Hyaluronan synthase polymerizing activity and control of product size are discrete enzyme functions that can be uncoupled by mutagenesis of conserved cysteines

Glycobiology

Volumn 22, Issue 10, 2012, Pages 1302-1310

  Weigel, Paul H ^a   Baggenstoss, Bruce A ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

active site cysteines; elongation rate; polymer length; size control; size control model

Indexed keywords

BACTERIAL ENZYME; BACTERIAL PROTEIN; CYSTEINE; HYALURONIC ACID; PROTEIN CYSTEINE226; PROTEIN CYSTEINE262; PROTEIN CYSTEINE281; PROTEIN CYSTEINE367; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; LASER; LIGHT SCATTERING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN POLYMERIZATION; STREPTOCOCCUS DYSGALACTIAE EQUISIMILIS; WILD TYPE;

CYSTEINE; GLUCURONOSYLTRANSFERASE; HYALURONIC ACID; KINETICS; MUTAGENESIS; STREPTOCOCCUS EQUI;

MAMMALIA; STREPTOCOCCUS DYSGALACTIAE SUBSP. EQUISIMILIS;

EID: 84865497466     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cws102     Document Type: Article

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