Preparation and characterization of Eudragit Retard nanosuspensions for the ocular delivery of cloricromene

AAPS PharmSciTech

Volumn 7, Issue 1, 2006, Pages

  Pignatello, Rosario ^a   Ricupero, Nadia ^a   Bucolo, Claudio ^b   Maugeri, Francesco ^b   Maltese, Adriana ^b   Puglisi, Giovanni ^a  

^a UNIVERSITY OF CATANIA   (Italy)

^b BAUSCH AND LOMB   (United States)

Author keywords

AD6; Cloricromene; Eudragit Retard; Nanoparticles; Nanosuspensions; Ophthalmic drug delivery; Quasi emulsion solvent diffusion; Stability

Indexed keywords

AGENTS ACTING ON THE EYE; BENZALKONIUM CHLORIDE; BUFFER; CLORICROMEN; DISPERSANT; ESTER; EUDRAGIT; EUDRAGIT RS; PHOSPHATE BUFFERED SALINE; POLYMER; POLYSORBATE 80; SODIUM CHLORIDE; SOLVENT; SURFACTANT; 8-CHLOROCARBOCHROMEN; ACRYLIC ACID RESIN; CARBOCROMEN; DRUG DERIVATIVE; NANOMATERIAL;

ARTICLE; CHEMICAL PARAMETERS; DIFFUSION; DRUG BIOAVAILABILITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; EMULSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MOLECULAR SIZE; MOLECULAR STABILITY; NANOPARTICLE; PHARMACOLOGICAL PROCEDURES; SHELF LIFE; STORAGE TEMPERATURE; SUSPENSION; TECHNOLOGY; VELOCITY; ZETA POTENTIAL; CHEMISTRY; EYE; METABOLISM; PARTICLE SIZE; SOLUBILITY;

ACRYLIC RESINS; CHEMISTRY, PHARMACEUTICAL; CHROMONAR; DRUG STABILITY; EYE; NANOSTRUCTURES; PARTICLE SIZE; SOLUBILITY; SUSPENSIONS;

EID: 33645462293     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/pt070101     Document Type: Article

References (20)

1. Li VHK, Wood RW, Kreuter J, Harmia T, Robinson JR. Ocular drug delivery of progesterone using nanoparticles. J Microencapsul. 1986;3:213-218.
2. Marchal-Heussler L, Sirbat D, Hoffman M, Maincent P. Poly(ε-caprolactone) nanocapsules in carteolol ophthalmic delivery. Pharm Res. 1993;10:386-390.
3. Zimmer AK, Serbe H, Kreuter J. Evaluation of pilocarpine-loaded albumin particles as drug delivery systems for controlled delivery in the eye, I: In vitro and in vivo characterization. J Control Release. 1994;32:57-70.
4. Calvo P, Vila-Jato JL, Alonso MJ. Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers. Int J Pharm. 1997;153:41-50.
5. Bucolo C, Maltese A, Puglisi G, Pignatello R. Enhanced ocular anti-inflammatory activity of ibuprofen carried by a Eudragit RS100® nanoparticle suspension. Ophthalmic Res. 2002; 34:319-323.
6. Pignatello R, Bucolo C, Spedalieri G, Maltese A, Puglisi G. Flurbiprofen-loaded acrylate polymer nanosuspensions for ophthalmic application. Biomaterials. 2002;23:3247-3255.
7. Pignatello R, Bucolo C, Ferrara P, Maltese A, Puleo A, Puglisi G. Eudragit RS100® nanosuspensions for the ophthalmic controlled delivery of ibuprofen. Eur J Pharm Sci. 2002;16:53-61.
8. Kawashima Y, Iwamoto T, Niwa T, Takeuchi H, Hino T. Size control of ibuprofen microspheres with an acrylic polymer by changing the pH in an aqueous dispersion medium and its mechanism. Chem Pharm Bull (Tokyo). 1993;41:191-195.
9. Perumal D, Dangor CM, Alcock RS, Hurbans N, Moopanar KR. Effect of formulation variables on in vitro drug release and micromeritic properties of modified release ibuprofen microspheres. J Microencapsul. 1999;16:475-487.
10. Pignatello R, Amico D, Chiechio S, Giunchedi P, Spadaro C, Puglisi G. Preparation and analgesic activity of Eudragit RS100 microparticles containing diflunisal. Drug Deliv. 2001; 8:35-45.
11. Squadrito F, Prosdocimi M, Altavilla D, Zingarelli B, Caputi A. Cloricromene. Cardiovasc Drug Rev. 1991;4:357-371.
12. 2 formation in human platelets. Pharmacol Res Commun. 1980;12:329-337.
13. 2 activity in human platelets stimulated with thrombin. Agents Actions. 1990;29:364-373.
14. Travagli RA, Zatta A, Banzatto N, et al. Molecular aspects of cloricromene (AD6) distribution in human platelets and its pharmacological effects. Thromb Res. 1989;54:327-338.
15. Bucolo C, Cuzzocrea S, Mazzon E, Caputi AP. Effects of cloricromene, a coumarin derivative, on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2003;44:1178-1184.
16. Kawashima Y, Niwa T, Handa T, Takeuchi H, Iwamoto T, Itoh K. Preparation of controlled-release microspheres of ibuprofen with acrylic polymers by a novel quasi-emulsion solvent diffusion method. J Pharm Sci. 1989;78:68-72.
17. Maltese A, Bucolo C. Simultaneous determination of cloricromene and its active metabolite in rabbit aqueous humor by high-performance liquid chromatography. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;767:153-158.
18. Benita S. Prevention of topical and ocular oxidative stress by positively charged submicron emulsion. Biomed Pharmacother. 1999;53:193-206.
19. Klang S, Abdulrazik M, Benita S. Influence of emulsion droplet surface charge on indomethacin ocular tissue distribution. Pharm Dev Technol. 2000;5:521-532.
20. Bucolo C, Maltese A, Maugeri F, Busà B, Puglisi G, Pignatello R. Eudragit RL100 nanoparticle system for the oplithalmic delivery of cloricromene. J Pharm Pharmacol. 2004;56:841-846.