman, A.H.1    Arcuri, K.E.2    Goldberg, A.I.3
  • 18
    • 0023876256 scopus 로고
    • Lisinopril: Dose-peak effect relationship in essential hypertension
    • Cirillo VJ, Gomez HJ, Salonen J, et al. Lisinopril: dose-peak effect relationship in essential hypertension. Br J Clin Pharmacol 1988; 25: 533-8.
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 533-538
    • Cirillo, V.J.1    Gomez, H.J.2    Salonen, J.3
  • 19
    • 0024501471 scopus 로고
    • Comparison of increase in the enalapril dose and addition of hydrochlorothiazide as second-step treatment of hypertensive patients not controlled by enalapril alone
    • Sassano P, Chatellier G, Billaud E, Corvol P, Menard J. Comparison of increase in the enalapril dose and addition of hydrochlorothiazide as second-step treatment of hypertensive patients not controlled by enalapril alone. J Cardiovasc Pharmacol 1989; 13: 314-9.
    • (1989) J Cardiovasc Pharmacol , vol.13 , pp. 314-319
    • Sassano, P.1    Chatellier, G.2    Billaud, E.3    Corvol, P.4    Menard, J.5
  • 20
    • 0024457980 scopus 로고
    • Lisinopril doseresponse relationship in essential hypertension
    • Gomez HJ, Cirillo VJ, Sromovsky JA, et al. Lisinopril doseresponse relationship in essential hypertension. Br J Clin Pharmacol 1989; 28: 415-20.
    • (1989) Br J Clin Pharmacol , vol.28 , pp. 415-420
    • Gomez, H.J.1    Cirillo, V.J.2    Sromovsky, J.A.3
  • 21
    • 50349094508 scopus 로고    scopus 로고
    • Aliskiren
    • Brown MJ. Aliskiren. Circulation 2008; 118: 773-84.
    • (2008) Circulation , vol.118 , pp. 773-784
    • Brown, M.J.1
  • 22
    • 0025073099 scopus 로고
    • Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition
    • Mooser V, Nussberger J, Juillerat, L, et al. Reactive hyperreninemia is a major determinant of plasma angiotensin II during ACE inhibition. J Cardiovasc Pharmacol 1990; 15: 276-82.
    • (1990) J Cardiovasc Pharmacol , vol.15 , pp. 276-282
    • Mooser, V.1    Nussberger, J.2    Juillerat, L.3
  • 23
    • 0025077634 scopus 로고
    • Determinants of angiotensin II generation during converting enzyme inhibition
    • Juillerat L, Nussberger J, Menard J, et al. Determinants of angiotensin II generation during converting enzyme inhibition. Hypertension 1990; 16: 564-72.
    • (1990) Hypertension , vol.16 , pp. 564-572
    • Juillerat, L.1    Nussberger, J.2    Menard, J.3
  • 24
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 1998; 32: 387-92.
    • (1998) Hypertension , vol.32 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.2    Price, D.A.3
  • 25
    • 0035048905 scopus 로고    scopus 로고
    • Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: A unifying hypothesis
    • Dzau VJ. Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis. Hypertension 2001; 37: 1047-52.
    • (2001) Hypertension , vol.37 , pp. 1047-1052
    • Dzau, V.J.1
  • 26
    • 74049153435 scopus 로고    scopus 로고
    • Major role for ACEindependent intrarenal ANG II formation in type II diabetes
    • Park S, Bivona B J, Kobori H, et al. Major role for ACEindependent intrarenal ANG II formation in type II diabetes. Am J Physiol Renal Physiol 2010; 298: F37-48.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Park, S.1    Bivona, B.J.2    Kobori, H.3
  • 27
    • 62349137899 scopus 로고    scopus 로고
    • A new addition to the renin-angiotensin peptide family: ProAngiotensin-12 (PA12)
    • Cummins PM. A new addition to the renin-angiotensin peptide family: proAngiotensin-12 (PA12). Cardiovasc Res 2009; 82: 7-8.
    • (2009) Cardiovasc Res , vol.82 , pp. 7-8
    • Cummins, P.M.1
  • 28
    • 38049049272 scopus 로고    scopus 로고
    • Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state
    • Miura S, Kiya Y, Kanazawa T, et al. Differential bonding interactions of inverse agonists of angiotensin II type 1 receptor in stabilizing the inactive state. Mol Endocrinol 2008; 22: 139-46.
    • (2008) Mol Endocrinol , vol.22 , pp. 139-146
    • Miura, S.1    Kiya, Y.2    Kanazawa, T.3
  • 29
    • 2942751868 scopus 로고    scopus 로고
    • Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
    • Zou Y, Akazawa H, Qin Y, et al. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol 2004; 6: 499-506.
    • (2004) Nat Cell Biol , vol.6 , pp. 499-506
    • Zou, Y.1    Akazawa, H.2    Qin, Y.3
  • 30
    • 66049138507 scopus 로고    scopus 로고
    • Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II
    • Yatabe J, Sanada H, Yatabe MS, et al. Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol 2009; 296: F1052-60.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Yatabe, J.1    Sanada, H.2    Yatabe, M.S.3
  • 31
    • 0036141048 scopus 로고    scopus 로고
    • Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels
    • Komine N, Khang S, Wead LM, Blantz RC, Gabbai FB. Effect of combining an ACE inhibitor and an angiotensin II receptor blocker on plasma and kidney tissue angiotensin II levels. Am J Kidney Dis 2002; 39: 159-64.
    • (2002) Am J Kidney Dis , vol.39 , pp. 159-164
    • Komine, N.1    Khang, S.2    Wead, L.M.3    Blantz, R.C.4    Gabbai, F.B.5
  • 32
    • 19644384705 scopus 로고    scopus 로고
    • Effect of angiotensinconverting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    • Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensinconverting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation 2005; 111: 2605-10.
    • (2005) Circulation , vol.111 , pp. 2605-2610
    • Ferrario, C.M.1    Jessup, J.2    Chappell, M.C.3
  • 33
    • 0037219665 scopus 로고    scopus 로고
    • Angiotensin II receptor blockade: Is there truly a benefit of adding an ACE inhibitor
    • Forclaz A, Maillard M, Nussberger J, Brunner HR, Burnier M. Angiotensin II receptor blockade: is there truly a benefit of adding an ACE inhibitor? Hypertension 2003; 41: 31-6.
