Regulatory T-cell profile in early and late lesions of cutaneous leishmaniasis due to leishmania major

Journal of Research in Medical Sciences

Volumn 17, Issue 6, 2012, Pages 513-518

  Hoseini, Shervin G ^a   Javanmard, Shaghayegh H ^c   Zarkesh, Sayyed H ^b   Khamesipour, Ali ^f   Rafiei, Laleh ^b   Karbalaie, Khadijeh ^d   Nilforoushzade, Mohamadali ^e   Baghaei, Mehdi ^g   Hejazi, Seyed H ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^e TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^f TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^g ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Cutaneous; Fluorescent antibody technique; Leishmania major; Leishmaniasis; Real time PCR; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3;

ADOLESCENT; ADULT; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; LEISHMANIA MAJOR; MALE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN BIOPSY; SKIN LEISHMANIASIS;

EID: 84865556730     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Pearson RD, Sousa AQ. Clinical spectrum of Leishmaniasis. Clin Infect Dis 1996;22:1-13.
2. Nylen S, Gautam S. Immunological perspectives of leishmaniasis. J Glob Infect Dis 2010;2:135-46.
3. Hepburn NC. Cutaneous leishmaniasis: An overview. J Postgrad Med 2003;49:50-4.
4. Karamian M, Motazedian MH, Fakhar M, Pakshir K, Jowkar F, Rezanezhad H. Atypical presentation of old-world cutaneous leishmaniasis, diagnosis and species identification by PCR. J Eur Acad Dermatol Venereol 2008;22:958-62.
5. Louis J, Himmelrich H, Parra-Lopez C, Tacchini-Cottier F, Launois P. Regulation of protective immunity against Leishmania major in mice. Curr Opin Immunol 1998;10:459-64.
6. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995;13:151-77.
7. Gaafar A, Veress B, Permin H, Kharazmi A, Theander TG, el Hassan AM. Characterization of the local and systemic immune responses in patients with cutaneous leishmaniasis due to Leishmania major. Clin Immunol 1999;91:314-20.
8. Louzir H, Melby PC, Ben Salah A, Marrakchi H, Aoun K, Ben Ismail R, et al. Immunologic determinants of disease evolution in localized cutaneous leishmaniasis due to Leishmania major. J Infect Dis 1998;177:1687-95.
9. Ajdary S, Jafari-Shakib R, Riazi-Rad F, Khamesipour A. Soluble CD26 and CD30 levels in patients with anthroponotic cutaneous leishmaniasis. J Infect 2007;55:75-8.
10. Jafari-Shakib R, Shokrgozar MA, Nassiri-Kashani M, Malakafzali B, Nikbin B, Khamesipour A. Plasma sCD26 and sCD30 levels in cutaneous leishmaniasis. Acta Trop 2009;109:61-3.
11. Shalev I, Schmelzle M, Robson SC, Levy G. Making sense of regulatory T cell suppressive function. Semin Immunol 2011;23:282-92.
12. Belkaid Y, Sun CM, Bouladoux N. Parasites and immunoregulatory T cells. Curr Opin Immunol 2006;18:406-12.
13. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol 2005;6:353-60.
14. Sacks D, Anderson C. Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice. Immunol Rev 2004;201:225-38.
15. Campanelli AP, Roselino AM, Cavassani KA, Pereira MS, Mortara RA, Brodskyn CI, et al. CD4 CD25 T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J Infect Dis 2006;193:1313-22.
16. Bourreau E, Ronet C, Darsissac E, Lise MC, Marie DS, Clity E, et al. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. J Infect Dis 2009;199:576-9.
17. Bourreau E, Ronet C, Darcissac E, Lise MC, Sainte Marie D, Clity E, et al. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect Immun 2009;77:1465-74.
18. Nasereddin A, Jaffe CL. Rapid diagnosis of old world leishmaniasis by high-resolution melting analysis of the 7SL RNA gene. J Clin Microbiol 2010;48:2240-2.
19. Berglund SR, Schwietert CW, Jones AA, Stern RL, Lehmann J, Goldberg Z. Optimized methodology for sequential extraction of RNA and protein from small human skin biopsies. J Invest Dermatol 2007;127:349-53.
20. Miyagawa Y, Kiyokawa N, Ochiai N, Imadome K, Horiuchi Y, Onda K, et al. Ex vivo expanded cord blood CD4 T lymphocytes exhibit a distinct expression profile of cytokine-related genes from those of peripheral blood origin. Immunology 2009;128:405-19.
21. Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008;3:1101-8.
22. Ji J, Masterson J, Sun J, Soong L. CD4 + CD25 + regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J Immunol 2005;174:7147-53.
23. Thomas BN, Buxbaum LU. FcgammaRIII mediates immunoglobulin G-induced interleukin-10 and is required for chronic Leishmania mexicana lesions. Infect Immun 2008;76:623-31.
24. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4 + CD25 + regulatory T cells control Leishmania major persistence and immunity. Nature 2002;420:502-7.
25. Anderson CF, Mendez S, Sacks DL. Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice. J Immunol 2005;174:2934-41.
26. Aseffa A, Gumy A, Launois P, MacDonald HR, Louis JA, Tacchini- Cottier F. The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 + CD25 + T cells. J Immunol 2002;169:3232-41.
27. Wohlfert E, Belkaid Y. Role of endogenous and induced regulatory T cells during infections. J Clin Immunol 2008;28:707-15.
28. Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4 (+)CD25 (-) Foxp3 (-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007;204:285-97.
29. Nagase H, Jones KM, Anderson CF, Noben-Trauth N. Despite increased CD4 + Foxp3 + cells within the infection site, BALB/c IL-4 receptor-deficient mice reveal CD4 + Foxp3-negative T cells as a source of IL-10 in Leishmania major susceptibility. J Immunol 2007;179:2435-44.
30. Radulovic S, Jacobson MR, Durham SR, Nouri-Aria KT. Grass pollen immunotherapy induces Foxp3-expressing CD4 + CD25 + cells in the nasal mucosa. J Allergy Clin Immunol 2008;121:1467-72, 72 e1.
31. Bovenschen HJ, van Vlijmen-Willems IM, van de Kerkhof PC, van Erp PE. Identification of lesional CD4 + CD25 + Foxp3 + regulatory T cells in Psoriasis. Dermatology 2006;213:111-7.
32. de Boer OJ, van der Loos CM, Teeling P, van der Wal AC, Teunissen MB. Immunohistochemical analysis of regulatory T cell markers FOXP3 and GITR on CD4 + CD25 + T cells in normal skin and inflammatory dermatoses. J Histochem Cytochem 2007;55:891-8.
33. Fujimura T, Okuyama R, Ito Y, Aiba S. Profiles of Foxp3 + regulatory T cells in eczematous dermatitis, psoriasis vulgaris and mycosis fungoides. Br J Dermatol 2008;158:1256-63.