Pharmacokinetics of topically applied econazole nitrate nanoparticles in rabbit eye

Chinese Journal of Experimental Ophthalmology

Volumn 30, Issue 8, 2012, Pages 677-680

  Wang, Bo ^a   Wang, Li Ya ^b   Chen, Peng ^a   Zhang, Jun Jie ^b  

^a Second People's Hospital of Zhengzhou   (China)

^b NONE

Author keywords

Econazole nitrate; High pressure liquid chromatography; Nanoparticles; Ocular pharmacokinetics

Indexed keywords

ECONAZOLE; EYE DROPS; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CORNEA; DIFFUSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG HALF LIFE; DRUG PENETRATION; EMULSION; EYE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGHT SCATTERING; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; RABBIT; TRANSMISSION ELECTRON MICROSCOPY;

EID: 84865559880     PISSN: 20950160     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.2095-0160.2012.08.002     Document Type: Article

References (12)

1. Sud U, Feingold D S. Mechanism of action of the anti-mycotic imidazoles [J]. J Invest Dermatol, 1981, 6:438-641.
2. Passerini N, Gavini E, Albertini B, et al. Evaluation of solid lipid microparticles produced by spray congealing for topical application of econazole nitrate [J]. J Pharm Pharmacol, 2009, 61:559-567.
3. Zimmer A, Zerbe H, Kreuter J. Evaluation of pilocarpine-loaded albumin particles as drug delivery systems for controlled delivery in the eye 1. in vitro and in vivo characterization [J]. J Control Release, 1994, 32:57-70.
4. Calvo P, Vila-Jato J L, Alonso M J. Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers[J]. Int J Pharm, 1997, 153:41-50.
5. Shome D, Poddar N, Sharma V, et al. Does a nanomolecule of carboplatin injected periocularly help in attaining higher intravitreal concentrations[J]? Invest Ophthalmol Vis Sci, 2009, 50: 5896-5900.
6. Zhang L, Li Y, Zhang C, et al. Pharmacokinetics and tolerance study of intravitreal injection of dexamethasone-loaded nanoparticles in rabbits[J]. Int J Nanomed, 2009, 4: 175-183.
7. Pignatello R, Ricupero N, Bucolo C, et al. Preparation and characterization of eudragit retard nanosuspensions for the ocular delivery of cloricromene [J/OL]. AAPS PharmSciTech, 2006, 7: E192-E198 [2011-08-22]. http://ukpmc.ac.uk/articles/PMC2750734.
8. Mandal B, Alexander K S, Riga A T. Sulfacetamide loaded Eudragit® RL100 nanosuspension with potential for ocular delivery [J], J Pharm Pharmaceut Sci, 2010, 13:510-523.
9. Jain V, Jain D, Singh R. Factors effecting the morphology of eudragit S100 based mierosponges bearing dicyclomine for colonic delivery [J]. J Pharm Sci, 2010, 100: 1545-1552.
10. Orlu M, Cevher E, Araman A. Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges [J]. Int J Pharm, 2006, 318: 103-117.
11. Jwala J, Boddu S H, Shah S, et al. Ocular sustained release nanoparticles containing stereoisomeric dipeptide prodrugs of acyclovir [J]. J Ocul Pharmacol Ther, 2011, 27: 163-172.
12. Raju H B, Goldberg J L. Nanotechnology for ocular therapeutics and tissue repair[J]. Expert Rev Ophthalmol, 2008, 3: 431-436.