Innovation in drug delivery by inhalation

ONdrugDelivery

Volumn , Issue 7, 2010, Pages 4-8

  Leone Bay, Andrea ^a   Baughman, Robert ^b   Smutney, Chad ^c   Kocinsky, Joseph ^d  

^a Pharmaceutical Development   (United States)

^b Clinical Pharmacology and Bioanalytics ^*  (United States)

^c Device Technology   (United States)

^d Pharmaceutical Technology Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFREZZA; EXCIPIENT; FUMARYLDIKETOPIPERAZINE; INSULIN; INSULIN ASPART; INSULIN GLARGINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; BODY WEIGHT; CHEMICAL STRUCTURE; COST EFFECTIVENESS ANALYSIS; COUGHING; CRYSTAL; CRYSTALLIZATION; DEVICE; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SAFETY; DRUG SELF ADMINISTRATION; DRUG TOLERABILITY; DRY POWDER; FLOW RATE; GEOMETRY; GLYCEMIC CONTROL; HUMAN; HYPOGLYCEMIA; INJECTION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; LUNG FUNCTION; MAJOR CLINICAL STUDY; MEDICAL TECHNOLOGY; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; POWDER INHALER; PRESSURE; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIDE EFFECT; SPRAY DRYING; TREATMENT OUTCOME; WEIGHT GAIN;

EID: 78650086929     PISSN: None     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Review

References (20)

1. Pfützner A, Mann AE, Steiner SS. Technosphere™/Insulin - a new approach for effective delivery of human insulin via the pulmonary route. Diabetes Technol Ther 2002; 4: 589-594.
2. Kaur N, Zhou B, Breitbeil F. A delineation of diketopiperazine self-assembly processes: understanding the molecular events involved in Nε-(fumaryl)diketopiperazine of L-Lys (FDKP) interactions. Mol Pharm 2008; 5: 294-315.
3. Bergeron RJ, Phanstiel O IV, Yao GW, Milstein S, Weimar WR. Macromolecular self-assembly of diketopiperazine tetrapeptides. J Am Chem Soc 1994; 116: 8479-8484.
4. Luo T-JM, Palmore GTR. Influence of structure on the kinetics of assembly of cyclic dipeptides into supramolecular tapes. J Phys Org Chem 2000; 13: 870-879.
5. Palacin S, Chin DN, Simanek EE et al. Hydrogen-bonded tapes based on symmetrically substituted diketopiperazines: a robust structural motif for the engineering of molecular solids. J Am Chem Soc 1997; 119: 11807-11816.
6. Palmore GTR, McBride MT. Engineering layers in molecular solids with cyclic dipeptide of (S)-aspartic acid. Chem Commun 1998; 1: 145-146 (Pubitemid 128686654)
7. Leone-Bay A, Grant M. Technosphere® technology: a platform for inhaled therapeutics. ONdrugDelivery 2006; 8-11
8. Angelo R, Rousseau K, Grant M, Leone-Bay A, Richardson P.. Technosphere® Insulin: Defining the Role of Technosphere Particles at the Cellular Level. J Diabetes Sci and Tech, 2009, 3, 545-554.
9. D Edwards, A Ben-Jabria, R Langer, Recent Advances in Pulmonary Drug Delivery, J. Appl. Physiol., 84(2): 379-385, 1998
10. De Koning JP, Dry Powder Inhalation. Technical and Physiological Aspects, Prescribing and Use, Thesis, University of Groningen 2001
11. Martonen T, Smyth H, Issacs K, Burton R, Issues in Drug Delivery: Concept and Practice, Respiratory Care, 2005, 50(9): 1228-1250 (Pubitemid 46177974)
12. Frijlink HW, de Boer AH, Dry Powder Inhalers for Pulmonary Drug Delivery, Expert Opinion on Drug Delivery, 2004, 1(1): 67-86
13. Svartengren K, Lindestad P, Svartengren M, Philipson K, Bylin G, Camner P, Added External Resistance Reduces Oropharyngeal Deposition and Increases Lung Deposition of Aerosol Particles in Asthmatics, American Journal of Respiratory Critical Care Medicine, 1995, 152(1): 32-27
14. Terzano C, Colombo P, State of the Art and New Perspectives on Dry Powder Inhalers, European Review for Medical and Pharmacological Sciences, 1999, 3:247-254
15. Patton, J.S., Bukar, J.G, Eldon, M.A. Clinical pharmacokinetics and pharmacodynamics of inhaled insulin, Clinical Pharmacokinetics, (2004) 43(12):781-801.
16. Gänsslen, M. Uber inhalation vo insulin. Kinische Wochenschrift (1925) 4:71
17. Heinemann, L., Heise, T. Current status of the development of inhaled Insulin. Br J Diabetes Vasc Dis (2004) 4:295-301 (Pubitemid 39462106)
18. Cefalu, W. Concept, Strategies, and Feasibility of Insulin Delivery. Diabetes Care (2004) 27(1):239-246.
19. Boss, A, H., 2006. Technospheres Insulin as effective as sc rapid acting insulin analogue in providing glycemic control in both patients with type 1 and type 2 diabetes. Presented at the Sixth Annual Diabetes Technology Meeting, November 2-4, 2006, Atlanta, GA.
20. Rosenstock J. et al., Prandial inhaled insulin plus basal insulin glargine versus twice daily biaspart insulin for type 2 diabetes: a multicentre randomised trial, Lancet (2010) 375:2244-53.