    • (2003) Hypertension , vol.41 , pp. 31-36
    • Forclaz, A.1    Maillard, M.2    Nussberger, J.3    Brunner, H.R.4    Burnier, M.5
  • 34
    • 28144458569 scopus 로고    scopus 로고
    • Sustained 24-hour blockade of the renin-angiotensin system: A high dose of a long-acting blocker is as effective as a lower dose combined with an angiotensin-converting enzyme inhibitor
    • Hasler C, Nussberger J, Maillard M, Forclaz A, Brunner HR, Burnier M. Sustained 24-hour blockade of the renin-angiotensin system: a high dose of a long-acting blocker is as effective as a lower dose combined with an angiotensin-converting enzyme inhibitor. Clin Pharmacol Ther 2005; 78: 501-7.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 501-507
    • Hasler, C.1    Nussberger, J.2    Maillard, M.3    Forclaz, A.4    Brunner, H.R.5    Burnier, M.6
  • 35
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999; 341: 709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 36
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003; 348: 1309-21.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 37
    • 21244461574 scopus 로고    scopus 로고
    • Aldosterone antagonism: An emerging strategy for effective blood pressure lowering
    • Pratt-Ubunama MN, Nishizaka MK, Calhoun DA. Aldosterone antagonism: an emerging strategy for effective blood pressure lowering. Curr Hypertens Rep 2005; 7: 186-92.
    • (2005) Curr Hypertens Rep , vol.7 , pp. 186-192
    • Pratt-Ubunama, M.N.1    Nishizaka, M.K.2    Calhoun, D.A.3
  • 38
    • 73349142401 scopus 로고    scopus 로고
    • Mineralocorticoid receptor blockers and chronic kidney disease
    • Jain G, Campbell RC, Warnock DG. Mineralocorticoid receptor blockers and chronic kidney disease. Clin J Am Soc Nephrol 2009; 4: 1685-91.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 1685-1691
    • Jain, G.1    Campbell, R.C.2    Warnock, D.G.3
  • 39
    • 34548500119 scopus 로고    scopus 로고
    • Aldosterone and end-organ damage
    • Marney AM, Brown NJ. Aldosterone and end-organ damage. Clin Sci (Lond) 2007; 113: 267-78.
    • (2007) Clin Sci (Lond) , vol.113 , pp. 267-278
    • Marney, A.M.1    Brown, N.J.2
  • 40
    • 0022337756 scopus 로고
    • Effect of aldosterone on vascular angiotensin II receptors in the rat
    • Schiffrin EL, Franks DJ, Gutkowska J. Effect of aldosterone on vascular angiotensin II receptors in the rat. Can J Physiol Pharmacol 1985; 63: 1522-7.
    • (1985) Can J Physiol Pharmacol , vol.63 , pp. 1522-1527
    • Schiffrin, E.L.1    Franks, D.J.2    Gutkowska, J.3
  • 41
    • 48749108107 scopus 로고    scopus 로고
    • Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes
    • Yamamuro M, Yoshimura M, Nakayama M, et al. Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes. Circ J 2008; 72: 1346-50.
    • (2008) Circ J , vol.72 , pp. 1346-1350
    • Yamamuro, M.1    Yoshimura, M.2    Nakayama, M.3
  • 42
    • 64949189157 scopus 로고    scopus 로고
    • Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt
    • Lea WB, Kwak ES, Luther JM, et al. Aldosterone antagonism or synthase inhibition reduces end-organ damage induced by treatment with angiotensin and high salt. Kidney Int 2009; 75: 936-44.
    • (2009) Kidney Int , vol.75 , pp. 936-944
    • Lea, W.B.1    Kwak, E.S.2    Luther, J.M.3
  • 43
    • 57449107043 scopus 로고    scopus 로고
    • Networking between systemic angiotensin II and cardiac mineralocorticoid receptors
    • Montezano AC, Touyz RM. Networking between systemic angiotensin II and cardiac mineralocorticoid receptors. Hypertension 2008; 52: 1016-8.
    • (2008) Hypertension , vol.52 , pp. 1016-1018
    • Montezano, A.C.1    Touyz, R.M.2
  • 44
    • 0019865836 scopus 로고
    • Rise in plasma concentration of aldosterone during long-term angiotensin II suppression
    • Staessen J, Lijnen P, Fagard R, Verschueren LJ, Amery A. Rise in plasma concentration of aldosterone during long-term angiotensin II suppression. J Endocrinol 1981; 91: 457-65.
    • (1981) J Endocrinol , vol.91 , pp. 457-465
    • Staessen, J.1    Lijnen, P.2    Fagard, R.3    Verschueren, L.J.4    Amery, A.5
  • 45
    • 0016792569 scopus 로고
    • Role of angiotensin II and potassium in the long-term regulation of aldosterone secretion in intact conscious dogs
    • McCaa R. E, McCaa CS, Guyton AC. Role of angiotensin II and potassium in the long-term regulation of aldosterone secretion in intact conscious dogs. Circ Res 1975; 36(Suppl 1): 57-67.
    • (1975) Circ Res , vol.36 , Issue.SUPPL. 1 , pp. 57-67
    • McCaa, R.E.1    McCaa, C.S.2    Guyton, A.C.3
  • 46
    • 0036314951 scopus 로고    scopus 로고
    • Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats
    • Naruse M, Tanabe A, Sato A, et al. Aldosterone breakthrough during angiotensin II receptor antagonist therapy in stroke-prone spontaneously hypertensive rats. Hypertension 2002; 40: 28-33.
    • (2002) Hypertension , vol.40 , pp. 28-33
    • Naruse, M.1    Tanabe, A.2    Sato, A.3
  • 47
    • 33744956091 scopus 로고    scopus 로고
    • Aldosterone breakthrough during RAS blockade: A role for endothelins and their antagonists
    • Rossi GP. Aldosterone breakthrough during RAS blockade: a role for endothelins and their antagonists? Curr Hypertens Rep 2006; 8: 262-8.
