Mutational showers during carcinogenesis

Pigment Cell and Melanoma Research

Volumn 25, Issue 5, 2012, Pages 566-568

  Kaufmann, William K ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MUTAGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOSINE; DOUBLE STRANDED DNA; GUANINE; MESYLIC ACID METHYL ESTER; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN TIMELESS; SINGLE STRANDED DNA;

CANCER CELL; CARCINOGENESIS; CHROMATID; COLORECTAL CANCER; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; GENE INACTIVATION; HUMAN; MELANOMA; NONHUMAN; NOTE; ONCOGENE K RAS; ONCOGENE N RAS; SOMATIC MUTATION; XERODERMA PIGMENTOSUM; YEAST CELL;

CELL TRANSFORMATION, NEOPLASTIC; DNA REPLICATION; DNA, FUNGAL; GENOME, HUMAN; HUMANS; MELANOMA; METHYL METHANESULFONATE; MUTAGENESIS; MUTATION; NEOPLASMS; SACCHAROMYCES CEREVISIAE;

EID: 84865534031     PISSN: 17551471     EISSN: 1755148X     Source Type: Journal    
DOI: 10.1111/j.1755-148X.2012.01034.x     Document Type: Note

References (10)

1. Berger, M.F., Hodis, E., Heffernan, T.P. et al. (2012). Melanoma genome sequencing reveals frequent PREX2 mutations. Nature 485, 502-506.
2. Kaina, B. (2004). Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. Cytogenet. Genome Res. 104, 77-86.
3. Kraemer, K.H., Lee, M.M., Andrews, A.D., and Lambert, W.C. (1994). The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch. Dermatol. 130, 1018-1021.
4. Loeb, L.A. (1991). Mutator phenotype may be required multistage carcinogenesis. Cancer Res. 51, 3075-3079.
5. Nedelcheva, M.N., Roguev, A., Dolapchiev, L.B., Shevchenko, A., Taskov, H.B., Shevchenko, A., Stewart, A.F., and Stoynov, S.S. (2005). Uncoupling of unwinding from DNA synthesis implies regulation of MCM helicase by Tof1/Mrc1/Csm3 checkpoint complex. J. Mol. Biol. 347, 509-521.
6. Nik-Zainal, S., Alexandrov, L.B., Wedge, D.C. et al. (2012). Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979-993.
7. Roberts, S.A., Sterling, J., Thompson, C. et al. (2012). Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol. Cell 46, 424-435.
8. Rogozin, I.B., Pavlov, Y.I., Bebenek, K., Matsuda, T., and Kunkel, T.A. (2001). Somatic mutation hotspots correlate with DNA polymerase eta error spectrum. Nat. Immunol. 2, 530-536.
9. Smith, K.D., Fu, M.A., and Brown, E.J. (2009). Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. J. Cell Biol. 187, 15-23.
10. Yang, Y., Gordenin, D.A., and Resnick, M.A. (2010). A single-strand specific lesion drives MMS-induced hyper-mutability at a double-strand break in yeast. DNA Repair (Amst) 9, 914-921.