Induction and characterization of endotoxin tolerance in equine peripheral blood mononuclear cells in vitro

Veterinary Immunology and Immunopathology

Volumn 149, Issue 1-2, 2012, Pages 97-102

  Frellstedt, Linda ^a   McKenzie, Harold C ^a   Barrett, Jennifer G ^a   Furr, Martin O ^a  

^a MARION DUPONT SCOTT EQUINE MEDICAL CENTER   (United States)

Author keywords

Endotoxin; Endotoxin tolerance; Equine; Interleukin 10; Interleukin 12

Indexed keywords

ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 12; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; ENDOTOXEMIA; ENDOTOXIN TOLERANCE; FEMALE; HORSE; IMMUNOLOGICAL TOLERANCE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PROTEIN EXPRESSION;

ANIMALS; ENDOTOXINS; FEMALE; HORSES; IMMUNE TOLERANCE; INTERLEUKIN-10; INTERLEUKIN-12; LEUKOCYTES, MONONUCLEAR; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; STATISTICS, NONPARAMETRIC; TUMOR NECROSIS FACTOR-ALPHA;

EQUIDAE;

EID: 84865568766     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2012.05.012     Document Type: Article

References (41)

1. Allen G.K., Campbell-Beggs C., Robinson J.A., Johnson P.J., Green E.M. Induction of early-phase endotoxin tolerance in horses. Equine Vet. J. 1996, 28:269-274.
2. Barton M.H. Endotoxemia. Current Therapy in Equine Medicine 2003, 104-111. Saunders, St. Louis. N.E. Robinson (Ed.).
3. Barton M.H., Morris D.D., Norton N., Prasse K.W. Hemostatic and fibrinolytic indices in neonatal foals with presumed endotoxemia. J. Vet. Intern. Med. 1998, 12:26-35.
4. Barton M.H., Collatos C., Moore J.N. Endotoxin induced expression of tumour necrosis factor, tissue factor and plasminogen activator inhibitor activity by peritoneal macrophages. Equine Vet. J. 1996, 28:382-389.
5. Berg D.J., Kuhn R., Rajewsky K., Muller W., Menon S., Davidson N., Grunig G., Rennick D. Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J. Clin. Invest. 1995, 96:2339-2347.
6. Burrows G.E. Equine Escherichia coli endotoxemia: comparison of intravenous and intraperitoneal endotoxin administration. Am. J. Vet. Res. 1979, 40:991-998.
7. de Waal Malefyt R., Abrams J.S., Bennett B., Figdor C.G., de Vries J.E. Interleukin 10 (IL10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 1991, 174:1209-1220.
8. de Waal Malefyt R., Moore K.W. Interleukin-10. The Cytokine Handbook 1998, 333-364. Academic Press Limited, San Diego. W.A. Thomson (Ed.).
9. Fiorentino D.F., Zlotnik A., Mosmann T.R., Howard M., O'Garra A. IL-10 inhibits cytokine production by activated macrophages. J. Immunol. 1991, 147:3815-3822.
10. Flohe S., Dominguez Fernandez E., Ackermann M., Hirsch T., Borgermann J., Schade F.U. Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 and HSP 70 in lung and liver during endotoxin shock. Cytokine 1999, 11:796-804.
11. Garton N.J., Gilleron M., Brando T., Dan H.H., Giguere S., Puzo G., Prescott J.F., Sutcliffe I.C. A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. J. Biol. Chem. 2002, 277:31722-31733.
12. Gerard C., Bruyns C., Marchant A., Abramowicz D., Vandenabeele P., Delvaux A., Fiers W., Goldman M., Velu T. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J. Exp. Med. 1993, 177:547-550.
13. Greisman S.E., Young E.J., Carozza F.A. Mechanisms of endotoxin tolerance. V. Specificity of the early and late phases of pyrogenic tolerance. J. Immunol. 1969, 103:1223-1236.
14. Hawkins D.L., MacKay R.J., MacKay S.L., Moldawer L.L. Human interleukin 10 suppresses production of inflammatory mediators by LPS-stimulated equine peritoneal macrophages. Vet. Immunol. Immunopathol. 1998, 66:1-10.
15. Heinzel F.P., Rerko R.M., Ling P., Hakimi J., Schoenhaut D.S. Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect. Immun. 1994, 62:4244-4249.
16. Kalinski P., Storkus W.J., Thomson A.W., Lotze M.T. Interleukin-12 Family (IL-12, 23, 12RA and 27). The Cytokine Handbook 2003, 383-408. Elsevier, London. A.W. Thomson, M.T. Lotze (Eds.).
17. Karp C.L., Wysocka M., Ma X., Marovich M., Factor R.E., Nutman T., Armant M., Wahl L., Cuomo P., Trinchieri G. Potent suppression of IL-12 production from monocytes and dendritic cells during endotoxin tolerance. Eur. J. Immunol. 1998, 28:3128-3136.
18. Krishnagopalan S., Kumar A., Parrillo J.E. Myocardial dysfunction in the patient with sepsis. Curr. Opin. Crit. Care 2002, 8:376-388.