    • (2006) Curr Hypertens Rep , vol.8 , pp. 262-268
    • Rossi, G.P.1
  • 48
    • 42349091319 scopus 로고    scopus 로고
    • Aldosterone and metabolic syndrome: Is increased aldosterone in metabolic syndrome patients an additional risk factor
    • Krug AW, Ehrhart-Bornstein M. Aldosterone and metabolic syndrome: is increased aldosterone in metabolic syndrome patients an additional risk factor? Hypertension 2008; 51: 1252-8.
    • (2008) Hypertension , vol.51 , pp. 1252-1258
    • Krug, A.W.1    Ehrhart-Bornstein, M.2
  • 49
    • 25644434249 scopus 로고    scopus 로고
    • Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor
    • Xue C, Siragy HM. Local renal aldosterone system and its regulation by salt, diabetes, and angiotensin II type 1 receptor. Hypertension 2005; 46: 584-90.
    • (2005) Hypertension , vol.46 , pp. 584-590
    • Xue, C.1    Siragy, H.M.2
  • 50
    • 9644287897 scopus 로고    scopus 로고
    • Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004; 15: 3126-33.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3126-3133
    • Azizi, M.1    Menard, J.2    Bissery, A.3
  • 51
    • 33847732236 scopus 로고    scopus 로고
    • Achieving the goal of optimised renin system suppression: Preclinical experience with a direct renin inhibitor
    • Luft FC. Achieving the goal of optimised renin system suppression: preclinical experience with a direct renin inhibitor. J Renin Angiot Aldost Syst 2006; 7: S12-S15.
    • (2006) J Renin Angiot Aldost Syst , vol.7
    • Luft, F.C.1
  • 52
    • 47049093197 scopus 로고    scopus 로고
    • Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans
    • Fisher ND, Jan Danser AH, Nussberger J, Dole WP, Hollenberg NK, et al. Renal and hormonal responses to direct renin inhibition with aliskiren in healthy humans. Circulation 2008; 117: 3199-205.
    • (2008) Circulation , vol.117 , pp. 3199-3205
    • Fisher, N.D.1    Jan Danser, A.H.2    Nussberger, J.3    Dole, W.P.4    Hollenberg, N.K.5
  • 53
    • 57449100853 scopus 로고    scopus 로고
    • Aliskiren accumulates in Renin secretory granules and binds plasma prorenin
    • Krop M, Garrelds IM, de Bruin RJ, et al. Aliskiren accumulates in Renin secretory granules and binds plasma prorenin. Hypertension 2008; 52: 1076-83.
    • (2008) Hypertension , vol.52 , pp. 1076-1083
    • Krop, M.1    Garrelds, I.M.2    de Bruin, R.J.3
  • 55
    • 0024495446 scopus 로고
    • Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy
    • Danser AH, van den Dorpel MA, Deinum J, et al. Renin, prorenin, and immunoreactive renin in vitreous fluid from eyes with and without diabetic retinopathy. J Clin Endocrinol Metab 1989; 68: 160-7.
    • (1989) J Clin Endocrinol Metab , vol.68 , pp. 160-167
    • Danser, A.H.1    van den Dorpel, M.A.2    Deinum, J.3
  • 56
    • 52449104845 scopus 로고    scopus 로고
    • Activation of the renal reninangiotensin system in diabetes--new concepts
    • Peti-Peterdi J, Kang JJ, Toma I. Activation of the renal reninangiotensin system in diabetes--new concepts Nephrol Dial Transplant 2008; 23: 3047-9.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 3047-3049
    • Peti-Peterdi, J.1    Kang, J.J.2    Toma, I.3
  • 57
    • 74349117848 scopus 로고    scopus 로고
    • The increase in renin during renin inhibition: Does it result in harmful effects by the (pro)renin receptor?
    • Danser AH. The increase in renin during renin inhibition: does it result in harmful effects by the (pro)renin receptor? Hypertens Res 33: 4-10.
    • Hypertens Res , vol.33 , pp. 4-10
    • Danser, A.H.1
  • 58
    • 27444447364 scopus 로고    scopus 로고
    • Renin, prorenin and the putative (pro)renin receptor
    • Danser AH, Deinum J. Renin, prorenin and the putative (pro)renin receptor. Hypertension 2005; 46: 1069-76.
    • (2005) Hypertension , vol.46 , pp. 1069-1076
    • Danser, A.H.1    Deinum, J.2
  • 59
    • 17144392551 scopus 로고    scopus 로고
    • Comparison of antihypertensive effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist and a diuretic in patients with hypertension not controlled by angiotensin receptor blocker monotherapy
    • Stergiou GS, Makris T, Papavasiliou M, et al. Comparison of antihypertensive effects of an angiotensin-converting enzyme inhibitor, a calcium antagonist and a diuretic in patients with hypertension not controlled by angiotensin receptor blocker monotherapy. J Hypertens 2005; 23: 883-9.
    • (2005) J Hypertens , vol.23 , pp. 883-889
    • Stergiou, G.S.1    Makris, T.2    Papavasiliou, M.3
  • 60
    • 67649361948 scopus 로고    scopus 로고
    • Plasma Renin test-guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension: A randomized controlled trial
    • Egan BM, Basile JN, Rehman SU, et al. Plasma Renin test-guided drug treatment algorithm for correcting patients with treated but uncontrolled hypertension: a randomized controlled trial. Am J Hypertens 2009; 22: 792-801.
    • (2009) Am J Hypertens , vol.22 , pp. 792-801
    • Egan, B.M.1    Basile, J.N.2    Rehman, S.U.3
  • 61
    • 18244406792 scopus 로고    scopus 로고
    • Systematic review of combined angiotensin-converting enzyme inhibition and angiotensin receptor blockade in hypertension
    • Doulton TW, He FJ, MacGregor GA. Systematic review of combined angiotensin-converting enzyme inhibition and angiotensin receptor blockade in hypertension. Hypertension 2005; 45: 880-6.
