Pregnancy loss and role of infant HIV status on perinatal mortality among HIV-infected women

BMC Pediatrics

Volumn 12, Issue , 2012, Pages

  Kim, Hae Young ^a,b   Kasonde, Prisca ^c   Mwiya, Mwiya ^c   Thea, Donald M ^d   Kankasa, Chipepo ^c   Sinkala, Moses ^e   Aldrovandi, Grace ^f   Kuhn, Louise ^a,b  

^a Columbia University ^*  (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c UNIVERSITY TEACHING HOSPITAL   (Zambia)

^d BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^e Lusaka District Health Management Team   (Zambia)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Adverse pregnancy outcome; HIV infection; Infant mortality; Perinatal mortality; Risk factors; Vertical transmission

Indexed keywords

VIRUS RNA;

ADULT; ARTICLE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN TISSUE; LIVE BIRTH; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; NEWBORN; PERINATAL MORTALITY; POLYMERASE CHAIN REACTION; PREGNANCY OUTCOME; PREMATURE LABOR; RISK ASSESSMENT; SPONTANEOUS ABORTION; STILLBIRTH; VIRUS LOAD; ZAMBIA;

EID: 84865566363     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-12-138     Document Type: Article

References (53)

1. World Health Organization Towards universal access: Scaling up priority HIV/AIDS interventions in the health sector: progress report 2010 2010, World Health Organization, Geneva, World Health Organization.
2. Brocklehurst P, French R. The association between maternal HIV infection and perinatal outcome: a systematic review of the literature and meta-analysis. Brit J Obstet Gynaec 1998, 105:836-848. 10.1111/j.1471-0528.1998.tb10227.x, 9746375.
3. Chi BH, Wang L, Read JS, Taha TE, Sinkala M, Brown ER, Valentine M, Martinson F, Goldenberg RL. Predictors of stillbirth in Sub-Saharan Africa. Obstet Gynecol 2007, 110:989-997. 10.1097/01.AOG.0000281667.35113.a5, 17978109.
4. Braddick MR, Kreiss JK, Embree JE, Datta P. Impact of maternal HIV infection on obstetrical and early neonatal outcome. AIDS 1990, 4:1001-1005. 10.1097/00002030-199010000-00009, 2261113.
5. Castetbon K, Ladner J, Leroy V, Chauliac M, Karita E, De Clercq A, Van de Perre P, Dabis F, . Pregnancy, Study Group HIV Low birthweight in infants born to African HIV-infected women: relationship with maternal body weight during pregnancy. J Trop Pediatrics 1999, 45:152-157. Pregnancy, Study Group HIV.
6. Temmerman MCE, Ndinya-Achola J, Plummer FA, Coppens M, Piot P. Maternal human immunodeficiency virus-1 infection and pregnancy outcome. Obstet Gynecol 1994, 83:495-501. 10.1097/00006250-199404000-00002, 7907777.
7. Ryder RW, Nsa W, Hassig SE, Behets F, Rayfield M, Ekungola B, Nelson AM, Mulenda U, Francis H, Mwandagalirwa K, et al. Perinatal transmission of the human immunodeficiency virus type 1 to infants of seropositive women in Zaire. N Engl J Med 1989, 320:1637-1642. 10.1056/NEJM198906223202501, 2786145.
8. Taha T, Dallabetta G, Canner J, Chiphangwi J, Liomba G, Hoover D, Miotti P. The effect of human immunodeficiency virus infection on birth weight, and infant and child mortality in urban Malawi. Int J Epidemiol 1995, 24:1022-1029. 10.1093/ije/24.5.1022, 8557435.
9. Zijenah LS, Moulton LH, Iliff P, Nathoo K, Munjoma MW, Mutasa K, Malaba L, Zvandasara P, Ward BJ, Humphrey J, . ZVITAMBO Study Group Timing of mother-to-child transmission of HIV-1 and infant mortality in the first 6 months of life in Harare, Zimbabwe. AIDS 2004, 18:273-280. 10.1097/00002030-200401230-00017, 15075545, ZVITAMBO Study Group.
10. Lambert G, Thea DM, Pliner V, Steketee RW, Abrams EJ, Matheson P, Thomas PA, Greenberg B, Brown TM, Bamji M, Kalish ML. Effect of maternal CD4 + cell count, acquired immunodeficiency syndrome, and viral load on disease progression in infants with perinatally acquired human immunodeficiency virus type 1 infection. J Pediatr 1997, 130:890-897. 10.1016/S0022-3476(97)70274-9, 9202610.
