Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia

Journal of Cardiovascular Pharmacology

Volumn 60, Issue 2, 2012, Pages 165-171

  Said, Tamer H ^a   Wilson, Lance D ^a   Jeyaraj, Darwin ^a   Fossa, Anthony A ^b   Rosenbaum, David S ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b ICardiac Technologies   (United States)

Author keywords

ion channels; optical mapping; proarrhythmia; QT interval; Torsade de Pointes; transmural dispersion of repolarization

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; BEPRIDIL; RISPERIDONE; VERAPAMIL;

ARTICLE; DISEASE MARKER; DOSE RESPONSE; DRUG INDUCED DISEASE; DRUG SCREENING; HEART MUSCLE CELL; HEART PERFUSION; HEART PROARRHYTHMIA; HEART REPOLARIZATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PREDICTOR VARIABLE; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; TORSADE DES POINTES;

ACTION POTENTIALS; ANIMALS; BEPRIDIL; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART CONDUCTION SYSTEM; HUMANS; LONG QT SYNDROME; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; PYRIDINES; RISK ASSESSMENT; RISPERIDONE; TIME FACTORS; TORSADES DE POINTES; TOXICITY TESTS; VERAPAMIL; VOLTAGE-SENSITIVE DYE IMAGING;

EID: 84865575137     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3182597f67     Document Type: Article

References (29)

1. Ben-David J, Zipes DP. Torsades de pointes and proarrhythmia. Lancet. 1993;341:1578-1582.
2. Fermini B, Fossa AA. The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Discov. 2003; 2:439-447.
3. Wilson LD, Said T, Rosenbaum DS. Disease models for elucidation of mechanisms and prediction of drug-induced proarrhythmia. Drug Discov Today. 2005;2:205-213.
4. Sicouri S, Antzelevitch C. A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: the M cell. Circ Res. 1991;68:1729-1741.
5. Akar FG, Yan GX, Antzelevitch C, et al. Unique topographical distribution of M cells underlies reentrant mechanism of torsade de pointes in the long-QT syndrome. Circulation. 2002;105:1247-1253.
6. Shimizu W, Antzelevitch C. Cellular basis for long QT, transmural dispersion of repolarization, and torsade de pointes in the long QT syndrome. J Electrocardiol. 1999;32:177-184.
7. Antzelevitch C. Role of transmural dispersion of repolarization in the genesis of drug-induced torsades de pointes. Heart Rhythm. 2005;2: S9-S15.
8. Akar FG, Antzelevitch YG, Rosenbaum DS. Reentrant mechanism of Torsdade de points based on topography and electrophhysiology of mid-myocardial cells: a transmural optical mapping study. Circulation. 1998.
9. Poelzing S, Akar FG, Baron E, et al. Heterogeneous connexin43 expression produces electrophysiological heterogeneities across ventricular wall. Am J Physiol Heart Circ Physiol. 2004;286:H2001-H2009.
10. Poelzing S, Roth BJ, Rosenbaum DS. Novel use of optical mapping to measure cell-to-cell coupling across the transmural wall. Pacing Clin Electrophysiol. 2002;24:604.
11. Wu JS, Biermann M, Rubart M, et al. Cytochalasin D as excitation- contraction uncoupler for optically mapping action potentials in wedges of ventricular myocardium. J Cardiovasc Electrophysiol. 1998; 9:1336-1347.
12. Fossa AA, Wisialowski T, Wolfgang E, et al. Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig. Eur J Pharmacol. 2004;486:209-221.
13. Redfern WS, Carlsson L, Davis AS, et al. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res. 2003;58: 32-45.
14. Rosenbaum DS, Kaplan D, Wilber D, et al. The precision of electrophysiological mapping: localizing depolarization wave fronts from digitized extracellular electrograms and the role of data sampling rate. J Cardiovasc Electrophysiol. 1990;1:2-14.
15. Rosenbaum DS, Girouard SD, Laurita KR. High resolution cardiac mapping with voltage sensitive dyes. Conf Proc IEEE Eng Med Biol Soc. 1992;14:1995-1996.
16. Girouard S, Laurita KR, Rosenbaum DS. Optical mapping can resolve propagation and recovery in the intact beating heart. Pacing Clin Electrophysiol. 1993;16:104.
17. Akar FG, Rosenbaum DS. Transmural heterogeneities of cellular repolarization underlie polymorphic ventricular tachycardia in failing myocardium. Am Heart Assoc. 2001:11-25.
18. Pajouh M, Wilson LD, Poelzing S, et al. IKs blockade reduces dispersion of repolarization in heart failure. Heart Rhythm. 2005;2:731-738.
19. Sicouri S, Moro S, Litovsky S, et al. Chronic amiodarone reduces transmural dispersion of repolarization in the canine heart. J Cardiovasc Electrophysiol. 1997;8:1269-1279.
20. Hondeghem LM, Carlsson L, Duker G. Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic. Circulation. 2001;103: 2004-2013.
21. Hondeghem LM, Dujardin K, De Clerck F. Phase 2 prolongation, in the absence of instability and triangulation, antagonizes class III proarrhythmia. Cardiovasc Res. 2001;50:345-353.
22. Carlsson L, Drews L, Duker G, et al. Attenuation of proarrhythmias related to delayed repolarization by low-dose lidocaine in the anesthetized rabbit. J Pharmacol Exp Ther. 1993;267:1076-1080.
23. Vos MA, Verduyn SC, Gorgels APM, et al. Reproducible induction of early after depolarizations and torsade de pointes arrhythmias by d-sotalol and pacing in dogs with chronic atrioventricular block. Circulation. 1995; 91:864-872.
24. De Groot SHM, Schoenmakers M, Molenschot MMC, et al. Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed after depolarization-dependent ventricular arrhythmias. Circulation. 2000;102:2145-2151.
25. Liu T, Brown BS, Wu Y, et al. Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of druginduced proarrhythmias. Heart Rhythm. 2006;3:948-956.
26. Panikkath R, Reinier K, Uy-Evanado A, et al. Prolonged Tpeak-to-tend interval on the resting ECG Is associated with increased risk of sudden cardiac death. Circ Arrhythm Electrophysiol. 2011;4:441-447.
27. Zhou ZF, Gong QM, Epstein ML, et al. HERG channel dysfunction in human long QT syndrome - intracellular transport and functional defects. J Biol Chem. 1998;273:21061-21066.
28. Kirsch GE, Trepakova ES, Brimecombe JC, et al. Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern. J Pharmacol Toxicol Methods. 2004;50:93-101.
29. Chouabe C, Drici MD, Romey G, et al. HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers. Mol Pharmacol. 1998;54:695-703.