    • (2005) Hypertension , vol.45 , pp. 880-886
    • Doulton, T.W.1    He, F.J.2    McGregor, G.A.3
  • 62
    • 0036330671 scopus 로고    scopus 로고
    • Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients
    • Krum H, Nolly H, Workman D, et al. Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients. Hypertension 2002; 40: 117-23.
    • (2002) Hypertension , vol.40 , pp. 117-123
    • Krum, H.1    Nolly, H.2    Workman, D.3
  • 63
    • 45149100695 scopus 로고    scopus 로고
    • Characterization of resistant hypertension: Association between resistant hypertension, aldosterone, and persistent intravascular volume expansion
    • Gaddam KK, Nishizaka MK, Pratt-Ubunama MN, et al. Characterization of resistant hypertension: association between resistant hypertension, aldosterone, and persistent intravascular volume expansion. Arch Intern Med 2008; 168: 1159-64.
    • (2008) Arch Intern Med , vol.168 , pp. 1159-1164
    • Gaddam, K.K.1    Nishizaka, M.K.2    Pratt-Ubunama, M.N.3
  • 64
    • 73849143844 scopus 로고    scopus 로고
    • Antihypertensive effects of double the maximum dose of valsartan in African-American patients with type 2 diabetes mellitus and albuminuria
    • Weir MR, Hollenberg, NK, Zappe DH, et al. Antihypertensive effects of double the maximum dose of valsartan in African-American patients with type 2 diabetes mellitus and albuminuria J Hypertens 28: 186-93.
    • J Hypertens , vol.28 , pp. 186-193
    • Weir, M.R.1    Hollenberg, N.K.2    Zappe, D.H.3
  • 65
    • 42049113227 scopus 로고    scopus 로고
    • Kidney in hypertension: Guyton redux
    • Coffman TM, Crowley SD. Kidney in hypertension: Guyton redux. Hypertension 2008; 51: 811-6.
    • (2008) Hypertension , vol.51 , pp. 811-816
    • Coffman, T.M.1    Crowley, S.D.2
  • 66
    • 67649763542 scopus 로고    scopus 로고
    • Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: Sub-analysis of a 52-week, randomized, doubleblind trial
    • Schmieder RE, Philipp T, Guerediaga J, Gorostidi M, Bush C, Keefe DL. Aliskiren-based therapy lowers blood pressure more effectively than hydrochlorothiazide-based therapy in obese patients with hypertension: sub-analysis of a 52-week, randomized, doubleblind trial. J Hypertens 2009; 27: 1493-501.
    • (2009) J Hypertens , vol.27 , pp. 1493-1501
    • Schmieder, R.E.1    Philipp, T.2    Guerediaga, J.3    Gorostidi, M.4    Bush, C.5    Keefe, D.L.6
  • 67
    • 69249202278 scopus 로고    scopus 로고
    • Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high-and low-baseline PRA levels, respectively
    • Stanton AV, Dicker P, O'Brien ET. Aliskiren monotherapy results in the greatest and the least blood pressure lowering in patients with high-and low-baseline PRA levels, respectively. Am J Hypertens 2009; 22: 954-7.
    • (2009) Am J Hypertens , vol.22 , pp. 954-957
    • Stanton, A.V.1    Dicker, P.2    O'Brien, E.T.3
  • 68
    • 67649306830 scopus 로고    scopus 로고
    • Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension
    • Littlejohn TW3rd, Trenkwalder P, Hollanders G, Zhao Y, Liao W. Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertension. Curr Med Res Opin 2009; 25: 951-9.
    • (2009) Curr Med Res Opin , vol.25 , pp. 951-959
    • Littlejohn III, T.W.1    Trenkwalder, P.2    Hollanders, G.3    Zhao, Y.4    Liao, W.5
  • 69
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007; 25: 217-26.
    • (2007) J Hypertens , vol.25 , pp. 217-226
    • Villamil, A.1    Chrysant, S.G.2    Calhoun, D.3
  • 70
    • 34548855067 scopus 로고    scopus 로고
    • A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
    • Strasser RH, Puig JG, Farsang C, Croket M, Li J, van Ingen H. A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J Hum Hypertens 2007; 21: 780-7.
    • (2007) J Hum Hypertens , vol.21 , pp. 780-787
    • Strasser, R.H.1    Puig, J.G.2    Farsang, C.3    Croket, M.4    Li, J.5    van Ingen, H.6
  • 71
    • 69849112971 scopus 로고    scopus 로고
    • Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertension
    • Andersen K, Weinberger MH, Constance CM, et al. Comparative effects of aliskiren-based and ramipril-based therapy on the renin system during long-term (6 months) treatment and withdrawal in patients with hypertension. J Renin Angiotensin Aldosterone Syst 2009; 10: 157-67.
    • (2009) J Renin Angiotensin Aldosterone Syst , vol.10 , pp. 157-167
    • Andersen, K.1    Weinberger, M.H.2    Constance, C.M.3
  • 72
    • 75149195876 scopus 로고    scopus 로고
    • Maintenance of blood-pressure-lowering effect following a missed dose of aliskiren, irbesartan or ramipril: Results of a randomized, double-blind study
    • Palatini P, Jung W, Shlyakhto E, Botha J, Bush C, Keefe DL. Maintenance of blood-pressure-lowering effect following a missed dose of aliskiren, irbesartan or ramipril: results of a randomized, double-blind study. J Hum Hypertens 24: 93-103.
    • J Hum Hypertens , vol.24 , pp. 93-103
    • Palatini, P.1    Jung, W.2    Shlyakhto, E.3    Botha, J.4    Bush, C.5    Keefe, D.L.6
  • 73
    • 34247644329 scopus 로고    scopus 로고
    • Aliskiren, the first renin inhibitor for treating hypertension: Reactive renin secretion may limit its effectiveness
    • Sealey JE, Laragh JH. Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. Am J Hypertens 2007; 20: 587-97.
    • (2007) Am J Hypertens , vol.20 , pp. 587-597
    • Sealey, J.E.1    Laragh, J.H.2
  • 75
    • 73849141617 scopus 로고    scopus 로고
    • Aliskiren monotherapy does not cause paradoxical blood pressure rises: Meta-analysis of data from 8 clinical trials
    • Stanton AV, Gradman AH, Schmieder RE, Nussberger J, Sarangapani R, Prescott MF. Aliskiren monotherapy does not cause paradoxical blood pressure rises: meta-analysis of data from 8 clinical trials. Hypertension 2010; 55: 54-60.