11. Abrams EJ, Wiener J, Carter R, Kuhn L, Palumbo P, Nesheim S, Lee F, Vink P, Bulterys M, . Perinatal AIDS Collaborative Transmission Study (PACTS) Group Maternal health factors and early pediatric antiretroviral therapy influence the rate of perinatal HIV-1 disease progression in children. AIDS 2003, 17:867-877. 10.1097/00002030-200304110-00012, 12660534, Perinatal AIDS Collaborative Transmission Study (PACTS) Group.
12. Thea DM, Steketee RW, Pliner V, Bornschlegel K, Brown T, Orloff S, Matheson PB, Abrams EJ, Bamji M, Lambert G, et al. The effect of maternal viral load on the risk of perinatal transmission of HIV-1. AIDS 1997, 11:437-444. 10.1097/00002030-199704000-00006, 9084790.
13. Garcia PM, Kalish LA, Pitt J, Minkoff H, Quinn TC, Burchett SK, Kornegay J, Jackson B, Moye J, Hanson C. Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission. N Engl J Med 1999, 341:394-402. 10.1056/NEJM199908053410602, 10432324.
14. Mofenson LM, Lambert JS, Stiehm ER, Bethel J, Meyer WA, Whitehouse J, Moye J, Reichelderfer P, Harris DR, Fowler MG. Risk factors for perinatal transmission of human immunodeficiency virus type 1 in women treated with zidovudine. N Engl J Med 1999, 341:385-393. 10.1056/NEJM199908053410601, 10432323.
15. Kuhn L, Steketee R, Weedon J, Abrams E, Lambert G, Bamji M, Schoenbaum E, Farley J, Nesheim S, Palumbo P, et al. Distinct risk factors for intrauterine and intrapartum human immunodeficiency virus transmission and consequences for disease progression in infected children. J Infect Dis 1999, 179:52-58. 10.1086/314551, 9841822.
16. Dreyfuss ML, Msamanga GI, Spiegelman D, Hunter DJ, Urassa EJ, Hertzmark E, Fawzi WW. Determinants of low birth weight among HIV-infected pregnant women in Tanzania. Am J Clin Nutr 2001, 74:814-826.
17. Kuhn L, Abrams EJ, Matheson PB, Thomas PA, Lambert G, Bamji M, Greenberg B, Steketee RW, Thea DM. New York City Perinatal HIVTCSG: Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results. AIDS 1997, 11:429-435. 10.1097/00002030-199704000-00005, 9084789.
18. Newell M-L, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, Dabis F. Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. Lancet 2004, 364:1236-1243. 10.1016/S0140-6736(04)17140-7, 15464184.
19. Marinda E, Humphrey JH, Iliff PJ, Mutasa K, Nathoo KJ, Piwoz EG, Moulton LH, Salama P, Ward BJ, . The Zvitambo Study Group Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 2007, 26:519-526. 10.1097/01.inf.0000264527.69954.4c, 17529870, The Zvitambo Study Group.
20. Fox MP, Brooks D, Kuhn L, Aldrovandi G, Sinkala M, Kankasa C, Mwiya M, Horsburgh R, Thea DM. Reduced mortality associated with breast-feeding-acquired HIV infection and breast-feeding among HIV-infected children in Zambia. J Acq Immun Def Synd 2008, 48:90-96.
21. Wei R, Msamanga GI, Spiegelman D, Hertzmark E, Baylin A, Manji KM, Fawzi WW. Association between low birth weight and infant mortality in children born to human immunodeficiency virus 1-infected mothers in Tanzania. Pediatr Infect Dis J 2004, 23:530-535. 10.1097/01.inf.0000129691.42964.eb, 15194834.
22. McCormick MC. The contribution of low birth weight to infant mortality and childhood morbidity. N Engl J Med 1985, 312:82-90. 10.1056/NEJM198501103120204, 3880598.
23. Simmons LE, Rubens CE, Darmstadt GL, Gravett MG. Preventing Preterm Birth and Neonatal Mortality: exploring the Epidemiology, Causes, and Interventions. Semin Perinatol 2010, 34:408-415. 10.1053/j.semperi.2010.09.005, 21094415.