19. Lopes M.A.F., Salter C.E., Vandenplas M.L., Berghaus R., Hurley D.J., Moore J.N. Expression of genes associated with inflammation induced by ex vivo exposure to lipopolysaccharide in peripheral blood leukocytes from horses with gastrointestinal disease. Am. J. Vet. Res. 2010, 71:1162-1169.
20. Marchant A. Interleukin-10 production during septicaemia. Lancet 1994, 343:707-708.
21. Moore J.N. An update on endotoxaemia. Part I. Mechanisms and pathways. Equine Vet. Educ. 1998, 10:300-306.
22. Moore J.N., Morris D.D. Endotoxemia and septicemia in horses: experimental and clinical correlates. J. Am. Vet. Med. Assoc. 1992, 200:1903-1914.
23. Peck O.M., Williams D.L., Breuel K.F., Kalbfleisch J.H., Fan H., Tempel G.E., Teti G., Cook J.A. Differential regulation of cytokine and chemokine production in lipopolysaccharide-induced tolerance and priming. Cytokine 2004, 26:202-208.
24. Rayhane N., Fitting C., Cavaillon J.M. Dissociation of IFN-gamma from IL-12 and IL-18 production in endotoxin tolerance. J. Endotoxin Res. 1999, 5:319-324.
25. Roy M.F. Sepsis in adults and foals. Vet. Clin. North Am. Equine Pract. 2004, 20:41-61.
26. Sanchez-Cantu L., Rode H.N., Christou N.V. Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor. Arch. Surg. 1989, 124:1432-1435. discussion 1435-1436.
27. Shnyra A., Brewington R., Alipio A., Amura C., Morrison D.C. Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J. Immunol. 1998, 160:3729-3736.
28. Steverink P.J., Sturk A., Rutten V.P., Wagenaar-Hilbers J.P., Klein W.R., van der Velden M.A., Nemeth F. Endotoxin, interleukin-6 and tumor necrosis factor concentrations in equine acute abdominal disease: relation to clinical outcome. J. Endotoxin Res. 1995, 2:289-299.
29. Sun W.C., Moore J.N., Hurley D.J., Vandenplas M.L., Linden J., Cao Z., Murray T.F. Adenosine A2A receptor agonists inhibit lipopolysaccharide-induced production of tumor necrosis factor-alpha by equine monocytes. Vet. Immunol. Immunopathol. 2008, 121:91-100.
30. Sutterwala F.S., Noel G.J., Clynes R., Mosser D.M. Selective suppression of interleukin-12 induction after macrophage receptor ligation. J. Exp. Med. 1997, 185:1977-1985.
31. Sykes B.W., Furr M., Giguere S. In vivo pretreatment with PGG-glucan fails to alter cytokine mRNA expression of equine peripheral blood mononuclear cells exposed to endotoxin ex vivo. Vet. Ther. 2005, 6:67-76.
32. Sykes B.W., Furr M.O. Equine endotoxaemia - a state-of-the-art review of therapy. Aust. Vet. J. 2005, 83:45-50.
33. Thoefner M.B., Ersboll A.K., Jensen A.L., Hesselholt M. Factor analysis of the interrelationships between clinical variables in horses with colic. Prev. Vet. Med. 2001, 48:201-214.
34. Tinker M.K., White N.A., Lessard P., Thatcher C.D., Pelzer K.D., Davis B., Carmel D.K. Prospective study of equine colic incidence and mortality. Equine Vet. J. 1997, 29:448-453.
35. van den Hoven R., Duvigneau J.C., Hartl R.T., Gemeiner M. Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides. Vet. Res. Commun. 2006, 30:921-928.
36. van der Poll T., Jansen J., Levi M., ten Cate H., ten Cate J.W., van Deventer S.J.H. Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees. J. Exp. Med. 1994, 180:1985-1988.
37. van der Poll T., Jansen P.M., Montegut W.J., Braxton C.C., Calvano S.E., Stackpole S.A., Smith S.R., Swanson S.W., Hack C.E., Lowry S.F., Moldawer L.L. Effects of IL-10 on systemic inflammatory responses during sublethal primate endotoxemia. J. Immunol. 1997, 158:1971-1975.
38. Veenman J.N., Dujardint C.L., Hoek A., Grootendorst A., Klein W.R., Rutten V.P. High volume continuous venovenous haemofiltration (HV-CVVH) in an equine endotoxaemic shock model. Equine Vet. J. 2002, 34:516-522.
39. Wanidworanun C., Strober W. Predominant role of tumor necrosis factor-alpha in human monocyte IL-10 synthesis. J. Immunol. 1993, 151:6853-6861.
40. Wysocka M., Kubin M., Vieira L.Q., Ozmen L., Garotta G., Scott P., Trinchieri G. Interleukin-12 is required for interferon-gamma production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 1995, 25:672-676.
41. Zisman D.A., Kunkel S.L., Strieter R.M., Gauldie J., Tsai W.C., Bramson J., Wilkowski J.M., Bucknell K.A., Standiford T.J. Anti-interleukin-12 therapy protects mice in lethal endotoxemia but impairs bacterial clearance in murine Escherichia coli peritoneal sepsis. Shock 1997, 8:349-356.