    • (2010) Hypertension , vol.55 , pp. 54-60
    • Stanton, A.V.1    Gradman, A.H.2    Schmieder, R.E.3    Nussberger, J.4    Sarangapani, R.5    Prescott, M.F.6
  • 76
    • 61349170589 scopus 로고    scopus 로고
    • Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy
    • Solomon SD, Appelbaum E, Manning WJ, et al. Effect of the direct Renin inhibitor aliskiren, the Angiotensin receptor blocker losartan, or both on left ventricular mass in patients with hypertension and left ventricular hypertrophy. Circulation 2009; 119: 530-7.
    • (2009) Circulation , vol.119 , pp. 530-537
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 77
    • 71749085323 scopus 로고    scopus 로고
    • Left ventricular mass and volume with telmisartan, ramipril, or combination in patients with previous atherosclerotic events or with diabetes mellitus (from the ONgoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial [ONTARGET])
    • Cowan BR, Young AA, Anderson C, et al. Left ventricular mass and volume with telmisartan, ramipril, or combination in patients with previous atherosclerotic events or with diabetes mellitus (from the ONgoing Telmisartan Alone and in Combination With Ramipril Global Endpoint Trial [ONTARGET]). Am J Cardiol 2009; 104: 1484-9.
    • (2009) Am J Cardiol , vol.104 , pp. 1484-1489
    • Cowan, B.R.1    Young, A.A.2    Anderson, C.3
  • 78
    • 0142085752 scopus 로고    scopus 로고
    • Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: The 4E-left ventricular hypertrophy study
    • Pitt B, Reichek N, Willenbrock R, et al. Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study. Circulation 2003; 108: 1831-8.
    • (2003) Circulation , vol.108 , pp. 1831-1838
    • Pitt, B.1    Reichek, N.2    Willenbrock, R.3
  • 79
    • 49149087718 scopus 로고    scopus 로고
    • Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): A multicentre, randomised, double-blind, controlled trial
    • Mann JF, Schmieder RE, McQueen M, et al. Renal outcomes with telmisartan, ramipril, or both, in people at high vascular risk (the ONTARGET study): a multicentre, randomised, double-blind, controlled trial. Lancet 2008; 372: 547-53.
    • (2008) Lancet , vol.372 , pp. 547-553
    • Mann, J.F.1    Schmieder, R.E.2    McQueen, M.3
  • 80
    • 67649790352 scopus 로고    scopus 로고
    • Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study
    • Sleight P, Redon J, Verdecchia P, et al. Prognostic value of blood pressure in patients with high vascular risk in the Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial study. J Hypertens 2009; 27: 1360-9.
    • (2009) J Hypertens , vol.27 , pp. 1360-1369
    • Sleight, P.1    Redon, J.2    Verdecchia, P.3
  • 81
    • 65249182083 scopus 로고    scopus 로고
    • Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): Rationale and study design
    • Parving HH, Brenner BM, McMurray JJ, et al. Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design. Nephrol Dial Transplant 2009; 24: 1663-71.
    • (2009) Nephrol Dial Transplant , vol.24 , pp. 1663-1671
    • Parving, H.H.1    Brenner, B.M.2    McMurray, J.J.3
  • 82
    • 0037120958 scopus 로고    scopus 로고
    • Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors
    • Maggioni AP, Anand I, Gottlieb SO, Latini R, Tognoni G, Cohn JN. Effects of valsartan on morbidity and mortality in patients with heart failure not receiving angiotensin-converting enzyme inhibitors. J Am Coll Cardiol 2002; 40: 1414-21.
    • (2002) J Am Coll Cardiol , vol.40 , pp. 1414-1421
    • Maggioni, A.P.1    Anand, I.2    Gottlieb, S.O.3    Latini, R.4    Tognoni, G.5    Cohn, J.N.6
  • 83
    • 7544249402 scopus 로고    scopus 로고
    • Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: Results of the CHARM low-left ventricular ejection fraction trials
    • Young JB, Dunlap ME, Pfeffer MA, et al. Mortality and morbidity reduction with Candesartan in patients with chronic heart failure and left ventricular systolic dysfunction: results of the CHARM low-left ventricular ejection fraction trials. Circulation 2004; 110: 2618-26.
    • (2004) Circulation , vol.110 , pp. 2618-2626
    • Young, J.B.1    Dunlap, M.E.2    Pfeffer, M.A.3
  • 84
    • 0037937463 scopus 로고    scopus 로고
    • Effect of Valsartan on hospitalization: Results from Val-HeFT
    • Carson P, Tognoni G, Cohn JN. Effect of Valsartan on hospitalization: results from Val-HeFT. J Card Fail 2003: 9: 164-71.
    • (2003) J Card Fail , vol.9 , pp. 164-171
    • Carson, P.1    Tognoni, G.2    Cohn, J.N.3
  • 85
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJ, Velazquez EJ, et al. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003; 349: 1893-906.
    • (2003) N Engl J Med , vol.349 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.2    Velazquez, E.J.3
  • 86
    • 0033534085 scopus 로고    scopus 로고
    • Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group
    • Packer M, Poole-Wilson PA, Armstrong PW, et al. Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. ATLAS Study Group. Circulation 1999; 100: 2312-8.
    • (1999) Circulation , vol.100 , pp. 2312-2318
    • Packer, M.1    Poole-Wilson, P.A.2    Armstrong, P.W.3
  • 87
    • 71549127400 scopus 로고    scopus 로고
    • Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): A randomised, double-blind trial
    • Konstam MA, Neaton JD, Dickstein K, et al. Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomised, double-blind trial. Lancet 2009; 374: 1840-8.