24. Thea DM, Vwalika C, Kasonde P, Kankasa C, Sinkala M, Semrau K, Shutes E, Ayash C, Tsai W-Y, Aldrovandi G, Kuhn L. Issues in the design of a clinical trial with a behavioral intervention-the Zambia exclusive breast-feeding study. Control Clin Trials 2004, 25:353-365. 10.1016/j.cct.2004.06.005, 15296810.
25. Kuhn L, Aldrovandi GM, Sinkala M, Kankasa C, Semrau K, Mwiya M, Kasonde P, Scott N, Vwalika C, Walter J, et al. Effects of early, abrupt weaning on HIV-free survival of children in Zambia. N Engl J Med 2008, 359:130-141. 10.1056/NEJMoa073788, 2577610, 18525036.
26. Kuhn L, Sinkala M, Semrau K, Kankasa C, Kasonde P, Mwiya M, Hu CC, Tsai WY, Thea Donald M, Aldrovandi Grace M. Elevations in mortality associated with weaning persist into the second year of life among uninfected children born to HIV-infected mothers. Clin Infect Dis 2010, 50:437-444. 10.1086/649886, 2805776, 20047479.
27. Walter J, Mwiya M, Scott N, Kasonde P, Sinkala M, Kankasa C, Kauchali S, Aldrovandi GM, Thea Donald M, Kuhn L. Reduction in preterm delivery and neonatal mortality after the introduction of antenatal cotrimoxazole prophylaxis among HIV-infected women with low CD4 cell counts. J Infect Dis 2006, 194:1510-1518. 10.1086/508996, 1773010, 17083035.
28. World Health Organization Antiretroviral therapy for HIV infection in adults and adolescents: recommendations for a public health approach 2010, World Health Organization, Geneva, World Health Organization.
29. Allison PD. Survival analysis using the SAS system: a practical guide 1995, SAS Institue Inc., Cary, NC.
30. Stringer EM, Vwalika B, Killam WP, Giganti MJ, Mbewe R, Chi BH, Chintu N, Rouse D, Goldenberg RL, Stringer JS. Determinants of stillbirth in Zambia. Obstet Gynecol 2011, 117:1151-1159. 10.1097/AOG.0b013e3182167627, 21508755.
31. Rollins NC, Coovadia HM, Bland RM, Coutsoudis A, Bennish ML, Patel D, Newell M-L. Pregnancy outcomes in HIV-infected and uninfected women in rural and urban South Africa. J Acq Immun Def Synd 2007, 44:321-328.
32. Kumar RM, Uduman SA, Khurranna AK. Impact of maternal HIV-1 infection on perinatal outcome. Int J Gynecol Obstet 1995, 49:137-143.
33. Kupka R, Kassaye T, Saathoff E, Hertzmark E, Msamanga GI, Fawzi WW. Predictors of stillbirth among HIV-infected Tanzanian women. Acta Obstet Gynecol Scand 2009, 88:584-592. 10.1080/00016340902835901, 2796303, 19306132.
34. Soeiro R, Rubinstein A, Rashbaum WK, Lyman WD. Maternofetal transmission of AIDS: frequency of human immunodeficiency virus type 1 nucleic acid sequences in human fetal DNA. J Infect Dis 1992, 166:699-703. 10.1093/infdis/166.4.699, 1527405.
35. Langston C, Lewis DE, Hammill HA, Popek EJ, Kozinetz CA, Kline MW, Hanson IC, Shearer WT. Excess intrauterine fetal demise associated with maternal human immunodeficiency virus infection. J Infect Dis 1995, 172:1451-1460. 10.1093/infdis/172.6.1451, 7594702.
36. Brossard Y, Aubin JT, Mandelbrot L, Bignozzi C, Brand D, Chaput A, Roume J, Mulliez N, Mallet F, Agut H, et al. Frequency of early in utero HIV-1 infection: a blind DNA polymerase chain reaction study on 100 fetal thymuses. AIDS 1995, 9:359-366.
37. Magder LS, Mofenson L, Paul ME, Zorrilla CD, Blattner WA, Tuomala RE, LaRussa P, Landesman S, Rich KC. Risk factors for in utero and intrapartum transmission of HIV. J Acquir Immune Defic Syndr 2005, 38:87-95. 10.1097/00126334-200501010-00016, 15608531.
38. Jourdain G, Mary J-Y, Le Coeur S, Ngo-Giang-Huong N, Yuthavisuthi P, Limtrakul A, Traisathit P, Mcintosh K, Lallemant M. Risk factors for in utero or intrapartum mother-to-child transmission of human immunodeficiency virus type 1 in Thailand. J Infect Dis 2007, 196:1629-1636. 10.1086/522009, 18008246.