    • (2009) Lancet , vol.374 , pp. 1840-1848
    • Konstam, M.A.1    Neaton, J.D.2    Dickstein, K.3
  • 88
    • 0034612118 scopus 로고    scopus 로고
    • Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: Randomised trial--the Losartan Heart Failure Survival Study ELITE II
    • Pitt B, Poole-Wilson PA, Segal R, et al. Effect of losartan compared with captopril on mortality in patients with symptomatic heart failure: randomised trial--the Losartan Heart Failure Survival Study ELITE II. Lancet 2000; 355: 1582-7.
    • (2000) Lancet , vol.355 , pp. 1582-1587
    • Pitt, B.1    Poole-Wilson, P.A.2    Segal, R.3
  • 89
    • 0141595104 scopus 로고    scopus 로고
    • Sustained reduction of aldosterone in response to the angiotensin receptor blocker valsartan in patients with chronic heart failure: Results from the Valsartan Heart Failure Trial
    • Cohn JN, Anand IS, Latini R, Masson S, Chiang YT, Glazer R. Sustained reduction of aldosterone in response to the angiotensin receptor blocker valsartan in patients with chronic heart failure: results from the Valsartan Heart Failure Trial. Circulation 2003; 108: 1306-9.
    • (2003) Circulation , vol.108 , pp. 1306-1309
    • Cohn, J.N.1    Anand, I.S.2    Latini, R.3    Masson, S.4    Chiang, Y.T.5    Glazer, R.6
  • 90
    • 79958249630 scopus 로고    scopus 로고
    • Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure
    • McMurray JJ, Pitt B, Latini R, et al. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circ Heart Fail 2008; 1: 17-24.
    • (2008) Circ Heart Fail , vol.1 , pp. 17-24
    • McMurray, J.J.1    Pitt, B.2    Latini, R.3
  • 91
    • 79953908298 scopus 로고    scopus 로고
    • For the Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) investigators. Effect of the divert renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction
    • [Epub ahead of print]
    • Solomon SD, Hee Shin S, Shah A, et al. For the Aliskiren Study in Post-MI Patients to Reduce Remodeling (ASPIRE) investigators. Effect of the divert renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction. Eur Heart J 2011 [Epub ahead of print].
    • (2011) Eur Heart J
    • Solomon, S.D.1    Hee Shin, S.2    Shah, A.3
  • 92
    • 0038188560 scopus 로고    scopus 로고
    • Retarding progression of chronic renal disease: The neglected issue of residual proteinuria
    • Ruggenenti P, Perna A, Remuzzi G. Retarding progression of chronic renal disease: the neglected issue of residual proteinuria. Kidney Int 2003; 63: 2254-61.
    • (2003) Kidney Int , vol.63 , pp. 2254-2261
    • Ruggenenti, P.1    Perna, A.2    Remuzzi, G.3
  • 93
    • 33744990564 scopus 로고    scopus 로고
    • Does albuminuria predict cardiovascular outcomes on treatment with losartan versus atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy
    • Ibsen H, Olsen MH, Wachtell K, et al. Does albuminuria predict cardiovascular outcomes on treatment with losartan versus atenolol in patients with diabetes, hypertension, and left ventricular hypertrophy? The LIFE study. Diabetes Care 2006; 29: 595-600.
    • (2006) The LIFE study. Diabetes Care , vol.29 , pp. 595-600
    • Ibsen, H.1    Olsen, M.H.2    Wachtell, K.3
  • 94
    • 0942298203 scopus 로고    scopus 로고
    • Treatment of the patient with diabetes mellitus and risk of nephropathy: What do we know, and what do we need to learn?
    • Hollenberg NK. Treatment of the patient with diabetes mellitus and risk of nephropathy: what do we know, and what do we need to learn? Arch Intern Med 2004; 164(2): p. 125-30.
    • (2004) Arch Intern Med , vol.164 , Issue.2 , pp. 125-130
    • Hollenberg, N.K.1
  • 95
    • 0037431774 scopus 로고    scopus 로고
    • Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): A randomised controlled trial
    • Nakao N, Yoshimura A, Morita H, et al. Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 2003; 361: 117-24.
    • (2003) Lancet , vol.361 , pp. 117-124
    • Nakao, N.1    Yoshimura, A.2    Morita, H.3
  • 96
    • 70349771914 scopus 로고    scopus 로고
    • Retraction--Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in nondiabetic renal disease (COOPERATE): A randomised controlled trial
    • Retraction--Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in nondiabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 2009; 374: 1226.
    • (2009) Lancet , vol.374 , pp. 1226
  • 97
    • 33750949862 scopus 로고    scopus 로고
    • Add-on angiotensin receptor blocker in patients who have proteinuric chronic kidney diseases and are treated with angiotensin-converting enzyme inhibitors
    • Kanno Y, Takenaka T, Nakamura T, Suzuki H. Add-on angiotensin receptor blocker in patients who have proteinuric chronic kidney diseases and are treated with angiotensin-converting enzyme inhibitors. Clin J Am Soc Nephrol 2006; 1: 730-7.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 730-737
    • Kanno, Y.1    Takenaka, T.2    Nakamura, T.3    Suzuki, H.4
  • 98
    • 48049100806 scopus 로고    scopus 로고
    • Role of remission clinics in the longitudinal treatment of CKD
    • Ruggenenti P, Perticucci E, Cravedi P, et al. Role of remission clinics in the longitudinal treatment of CKD. J Am Soc Nephrol 2008; 19: 1213-24.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1213-1224
    • Ruggenenti, P.1    Perticucci, E.2    Cravedi, P.3
  • 99
    • 38149030811 scopus 로고    scopus 로고
    • Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: A systematic review
    • Bomback AS, Kshirsagar AV, Amamoo MA, Klemmer PJ. Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis 2008; 51: 199-211.
    • (2008) Am J Kidney Dis , vol.51 , pp. 199-211
    • Bomback, A.S.1    Kshirsagar, A.V.2    Amamoo, M.A.3    Klemmer, P.J.4
  • 100
    • 33845302661 scopus 로고    scopus 로고
    • Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease
    • Bianchi S, Bigazzi R, Campese VM. Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int 2006; 70: 2116-23.
    • (2006) Kidney Int , vol.70 , pp. 2116-2123
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 101
    • 33750274950 scopus 로고    scopus 로고
    • Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function
    • van den Meiracker AH, Baggen RG, Pauli S, et al. Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function. J Hypertens 2006; 24: 2285-92.
    • (2006) J Hypertens , vol.24 , pp. 2285-2292
    • van den Meiracker, A.H.1    Baggen, R.G.2    Pauli, S.3
  • 102
    • 72049109463 scopus 로고    scopus 로고
    • Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy
    • Mehdi UF, Adams-Huet B, Raskin P, Vega GL, Toto RD. Addition of angiotensin receptor blockade or mineralocorticoid antagonism to maximal angiotensin-converting enzyme inhibition in diabetic nephropathy. J Am Soc Nephrol 2009; 20: 2641-50.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 2641-2650
    • Mehdi, U.F.1    Adams-Huet, B.2    Raskin, P.3    Vega, G.L.4    Toto, R.D.5
  • 103
    • 40149090641 scopus 로고    scopus 로고
    • Effect of reninangiotensin-aldosterone system triple blockade on non-diabetic renal disease: Addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker
    • Furumatsu Y, Nagasawa Y, Tomida K, et al. Effect of reninangiotensin-aldosterone system triple blockade on non-diabetic renal disease: addition of an aldosterone blocker, spironolactone, to combination treatment with an angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker. Hypertens Res 2008; 31: 59-67.
    • (2008) Hypertens Res , vol.31 , pp. 59-67
    • Furumatsu, Y.1    Nagasawa, Y.2    Tomida, K.3
  • 104
    • 49749125234 scopus 로고    scopus 로고
    • Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: An open-label crossover randomized controlled trial
    • Tylicki L, Rutkowski P, Renke M, et al. Triple pharmacological blockade of the renin-angiotensin-aldosterone system in nondiabetic CKD: an open-label crossover randomized controlled trial. Am J Kidney Dis 2008; 52: 486-93.
    • (2008) Am J Kidney Dis , vol.52 , pp. 486-493
    • Tylicki, L.1    Rutkowski, P.2    Renke, M.3
  • 105
    • 77949655427 scopus 로고    scopus 로고
    • Intensive versus conventional therapy to slow the progression of idiopathic glomerular diseases
    • Bianchi S, Bigazzi R, Campese VM. Intensive versus conventional therapy to slow the progression of idiopathic glomerular diseases. Am J Kidney Dis 2010; 55: 671-81.
    • (2010) Am J Kidney Dis , vol.55 , pp. 671-681
    • Bianchi, S.1    Bigazzi, R.2    Campese, V.M.3
  • 106
    • 0035922444 scopus 로고    scopus 로고
    • The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes
    • Parving HH, Lehnert H, Bröchner-Morlensen J, et al., The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 2001; 345(12): p. 870-8.
    • (2001) N Engl J Med , vol.345 , Issue.12 , pp. 870-878
    • Parving, H.H.1    Lehnert, H.2    Bröchner-Morlensen, J.3
  • 107
    • 30944466929 scopus 로고    scopus 로고
    • Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria
    • Rossing K, Schjoedt KJ, Jensen BR, Boomsma F, Parving HH. Enhanced renoprotective effects of ultrahigh doses of irbesartan in patients with type 2 diabetes and microalbuminuria. Kidney Int 2005; 68: 1190-8.
    • (2005) Kidney Int , vol.68 , pp. 1190-1198
    • Rossing, K.1    Schjoedt, K.J.2    Jensen, B.R.3    Boomsma, F.4    Parving, H.H.5
  • 108
    • 0035719910 scopus 로고    scopus 로고
    • Optimal antiproteinuric dose of losartan in nondiabetic patients with nephrotic range proteinuria
    • Laverman GD, Henning RH, de Jong PE, Navis G, de Zeeuw D. Optimal antiproteinuric dose of losartan in nondiabetic patients with nephrotic range proteinuria. Am J Kidney Dis 2001; 38: 1381-4.
    • (2001) Am J Kidney Dis , vol.38 , pp. 1381-1384
    • Laverman, G.D.1    Henning, R.H.2    de Jong, P.E.3    Navis, G.4    de Zeeuw, D.5
  • 109
    • 34249897487 scopus 로고    scopus 로고
    • Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: A randomized controlled study of benazepril and losartan in chronic renal insufficiency
    • Hou FF, Xie D, Zhang X, et al., Renoprotection of Optimal Antiproteinuric Doses (ROAD) Study: a randomized controlled study of benazepril and losartan in chronic renal insufficiency. J Am Soc Nephrol, 2007. 18(6): p. 1889-98.
    • (2007) J Am Soc Nephrol , vol.18 , Issue.6 , pp. 1889-1898
    • Hou, F.F.1    Xie, D.2    Zhang, X.3
  • 110
    • 57249089007 scopus 로고    scopus 로고
    • Optimal dose of lisinopril for renoprotection in type 1 diabetic patients with diabetic nephropathy: A randomised crossover trial
    • Schjoedt KJ, Astrup AS, Persson F, et al. Optimal dose of lisinopril for renoprotection in type 1 diabetic patients with diabetic nephropathy: a randomised crossover trial. Diabetologia 2009; 52: 46-9.
    • (2009) Diabetologia , vol.52 , pp. 46-49
    • Schjoedt, K.J.1    Astrup, A.S.2    Persson, F.3
  • 111
    • 34548444609 scopus 로고    scopus 로고
    • Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus
    • Hollenberg NK, Parving HH, Viberti G, et al. Albuminuria response to very high-dose valsartan in type 2 diabetes mellitus. J Hypertens 2007; 25: 1921-6.