39. Lopez M, Figueras F, Hernandez S, Lonca M, Garcia R, Palacio M, Coll O. Association of HIV infection with spontaneous and iatrogenic preterm delivery: effect of HAART. AIDS 2012, 26:37-43. 10.1097/QAD.0b013e32834db300, 22008651.
40. Tuomala RE, Shapiro DE, Mofenson LM, Bryson Y, Culnane M, Hughes MD, O'Sullivan MJ, Scott G, Stek AM, Wara D, Bulterys M. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med 2002, 346:1863-1870. 10.1056/NEJMoa991159, 12063370.
41. Shapiro RL, Hughes MD, Ogwu A, Kitch D, Lockman S, Moffat C, Makhema J, Moyo S, Thior I, McIntosh K, et al. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med 2010, 362:2282-2294. 10.1056/NEJMoa0907736, 2999916, 20554983.
42. Mphatswe W, Blanckenberg N, Tudor-Williams G, Prendergast A, Thobakgale C, Mkhwanazi N, McCarthy N, Walker BD, Kiepiela P, Goulder P. High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis. AIDS 2007, 21:1253-1261. 10.1097/QAD.0b013e3281a3bec2, 17545701.
43. Shearer WT, Quinn TC, LaRussa P, Lew JF, Mofenson L, Almy S, Rich K, Handelsman E, Diaz C, Pagano M, et al. Viral load and disease progression in infants infected with human immunodeficiency virus type 1. N Engl J Med 1997, 336:1337-1342. 10.1056/NEJM199705083361901, 9134873.
44. The Working Group on Pediatric Care Treatment and the Interagency Task team on Prevention and Treatment of HIV infection in Pregnant Women, Mothers and their Children Pediatric advocacy toolkit: For improved pediatric HIV diagnosis, care and treatment in high HIV prevalence countries and regions 2011, WHO and UNICEF, Geneva, The Working Group on Pediatric Care Treatment and the Interagency Task team on Prevention and Treatment of HIV infection in Pregnant Women, Mothers and their Children.
45. Violari A, Cotton MF, Gibb DM, Babiker AG, Steyn J, Madhi SA, Jean-Philippe P, McIntyre JA. Early antiretroviral therapy and mortality among HIV-infected infants. N Engl J Med 2008, 359:2233-2244. 10.1056/NEJMoa0800971, 2950021, 19020325.
46. Goetghebuer T, Haelterman E, Le Chenadec J, Dollfus C, Gibb D, Judd A, Green H, Galli L, Ramos JT, Giaquinto C, et al. Effect of early antiretroviral therapy on the risk of AIDS/death in HIV-infected infants. AIDS 2009, 23:597-604. 10.1097/QAD.0b013e328326ca37, 19194272.
47. Mehta S, Manji KP, Young AM, Brown ER, Chasela C, Taha TE, Read JS, Goldenberg RL, Fawzi WW. Nutritional indicators of adverse pregnancy outcomes and mother-to-child transmission of HIV among HIV-infected women. Am J Clin Nutr 2008, 87:1639-1649. 2474657, 18541551.
48. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJN, McGrath N, Mwakagile D, Antelman G, Mbise R, Herrera G, Kapiga S, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 1998, 351:1477. 10.1016/S0140-6736(98)04197-X, 9605804.
49. Olausson PO, Cnattingius S, Haglund B. Teenage pregnancies and risk of late fetal death and infant mortality. BJOG 1999, 106:116-121.
50. Gilbert WM, Jandial D, Field NT, Bigelow P, Danielsen B. Birth outcomes in teenage pregnancies. J Matern Fetal Neonatal Med 2004, 16:265-270. 10.1080/jmf.16.5.265.270, 15621541.
51. Chen X-K, Wen SW, Fleming N, Yang Q, Walker MC. Increased risks of neonatal and postneonatal mortality associated with teenage pregnancy had different explanations. J Clin Epidemiol 2008, 61:688-694. 10.1016/j.jclinepi.2007.08.009, 18538263.
52. Smith GCS, Pell JP. Teenage pregnancy and risk of adverse perinatal outcomes associated with first and second births: population based retrospective cohort study. BMJ 2001, 323:476. 10.1136/bmj.323.7311.476, 48130, 11532837.
53. Kline J, Stein Z, Susser M. Conception to Birth: Epidemiology of Prenatal Development (Monographs in Epidemiology and Biostatistics) 1989, Oxford University Press, New York.