    • (2007) J Hypertens , vol.25 , pp. 1921-1926
    • Hollenberg, N.K.1    Parving, H.H.2    Viberti, G.3
  • 112
    • 33645060064 scopus 로고    scopus 로고
    • Additional antiproteinuric effect of ultrahigh dose candesartan: A double-blind, randomized, prospective study
    • Schmieder RE, Klingbeil AU, Fleischmann EH, Veelken R, Delles C. Additional antiproteinuric effect of ultrahigh dose candesartan: a double-blind, randomized, prospective study. J Am Soc Nephrol 2005; 16: 3038-45.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3038-3045
    • Schmieder, R.E.1    Klingbeil, A.U.2    Fleischmann, E.H.3    Veelken, R.4    Delles, C.5
  • 113
    • 65249126924 scopus 로고    scopus 로고
    • SMART (Supra Maximal Atacand Renal Trial) Investigators. Supramaximal dose of candesartan in proteinuric renal disease
    • Burgess E, Muirhead N, Rene de Cotret P, Chiu A, Pichette V, Tobe S. SMART (Supra Maximal Atacand Renal Trial) Investigators. Supramaximal dose of candesartan in proteinuric renal disease. J Am Soc Nephrol 2009; 20: 893-900.
    • (2009) J Am Soc Nephrol , vol.20 , pp. 893-900
    • Burgess, E.1    Muirhead, N.2    Rene de Cotret, P.3    Chiu, A.4    Pichette, V.5    Tobe, S.6
  • 115
    • 41149101190 scopus 로고    scopus 로고
    • Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: A systematic review and meta-analysis of randomized controlled trials
    • Lakhdar R, Al-Mallah MH, Lanfear DE. Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of randomized controlled trials. J Card Fail 2008; 14: 181-8.
    • (2008) J Card Fail , vol.14 , pp. 181-188
    • Lakhdar, R.1    Al-Mallah, M.H.2    Lanfear, D.E.3
  • 116
    • 3442888821 scopus 로고    scopus 로고
    • Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system
    • Palmer BF. Managing hyperkalemia caused by inhibitors of the renin-angiotensin-aldosterone system. N Engl J Med 2004; 351: 585-92.
    • (2004) N Engl J Med , vol.351 , pp. 585-592
    • Palmer, B.F.1
  • 117
    • 65949109277 scopus 로고    scopus 로고
    • The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy
    • Khan NA, Hemmelgarn B, Herman RJ, et al. The 2009 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2--therapy. Can J Cardiol 2009; 25: 287-98.
    • (2009) Can J Cardiol , vol.25 , pp. 287-298
    • Khan, N.A.1    Hemmelgarn, B.2    Herman, R.J.3
  • 118
    • 53549085406 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: The Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein K, Cohen-Solal A, Filippatos G, et al., ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008; 10: 933-89.
    • (2008) Eur J Heart Fail , vol.10 , pp. 933-989
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3
  • 119
    • 33745524927 scopus 로고    scopus 로고
    • Long-term safety of high-dose angiotensin receptor blocker therapy in hypertensive patients with chronic kidney disease
    • Weinberg AJ, Zappe DH, Ramadugu R, Weinberg MS. Long-term safety of high-dose angiotensin receptor blocker therapy in hypertensive patients with chronic kidney disease. J Hypertens Suppl 2006; 24: S95-9.
    • (2006) J Hypertens Suppl , vol.24
    • Weinberg, A.J.1    Zappe, D.H.2    Ramadugu, R.3    Weinberg, M.S.4
  • 120
    • 78649929199 scopus 로고    scopus 로고
    • AVOID study investigators. Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy
    • Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH; AVOID study investigators. impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy. Diabetes Care 2010; 33: 2304-9.
    • (2010) Diabetes Care , vol.33 , pp. 2304-2309
    • Persson, F.1    Lewis, J.B.2    Lewis, E.J.3    Rossing, P.4    Hollenberg, N.K.5    Parving, H.H.6
  • 121
    • 0031748479 scopus 로고    scopus 로고
    • The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide
    • Buter H, Hemmelder MH, Navis G, de Jong PE, de Zeeuw D. The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide. Nephrol Dial Transplant 1998; 13: 1682-5.
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 1682-1685
    • Buter, H.1    Hemmelder, M.H.2    Navis, G.3    de Jong, P.E.4    de Zeeuw, D.5
  • 122
    • 44049101711 scopus 로고    scopus 로고
    • Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan
    • Vogt L, Waanders F, Boomsma F, de Zeeuw D, Navis, G. Effects of dietary sodium and hydrochlorothiazide on the antiproteinuric efficacy of losartan. J Am Soc Nephrol 2008; 19: 999-1007.
    • (2008) J Am Soc Nephrol , vol.19 , pp. 999-1007
    • Vogt, L.1    Waanders, F.2    Boomsma, F.3    de Zeeuw, D.4    Navis, G.5
  • 123
    • 58049159166 scopus 로고    scopus 로고
    • Role of sodium intake in the progression of chronic kidney disease
    • Ritz E, Koleganova N, Piecha G. Role of sodium intake in the progression of chronic kidney disease. J Ren Nutr 2009; 19: 61-2.
    • (2009) J Ren Nutr , vol.19 , pp. 61-62
    • Ritz, E.1    Koleganova, N.2    Piecha, G.3
  • 124
    • 39449104268 scopus 로고    scopus 로고
    • Protocol of the Long-term Impact of RAS Inhibition on Cardiorenal Outcomes (LIRICO) randomized trial
    • Maione A, Nicolucci A, Craig JC, et al. Protocol of the Long-term Impact of RAS Inhibition on Cardiorenal Outcomes (LIRICO) randomized trial. J Nephrol 2007; 20: 646-55.
    • (2007) J Nephrol , vol.20 , pp. 646-655
    • Maione, A.1    Nicolucci, A.2    Craig, J.C.3
  • 125
    • 66849128220 scopus 로고    scopus 로고
    • Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHROND)
    • Fried LF, Duckworth W, Zhang JH, et al. Design of combination angiotensin receptor blocker and angiotensin-converting enzyme inhibitor for treatment of diabetic nephropathy (VA NEPHROND). Clin J Am Soc Nephrol 2009; 4: 361-8.
    • (2009) Clin J Am Soc Nephrol , vol.4 , pp. 361-368
    • Fried, L.F.1    Duckworth, W.2    Zhang, J.H.3
  • 126
    • 74949131237 scopus 로고    scopus 로고
    • Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: Prospective cohort analysis
    • Li NC, Lee A, Whitmer RA, et al. Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis. BMJ 2010; 340: b5465.
    • (2010) BMJ , vol.340
    • Li, N.C.1    Lee, A.2    Whitmer, R.A.3


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